6HQI,1LNL,3W6W


Conserved Protein Domain Family
Tyrosinase

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pfam00264: Tyrosinase (this model, PSSM-Id:395203 is obsolete and has been replaced by 425566)
Click on image for an interactive view with Cn3D
Common central domain of tyrosinase
This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.
Statistics
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PSSM-Id: 395203
Aligned: 121 rows
Threshold Bit Score: 102.931
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6HQI_A    83 PIGFKQQANIHc--------AYCNGGYsidg-----------------------------------kvlqVHNSWLFFPF 119 tomato
EAP72699 143 TGRFTDFRNMHv-------aGLADKQ--------------------------------------------AHDGPGFLPW 171 Ralstonia solanacea...
Q70KX7   179 VSTYNFFIFLH-----------NFIARdgtqacqkv--------------------------nkdnivdfAHSGPSFPVW 221 Suberites domuncula
Q8T777   161 ISVYDYFVAVH----------YYASREtlppsstgic-----------------------veekdcsldfAHEGAGFPTW 207 Florida lancelet
Q5DB10   171 ASIQYYLTYVHr-------yGSRSTLYkdirdce-----------------------------eygilnfNHDGVCFPTW 214 Schistosoma japonicum
Q5DHS0   178 VDVQYLFTFLHr-------yASRATLFhdnkdci-----------------------------qhqhldnNHDTVGFLTW 221 Schistosoma japonicum
Q33CJ6    88 ASVFDVGAWVR---------YYAYKPIlqnnif-------------------------------nysttfATRGPAFLTW 127 Japanese firebelly ...
Q19VI0   174 VSVYDLFVWMHyyvsrdtllGGPGNVWqdi--------------------------------------dfAHESAAFLPW 215 Atlantic salmon
Q868D0   174 ITIYNLFVWMHyy-----isRSNFAITeevynnlttdvgprdftniplenlqrflnnssnllvinndldyAHEGPSFLPW 248 Halocynthia roretzi
Q3UFK6   182 ISVYNYFVWTHyysvkktflGTGQESFgdv--------------------------------------dfSHEGPAFLTW 223 house mouse
6HQI_A   120 HRWYLYFYERILgsl----idDPTFGLPFWNWDHP-------------------KGMRFPPMFDVp-----------GTA 165 tomato
EAP72699 172 HRAYLLDLERELqa------iDPAVTIPYWRFDRAapnl------------fttDFIGVPDALGTvgf-------spANP 226 Ralstonia solanacea...
Q70KX7   222 HRRYMLTVEKEFqri----mgNDTFGFPYWQWEENdmspftpeyfgvpangfspNAVNVSGSLVNpqdw----nticDLS 293 Suberites domuncula
Q8T777   208 HRAFLLEAERALqev----ngDPDWTLPYWDWGAAeqhqcdi-----ctneyvgANDEHGNLGTEsifaawrticehQVP 278 Florida lancelet
Q5DB10   215 HRYYILLWERLMskitkvifgITDYATPYWDWVGLkhcdic-------tnryigAPGRRSERGIHis---------tGSP 278 Schistosoma japonicum
Q5DHS0   222 HRYYMLFWEKQLrkiairlygwTDFTLPYWDWVDStkcdvcv------nsllgaYGQWVGSTRLId----------sKSP 285 Schistosoma japonicum
Q33CJ6   128 HRWHLAFIEREIqvi----tgDDNFTIPYYDWSRDgkhceic------tdefmgKSDSQGVLTSSsyfan--wksicSGY 195 Japanese firebelly ...
Q19VI0   216 HRVYLLHWEHEIrkm----tgDFNFTIPYWDWRDAtdctvc-------tdtmmgGRSPLNPNLISp-----------GSV 273 Atlantic salmon
Q868D0   249 HRYFLLKWEEEIrnv---vlnSESFGLPYWDWTASqdcdmc-------sdeyfgGRNPSDDKLLSegsvfs-qwdiiCTK 317 Halocynthia roretzi
Q3UFK6   224 HRYHLLQLERDMqem----lqEPSFSLPYWNFATGknvcdvc------tddlmgSRSNFDSTLISp-----------NSV 282 house mouse
6HQI_A   166 LYDERRgd--------qiHNGNf------IDLGSFGDQVETTQLQLMTNnltLMYRQLVTnspc------------plmf 219 tomato
EAP72699 227 LQFWATd----------------------GVQGVLRRQLGVSPGDQANPnirTETQTLAL-------------------- 264 Ralstonia solanacea...
Q70KX7   294 YWNSNLnc--------sdYWRPcnp-addLALARPVQRGGGSSYLPNTVevmISLAAPSYdasnln---------gdfir 355 Suberites domuncula
Q8T777   279 FYNATHt----------nHTKPcdv--tkPTGRLKRNPGHQDPNRFGPSmtrLPLATEVDfalrfpv------fdtppys 340 Florida lancelet
Q5DB10   279 FHNLTEy-----------CYEPi------RDMLCSGCQRGGNRGTITRNf--YRSDLPDIddlefvlsie-kfyvpgern 338 Schistosoma japonicum
Q5DHS0   286 FYLWPE------------YCSPp------TVGSNCYSCHAGWPNFKVLTryyEATAFPTTdnllfvlrketfylpqtted 347 Schistosoma japonicum
Q33CJ6   196 YFEYKYcpva----edgcKMEP---------LQRSPGADPGIPRLPTVKdveDTIQWGSYdtp--------------pyd 248 Japanese firebelly ...
Q19VI0   274 FSSWKVictqpeeynsraALCPg-----tGEGPLLRNPGNHDPNRVRRLptsADVEFVVGietye----------tgamd 338 Atlantic salmon
Q868D0   318 LDQYTLngqq----cageKEGP-------LLRNFGNYDPQRSSDIPTREeveQSLRFSTYdtf--------------pyd 372 Halocynthia roretzi
Q3UFK6   283 FSQWRVvcesl---eeydTLGTlcnstegGPIRRNPAGNVGRPAVQRLPepqDVTQCLEVrvfdt-----------ppfy 348 house mouse
6HQI_A   220 FGGPYTLGSTVEAagtv-------------------eniPHSPVHI-WVGtrrgsvlpdgkisngEDMGNFYS-AGLDPL 278 tomato
EAP72699 265 GSAYQNFRTMQGN--------------------------PHGSAHVnYFG---------------GSISSIPT-AAKDPL 302 Ralstonia solanacea...
Q70KX7   356 DGPRTSFRSRLEGwnkicsavnc------vggmdvdqqhMHNNVHV-WVG---------------GQMDVVPA-AVNDPI 412 Suberites domuncula
Q8T777   341 RTSNCNFRNLLEGfadtstgkyrgdrthedgtlvpgahtLHNHVHL-YLN---------------GTMSTGVItAANDPI 404 Florida lancelet
Q5DB10   339 SKKCKSFHMALEGfcgrpga-------------ypnmrwFHNKVHV-LID---------------GSMC-CTGtASNDPI 388 Schistosoma japonicum
Q5DHS0   348 LGKCRGFHQALEGfrsipgs-------------ntsysfMHNKVHN-MVS---------------GTFC-RSAtAANDPL 397 Schistosoma japonicum
Q33CJ6   249 TRANKSFRNVLEGfkspsdg-------------vtgklsMDSLVRS-FMG---------------GSMS-QDTvCGADPL 298 Japanese firebelly ...
Q19VI0   339 RQANMSFRNSLEGfaspetgm-----------aitgqstMHNALHV-FMN---------------GTMSSVQG-SANDPI 390 Atlantic salmon
Q868D0   373 NSSNQSFRNILEGfadsengt-----------apnhistLHNAIHL-YMN---------------GTMSLVPS-SANDPL 424 Halocynthia roretzi
Q3UFK6   349 SNSIDSFRNTVEGysaptgk------------ydpavrsLHNLAHL-FLN---------------GTGGQTHL-SPNDPI 399 house mouse
6HQI_A   279 FYCHHSNVDRMWNEWKAT 296 tomato
EAP72699 303 FFLLHCNVDRLWAKWQSQ 320 Ralstonia solanacearum UW551
Q70KX7   413 FNLHHCNVDRIFESWLKQ 430 Suberites domuncula
Q8T777   405 FLLHHSNVDRLFETWIRR 422 Florida lancelet
Q5DB10   389 FVLHHALTDKIFDCWLRT 406 Schistosoma japonicum
Q5DHS0   398 FLVHHTQIDRIFQLWYEY 415 Schistosoma japonicum
Q33CJ6   299 FLFHHAYIDKIFETWIQK 316 Japanese firebelly newt
Q19VI0   391 FLLHHTFIDSIYEQWLRR 408 Atlantic salmon
Q868D0   425 FLVHHVFIDSIYERWLQD 442 Halocynthia roretzi
Q3UFK6   400 FVLLHTFTDAVFDEWLRR 417 house mouse
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