2ECN


Conserved Protein Domain Family
RING-HC_RNF141
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cd16545: RING-HC_RNF141 (this model, PSSM-Id:319459 is obsolete and has been replaced by 438207)
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RING finger, HC subclass, found in RING finger protein 141 (RNF141) and similar proteins
RNF141, also known as zinc finger protein 230 (ZNF230), is a RING finger protein present primarily in the nuclei of spermatogonia, the acrosome, and the tail of spermatozoa. It may have a broad function during early development of vertebrates. It plays an important role in spermatogenesis, including spermatogenic cell proliferation and sperm maturation, as well as motility and fertilization. It also exhibits DNA binding activity. RNF141 corresponding ZNF230 gene mutation may be associated with azoospermia. RNF141 contains a C3HC4-type RING finger domain that may function as an activator module in transcription.
Links
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Statistics
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PSSM-Id: 319459
Aligned: 17 rows
Threshold Bit Score: 69.3553
Created: 2-May-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteRING-HC finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2ECN; Homo sapiens RNF141 binds two Zn2+ ions through its RING-HC finger.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #          # #  #  #           #  # 
2ECN_A        17 ECCICMDgraDLILPCAHSFCQKCIDKWSdrh-rnCPICR 55  human
ELU04440     147 ECCICMDrkaGIILPCAHVYCEQCIDAWNvnh-ntCPICR 185 Capitella teleta
EDO48726     159 ECCICMEqqsEIILACVHSFCKSCIDRWSdsh-ntCPICR 197 starlet sea anemone
EKC30700     197 ECCICMErrsEIILPCTHQFCEGCIDTWNvtn-ktCPICR 235 Pacific oyster
EEC05440      64 ECCVCMErkpEVTLPCTHSYCLFCIEQWNvsn-ttCPLCR 102 black-legged tick
Q8WVD5       154 ECCICMDgraDLILPCAHSFCQKCIDKWSdrh-rnCPICR 192 human
XP_013410899 151 ECIICMErkaDVILPCAHLYCEQCIDRWSvss-htCPVCR 189 Lingula anatina
XP_006812631 157 ECCICMDartDIILTCNHMYCEKCIDKWNvnh-hqCPICR 195 Saccoglossus kowalevskii
KRT82390     153 VCCICFDrktEVLLPCTHSYCLICIEEWNedh-dtCPVCR 191 Oryctes borbonicus
KHN84447     133 ECIICMErapDTILPCAHSYCLVCIEQWKaygkslCPVCR 172 dog roundworm

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