Conserved Protein Domain Family
PLN03128

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PLN03128: PLN03128 
DNA topoisomerase 2; Provisional
Statistics
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PSSM-Id: 215593
Aligned: 14 rows
Threshold Bit Score: 1615.16
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
224007305    1 ETIEDTYSRKTPLEHILLRPSMYIGPTEHADPKSCSSTNSp------wTMQRQELSYVPALLKIFDEILVNASDNRLRHP 74  
145353138   26 KSVEEIYQKKTQLEHILLRPDTYVGSCERAEEKAWVYDAAt------kSLTHKQVSFVPGLYKIFDEILVNATDNKVRDP 99  
159484508   17 KSIEEMYQKKTQLEHIILRPDTYIGSTERQPNHVWVHTGQ--------KMEYKQVSYPPGLYKIFDEILVNAADNKVRDA 88  
219121754    1 --LEDQYSRKTPLEHVLLRPSMYVGSNEK-AQPIACWVPDpiptppteELLMKTTS-------VFDEILVNAADNLQRHP 70  
219121760    3 KTVEETYQKMSQLEHILIRPDTYIGSVEPHTKLMFILEDD--------KIIEKEITYTPGLFKIFDEIVVNAADNKQRDP 74  
224007445   39 KTIEETYQKKTQLEHILLRPDTYIGSTEPLTQPMFVLNAEt------nRIAQRDVTYTPGLYKIFDEIVVNAADNKQRDP 112 
224007473    1 KTIEETYQMKTQLEHILLRPDTYIGSTEPLTQPMFVLSTTtntppsppRIIQREVTYTPGFLKIYDEIIVNAADNKQRDP 80  
302782265   12 KTIEEIYQKKTPLEHVLLRPDTYVGSIEKHTQTLWVYEGG--------QLVNRAVTYVPGLYKIFDEILVNAADNKQRDP 83  
302812673   12 KTIEEIYQKKTPLEHVLLRPDTYVGSIEKHTQTLWVYEGG--------QLVNRAVTYVPGLYKIFDEILVNAADNKQRDP 83  
302844478    1 -----MYQKKTQLEHIILRPDTYIGSTERQPNTIWVHNGQ--------KMELKTVNYPPGLYKIFDEILVNAADNKVRDP 67  
224007305   75 gSCNHFPSSSDP-------YISITNNGKSIPIQIHRKENMYIPELLFGHLLTGSNFNDDQKR---------------LTG 132 
145353138  100 -KMKELRVDIDVeq----gLIRVYNDGNGIPVEMHKDEGVYVPELIFGHLLTSSNYDDNEKK---------------VVG 159 
159484508   89 -TMDTIKVDIDAat----nSIRVWNNGKGIPVDVHKEEGVYVPELIFGHLLTSSNYNDSEKKaltvhtnipyapppqITG 163 
219121754   71 dSCTRIDVIIDPgsdnrdpFIRVRNDGKGIPVQVHQKEGMYVPEMLFGHLLTGSNFDDNEKR---------------LTG 135 
219121760   75 -NMDKLDVTINAee----nVISIQNNGKGIPIVMHKEHGIYVPELILGHLLTGSNFDDGERK---------------TTG 134 
224007445  113 -NMDRMEVTVDAes----gTISVLNNGKGIPVVMHKEHNCYVPTLIFGHLLTGSNFDDDEKK---------------TTG 172 
224007473   81 -NMDRLDVDIDVeg----gVISVCNNGKGIPVVIHKDQGCYVPTMIFGHLLTGSNFDDDEMK---------------TTG 140 
302782265   84 -IMDAVKVTISVeq----nTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKK---------------TTG 143 
302812673   84 -SMDAVKVTISVeq----nTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKK---------------TTG 143 
302844478   68 -TMDTIKVDVDPan----nSIRVWNSGRGIPVEVHKEEGVYVPELIFGHLLTSSNYNDSEKK---------------ITG 127 
224007305  133 GRHGYGAKLTNVFSKQFVVEIGDGHsskgKIKTYKQVWEDNMSVCHEAEVVSRDKKDadgkgnlDYTRISFIPDLARLTG 212 
145353138  160 GRNGYGAKLANIFSTEFIVETCDGS----RGKRYRQVFKNNMSVKGEPELSKCKKSE-------NWTCITFKPDFEKFGM 228 
159484508  164 GRNGYGAKLANIFSTEFIIETCDGS----RLKRYKQTFTKNMQVKGTPKITDCKASD-------NWTSITFKPDLARFGM 232 
219121754  136 GRHGFGAKLTNIFSKSFTVETLDSR----KRLKYRQTWSSNMTNASSPEIVEVPADAt------DYTCVSFVPDVARLTN 205 
219121760  135 GRNGYGAKLANVFSTEFVVECADTE----NGLKYRQVFRENMKQKDKPVVKALTAKEmk---aaDYVKITFSPDLERFKM 207 
224007445  173 GRNGYGAKLANIFSTEFIVECVDSN----EGMKFKQVFRNNMHVKEDPKVKKCTAAElk---kgDYTKITFKPDLNRFNM 245 
224007473  141 GRNGYGAKLANIFSTEFIVECVDSN----EGLKFKQVFRNNMHKTEEPKIKKCSASEmk---kgDYTKITFKPDFEKFSM 213 
302782265  144 GRNGYGAKLANIFSTEFVIETADGK----RGKKYKQVFSNNMSAKSEPAISSCKSNE-------NWTKVTFKPDLAKFHM 212 
302812673  144 GRNGYGAKLANIFSTEFVIETADGK----RGKKYKQVFSNNMSAKSEPAISSCKSNE-------NWTKVTFKPDLAKFHM 212 
302844478  128 GRNGYGAKLANIFSTEFTVETCDGS----RQRRYKQTFTNNMQQKGTPKITDCKASD-------NWTCITFKPDLAKFGM 196 
224007305  213 DRktemLPEEEYQLMKRRVVDIAGCS----GGKLTVTLNGEEISVSGFEDYANLYRQPEss--------atPLPPMVYHK 280 
145353138  229 ESl---VNEDVAALMCKRVYDAAGNI----GKNTNIYLNGEKLEVKGFSDYVSLYLDGQ------------ANAPKIFEK 289 
159484508  233 EA----LDEDVVSLLRRRVYDMAGVL----GKGAKVYYNGERLSIKSFQEYVDMYLGPK------------NGVPRFCER 292 
219121754  206 DAsalsISKEDYALMCRRVLDVAGCS----AGRLRVTLNGVDVTMGSFPDYARLYRKQD-------------SLPVCFDA 268 
219121760  208 DR----LDEDTVGLLSKRAYDIAGTMsqssGKKLLVSLNGKKLPIKSFKDFIGVFEGIN--------------KPSAFET 269 
224007445  246 TS----LDTDTVGLLSKRAYDIAGSMankeGKKLSVYLNGKKLPVKDFKSYLALFDGIT--------------PPAAYEK 307 
224007473  214 TR----LNEDAVGLLAKRAYDIAGTMgskeGKKLSVYLNGKKLSVKGFKSYLALFDGIN--------------PPAAYEK 275 
302782265  213 TY----LEEDVVALMSKRVLDIAGCL----GRTVKVELNGQKLPVKTFSDYVGLYLASAqkg-------keETLPRIYER 277 
302812673  213 TY----LEEDVVALMSKRVLDIAGCL----GRTVKVELNGQKLPVKTFSDYVGLYLASAqkg-------keETLPRIYER 277 
302844478  197 SE----LDEDIVSVLRRRVFDMAGVL----GKGVKVFYNGERLSIKSFQEYVDMYLGPKvkrtwfrgvphdNGIPRFCER 268 
224007305  281 L----NSRWEVAVGLSEtKSLESISFVNGMNTSRGGTHVDALARQISQYIADHINNKmarqldnlqSGQPISVSVR-MVR 355 
145353138  290 T----MDRWEVCVTISDtAQFQQCSFVNGICTMKGGTHVNSVADQISQKLLEKIQKK---------EKSCKNLKAF-QVK 355 
159484508  293 I----NDRWEVCISITD-GSFQQVSFVNSISTQKGGTHVDYIVNQVVKHATEKLSKK---------TTKTAAIKPA-MVK 357 
219121754  269 I----NSRWTVGVGLSEtGSFEMVSFVNGMATSRGGTHVNSILQQVIKKIQEKIEKT---------DPELVQMASQgVIR 335 
219121760  270 VrlanSDRWEVGVAASDdAAMKQVSFVNSISTSKGGTHVQYIADQVASHLAKAITKK---------NKKGGEVKAS-FIK 339 
224007445  308 V----GDRWEVGISVSD-GSFQQISFVNAIATTKGGGHVNYIADQVAKSLQASVKKK---------NKGGTEIKPN-QIK 372 
224007473  276 V----GDRWEVGISVSD-GSFQQISFVNSISTTKGGGHVDHIAEMVVTRLKDLVKKK---------NKGGAHVKPA-QIK 340 
302782265  278 A----NDRWEVCVSLSD-GQFQQVSFVNSIATIRGGTHVQHVSEQIVSHIQEIVNKK---------NKNA-NVKGF-QIR 341 
302812673  278 A----NDRWEVCVSLSD-GQFQQVSFVNSIATIRGGTHVQHVSEQIVSHIQEIVNKK---------NKNA-NVKGF-QIR 341 
302844478  269 L----NDRWEICISLTD-GSFQQVSFVNAISTQKGGTHVEYIVNQIVKHCIEKLSKK---------TAKTTAIKPA-MVR 333 
224007305  356 RHLFLCVNCLIENPSFDSQ---------MKECLTSNPDNFGSHFELSNSFLRKLV------GPGIVEEVLRMAMGAQQVN 420 
145353138  356 NHLWVFVNALIENPAFDSQ---------TKETLITRPNKFGSAYAPSDAIIKKLM------ESGVVDNIMSWAQFKQSKE 420 
159484508  358 NHLWVFLNCYVENPAFDSQ---------TKETLTLRATAFGSKCELPVPLLDKVL------KAGLSDSIIRFAEFKSQKE 422 
219121754  336 RHLFVSVAALIENPTFDSQ---------MKECLTSSPADFGSSFSLSESFIKSVLqseeegGPGIVEEIRRAAQSRQQAT 406 
219121760  340 NHLAIFVNCLIENPAFDSQ---------TKEFMTSKPKDFGSTCKLSDSFLKKLE------KSAIVENVLAFSQFRDRQA 404 
224007445  373 NHLSVFVNCLVENPTFDSQ---------TKENLTTRPSAFGKEGQLSDKFMKQVE------KCGVVDAIMSYAKFKQNQA 437 
224007473  341 NHLSIFVNCLVENPKFDSQ---------TKENLTTKKSTFRSEVQLSEKFLKQVD------KCGVVDSIMAYAKFKEGQA 405 
302782265  342 NHLWVFVNSLIDNPAFDSQ---------TKETLTTRQTSFGSKCELSPEFLKKVS------KCGVVDNVLSWADFKQSKE 406 
302812673  342 NHLWVFVNSLIDNPAFDSQ---------TKETLTTRQTSFGSKCELSPEFLKKVS------KCGVVDNVLSWADFKQSKE 406 
302844478  334 NHLWIFLNCYVENPAFDSQaspfkivllTKETLTLRSTSFGSKCELPIPLLDKVL------KAGLSDSIIKYAEFKSQKD 407 
224007305  421 MARLLKEQt-KRQVLSIPKLEDANLAGSTDigtENPCTLILTEGDSAKALAVAGLEVVGRDHYGVFPLRGKFMNVRNVTV 499 
145353138  421 LKKTDGAK--RSRLTGIPKLDDANDAGGRN---SESCTLILTEGDSAKALAVSGLSVVGRDKYGVFPLRGKLLNVRDASH 495 
159484508  423 LKKGDGTK--RSRLHGITKLDDANDAGGPR---SRECTLILTEGDSAKALAISGLGVVGRDHYGVFPLRGKLLNVREASA 497 
219121754  407 LLKVIGGKtsKRQLLSIPKLEDAHHAGTKS---GSECTLILTEGDSAKALAVAGLEVIGRARYGVFPLRGKLLNVREAAV 483 
219121760  405 LKNKSGKK--KAKLTGIDKLDDANFAGTAK---SKDCTLIITEGDSAKSLAMAGLSVIGRDYYGVFPLRGKPLNVRDAPI 479 
224007445  438 LKRKGGTK--KTKLTGITKLDDANNAGTAK---SKDCTLIITEGDSAKSLAVSGLSVVGRDFYGVFPLKGKPLNVRDATH 512 
224007473  406 LKRKGGTK--KNKLTGITKLDDANHAGTAK---SKDCTLIITEGDSAKSLAVSGLSVVGRDFYGVFPLKGKPLNVRDATH 480 
302782265  407 LKKNDGAK--RQRLTGIAKLDDANDAGGKN---SEACTLILTEGDSAKALAMSGISVVGRNHYGVFPLRGKLLNVREATH 481 
302812673  407 LKKNDGAK--RQRLTGIAKLDDANDAGGKN---SEACTLILTEGDSAKALAMSGISVVGRNHYGVFPLRGKLLNVREATH 481 
302844478  408 LKKGDGVK--RSRLVGMAKLDDANDAGGPR---STDCTLILTEGDSAKSLAVSGLGVVGRNHYGVFPLRGKLLNVREASA 482 
224007305  500 KQLATNAELKAMCAILGLQFEKSYdtaKERQELRYGHVMLMTDQDADGSHIKGLIMNMFRFFWPALLKPPs--------- 570 
145353138  496 EQIKNNTEINHIKQILGLQHGKEY---DSAKSLRYGKLMIMTDQDHDGSHIKGLLINFLHAHFPSLLKIP---------- 562 
159484508  498 AQIAANAEIQNIKQIMGLQHGKVY---ENTTSLRYGHLMIMTDQDHDGSHIKGLIMNFLHSFFPSLLRIP---------- 564 
219121754  484 SQMAKNAEVTALCAIIGLDFDKTYetiEERRKLRYGKVMLMTDQDTDGSHIKGLVMNFFRYFWPNLLKPPvdlqvndede 563 
219121760  480 KAVTSNEEIKNVVEIMGLKFQTVYd-eTNIKQLRYGHLMIMADQDNDGSHIKGLIINFIHNFWPSLLDIP---------- 548 
224007445  513 SQIMKNEEIMNLVEIMGLKFGTTYt-eENIKSLRYGHLMIMADQDHDGSHIKGLIINFIHHFWPSLLDIP---------- 581 
224007473  481 FQIMKNEEISNLVAIMGLKFDTTYt-eENIKSLRYGHLMIMTDQDHDGSHIKGLIINFLHKFWPSLLDIP---------- 549 
302782265  482 KQIMDNAEITSIKQILGLQQGKGY---ENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVP---------- 548 
302812673  482 KQIMDNAEITSIKQILGLQQGKGY---ENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVP---------- 548 
302844478  483 VQIAANQEIQNIKQIMGLQHGRVY---DSTSSLRYGHLMIMTDQDHDGSHIKGLIMNFMHSFFPSLLKIP---------- 549 
224007305  571 -rPFMSMFITPLLKATKKGkKkdSISFFSVAEYNSWRESLEDEDeisKWTVKYYKGLGTSTPTEAKDYFLSFVRHYRPFK 649 
145353138  563 --GFLLEFITPIIKATKGK-Q--SKVFYTMPEYEAWKEANDGTS---GWSIKYYKGLGTSTANEAKEYFASLDHHRKSFV 634 
159484508  565 --GFLLEFITPIVKARRGR-D--TKVFYTMPEYEAWKESLGNATt--AWDIKYYKGLGTSTKEEAQEYFSRLDLHRKEFV 637 
219121754  564 tpPFLSSFVTPLLKASKKSsKtgTLSFYSMAEYKKWRGSIEAEDf-kKWTVKYYKGLGTSTPAEAREYFSAFNDHFRPFL 642 
219121760  549 --GFLQQFITPIVKVSKGQ-K--SQSFFNLPEYENWLESTGKNGh--GWKIKYYKGLGTSTSAEAKEYFSNLDLH--EVL 619 
224007445  582 --DFLMQFITPIVKCTKGK-K--SHTFFTLPEYEEWKEGTGNDAk--GWTIKYYKGLGTSTSSEAKEYFSNLDIHEILDN 654 
224007473  550 --DFLMQFITPIVKCTKGK-K--FHTFFTLPEYEEWKEGTGNDAk--GWTIKYYKGLGTSTSSEAKEYFSNLDIHEIIFN 622 
302782265  549 --GFLVEFITPIVKATHKNgK--VLSFYTMPEYESWKESLRGETk--GWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFA 622 
302812673  549 --GFLVEFITPIVKATHKNgK--VLSFYTMPEYESWKESLRGETk--GWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFA 622 
302844478  550 --GFMLEFITPIVKARRGR-E--TKVFYTMPEYEAWKESLDNNTs--GWDIKYYKGLGTSTKEEAQEYFSRLNLHRKEFV 622 
224007305  650 WQSeK----NDGERIDMAFEKDRANDRKDWiLTEYDEKSAVtvdERDGNSITYGDFVDNELIHFSNANNIRSLPNVVDGL 725 
145353138  635 WQS-D----GDGDLIDMSFSKKRVVDRKAW-LTAYEPGTFL---DMTGEDIRYDEFINKELILFSRADLLRSIPSMVDGF 705 
159484508  638 WEG-D----EDGDSIELAFSKKRVDDRKEW-LSNFVPGTFL---DQSADRISYSDFINRELILFSRADLDRSIPSMLDGL 708 
219121754  643 WNS-D----IDGELLDMVFDGERAADRRAWiLDVYDETSNLlndPSAGNNVSYEDFINKEMIHFSNADNIRSIPSAIDGL 717 
219121760  620 PDTvQ----SGNDLIDMVFRKNRVEDRKQW-LNAIAKDTFLnysEVSKEGVMYSEFINREYILFSKSDNERSIPHLLDGF 694 
224007445  655 DAI-T----SGAGLIDMAFSKSKVEERKKW-LNRVEKDTFLnysAAQRNGVNYSEFINRELVLFSQYDNVRSIPHIMDGF 728 
224007473  623 EIS-DcipsTGSALIDMAFSKSKVEERKKW-LNRVEKDTFLnyrDAQRNGVNHSEFVNRELVLFSQYDNVRSIPHIMDGF 700 
302782265  623 WDN-D----EDGDSIELAFSKKKTEARKIW-LRGYQPGTFL---DQTQRVITYSDFINKELILFSLADLARSVPSMVDGL 693 
302812673  623 WDN-D----EDGDSIELAFSKKKTEARKIW-LRGYQPGTFL---DQTQRVITYSDFINKELILFSLADLARSVPSMVDGL 693 
302844478  623 WTG-D----EDGDAIELAFSKKRVDDRKEW-LSNFVPGTYL---DQSAEKISYADFINKELILFSRADLDRSIPNVLDGL 693 
224007305  726 KPSQRKVLYACFKRNLKDEIKVAQLAGYCAEHTAYHHGEASLHSTIIGMAQDFCGSNNINLLTPSGQFGTRLMGGNDAAS 805 
145353138  706 KPSQRKVLFSCFKRKLKSDIKVAQLSGYVSEHSAYHHGEASLAMTIVNLAQDFVGSNNINLLVPSGQFGTRLQGGKDHAS 785 
159484508  709 KPGQRKILYACFKRNLKKDIKVAQLSAYVAEHSAYHHGEGSLASTIVNLAQDFVGSNNVNLLHPSGQFGTRLQGGKDAAS 788 
219121754  718 KPSQRKVLYACFKRKLKSEIKVAQLTGYCAEHTAYHHGEASLQSTIIGMAQDFVGSNNINLLVPSGQFGTRIMGGADAAS 797 
219121760  695 KPSQRKILFACFKRKLKGEIKVAQLTGYVAEHSAYHHGEASLQATIVNMAQNFCGSNNINLLTPSGQFGTRRMGGKDAAS 774 
224007445  729 KPSQRKVLYACFKKKLKAEIKVAQLAGYIGEHSAYHHGDMSLNGTIIGMAQSYCGSNNLNLLYPSGQFGTRRMGGKDHAS 808 
224007473  701 KPSQRKVLYACFKKKLKAEIKVAQLAGYIGEHSAYHHGDMSLNGTIIGMAQSYCGSNNLNLLYPSGQFGTRRMGGKDHAS 780 
302782265  694 KPGQRKILFAAFKRNFTSQAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFVGSNNINILAPIGQFGTRSQGGKDHAS 773 
302812673  694 KPGQRKILFAAFKRNFTSQAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFVGSNNINILAPIGQFGTRSQGGKDHAS 773 
302844478  694 KPGQRKIMFACFKRNLKKDIKVAQLSAYVAEHSAYHHGEQSLASTIVNLAQDFVGSNNINLLHPSGQFGTRLQGGKDAAS 773 
224007305  806 PRYIFTHLSPLSRLLFPVDDDMLLNYKEEDGQMIEPEYFCPIIPLLLVNGCQGIGTGWSTFIPQHNPLDVLNYIRAKLDE 885 
145353138  786 PRYIFTRLHEVCRAMFPECDDALLNYLDEDGQRIEPDYYYPVLPLVLVNGAEGIGTGWSTSIPNFNPRDLIANIRLVLEG 865 
159484508  789 ARYIYTRLAALTRHLFNENDDQLLTYLNEEGQSIEPEWYMPILPTVLINGADGIGTGWSTTIPNYNPRDIMANLRRLLEG 868 
219121754  798 PRYIYTYLAPIARSLFPEADDTLLSYLEDDGQQIEPEFYCPIIPLLVVNGCQGIGTGWSTFIPPHSANDVLEYILAKLDG 877 
219121760  775 ARYIFTKLEPITRAIFHPDDDELLSYINDDGVTVEPEYYVPVIPMILVNGADGIGTGWSTSVNNYNPREIVRNLRRKIAG 854 
224007445  809 ARYIFTRLEKIARAIFHPDDDALLNYLNDDGLSIEPEYYMPVIPMVLVNGSDGIGTGWSSTIQNHDPREVIANIKKMING 888 
224007473  781 ARYIFTRLEKIARAIFHPDDDALLNYLNDDGLSIEPEYYMPVIPMVLVNGSDGIGTGWSSTIQNHDPREVIANIKKMING 860 
302782265  774 ARYIYTSLTPLTRTIFPKPDDILLNFLREDGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRD 853 
302812673  774 ARYIYTSLTPLTRTIFPKPDDILLNFLREDGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRD 853 
302844478  774 ARYIYTRLEKLTRHLFNEHDDVLLKYLNEEGQSIEPEWYLPILPTVLVNGAEGIGTGWSTFIPNYNPRDIIANLRRLLNG 853 
224007305  886 -TKKPAIRPWVKGFEGGITVDS----KRGDYVTEGIITPQKNSSVVISELPVGVWTNDYKATLVAM---------LKKAE 951 
145353138  866 -ESPVQMHPWYRHFKGSITEELv--kGETRYNVTGSYNIRDECTLEVTELPLRSWTSDYKEFLEEMlvp---ktkTAKPF 939 
159484508  869 -EAQEAMHPWYRGFNGNIAEAAthksGSRSYVVSGTVTQTGPNTIEITELPIRKWTQDYKEFLETLlrptekvrrDEAPI 947 
219121754  878 aERLPKIHPFARGFQGRIEPDP----NGNGYVSFGRSSCISDRTILIDELPLRCWTNKYKGILLKM---------RDRGE 944 
219121760  855 -EDFVAMAPFYSGFKGEIIPVDsnsrRSGSYDMLGKVERINDTTIIISELPVRKWTQDYKAFLEIMltg---dgkKKLPE 930 
224007445  889 -EEPELMHPHFAGYTGEITAESg--sREGSYIVEGKIERTGDTTLLITELPIGKWTQDYKGFLEGLmig----tdKSPSE 961 
224007473  861 -EEPELMHPHFAGFTGEITAESg--sREGSYIVEGKIERTGDTTLLITELPVGKWTQNYKAFLEGLmsg----tdKDPSE 933 
302782265  854 -EPLEPMDPWYKGFKGTIVKSAsk-eSGVSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLEALlcg---tekIKEPS 928 
302812673  854 -EQLEPMDPWYKGFKGTIVKSAtk-eSGVSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLEALlcg---tekIKEPS 928 
302844478  854 -EEQDPLHPWYRGFTGTITEVPhk-sGSRSYVVGGLVAQTGPNTIEVTELPVRKWTQDYKEFLETLlrp---qdkDEAPL 928 
224007305  952 IKSFSQNHTTTTVSFNVKVNAAKLNRLLKG--DMLKTFKLRKALSTRNMHAFTTDMKIARYNSPEEIADAFFPVRLDLYA 1029
145353138  940 ITDYKEYHTDSTVHFVITMPPENLAAAQAS--GIEKKFKLSTKLNITNMHLFNEQGVITKYSSPVAILEAFVPLRLKAYS 1017
159484508  948 IADYSEHHSDSNVHFVVELLPGKMEELLASpgGLDGKFKLTTKIATSNMMLFDHSGMIKHYSSPEMIVAEFYELRLDYYE 1027
219121754  945 VTSFVENHNTSKVSFLVTLKSAQLARMTQA--GLEKSFKLKTNLQTTNMHAFNKDGQICKFDTAESIVEAFFPVRMQLYQ 1022
219121760  931 IKDFTENHTETTVSFTIIAEKEKIDEFEKEkaGLMGKFKLTGSLSTSNMTLFDERGRITRFEDPESIMNAFYDIRLDFYD 1010
224007445  962 ISDFKENHTDTTVSFTVTASKDAIDKFEKEkgGLVGKFKLSTTISTKNMTLFDTNGKIHKYKASVDILRTFFHHRLEYYV 1041
224007473  934 ISDFKENHTDTTVSFTVTATEENINKFEYGkgGLLKKFKLSTTMSTANMHLFSEDGKIVKYNGSVDILRTFFHHRLEYYV 1013
302782265  929 IKDYREHNTDTRVHFEISLSEEKMAEALAE--GLTKKFKLSTTISTSNMNLFDKDGHIRKYDTPEQILEDFYHIRLELYV 1006
302812673  929 IKDYREHNTDTRVHFEISLSEEKMAEALAE--GLTKKFKLSTTISTSNMNLFDKDGHIRKYDTPEQILEDFYHIRLELYV 1006
302844478  929 IADYHEHHSDSNVHFVVELLPGKLDELLATpgGLEAKFKLQAKVTTSNMMLFQKDGIIKHYQSPEAIIAEFFELRLDYYE 1008
224007305 1030 DRKSVLESNMEYSASLMRNKARFIEAVSANKIDLlhGRKSKEATTALLEEMEFSKQSELDAIKSNnniaqrressNVVMD 1109
145353138 1018 QRREMLIRLAESQLKRLSNKMRFILAVVDGSLVV--NRKKKQELIAELEALCYDRLPKTDKGSVA----------ELDED 1085
159484508 1028 KRRIAMLKVASLDQKRADNRIRFILAVVEGRLEV--RGRKRADLERDLEAQGFDRLGKAGAKVKVritevaedgeEGEGG 1105
219121754 1023 DRIALLQSLLNYEASILRNKAGFIKAVTSGDIDLtsGRRSKQETSKKLKEHGFLDSVELNAIKNEnvlw--krrqFASEK 1100
219121760 1011 KRKRLLVKKLKEEQRKLSNKARFVEEVCRVELVV--NNRKRQDILHELRNRGYETFGADARSKETsds----dgeEDSIN 1084
224007445 1042 KRKDMLLEKMRRELKVYDNKARFVEEVCKGDLVV--SNRKRAELLADLQLRGYDLYPREVKKSETee------edDTSVE 1113
224007473 1014 KRKDMLLEKLRRELKVYDNKARFVEEVYKGDLVV--SNRKRSELLFELRDKEYDIYPKESNQAETdde----desMESVE 1087
302782265 1007 KRKEVQVENLQYELLKLDNKVRFILGVVKGEIVV--NNRKRAELLVELKTKGFTPFPKKAKASDLpvvggdgsdvEADDE 1084
302812673 1007 KRKEVQVENLQYELLKLDNKVRFILGVVKGEIVV--NNRKRAELLVELKTKGFTPFPKKAKASDLpvvggdgsdvEADDE 1084
302844478 1009 KRRIAMLRFAQMDQMRADNKVRFILAVVHGKLEV--RNRKRVDIEKDLEAQGFDRMSKTNTATKVnl-----------si 1075
224007305 1110 EFMSDEESAKGaakeYDYLLNLPLSSLTLE-KIDALNDDAAKTDTKLEQIKNTTPADLWREDLNRLEPHLQ 1179
145353138 1086 GEFIANDVAGS----YDYLLGMPLWNLTLE-KVDELCAEKEAKEAEVAELHKTTEKDLWMKDLDTLEQTLE 1151
159484508 1106 EAAVTASNGAS----YDYLLSMSIYNLTRE-KIAKLQEEAAKAKERVEYLCSITGRDMWAQDLDAFE---- 1167
219121754 1101 GEGGSNLEPMN----FDYLLNMPLSSLTSE-KIRELGEHAATKDKELEEMKSTTPVDLWRRDLQKLALLL- 1165
219121760 1085 ESQSDAELARG----YEYLLGMKIWSLTFE-KAEELRRKLGEKTTELNALQGTSPSELWLNDLD------- 1143
224007445 1114 EDASDAELAKG----YEYLLGMKIWSLTFE-RAEELRRQKAEKADEVEKLEGTSPEAIWMTDLEAIEEALD 1179
224007473 1088 ENASDAELAKG----YEYLLGMKIWSLTFE-RAKELRRQKTEKAEDVEKLEGTSPEAIWQTDLDAIEEALD 1153
302782265 1085 EKLNKGVRAGD----YEYLLSMPIGTLTLE-KVQQLCNERDKLEGDVEELKKCTPKDLWEKDLDNFLEQLT 1150
302812673 1085 EKLNKGVRAGD----YEYLLSMPIGTLTLE-KVQQLCNERDKLEGDVEELKKCTPKDLWEKDLDNFLEQLT 1150
302844478 1076 PVVQSCMLNPS----FNFVDRSTTYLLRGTmRTARRRARRANQVTSTCYPCQFTA---------------- 1126
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