1PUJ,3CNL


Conserved Protein Domain Family
YlqF
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cd01856: YlqF 
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Circularly permuted YlqF GTPase
Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).
Links
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Statistics
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PSSM-Id: 206749
Aligned: 86 rows
Threshold Bit Score: 152.297
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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  next features
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:1PUJ_A: B. subtilis Ylqf Gtpase binds GTP/Mg2+, defined using 3.5 A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                             ## ##                   
1PUJ_A      5 WFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPmied---ilknKPRIMLLNKADKADaa-----vTQQWKEHFE 76  Bacillus subtilis
EGZ31336   10 WFPGHMQKSMRLFSDEIKNIDFFIEVIDARAIKQSSNYelnq---lfnnKIKITVAVKSDLVD--------VKKYTKLYP 78  Mycoplasma iowae 695
NP_078431  10 WFPGHMKKATDEILKNLKNVDFFIQLVDARCPLTSSNIellk---evssKPVINLANKADLSDw-------KKNFDNNFL 79  Ureaplasma parvum ...
NP_757439   9 WFIGHMKRTVDILESKKKNIDFVIEVVDARLPYGSSNLells---vfenKPIIKIALKSDLVK--------KDHYQNGFF 77  Mycoplasma penetra...
Q49435     11 WFPGHMKKIHDQLKKLSSQIDGIIEIVDARAPTLTHNSeiis---yflnKPKLILALKTDLAQyk----pnKKILFGSLK 83  Mycoplasma genitalium
AAC67000    7 WFPGHMKRALDLIKNNLQKANIVLEILDARAPFSSKNPltek---itknQAKIILLHKSDVAQin-----eIIKWKKYFE 78  Borrelia burgdorfe...
EAK94151   18 NFKGHHQKALSKFGHLAPQLDMILEVRDSRAPISTTNVlfdk---vlpsKKKLILYSKKDLSIlkp---rlLEKWHKSKN 91  Candida albicans S...
AET41233   20 DFKGHQQKALQRINMLLPQQNLFLELRDSRAPLSTRNVlfdql-amyhrIPKLIIYTKRDQCPpst--iaaLNRWHAENS 96  Eremothecium cymba...
CAG97919   34 DFKGHQKKAIQRAQNLLPQLNLLVELRDSRAPIATRNLifdyl-slekkVDRLVVYTKTDQCDpai--iasLNKWHKEMD 110 Kluyveromyces lact...
Q03151     33 DFKGHQVKALKTFEKLLPQMNMIIELRDIRAPLSTRNVvfdriarkehdVMKLVVYTRKDLMPgnkpyigkLKNWHEELG 112 baker's yeast

Feature 1               ###                                           #######                 
1PUJ_A     77 nq-gIRSLSINSVNGQglnqivpaskeilqe---kfdrmrakgvkpraiRALIIGIPNVGKSTLINRLAKkni------- 145 Bacillus subtilis
EGZ31336   79 d---IIFISIHNKNDRnriineiknkcfqk-----inslikkgyvnyqlFGMVIGLPNVGKSSLINFILNkkh------- 143 Mycoplasma iowae 695
NP_078431  80 listKKRNDKNKIIQHlyqlfdqkiki-----------yqkkglinpkfVGMIIGLPNIGKSSLINFLAPkkv------- 141 Ureaplasma parvum ...
NP_757439  78 yasiKNPADRKKIINYidsclkekkdr-----------likkglrnptfIGIVVGLPNIGKSSLINYLSNkks------- 139 Mycoplasma penetra...
Q49435     84 e--pFKLKKKVLKTLTtlfankrqql-------------kakgllikqfRLAVIGMPNVGKSSLINLLINknh------- 141 Mycoplasma genitalium
AAC67000   79 nl-gNTVIISNIYKKGmrkqiidiikkla--------ivkkiknykekiKVLIIGVPNVGKSSIINLLSGkks------- 142 Borrelia burgdorfe...
EAK94151   92 ----EQYMFVDCRSKRdgkkiineikkl---------ydsmetppplglRTMIIGMPNVGKSSLVNTLRYvglsdgenav 158 Candida albicans S...
AET41233   97 ----EQFMMLDCRRRAdvhnllhifkskynsl--ctenesaggilplgyRILIAGMPNVGKSTLINSLTTlldnngdtad 170 Eremothecium cymba...
CAG97919  111 ----EQYIMIDGRSKKgakdllhilkwkydkflqkndpgkktvglplgyRMLIGGMPNVGKSTLVNSLRFtgyagldhsd 186 Kluyveromyces lact...
Q03151    113 ----EKFILLDCRNKTdvrnllkilewqny------eletnggylpmgyRALITGMPNVGKSTLINSLRTifhnqvnmg- 181 baker's yeast

Feature 1                                                #  
1PUJ_A    146 -------aktGDRPGITTS-QQWVKVg-------kELELLDTPGIL 176 Bacillus subtilis
EGZ31336  144 -------lvvQNKPGVTRK-KQWTKVt-------dNIMLLDTPGVF 174 Mycoplasma iowae 695
NP_078431 142 -------lkvENRPGVTKT-QCIRQIn-------qHFYLIDTPGIF 172 Ureaplasma parvum serovar 3 str. ATCC 700970
NP_757439 140 -------lnvENRPGVTRK-TENIKIs-------dSLFLIDTPGVF 170 Mycoplasma penetrans HF-2
Q49435    142 -------lkvANRAGITKS-LNWIQIs-------pELLLSDTPGVF 172 Mycoplasma genitalium
AAC67000  143 -------akvANKPGYTKN-IQIVKIn-------eEINLFDMPGIL 173 Borrelia burgdorferi B31
EAK94151  159 stkirkvartGGQPGVTRStSEIIRLsr-----dpEIMVYDTPGVF 199 Candida albicans SC5314
AET41233  171 pqkrkkvartGSHPGITRSvSESIKIsny----rfGIYLYDTPGVS 212 Eremothecium cymbalariae DBVPG#7215
CAG97919  187 gskpkkvaktGDQAGVTRNtSECIRIsdy----kgGLFLYDTPGIS 228 Kluyveromyces lactis NRRL Y-1140
Q03151    182 -rkfkkvaktGAEAGVTRAtSEVIRVtsrntesrnEIYLIDTPGIG 226 baker's yeast

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