Conserved Protein Domain Family
SASA

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pfam03629: SASA 
Carbohydrate esterase, sialic acid-specific acetylesterase
The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.
Statistics
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PSSM-Id: 427409
Aligned: 74 rows
Threshold Bit Score: 199.351
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CDH50429      58 VGDVWVMSGQSNMRG-NGFYEDpWTDPPTSYLDHVNnnIHLFQCNET-WTLAQEPT--HRLdQSIrqvNhnlsdpsvkdp 133
WP_008177623  60 KMSLFILAGQSNMSG-TGKLT-------PASSVTHPn-VFVFGNDYR-WHLGKEPIdsPSGqVDKvseD----------- 118 Moorena producens
EGN39579     120 VGNLFLIAGQSNSAG-YGK----------DYCTDPPhlCVHLFRNRNqWDLASHPM--NES-TAAgslP----------- 174
WP_009324801 123 VGDVFVIAGQSNAAG-RAKN---------PVADDPElgVHVLRTSAR-WELATHPL--GET-TNAlhvGhye-------- 180 Subdoligranulum...
CDC71334     106 VGDVFVIAGQSNSAG-FSKT---------PGCREPAagIHMFRNRCR-WDIASDPM--NEK-TDTahpE----------- 160
EIE90801      50 VGDVWVMAGQSNMRG-HGFLRNpFDNQS--LVISPVnnICLYASNEK-WMEASEPTh-NLF-ASPravHhtl-----pdp 118
WP_015250354 149 VGDLWVLAGQSNMEG-VGNLTD---------VTPPSdrVAALGMDGK-WVKAEEPLhwLVDsPDPvhsGnpdd----rea 213 Singulisphaera ...
WP_009508720  97 VGDVWLLAGQSNMEG-CGRMDG-------GAARPHPl-VRAFSMRRE-WRQAADPLhlRMEsPDSchnDgaqh----tre 162 Opitutaceae bac...
WP_013994834  28 PVKVFILGGQSNMDG-TGKSED-----LPEKYRSHPdeVMIWDNKKEkWVSLGTDS--FSE-------R----------- 81  Zobellia galact...
EKE74285       6 PSDLILMAGQSNMAGhKVGVDD------LAETERGLieGARIWANGA-W----VPL--AVD-AGY---Q----------- 57 
CDH50429     134 Kyh-----lWRGFSLGTSFATEYRKhmnNVPVGLIATAHGGTTLdE--WSpSl------mEnttdpyNnTLYGAMLARLR 200
WP_008177623 119 K--------SAGVGPGMAFATELLKynpELIIGLIPCAKSGTAI-Qq-WQ-Rsl------------sEdTLYGSCLKRVG 175 Moorena producens
EGN39579     175 Nee----mgIPGVSPYLSFGKKYYel-tGMPVGLIQTAQGGSSI-Er-WN-P--------K------DgDLYGNMMNKIR 232
WP_009324801 181 -------nhNPGHSPWLHFAKRLKre-lGYPIGLVPCAYGGAPLr--wWNpee-------------ngaLFTNMLEMLAD 237 Subdoligranulum...
CDC71334     161 Nae----lfLPGQSPWLAFALALKre-lGYPIGLIQTSVGGSPL-Sa-WN-Pee-----nG--------ILFRNMIRTVS 219
EIE90801     119 TvanpdickFRGASLGLAFAKEYQRlnnGIPVGLVACAHGGTSLeD--WQrPeeinkntaQ------T-TLYGAMIDKIH 189
WP_015250354 214 RskaahrdrTKGAGLGLPFGVAMAaa-tNVPVGLVVCAHGGTSMeQ--WD----------ParkgegGnSLYGSMIRQIK 280 Singulisphaera ...
WP_009508720 163 QaenarrtaQRGVGAGVFFAREMLar-sGVPQGLVCIAHGGTSMeQ--WN----------PvhkksgGaSQYGSMLLSLR 229 Opitutaceae bac...
WP_013994834  82 R--------KFKFGPEIAFSHLMAKkfpNHTIAIVKTSGGGTKL-WkhWL-P--------G------Q-PMYTRFLKNMD 136 Zobellia galact...
EKE74285      58 K---------RGFGPELSFARQWQvq-tGRPLSIVKLAKGGSYL-SrgWS-Aeg-----rG------G-PLYQRLVAEVR 113
CDH50429     201 KQEN---------QVAGILWYQGESDAEKT-ENA------ENYKDKFEKFITTTRERLDANQLPFLFVQI-AR------Q 257
WP_008177623 176 AASVm-------gEITGILFFQGEKDAQKPsQDDeitffpNQWADKFVTLVKDFRQDLGKPELPVVFAQI---------G 239 Moorena producens
EGN39579     233 ETKG---------RYAGVLWYQGCED-TRP-EQA------EAYGEHFRELAEALRAALGY-EIPFFTMQL-NR------F 287
WP_009324801 238 YDI----------HPRAVLWYQGEAE-GYE-DSA------QTYLERFAVFVRHTRAALGQPELPFLTVQLnRCmegpseK 299 Subdoligranulum...
CDC71334     220 MCGG---------RVKGVLWYQGETDAGGE-TET------AGYLERFAGFVSAVRREMNDPLLPFFTVQL-NKflsctdP 282
EIE90801     190 AIGN---------HVAGILWYQGESDAVKL-ETS------KTYYERFQHWLDLLRADT-RVDMPVAFVQI-GAhridrpE 251
WP_015250354 281 LAGG---------KVRGILWYQGESDAMQP--AA------AKFAENFTKFIGAVRADLDQPELPFYYVQI---------G 334 Singulisphaera ...
WP_009508720 230 ATGQ---------PCAGVLWYQGESDTAAP-LAA-------VYTDRMKKLVAATRRDLHQPDLPWIIVQL-ARvfg---- 287 Opitutaceae bac...
WP_013994834 137 NALQnlkgqgvayEVSGMLWMQGESDAETL-EWA------NAYEENLKVLYKDVRKETGKKNLPIVMGRI-SIgllrktP 208 Zobellia galact...
EKE74285     114 AAMAtg-----pvRLRGLIWMQGESDALDH-EDA------QAYGTRFEGFVARLRQDLGVPDLPI-VAGL-IT------- 172
CDH50429     258 iqggqDIdnEWSMIRDAq-RLvNDdyDPKRVGAVTTIDLP-MDDRIHLSAVGQKRVGQRLARAAAN 321
WP_008177623 240 tttdpEKlpNWETVKAQ--QEtVQ---LPATRMITTDDLA-LQDYVHLTTESYLIVGKRFAKAFWK 299 Moorena producens
EGN39579     288 i---nGP--FDEAWGMVreAQrRAalSIPAVFVLPTTNLS-LSDSVHNSAQANVALGIRLARQCAC 347
WP_009324801 300 l----DR--QWGMVREAqrQAwHT---LEHVTVVPAADLAlYDFI-HNASEGNLVVGERCARAALA 355 Subdoligranulum sp. 4_3_54A2FAA
CDC71334     283 d---tDR--RFAEIREAqrKAgKI----PGVTVIPSLDLT-LSDEIHNNSASNNALGERIAFTALG 338
EIE90801     252 g----IEa--WKNVQEHqrKLfGY---KSITAGVASLDCS-LDDRVHLSASGLIKVGKRLAHAAIE 307
WP_015250354 335 rfvaaVDpqGWHVVRDA--QR-LIadKVPNTAVVTAIDLElDDLI-HVGTHGLKRLGRRLARIAQR 396 Singulisphaera acidiphila
WP_009508720 288 ---hrSEtgWNSVQEQQ--RLlPA--KIRNLATVAAIDLAlDDPI-HISATAFPRLAARLARAADR 345 Opitutaceae bacterium TAV5
WP_013994834 209 w---nFD--HTEVVQAA--QD-KVaaEDKNVFIINTDKLEtLNDNTHFNSESNIWLGEKMGKLMWK 266 Zobellia galactanivorans
EKE74285     173 -----APggHVDLVRDAmaSA-----DVTAFKTVETRDLAhRSGAVHLTASGLAALGQRFADALSS 228
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