Conserved Protein Domain Family
TMEM18

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pfam14770: TMEM18 
Transmembrane protein 18
The function of this family is not known, however it is predicted to be a three-pass membrane protein.
Statistics
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PSSM-Id: 405460
Aligned: 48 rows
Threshold Bit Score: 96.8944
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAM71136      58 NFYTAVNWSEPFFRYLGVFHAVVWVAAITAtwGAvSDERIMVVCAVLGVLVLSGIPANSYAGRHAERLFQEpgvNYFTED 137
Q381E2        49 AFISAVNWWEPYFRYLALFHLTVAVTVVLTtwRA-SIDRIFVVTVLLLLVVWGSSYLNEWGSSHASQIFVEkgaNYFDPS 127 Trypanosoma brucei
Q4DAM3        51 DFVAAVNWSEPFFTYLALFHTLVIVLVLVLtwRA-SAERIFVVAFFVLLLGWCSSYLNEYGRLHAAEIFVEkgvNYFDRG 129 Trypanosoma cruzi
KJE93691      40 AILRETDWTEPWLVGLLSFHVFNVIVALFA--RR-HSTFQATYFCVLMVLAYSTEHLNKWAVDNWQQFSAK---AYFDVH 113
XP_002899645  22 KWYEAVDWTEPLIVGLLSFHVVLLATLWLT--RK-RLYTQFALFVLIILLVMSTEALNKWARENWRLFATQ---RYFDEQ 95 
XP_002970533   2 AFVHAVDWTEPWIGALVAFHLFLLVFILWT--RR-NTDLQMAIFFLSMFGIYLAQTINSFLARHWQKFSRQ---PYFDKR 75 
EAY23463      21 GIFAKVKWTDIPIVTTIILYLILLIIALKV--RR-NPRRRTIVFVLCLGITLGIGQLGPIMEKNWKIFGFSd--NYFDEF 95 
XP_002177251  99 AFRHAITWSEPFILFLIAFQCVIFGLSLWVskRDrGLAPRLILMSVIAGTVRSSELLNSYAAQNWGKFCTQ---NYFDDR 175
EED93362      13 AFSAAITWNEPFIRCLIAFHVLFIVAAIVLirKG-DIYFRMGFMVVIGVIVRLAERLNQYGNNHWREFSTQ---NYFDRS 88 
CBN75919      63 AFRSAVDWSEPWIQGILVFHLLLWVFFIVT--RR-SFGAQVGLFAVVLTGTRLSEFINTCLRDRWQNFSRQ---NYFDEH 136
CAM71136     138 GTMMMVVYLLPLLVLLVYLQLRQGYRVVSLMVQL---KRAQLRRRMR 181
Q381E2       128 GLFIMVTLDMPLFLLVLWLQARAFLQLLRLMVVV---KRNQIKREME 171 Trypanosoma brucei
Q4DAM3       130 GLFISVVYFCPIFLVALLLQGRILLQMLRLMVDT---KRRQLRKEMA 173 Trypanosoma cruzi
KJE93691     114 GLFISTVFAGPLLLTSLLFVVVWMKTAADLLVKV---KRAELRTRAR 157
XP_002899645  96 GVFMGIFYAGPLLASGFFQLLLSMKNMVDMVVIV---KRAEYRQQLK 139
XP_002970533  76 GVFISTLWSGPLLVTSMVILVNSLLQMVRLMVKW---KRAELKHKAR 119
EAY23463      96 GVFLTFFFALPPVFIAILLLSQLVGNITDKVIHRyvnNRTEHNEPAE 142
XP_002177251 176 GIFVMIMVCAPLLLDSLIMLILFMKEAAQLLVQV---KSAELKKKHG 219
EED93362      89 GIFMGIMICAPLLVICFVLLVTLIREASNLLVDV---KRMKM----- 127
CBN75919     137 GIFMGVMWAGPLLILGFTMLVSLLCQTASLLVTV---KTKQFKREIA 180
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