1VTN


Conserved Protein Domain Family
FH_FOXA3
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cd20040: FH_FOXA3 
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Forkhead (FH) domain found in Forkhead box protein A3 (FOXA3) and similar proteins
FOXA3, also called hepatocyte nuclear factor 3-gamma (HNF-3-gamma or HNF-3G), fork head-related protein FKH H3, or transcription factor 3G (TCF-3G), acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410814
Aligned: 5 rows
Threshold Bit Score: 208.427
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1VTN; Homo sapiens FOXA3 binds DNA through its Forkhead domain, contacts at 4A.
    - View structure with Cn3D
  • Citation:PMID 8332212
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ##                 #                   #  ## ##  #      #          ## #   
1VTN_C         1 HAKPPYSYISLITMAIQQApgKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALH 80  human
P55318       115 HAKPPYSYISLITMAIQQApgKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALH 194 human
EMP25213     108 HAKPPYSYISLITMAIQQApsKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALH 187 Green sea turtle
XP_005996099 143 HAKPPYSYISLITMAIQQShsKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLH 222 coelacanth
AAI62391     141 HAKPPYSYISLITMAIQQSqsKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALH 220 zebrafish

Feature 1                    ### ##    
1VTN_C        81 PsSGNMFENGCYLRRQKRFKLA 102 human
P55318       195 PsSGNMFENGCYLRRQKRFKLE 216 human
EMP25213     188 PnSGNMFENGCYLRRQKRFKIE 209 Green sea turtle
XP_005996099 223 PnSGNMFENGCYLRRQKRFKLE 244 coelacanth
AAI62391     221 PnSGNMFENGCYLRRQKRFKIE 242 zebrafish

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