Conserved Protein Domain Family
IlvB

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COG0028: IlvB 
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Statistics
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PSSM-Id: 439799
Aligned: 874 rows
Threshold Bit Score: 237.751
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_075968145  20 TPFEGGDLIVHYLQQIGVEYIFGVPGGAIEPLVNAIARGMRrggPKLVVARHESGAAFMADGYARETGKLGVCFATTGPG 99 
WP_062165638  12 DARSGADILLEILASEGVEYIFGNPGTTELPLMDSLLRRPD---ISYILGLQEASAVAMADGYAQAAGRPGFLNLHTAGG 88 
WP_096461058   1 --MNGVDYFLELLRQQGVRYLFGNPGHTELKMLDRLVDMPE---MDYVLGLHEGAALTMADGYAMASGRLGVFCGHVMPG 75 
WP_126449329   1 --MRAAEYVFAFVRLARAKKVFGNPGTTELPLLRRI--PGD---IQYVLSLHDGLAVGMAEGAFLISGRPQFVSLHGAIG 73 
WP_084244527  62 pVMSGKRAFLDLLKQEGVGIVFGNPGTTELPLMDAFAVEHD---IRYILGLQEAALMAMADGYAQASGRLTVLNLHVAPG 138
WP_014491850   3 nKITGRSAFLALLKDEGITHLFGNPGTTELPIMHALKDHPD---LTYVMAMQESLVVAIADGYSRASGKLVACNVHVAPG 79 
WP_009886623   2 IAMIGYKILNKTLKNMKLFPVFGNPGTTEIPMLEGV--SSD----EYILTLHDSISVGMADGRAQLTRKPSFVNLHSILG 75 
WP_014133264   2 PARPGKAALFEQFAADGITHMFGNPGTVEQGFLD-LAGAGA---TRYVLALHESVAVAMADGYARAAQRPSVVQLHSGVG 77 
WP_010900925   1 --MKASQIFSDFLKRNGLHPLFGNPGTTEIPMLSNV--E------DYVLTLHDSISVAMADAYAQYTGHPSIVNLHSLPG 70 
WP_025437721  14 GGRRGADILLEILESEGVRYIFGNPGTTELPLIDALQRRPD---LKYILALQEASVVAMADGYAQAAGRPGFLNLHTAGG 90 
WP_075968145 100 ATNMITGVANAYQDGIPLLAITAQTRLENFGRGGLQESsctsiDTVSIYKNCTLYNSLVSHTKQLENKLISAILAAFREP 179
WP_062165638  89 LGHGMGNLLNAHVSQTPLVVTAGQQDLRHAVTDPLLFG-----DLLKIAEPAVKWGKEVASAEQLPTLVRRAFHDADAAP 163
WP_096461058  76 FGNAMGMLFNASKHGTPLLVTAGQQDLAFAQTEPFLWG-----DLARMARPLVKWAHEVQNVGELERVLTRAVKVALTPP 150
WP_126449329  74 LSNAIGYIRSALMDRAPLLVLVGQQHSEFLSDEPLIWG-----DILKIARPVVKDAFEVRTPIDVPKLLTRALKVAVAPP 148
WP_084244527 139 LGNAMGMLYDAQMAGSPILVTAGQQDTEYLVEEPILSA-----DLTSLAKPFVKFSAQVERLKDLPVLVHRAAKTALAPP 213
WP_014491850  80 LGNAMGSLYNAQFTGTPMILTAGQQEQGHGLMEPVLYG-----PLVRMAEPLVKWAVEVTRLEDLPRIVRRAAKVAMTPP 154
WP_009886623  76 VGNSMAFIYSAFVHRVPVIITAGEQDSRHIFYDPLLSG-----NIGDMISPYVKYKFEVNSANDIEKSIRRAYTSSMAPP 150
WP_014133264  78 LGNAAGMLYQAKRGGSPLVALVGEAGVRYDAMDAQMAA-----DLVAMAAPVTKYATRVLDPSSVLRVLRRAVKIAMTPP 152
WP_010900925  71 ISNSMAFIISAMKDNAPVIITAGQQDRRHLYYDPLLSG-----DQIGMVSNYVKYAYEVRRPEEIPLALKRAYEISMTPP 145
WP_025437721  91 LGHGMGNLLNASVSQTPLVVTAGQQDSRHTISDPLLFG-----DLVSIATPAVKWAQEVLHADQLPVLVRRAFNDSMAAP 165
WP_075968145 180 GGSVHLSLPLDVTRAQAHApkfvndlenL--IKpREFVDETSIALLLKKIWSA------RKISFVLGEGAK--GAVGRIL 249
WP_062165638 164 SGPIFLSLPMDVMEEMSTVsa-----gaPsrI------DRNAVAGALPELANAlaaiapGRLALIAGDEIHasRAAAETA 232
WP_096461058 151 TGPVFLSLPKDVMAAEGAFsl-----arPtvVApRLCADREAIGEAAAALLAA------RSPLIIAGDEVGksGAEPELR 219
WP_126449329 149 WGPAVVSLPFDIVDEDVKEsp------aIptFSfSILCEDSSVQEVASWLTGG------SKVAIVAGYEVDvyMAHEELR 216
WP_084244527 214 TGPVFLSLPGDILKNDGDIel-----lePtrVApRIRGDLDAVNAAADLLAKA------ERPVIIAGDAVAqsRGHRELA 282
WP_014491850 155 TGPVFISLPGDILNSEAGIdl-----grStrIDaRVKPSDEALKAFAARLLKA------ERPVIVTMDEVVksDALKEAA 223
WP_009886623 151 YSLSFLGFPMDIMGEEGKYsg------lNlpDSnSNVVDINAVKYIAEMINSS------KNPVMVTGYELDmyGGIGYAR 218
WP_014133264 153 RGPVLVVLPADVLDQDTAEsa-----vaTlvPSlRAVPEPAAVAEAARLLTSG------TAPLVLMGDGIAasGAQRQLT 221
WP_010900925 146 FGPTFVSFPMDIMDEDATPie------sEvkYHtQMCLGEDDIRSIMDRINSA------DRVALVFGSEVDmyGSMEDAR 213
WP_025437721 166 SGPVFLSLPMDVMEEPSDVdv-----gsPsvI------NRDSIAGGLPDLARAlagitpGRLAIIAGDEVHgaDAAAQVA 234
WP_075968145 250 ALALELDATVVATPFGKG-LISPYHRQFRGIIGmAGHSSAVA-ALSDPsvDCIIAVGTSLgefAT---ANWNgPALL-NH 323
WP_062165638 233 ALAETLGAPVYGSSWPSRvPFPTAHPLWRGNLP-TTARGIAE-VLSQY--DAIFAIGGKS---LItilYTEG-SAIPeGC 304
WP_096461058 220 QLADLLGSRVYSECASTTfNFPIAHPLYQGALA-RTQKEVRE-VLDTA--DVIFAVGAEV---FTlaaYART-EPLPpGV 291
WP_126449329 217 TLAERISATVFAEPNAHRsPFYSSHPLFEGDLP-WEADEMLK-KLSVY--DRILIVGGTL---NFltpPTEK-DF---KL 285
WP_084244527 283 ALAEAIGAPVYTEFVPNTaSFPSSHPLYRGSMT-RSQQGVRE-VLDKH--DLLFSVGGDL---FTwslPSKV-KPIPaGM 354
WP_014491850 224 ELAELLGGAAYQSSTPYGsHFLSESPSFVGTLA-RVQKAARD-TLAPY--DLLIALGGDP---LRmsvYSEV-DALPdGL 295
WP_009886623 219 AFASKLGIPVFAEPFASRaPFDSGDKNYAGDLP-PVAALIND-KLSEH--DLIIIVGGDI---Nly-pYSKA-DLLEgKE 289
WP_014133264 222 AVAERLGAPVWGVN-SSEvNFDTTHPLFAGNLG-HMSGADSArVVGGA--DTVLIAGTYV---FPevfPSLA-NPFApGA 293
WP_010900925 214 SFAHALNAPVYVEPWSQSsSYYRDD-LYVQDLP-SSFQAMNR-ILNQY--DLIVFIGSDI---Fvy-pYTGE-DPSFaDR 283
WP_025437721 235 EVATILGAPVYGASWPSRiPFATSCPLWAGNMP-TRATDIAH-RLADY--DAIFALGGKS---LItilYSEG-SPVPpGC 306
WP_075968145 324 RLIHIDANAHNFSGSPIAQMHVHSNPVQVFEHlEQGVRqlrltlpGSNAdlqldnpttPRrPK-PVLAYShravpegslr 402
WP_062165638 305 TVYQLSADVNDLGRTYPTALSTCGHLKASLNAlQSLVE-------NASL---------AH-AP-AYDALRr--------- 357
WP_096461058 292 RLIQLSADAWQLGKNYRAEPAMLGDAKATLAAlVEAVR-------ARCG---------SD-QS-RIAADRa--------- 344
WP_126449329 286 NIFQVTSDPEEAEKR--KWNTICCNVKEFLTKlNSAL--------PRSS---------IS-LKiETERp----------- 334
WP_084244527 355 PLIHLDTDPWQIGKSYPAQVGIFGDPKATLPDiTAAVQ-------SRMT---------AG-AK-GAAAARl--------- 407
WP_014491850 296 GIVQIGLVDWEIAKNYGAEIALKADLKETLRAlIPVLK-------EMGG---------AA-LA-SRAKQRl--------- 348
WP_009886623 290 IIKIGMDI----SGK--IGDSYFMNPAAFLQSvIEYIK-------PRKP---------SV-IPgKPA------------- 333
WP_014133264 294 RIVHIDADAYEIAKNFPVDLGLAGDPALALGAlGAELA-------SRGG---------AA-PA-RPAAPRr--------- 346
WP_010900925 284 SIFISTRS----GHY--IGDTYRSDPKCFLQSaLKYAR-------PKEK---------FV-PKv---------------- 324
WP_025437721 307 AVYQVSADVRDLGRTFQTPLSLVGNIRASLDVlIPLLQ-------QATH---------PR-QA-EFSAARt--------- 359
WP_075968145 403 akpncilDEp----D----KYf---S---DATPIKPQR------------VMADLPALLPPGTRFVADGTGANFWAIHYL 456
WP_062165638 358 ------kAat--qrAseraTLhgraDaamNEAVIPPIL------------AAREAVRAVGPDTPIVDEAIATSGFVRSFL 417
WP_096461058 345 ------lAser-rkAellaGVkrqaAadrQQRPLRGTV------------VMQEIVAHAPDDAVIVDESATTGMSLRRFM 405
WP_126449329 335 -------Kpvg---------------ttiIN-------------------FLEELASNSQ-DREKFAEASSLMGEIRRTM 372
WP_084244527 408 ------kAatd-aiKsereTFrakaRalaGKTPVQPLA------------LLEAIGAMLPKDAVVIEEVLSSAPGARSLI 468
WP_014491850 349 ------aELapknwTarraALveqiGrsaGRSPIDPDF------------LVLQMVEAMPDHAILVDEGLTSSRQVTALR 410
WP_009886623 334 -------Idkn---------------sqiQR-------------------VMLKISKNFG-DYTISDESISASPFLRNIV 371
WP_014133264 347 ------pHgph-gpHgphgRDgqqgRdgrDGQHGQHGRdgrqgreglmeaFARELAARAPANLAVFDEALTASPALTRHL 419
WP_010900925 325 -----------------------------VKEKLVYED------------IIAKIHRHLK-GYTAVDEAVTASGSVRKYF 362
WP_025437721 360 ------rVta--arAsrrmDAetlvAqhrDDPVIAPCV------------AAHEVVRAIGPRVAIVDEAIATSSYTRMFL 419
WP_075968145 457 HVpdrrgaerrlaterrqspgamsghrnslprrradqrkVWESLYRCPGEfGSMGWGLGAGIGTAFGSPNMPVVILTGDG 536
WP_062165638 418 ES-------------------------------------SDPSQYSFLRG-GALGWGMPAAIGCSLGLKREPVVCLVGDG 459
WP_096461058 406 QE-------------------------------------RD-LGYFGLKG-GGLGWGLGASIGVHLALPERPVLCLVGDG 446
WP_126449329 373 GY--------------------------------------FPSRFFGLKS-GLLGWSLTAAVGAALEGAR--PLVLIGDG 411
WP_084244527 469 NS-------------------------------------DDEQSFFALRG-GGIGWGLPAAIGAKLAQPDRPVVALVGDG 510
WP_014491850 411 PH-------------------------------------RDRYGYHGLAS-GGIGWGLPASVGASIANPDRPVVCFSGDG 452
WP_009886623 372 GY--------------------------------------KPDSYFIGKS-GQIGWALPAAAGMATVKDK--VLCVIGDG 410
WP_014133264 420 PP-------------------------------------RVPGTYFQTRG-GSLGVGIPGAIGVKLARPDLQVVGFTGDG 461
WP_010900925 363 AD--------------------------------------GPKTYFTSRG-GPLGWGDAATVSVAMANSK--TVGIIGDG 401
WP_025437721 420 DS-------------------------------------DWAAQYSFLRG-GALGWGMPAAVGASLGLGREPVVCLVGDG 461
WP_075968145 537 SMLMNGQEITVALQHQ-LTVIFVVLNDRALGTVKHGQRLAG-----A-ER-I-GFEL--PDIDFAAMASAMGVEACRIRS 605
WP_062165638 460 AALYSPQALWTAAHEN-LPITFVVMNNCEYNVLKNFMRGQQnytaaQtGRfI-AMDIvnPTIDYQALATSMGLPAQRLTR 537
WP_096461058 447 AALFGIQALWTAANRR-AKVTYVVCNNRQYRLIKHRLHLHGggasaRaKRyY-GSELndPPIDFVGLAQSFGIPAMQVES 524
WP_126449329 412 GFHYSCQSLWTASNYGaTELRAVVFNNRGYEILRRHf--------------R-DEPWlsPLTSPYKVAEAYGVEAKKVG- 475
WP_084244527 511 SAMYTMQALWTAAHYK-LPVIWVIFNNTSYRILKQRLVAMRgl-aeQaDNfV-GMELtdPAIDFVGLARSLGIEGARAKT 587
WP_014491850 453 SAMYSIQSLWTAAHHK-LPLNVVIANNGGYRIIKQRLLAFH-----GdDNyV-GMDFvdPPVDFAGIATALGCEAIKVSD 525
WP_009886623 411 AFMYTSQTLWTIKNYN-LPVKIIILDNHGYGILKKFSDVNY-------KEsK---KYlsFSIELKKVLDSFNIESREN-- 477
WP_014133264 462 ASMYTVQALWTAARYG-VSAGFVVCNNRRYRLLDLNIERYWqeqgiApHAyPdAFDLsrPEIRFADLARSLGVAGQRVDA 540
WP_010900925 402 AFMYTPQSLWTAYRYG-IPAKFIVIRNNGYNILRSYSRTFG-------YGiE-NADYlrFNFRIEKVAEGFGVDVRTY-- 470
WP_025437721 462 AALYSPQALWTAAHEQ-LPVTFVVMNNREYNVLKGFMRGQThyvsaQeGNfL-AMDLrdPPIDYQAMATSYGLESCLITR 539
WP_075968145 606 PRELRAVNFDEIcQGRRPYLLDILIDAEEv---------lPLgGR 641
WP_062165638 538 AGDIAPAIQAGI-ASGKANLIEIMISR------------------ 563
WP_096461058 525 ADDIADAMRAAR-DREGPSLIDVLVEGSYpereeaakvaaPAtSS 568
WP_126449329 476 LKEASKEISWLV-RGKGPKLLQVDFA------------------- 500
WP_084244527 588 VKDATDLIAKAL-KDGTPFLIDVDMERNYkpm------------- 618
WP_014491850 526 PRELKATLSSAF-NRPGTKLIEVMVDGKV---------------- 553
WP_009886623 478 -DETMEDIEWLR-NIKGPAALIVNVDKpygynlfg---------- 510
WP_014133264 541 PEQVGPAVHAML-THDGPYLVDLVTG------------------- 565
WP_010900925 471 -SGE-GDLEWIS-SGNTPKVLVLDADNEIpdlf------------ 500
WP_025437721 540 AGDIVPAIQAAM-ASGRPNLVEIVISTI----------------- 566
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