Conserved Protein Domain Family
Sin3

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COG5602: Sin3 
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
Statistics
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PSSM-Id: 227889
Aligned: 5 rows
Threshold Bit Score: 1219.38
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2507475    75 HAAHILGYPPPHSNAMPSIATDSALKQPHEYHPrpkSSSSSPSINASLMNAgpAPLPTVGAASFslsrfdnplPIKAPVH 154  baker's yeast
19074819    1 -------------------MDGKLKQISRKKHP---SMARDHDKNLGSQES--EPWQDTGSIRK---------KSYSEES 47   Encephalitozoon c...
12230513      --------------------------------------------------------------------------------      fission yeast
19112804   42 GNAPLFTQAPPHTNPQGPPPFPLFNSISPVYDPa-tGRLLYRNVNTQVSHTa-IPNPANGYAAVyg-----gpPSQLPPP 114  fission yeast
19112225    1 MDVMNVPVDSERDNPGDKVETQSDKNHLPKASP---SQSQ-SPVNTSLHNG---DGKDNGVATE---------PVENKQI 64   fission yeast
2507475   155 TEepkSYNGLQEEEKATQRPQDCKEVPAGVQPADAPDPSSNHADANd--dNNNNENSHDEDADYRPLNVKDALSYLEQVK 232  baker's yeast
19074819   48 MS---RYGGPMDMRSGARGYYSDVNQMPSSMAGKNRDSTIDHGFHS-----RGMARSPPPRIPHEDADLSDAMMFLNKIK 119  Encephalitozoon c...
12230513    1 -----------------------MEQTLAILKNDN---STLVAEMQ----NQLVHDFSPNGTALPEL---DIKAFVQKLG 47   fission yeast
19112804  115 PQp-qSHPNVTVISASPARAIEQQPTILSSTDSNIPRPGTVKSSASpfvpNQNPSAPPPPPQEYRQLNVTDALSYLDLVK 193  fission yeast
19112225   65 LS----------ERSVTRDDYEKGKTIVSSLALSS--ISGKDGSIS----SQNAEGLS--SSSNRPLDVNDALSYLELVK 126  fission yeast
2507475   233 FQFSSRPDIYNLFLDIMKDFKSQAIDTPGVIERVSTLFRGYPILIQGFNTFLPQGYRIECSS-NPD--DPIRVTTPMGTT 309  baker's yeast
19074819  120 EEYMNDMVTYDNFLETMRDFKFGKIDAEEVCRAVRVLFRDKPHLIETFNDYLPSHLKFYGSLpQGSg-SRLHDRPPQAVG 198  Encephalitozoon c...
12230513   48 QRLCHRPYVYSAFMDVVKALHNEIVDFPGFIERISVILRDYPDLLEYLNIFLPSSYKYLLSNsGAN--FTLQFTTPSGPV 125  fission yeast
19112804  194 LQFHQEPEIYNEFLDIMKEFKSQAIETPEVITRVSKLFAGYPNLIQGFNTFLPPGYSIEISSaDPGslAGIHITTPQGPL 273  fission yeast
19112225  127 YYFSERREIYNRFLEIMRDFKSQALDTLGVINRVSELFNGYPQLIEGFNTFLPSGYKIEVQLdSSNt-SVVRVGTPMHPL 205  fission yeast
2507475   310 TVNnnispsgrgttdaqelgsfpesdgngvqqpsnvPmVPSSVYQSEQNQDQQQSLPLLatssglPSIQQPEMPAHRQIP 389  baker's yeast
19074819  199 SSP--------------------------------------QYRGGPCVHGGRTSHP------------QAEVSGPSHMN 228  Encephalitozoon c...
12230513  126 STP--------------------------------------STYVATYN-----------------------D------- 137  fission yeast
19112804  274 MINdlgkttap-----------------ppphgsttPlPAAASYTSMNMKQSSASHPVLqp--paPSTLQFNPSPSPAAP 334  fission yeast
19112225  206 PQQ---------------------------------G-VQSTLPVAPSNEDQRTMESTS------PTDSQPQPSAPNLVS 245  fission yeast
2507475   390 QsqslvpqeDAKKNVDVEFSQAISYVNKIKTRFADQPDIYKHFLEILQTYQREQKPINEVYAQVTHLFQNAPDLLEDFKK 469  baker's yeast
19074819  229 P---------QRGIHQGYINQPLIMHSSVKVSGQNGKRMPYDQRRSEEFERMKARQAQDFIQRVKKRYSHNPSVYRSFVE 299  Encephalitozoon c...
12230513  138 ----------L-PC--T-YHRAIGFVSRVRRALLSNPEQFFKLQDSLRKFKNSECSLSELQTIVTSLLAEHPSLAHEFHN 203  fission yeast
19112804  335 Syp----pvDASVKQAADLDQAINFVNNVKNRFSHKPEAYNSFLDILKSYQHDQRPIQLVYFQVSQLFAEAPDLLEEFKR 410  fission yeast
19112225  246 S--------TENEKPRVDFNYAIAYMNKVKARYPPNSDTYMEFLGVLRTYQKAQKSIFEVRARVAEIFKDSPDLLEEFKL 317  fission yeast
2507475   470 FLPDSSASAnqqvqhaqqhaqqqheaqmhAQAQAQAQAqaqveqqkqqqqflypasgyyghPsnrgipQQNLPPIGSFSP 549  baker's yeast
19074819  300 LLQSHQVKS------------------------------------------------------------------GLFEK 313  Encephalitozoon c...
12230513  204 FLPSSIFFG-----------------------------------------------------------SK--PPLGSFPL 222  fission yeast
19112804  411 FLPDVSVNApaetqd---------kstvvPQESATATPkr--------------------sPsa--tpTSALPPIGKFAP 459  fission yeast
19112225  318 FLPDNVDST--------------------EPSTPNVQK-----------------------S------PNRLPPVGNFSL 348  fission yeast
2507475   550 PTNgstvheayqdqqhMQpphFMPLPSIVQHGPNMVHQGIAnENppLsDLRTSLTEQYAPSSIQhqqqhpqsiSPIANtq 629  baker's yeast
19074819  314 MKA------------------EVN--SLLWESP---------------DLCEDFERNFVPIRKH---------MPSD--- 346  Encephalitozoon c...
12230513  223 RGI-------------------Q--SSQFTLS-----NIS---------DLLSQSR---PDNLS----------PFSH-- 252  fission yeast
19112804  460 PTT-------------AK---AQPAPEKRRGEPAVQTRNHS-KR--T-RTATSSVEETTPRAFN---------VPIAq-- 508  fission yeast
19112225  349 PPS-------------APvreKRNRPAHSAQISRSISKTSRmYRqtAeEPLNSYSLHVYPQKIT---------APTSPy- 405  fission yeast
2507475   630 ygdipvrpeidldpsIVPvvpePTEpiennislneevTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFY 709  baker's yeast
19074819  347 ----------------------EKS-------------ILQRIKELLKSKNLLDDFLKCINYFNQKFINEKDLLE-LVAP 390  Encephalitozoon c...
12230513  253 ---------------LSN----ESS------------DFFKNVKNVLTDVETYHEFLKLLNLYVQGIIDRNILVSRGFGF 301  fission yeast
19112804  509 ---------------NKN----PSEl-----------EFLEHARQYLANESKYNEFIKLLELYSQEVFDKNALVERCYVF 558  fission yeast
19112225  406 ---------------AAT----QEEl-----------LAFTTIRQHLPDTLAFHKFLELLHLYREKLLDKTELLN-SFSK 454  fission yeast
2507475   710 LGSNKELFTWFKNFVGYQEkTKciEnIVHEKHRLDLDLCEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWA 789  baker's yeast
19074819  391 LLRSEELIRGFKAFINYKE-------P-LRETPKSLEKYRKEG-SYRILP---EEIKEGKQDPIAKEVLNFTCVGCPTFE 458  Encephalitozoon c...
12230513  302 LKSNSGLWRSFLSLTSLSP--E----EFLSVYNSACSDFPECGPSYRLLPVEERNISCSGRDDFAWGILNDDWVSHPTWA 375  fission yeast
19112804  559 FGSNEHLMNWLKDLVKYNP-AN--P-IPVPRPRVDLTQCKSCGPSYRLLPKIELLLPCSGRDDLCWTILNDAWVSFPTLA 634  fission yeast
19112225  455 LVRNDNLTLWFSEFIRWSDnPIlvKnEPVDERVYLPETFECISLTYRKLPDSWKQDKCSGRDDLDNSVLNDDYISVAPKP 534  fission yeast
2507475   790 SEDSGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLETIVNKIENMTENEKANFKLPPGLGHTSMTIYKKVIRK 869  baker's yeast
19074819  459 SEDSNYVFLKRNVHEEALFRIEDERSEADLAIERIQHLINALEQIIDLNKDSEISMKDIKMSPG--------IIKEILKS 530  Encephalitozoon c...
12230513  376 SEESGFIVQRKTPYEEAMTKLEEERYEFDRHIEATSWTIKSLKKIQNRINELPEEERETYTLEEGLGLPSKSIYKKTIKL 455  fission yeast
19112804  635 SEDSGFIAHRKNQFEENLHKLEEERYEYDRHIGANMRFIELLQIHADKMLKMSEVEKANWTLPSNLGGKSVSIYHKVIKK 714  fission yeast
19112225  535 S-HVKNIMHHENQYLQALQLVEDERYDYDRVLNTTESAIKILANFCEPTIHEH-LETALQELER-----SKRIIKNALII 607  fission yeast
2507475   870 VYDKERGFEIIDALHEHPAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGLTFKQADKKLLTTKQLI 949  baker's yeast
19074819  531 IYDKS-APEILEGILMKPHIAIPIVIKRLYMVNKKVRLCMRERRKIWREVMERNYHKALDVMGPSYKSSEKSIFTTKNIV 609  Encephalitozoon c...
12230513  456 VYTSEHAEEMFKALERMPCLTLPLVISRLEEKNEEWKSVKRSLQPGWRSIEFKNYDKSLDSQCVYFKARDKKNVSSKFLL 535  fission yeast
19112804  715 VYGKEHAQQIIENLQKNPSVTIPIVLERLKKKDREWRSLQNHWNELWHDIEEKNFYRSLDHQGVSFK------------- 781  fission yeast
19112225  608 VYGKEHANLALDTLFKKLPTAAPVLLKRIKTKDQEWRRSKREWSKIWRQIEKKNAQAAFDDRYCRIEGRDRRGLSYSRIL 687  fission yeast
2507475   950 SEISsikvDQTNKKIHWLT-PKPKSQLDFDFPDKNIFYDILCLADTFITHTT-AYSNPDKERLKDLLKYFISLFFSISFE 1027 baker's yeast
19074819  610 ETGE-------R-GIRVSIdDQKVMADVMDLCKTYIRVNQADGKKTLVSNMD-SVLESIFEKLGANEFTIVSDFPLLCIF 680  Encephalitozoon c...
12230513  536 AEADi---LRSQAKLHFPLrSRSAFEFSFVYDNEIVLFDTCYMVCTYIVCNSpSGLKKVEHFFKNILPLHFGLEKDKFSI 612  fission yeast
19112804      --------------------------------------------------------------------------------      fission yeast
19112225  688 RDID----DIYQRQKHRIDgAKLGFQFTQVLCDSLIFLNILRLSDAQLTNSS-FYSYADKGRISAVLKALLSQFFG---- 758  fission yeast
2507475  1028 KIEESLYSHKQNVSESSGSDDGSSIASRKRPYQQEMSLLDilhrsryq-----klkrsndeDGKVPQLSEPpeee----- 1097 baker's yeast
19074819  681 RFIIIVYERLLEIKGLNLDGLSADDSSSKDESASRYAKVK---------------------NLCLEFVKKN--------- 730  Encephalitozoon c...
12230513  613 FLDQVFRGPDYDVNAPNIVGNKPVRRKRSNSITQLTEFVKqpkingqresrsaaaarkkeeSGNKSQSNSQnslsdesgn 692  fission yeast
19112804      --------------------------------------------------------------------------------      fission yeast
19112225  759 -IPLPREALETNLASENIESVKKHRDGLSKIFIRPESADN---------------------S-NNTNVSFQ--------- 806  fission yeast
2507475  1098 ------pntiEEEELIDEEAKNPWLTGNLVEEANSQGIIQNRSIFNL----FANTNIYIFFRHWTTIYERLLEIKQMNER 1167 baker's yeast
19074819  731 ----------IDGYAFEDRIRELTECKGFKLYNIKKMISKIEKQVIAlt-eNKQSLDSLYGVHRFDSGEGLYCFRKIKNA 799  Encephalitozoon c...
12230513  693 vtpvskkqlsQPAAAIKASLKYPSHPDSLLEHQDHAGDTENEMHDDVdkeqFGYSSMYVFFRLFNLLYERLYELQRLEDQ 772  fission yeast
19112804      --------------------------------------------------------------------------------      fission yeast
19112225  807 ----------TDETQTEDETMSDIHPDDVENHSKSKFLGEESKNIIGyn-fFGNATMYVLFRLICVCYSRLEHIKLFVES 875  fission yeast
2507475  1168 VTKEINTRStvtfakdldllssqlsemgldfvgedAYKQVLRLSRRLINGDLEHQWFEESLRQAYNNKAFKLYTIDKVTQ 1247 baker's yeast
19074819  800 IEIGMMEPG----------------------------RNEEWDSYVEKFKALTPCEDVKPDAPFLPRTCKKPPITGRLRQ 851  Encephalitozoon c...
12230513  773 VSIIQQRIIpnpvsqkqkiwrdrwndlsdvpdektHYENTYVMILRLIYGIVDQSAFEDYLRFYYGNKAYKIYTIDKLVW 852  fission yeast
19112804      --------------------------------------------------------------------------------      fission yeast
19112225  876 STIYASSTG--------------------------GYENILNICEKYLKGSCSRLEFRKYLQKFNNETCYMICSIERLLK 929  fission yeast
2507475  1248 SLVKHAHTLMTDAKTAEIMALFVKDRNASTTSAKDQIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQYIALDDLTLKEP 1327 baker's yeast
19074819  852 NLKIQLSPGTYKIKYIAKSESLYMNSAASSKRKQLPTKSH---------------------------------------- 891  Encephalitozoon c...
12230513  853 SAAKQVHHIVSDGKYKFVTSLVEQNSSASPKKNYDDFLYRLEIEKLLNPDEILFRFCWINKFKSFGIKIMKRANLIVDQS 932  fission yeast
19112804      --------------------------------------------------------------------------------      fission yeast
19112225  930 VIFYRIHEILLDPKLGQLLLLFESDGANSVTTPREQMVYRNHVESILAPESKIFNMRWYPLEKRLCIQQLLPADLTMHDF 1009 fission yeast
2507475  1328 KADED-KWKYYVTSYALPHPTEGIPHEKLKIPFLERLIEFGQdidgtevdeefspegiSVSTLKIKIQPITYQLHIENGS 1406 baker's yeast
19074819      --------------------------------------------------------------------------------      Encephalitozoon c...
12230513  933 LDTQRrVWKKYVQNYRIQKLTEEISYKNYRCPFLCRNIEKER----------------TVEQLVSRLQTKLLRSAELVSG 996  fission yeast
19112804      --------------------------------------------------------------------------------      fission yeast
19112225 1010 ENPAK-AFMYYVDSYAISHITEGVDLMQVKMPFLRRSLQRISqq-------------gYLAGRGSGRLHSLFNEHFCKSN 1075 fission yeast
2507475  1407 YDVFTRKATNKYPTIANDNTQKGMVSQKKELISKFLDCAvglrnnldeAQKLSMQKkWENLKDSIAKTSAGNQGIESETE 1486 baker's yeast
19074819      --------------------------------------------------------------------------------      Encephalitozoon c...
12230513  997 LQAKLCLDSFKLLYLPRTEDSYIDASYLRLRDTDFLDCQn--------KRKQRWRNrWESLLKSVRGTSDNTAEVNFDAD 1068 fission yeast
19112804      --------------------------------------------------------------------------------      fission yeast
19112225 1076 LQLFFSTDTYVIFFEPNTENVYINSYNLWVDQSSQSKKQ---------NRTTNWRR-WLESDEGWRKSKANTDIKFFSET 1145 fission yeast
2507475  1487 KGKITKQ 1493 baker's yeast
19074819      -------      Encephalitozoon cuniculi
12230513 1069 INALFIP 1075 fission yeast
19112804      -------      fission yeast
19112225 1146 TLDQCIE 1152 fission yeast
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