Conserved Protein Domain Family
Secretogranin_V
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pfam05281: Secretogranin_V 
Neuroendocrine protein 7B2 precursor (Secretogranin V)
The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia.
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Statistics
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PSSM-Id: 368368
Aligned: 7 rows
Threshold Bit Score: 306.442
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WGS:AANI:GJ11108-PA  45 DLLNRMDNDMQV---GYYDVDNeGDL-AavAAAAAKDNVDLVSRS-----EYARLCNGGS---DCLLQ-----SNNAHPS 107
XP_002070064         44 ELLNRMAKDIQV---GYYDVDD-GNM-A--SPVIDNDNVDLVSRS-----EYARLCGSDSrnaDCMLQa---lAPNPNPS 108
EDV94765             45 ELLNRMDNDMQV---GYYDVDNeGDL-AaaAASAAKDNVDLVSRS-----EYARLCDGGH---DCLLQ-----SESSNPS 107
XP_001953349         44 DLLNRMDNDMQV---GYYDVENdGDM----AAAVPKDNVDLVSRS-----EYSRLCDGGS---DCVLQs----GASSNPS 104
Q9VNB0               40 DLLNRMDKDMQV---GYYDVGNe-------AAAGSKDNVDLVSRS-----EYARLCDGGS---DCILQsgsasGAASHPS 101 fruit fly
Q7Q3X2               70 ELVDRMGKDLAEaadSYIDPSAmDELpAsrLALMARVTKDLESEQl----DY-----------DALLD-----GSNPNPS 129 Anophele...
EEB20311             35 DVVDRMGKDLAEaadSYLDMPDnERL-QtnGFLSNRVIKDLENEEtsdpiDY-----------DRL-------SNNPNPS 95 

WGS:AANI:GJ11108-PA 108 LRDQEFLQHSSLWGHQYVSGGMGEVPNRYNT--------IVKTDASLPAYCNPPNPCPEGYDTE-QQAGNCISDFDNTAI 178
XP_002070064        109 LRDQEFLQHSSLWGHQFVSGGMGEMPNRYNT--------IVKTDASLPAYCNPPNPCPEGYDVE-TQGANCIVDFENTAI 179
EDV94765            108 LRDQEFLQHSSLWGHQYVSGGMGEMPNRYST--------IVKTDASLPAYCNPPNPCPEGYTLEqQQAADCIMDFENTAS 179
XP_001953349        105 LRDHEFMQHSSLWGHQFISGGMGEGPNRYQA--------IVKNDAGLPAYCNPPNPCPEGYDVE-TQGGSCIADFENTAI 175
Q9VNB0              102 LRDDEFLQHSSLWGHQFISGGMGEGPNRYPT--------IVKNDAGLPAYCNPPNPCPEGYDME-TQGGSCIVDFENTAI 172 fruit fly
Q7Q3X2              130 PRDQEYLQHSSLWGHQYVSGGAGEGPNRPKP--------QVKTDASLPAYCNPPNPCPVGY----TEDQGCTMDFENTAA 197 Anophele...
EEB20311             96 LRDREYLQHSSLWGHQFVAGGAGEGKQRLKPdgsvqnqqQVKTDETLPAYCNPPNPCPIGY----TGEDGCLEEFENTAA 171

WGS:AANI:GJ11108-PA 179 YSREFQAAQECTCDSEHMFDCAd---QENAAGVGpgnsDLNSAVEKFLLhQFGNENVLD-NANVVAKKAGH---MPAL-R 250
XP_002070064        180 FSRQFQAGQECTCDSEHMFDCS----QDGVESVK----DEDELVEQFLR-QFGHENSVNsNGNNLVKKAGGvyeMPDP-R 249
EDV94765            180 FCREFQAAQECTCDSEHMFDCAd---QENASGTGtgdgDINSAVEKFLLhQFGNDNVLD-NDNGVVKKAGH---LP---- 248
XP_001953349        176 FSREFQAAQDCTCDSEHMFDCS----EQESGDSRsdkgDLNSAVEQYIL-QMGQENSLN-NVNSLVKKAGYpagMVDPrI 249
Q9VNB0              173 FSREFQAAQDCTCDNEHMFDCS----EQDSADVGgdkgDLNSAVEQYIM-QMGQENSLN-NVNSLAKKAGYp-vMPDPrL 245 fruit fly
Q7Q3X2              198 FSREYQAAQDCMCDAEHMFNCP-------AAAQSesnpQMDSDLENFIArQFHTQ-----EHKNLVAKKFHv-------- 257 Anophele...
EEB20311            172 FSRDYQTSQDCMCDSEHMFECPvrdfQSHGNDLNeedlDLDRIMEELTEgE---------QHKNLVAKKFHt-------- 234

WGS:AANI:GJ11108-PA 251 MDSIPNPFLQvapGDRLPIAAKKGNMLF 278
XP_002070064        250 IEAVINPFLE---GDRLPIAAKKGNMLF 274
EDV94765            249 --GLPNPFLQvgpGDRLPIAAKKGNMLF 274
XP_001953349        250 EPAVMNPFLQ---GDRLPIAAKKGNLLF 274
Q9VNB0              246 DDAVINPFLQ---GDRLPIAAKKGNLLF 270 fruit fly
Q7Q3X2              258 -kKSYNPFLQ---GEKLPVAAKKG-FNV 280 Anopheles gambiae str. PEST
EEB20311            235 -kKDVNPYLN---GEKLPVAAKKG-INL 257
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