3UWL,2AAZ,3NRR,5H3A,3KGB,1TIS


Conserved Protein Domain Family
Thymidylat_synt

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pfam00303: Thymidylat_synt (this model, PSSM-Id:395239 is obsolete and has been replaced by 459753)
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Thymidylate synthase
This is a family of proteins that are flavin-dependent thymidylate synthases.
Statistics
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PSSM-Id: 395239
Aligned: 462 rows
Threshold Bit Score: 209.564
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3UWL_A            3 EAYLALGKKILEEGHFKED-RTGTGTYSLFGYQMRFDLAKG-FPLLTTKRVPFGLIKSELLWFLKGDTNIRYLLERNNHI 80  Enterococcus...
WP_004242187      2 EQYLDIAKRILEEGKWIENkRTGKRCLTIINADFTYHVDKNeFPLVTTRKAFWKAAIAEMLGYLRGYDSAAQFRAIGCNT 81  Morganella
CCO61682          6 SQYEDLCKRVIDEGIWIENdRTGKRCLTVINADLEYDLTANeFPLVTTRKAFWKSAIAEMLGYLRGYDNAADFRKLGTKT 85  Vibrio nigri...
Q87SA0            2 KQYLDLCQRIVDQGVWVENeRTGKRCLTVINADLTYDVANNqFPLVTTRKSFWKAAVAELLGYIRGYDNAEDFRKLGTKT 81  Vibrio parah...
Q15P51            2 KQYLDLCQRIVDDGKWVNNeRTGKKCLTVINADLTYNVGNGeFPLVTTRKSFYKSAIAEMIGYIRGYDNAADFRKIGTST 81  Pseudoaltero...
Q07YY3            2 KQYLDLCKRIVDEGEWVNNaRTNKKCLTVINADLVYDVGNNqFPLVTTRKSFWKSAIAEILGYLRGYQNAADFRALGTKT 81  Shewanella f...
Q47Y31            2 RAYLDLCQRIIDQGTWVENeRTGKRCLTVINADLEYNVGNNeFPLITTRKSFFKSAIAEFIGYIRGYDSAADFRKLGTKT 81  Colwellia ps...
Q6LUM1            2 KQYLELCQRIVDDGVWIENkRTNKRCLTVVNADLTFDVANNqFPLITTRKSFWKSAIAELLGYIRGYDNAADFRALGTKT 81  Photobacteri...
tigr:RIEPE_0366   2 KQYIDLCRKIIHEGCWIKNnRTKTRCLTIINADLEYDVENNqFPLITTRKISYKSAISEMIGHIRGYRSAKQFRDLGCNV 81  Candidatus R...
Q5R064            2 KQYLQLCQRIVDEGVWVKNeRTGINCLTVINADLEYDVANNqFPLITTRKSYYKSAIAELLGYLRGYNSAAQFRDIGCKT 81  Idiomarina l...
3UWL_A           81 WD-------EWaferyvksadyqgpdmtdfghrvlqdpafaeqykeehqkfcdailndaefA-EKY----GELGNIYGAQ 148 Enterococcus...
WP_004242187     82 WNananentDW--------------------------------------------------LaNPNrkgeDDMGRVYGVQ 111 Morganella
CCO61682         86 WDananqneAW--------------------------------------------------LnNTHrngeDDMGRVYGVQ 115 Vibrio nigri...
Q87SA0           82 WDananlndAW--------------------------------------------------LnNPYrkgeDDMGRVYGVQ 111 Vibrio parah...
Q15P51           82 WDananqnqAW--------------------------------------------------LdNPHrkgeDDCGLIYGKI 111 Pseudoaltero...
Q07YY3           82 WDananenqAW--------------------------------------------------LdNPNrkgpDDMGLIYGAL 111 Shewanella f...
Q47Y31           82 WDananlndAW--------------------------------------------------LnNTHrkgeDDMGRVYGIQ 111 Colwellia ps...
Q6LUM1           82 WDmnandnlAW--------------------------------------------------LnNPHrkgeDDMGRVYGVQ 111 Photobacteri...
tigr:RIEPE_0366  82 WEananqnkSW--------------------------------------------------LsNPYrkgrDDLGRIYGVQ 111 Candidatus R...
Q5R064           82 WDananenqAW--------------------------------------------------LnNPNrkgeDDMGRVYGVQ 111 Idiomarina l...
3UWL_A          149 WRHWETK-------------------DGSF----------IDQLANVIEMIKTNPDSRRLIVSAWNPEDVpS-MALPPCH 198 Enterococcus...
WP_004242187    112 GRQ-LKVspteaqydlllslndsgdkEGVKtlinelrkntFDQLRKVYDNLKKGIDDRGEIISFWNPGEF-NqGCLRPCM 189 Morganella
CCO61682        116 GRKWAKP-------------------DGGF----------VDQYKKIIDHLSKGIDDRGEILNFYNPGEF-HmGCLRPCM 165 Vibrio nigri...
Q87SA0          112 GRAWAKP-------------------DGGH----------IDQLRKIVDDLTRGVDDRGEILNFYNPGEF-HmGCLRPCM 161 Vibrio parah...
Q15P51          112 GRNFPKP-------------------DGGS----------IDLLAKIIYDLKNGIDDRGEIFTFYHPGAF-HmGCLRPCM 161 Pseudoaltero...
Q07YY3          112 GRAFPKP-------------------DGGH----------VDLLQQIVDDLSNGIDNRGEILTFYHPGAF-DlGCLRPCM 161 Shewanella f...
Q47Y31          112 GRAWAKP-------------------DGGT----------IDQLKKIVDNLKDGIDDRAEIMTFYNPGEF-HmGCLRPCM 161 Colwellia ps...
Q6LUM1          112 GRSWQKP-------------------DGST----------IDQLRKIVDNLSEGIDDRGEILTFYNPGEF-DlGCLRPCM 161 Photobacteri...
tigr:RIEPE_0366 112 GRSWKKH-------------------DGSH----------LDQLRKVIQHLKDGIDDRAEIITFYNPGEI-EmGCLIPCM 161 Candidatus R...
Q5R064          112 GRSWQKP-------------------DGSH----------LDQLKKVINNLSKGIDDRGEIVTFYNPGEF-ElGCLRPCM 161 Idiomarina l...
3UWL_A          199 TMFQFYVnegkLSCQLYQRSADVFLGVPFNIASYALLTHLIAHETGLEVGEFVHTLGDAHLYQNHVEQM-QEQLSREVRS 277 Enterococcus...
WP_004242187    190 FMHHFSVldgtLYLNSYQRSCDYALGYVFNAPQCYFLLAIMAQITGLKCGKVYHKVVNLHLYEDQLELMrDVQIARKPFA 269 Morganella
CCO61682        166 YSHHFSLlgdsLYLNSTQRSCDVPLGLVFNQIQVAWLLQITAQITGLKAGKAFHKIVNAHIYEDQVELMkD-QIKREPYA 244 Vibrio nigri...
Q87SA0          162 YSHHFSLlddtLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKPGQAFHKIVNAHIYEDQLELMrDVQLKREPLQ 241 Vibrio parah...
Q15P51          162 YSHHFSLlddtLYLNSTQRSCDVPLGLNFNMVQVYFLLAIVAQITGKKAGMAYHKIVNAHIYEDQLELMrDVQLKREPLG 241 Pseudoaltero...
Q07YY3          162 YEHHFSLlgdtLYLNSTQRSCDVPLGLNFNMVQVYVLLALMAQITGHKPGKAYHKIVNAHIYEDQLEPMrDVQLAREPFA 241 Shewanella f...
Q47Y31          162 HTHNFSLlgdtLHLTSFQRSCDVPLGLNFNQVQVFVFLALMAQITGKKAGMAYHKIVNAHIYEDQLPLMkEVQLKREPLA 241 Colwellia ps...
Q6LUM1          162 HTHTFSLlgdtLHLTSYQRSCDVPLGLNFNQVQVYTLLALVAQITGKKPGLAYHKIINAHIYEDQLSLLrDVQLTRTPFA 241 Photobacteri...
tigr:RIEPE_0366 162 HTHTFSIldkkLYLTSYQRSCDVPLGLSFNQIQCFILLALVAQITNYKPGKVYHKIVNAHIYENQLSLMrDVQLKRSPYP 241 Candidatus R...
Q5R064          162 HTHNFSLlgdtLYLTSYQRSCDVPLGLNFNQIQCFALLALVAQITGHKPGKAYHKIVNAHIYENQLELMrDVQLKREPFP 241 Idiomarina l...
3UWL_A          278 FPTLVLN--PDkaSVFDFD----MEDIKVEGYDPHPTIKAPIAV 315 Enterococcus faecalis
WP_004242187    270 SPKLHINpdIK--TLDDLMtwvtTDDFTVTDYQHHDPIKYPFSV 311 Morganella
CCO61682        245 APKLIINpeIK--SLEDLEtwvtVDDFEVVGYQHHEPIKYPFSV 286 Vibrio nigripulchritudo
Q87SA0          242 APTFHINpeIK--SLEDLEtwvtLDDFWVEGYEHHDPIRYPFSV 283 Vibrio parahaemolyticus RIMD 2210633
Q15P51          242 MPKLIINpdIK--SLEDLEtwvtMDDFSIEGYAHHPAIKYPFSV 283 Pseudoalteromonas atlantica T6c
Q07YY3          242 SPKLIINpkIK--TLKDIEtwvtLDDFSVEDYQHHDAIKYPFAV 283 Shewanella frigidimarina NCIMB 400
Q47Y31          242 LPKLIINpeIK--SLEDLEtwvtMDDFKVEGYECHEAIKYPFAV 283 Colwellia psychrerythraea 34H
Q6LUM1          242 APKLIINpkIK--CLEDLEtwvtMDDFDVIGYEHHEAIKYPFSV 283 Photobacterium profundum SS9
tigr:RIEPE_0366 242 LSKLIINpkIK--KLEDIEnwvsSDDFKVINYRFHGKISYPFNV 283 Candidatus Riesia pediculicola USDA
Q5R064          242 SPQLHINpeIK--SLEDIEtwvsKDDFIVSGYQCHDPIKYPFAV 283 Idiomarina loihiensis L2TR
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