Conserved Protein Domain Family
PP1_inhibitor
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pfam05361: PP1_inhibitor 
PKC-activated protein phosphatase-1 inhibitor
Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its inhibitory potency 1000-fold, creating a molecular switch for regulating contraction.
Links
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Statistics
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PSSM-Id: 461630
Aligned: 5 rows
Threshold Bit Score: 192.022
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_957104      1 MAANRVGRRYNNKIHSPNRgasreAGLS---VQKRQARVTVKYNRKELQRRLDVEKWIDCGLDELYLGREDEMPEEVNID 77 
XP_007257527  13 AEEQNGGRREEDGERLFPR-----AALS---AQKRQSRVTVKYNRKELQKRLDVETWIEEALEELYAGLEDEMPDEIDID 84 
Q66KC0         1 MAANKVGKRFPNKPHSPSKtr--dSNQG---IQRRQARVTVKYDRKELQKRLDVEKWIDEQMEELYLGREVDMPDEVNID 75  tropical clawed...
O18734         1 MAAQRLGKRVLSKLQSPSRar--gPGGSpggLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGREADMPDEVNID 78  pig
XP_005991672   1 MAANKVGKRAQNKFLSPSRnr--eAGLA---VQKRQARVTVKYDRKELQKRLDVEKWIDERLEELYLGREKEMPEELNID 75  coelacanth

NP_957104     78 ELLDLQSDEERTQKLKDILHACSNNTEVFITELVKKLHGLQKQEDLHNNGIEHPQLHIFPERQGS-S 143
XP_007257527  85 ELLVLQSDEERVQKIQELLQTCTNSTQAFITELLQKLHGLQKQEELQNKGIGHPCLHSYPHHHGNvH 151
Q66KC0        76 DLLDLETDEDRRQSLQVILKSCTNNTEAFIRELLLRLKGLQKQTLIKKNGLEVSSEEHIVEHa---- 138 tropical clawed frog
O18734        79 ELLELESEEERSRKIQGLLKSCTNPTENFVQELLVKLRGLHKQP-----GLRQPS----PSGDGS-L 135 pig
XP_005991672  76 DLLDLASDEERSRKLKDMLHSCNSNIEEFTTELLIKLHGLPKQNVLQRNGIEHQEVEKp-------- 134 coelacanth
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