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Conserved Protein Domain Family
Synuclein
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pfam01387: Synuclein (this model, PSSM-Id:396110 is obsolete and has been replaced by 460186)
Synuclein
There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.
Links
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Statistics
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PSSM-Id: 396110
Aligned: 14 rows
Threshold Bit Score: 127.726
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6LRQ_A         1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQK 80 
XP_015203361   1 MDVLKKGFSIAKEGVVAAAEKTKQGVEEAAAKTKEGVMYVGTKTKEGVVHSVNTVAQKTTEQANIVGETVVGSANQVSAK 80  spotted gar
Q28F65         1 MDVFKKGFSMAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVGAKTKEGVVHSVSTVAEKTKEQANVVGGAVVSGVNQVASK 80  tropical clawed...
XP_003455005   1 MDALMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMYVGTKTKDG----VTTVAGKTVSGVSQVGEAVVTGVTAVAQK 76  Nile tilapia
XP_011602812   1 MDAFMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMFVGTKTKDG----VTVVAGKTVSGVSQVGGAMVTGVTAVAQK 76  torafugu
XP_012321796   1 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFS-------- 72  Ma's night monkey
XP_007478272   1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKTKEGVVQSVTSVAEKTKEQANLVSDVMVASVNTVANK 80  gray short-tail...
XP_003994186   1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVTSVNTVAIK 80  domestic cat
O76070         1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATK 80  human
XP_008112683   1 MDVFKKGFSIAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVGAKTKEGVVQSVTSVAEKTKEQANLVGESVVASVNTVAKQ 80  green anole

6LRQ_A        81 TVEGAGSIAAATGFVKKDQLg---kNEEGAPQegile--dmpvDPDNEAYEMPSEE 131
XP_015203361  81 TVEGVENVVASTGVVNPDDAv----NQEDFSR-----------PPEGTVEQATDAV 121 spotted gar
Q28F65        81 TVEGTENIVGTTGLVKKEDLhp-gqPEEPAAE-------------EEPAVEATEST 122 tropical clawed frog
XP_003455005  77 TVEGAGTIAAATGLVKKD-------PAKQSDDasavq-dvaesPVDTDPADVTEED 124 Nile tilapia
XP_011602812  77 TVESAGSIAAATGLVKKE-------PGKQGDDaatae-nmaesPDVTDPAEATEED 124 torafugu
XP_012321796  73 ---GAGNIAAATGLVKREEFptdlkPEEVAQEaaeeplieplmEPEGESYEDPPQV 125 Ma's night monkey
XP_007478272  81 TVEEAENIVVTSGIVRKEDLvn-paQPEHGAP-------------EEQPAEAAEVT 122 gray short-tailed opossum
XP_003994186  81 TVEEAENIAITSGVIRKEDLeq-paPSQEDKAa----------KAEEEVAEEAKSG 125 domestic cat
O76070        81 TVEEAENIAVTSGVVRKEDLrp-saPQQEGEAs----------KEKEEVAEEAQSg 125 human
XP_008112683  81 TVEGAETVVSSTGVVKMEDLhp-eqPEEPLAD-----------AEEDAPVEATETS 124 green anole
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