Conserved Protein Domain Family
Erv26

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pfam04148: Erv26 
Transmembrane adaptor Erv26
Erv26 is an integral membrane protein that is packed into COPII vesicles and cycles between the ER and Golgi compartments. It directs pro-alkaline phosphatase into endoplasmic reticulum-derived COPII transport vesicles.
Statistics
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PSSM-Id: 461197
Aligned: 73 rows
Threshold Bit Score: 198.545
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EMF10243               1 MWILPLLGYLGLVGGFLFLTLAIASGLYYLSELVEEHTVLSKKLLSRLIYTVIAIQFLLAAIDRFPLALSAFSIASHVIY 80  
XP_002434873           1 MLYFYLLSWLATVIQICFIILAVAAGLYYVAELVEEFTVMTGKIIRILILLTLAVYAGLFVFEDLPLTMIGCGVLSQVMH 80  
ETN66050              55 MSFLGLLSYVSLLVQICFITVSIAAGLYYLAELVEEYTVVAKKVISYLVLGTATLYVVFIFTESFPWSMVLCGLGSQLLH 134 
WGS:AANI:GJ20961-PA    1 MGFLFILSWISLAIQITFMTLSIVAGLYYLAELAEEYSTPARRFILFMISFTIFVYILLIFFEDFPWTMMSCGLAAQAFH 80  
EMR08870               1 mygLIFLSYFGFIAGFIFLTVCIACGLYYLSEFIEEYAEFSKRILKRLIYIVIFLHLILFIVDGFPFFSTLFSILLHIIY 80  
CCJ29403               5 I----FLSYLGLISGFLFLTVCIACGLYYLSEFIEEYTEFSKKLLRKMIYFVIFLHLVILILDKFPFFLIMFSILSHILY 80  
EAU84659               1 MALLQYLSYIAIVAAFAFVTLSLASGLLYVSELIEEHSRLAKIYGKRGTYTIIALHILLYFTDNLPFPQTLFSIICHIIY 80  
CCA72541               1 MGLLYLLSYVAAVVAVVYVVLSLASGLLWIAELIEEHSRLAKTVGQRAIWVIVIIHLLLYF-DGLPPTHIAFSIFCHFVY 79  
Q5KP20                 1 MGLLHLLAVAGGIAAFLFVTLSLASGLLWLAELIEEHSKYAKTVGMRAIYAIIGLHIVLYFTDNLPITPILFSITCHFVY 80   Crypto...
Q1MTR8                 1 MIVLNALSYLGIVLGFIGMTVSIASALYYISEFVEEHSRLAKAFLCRLVYFIMAVMVFLVIFDGFPFWLSAFSIFSHYIY 80   Schizo...
EMF10243              81 SLNL-RRFPVVKLTDPIFLAS-----CVLVLVNHYLWFTHFSVT------SAPTHHSngrysyldPPSSKd------VPS 142 
XP_002434873          81 LLVL-RSFPFFNLYSVPFLLA-----SVLVVVNHILAFSFFSGK---------------------------------VYA 121 
ETN66050             135 AFIL-TDFPYVRFLSPAFLGA-----VILLLVNHYLAFVYFQVQ---------------------------------YHA 175 
WGS:AANI:GJ20961-PA   81 FCIM-TNFPFIQLLSVSFIGS-----LAMLVINHVLAFQYFTSV---------------------------------YVP 121 
EMR08870              81 FINL-RSFPCISVSSYQFITA-----IIFTVLNNLLWIWHFRSYfgllltYSSV-----------YVHKKdt----kDYT 139 
CCJ29403              81 LSNL-RSFPCISVYFLHIIYMnhlnlLVFTVLNHLFWIWHFRLYfsslltNSFT-----------YSKKKny----eGFT 144 
EAU84659              81 LQNFsASWPLIDLTSLSFIAS-----CICVVADHFLWFFYFAKVtnearrLRTYRAVvp-----------------ePPG 138 
CCA72541              80 SRNItPRWPLISLTSPSFILS-----CIFVFVDHALFFNYFSQQkklarqRGRAPL---------YYRDApifangrEYS 145 
Q5KP20                81 LSNFsSSWPLISLTSPRFILS-----CILVVGDHFVWFFHFAAVaqe-akDYRVPKY--------RYGGQqakaagnNPS 146  Crypto...
Q1MTR8                81 KINF-DTFPFFSFKRMRFLLA-----CFLIVANHILWVRFFQVH------EFPIKPRgltydfv------gqrlltsRAS 142  Schizo...
EMF10243             143 FTEIASFFGLEVWFVPFALFVSLSAGENVLPSMGSEYATGAGSSFITPGQtptlnagagsgsymdvqaqhaggreefrgr 222 
XP_002434873         122 FSEVLAYFTICLWLVPFAFVVSLNANDSVLPTLAEKRPLLNDDN--DVVSny---------------------------- 171 
ETN66050             176 FTEVMAYFTLCLWLVPFALFVSLSANDNVLPTSNERTHLLGGTD--DVVTny---------------------------- 225 
WGS:AANI:GJ20961-PA  122 FTQVLAYFTVCLWMVPFALFVSLSANDNVLPTTISTNERRLGSSNPDVVSny---------------------------- 173 
EMR08870             140 LGQIASFFAICIWLIPFSLFVSLPAGDNILPISSNDYLSSGSSINYMR-------------------------------- 187 
CCJ29403             145 FNQIASFFAICVWLIPFSLFISLPAGDNVLPISLNDCSRPGSRIILTQ-------------------------------- 192 
EAU84659             139 FTEIASFFGLCVWLVPLFLFLSLSANDHAIPLTAVERPSSPQSFASQQ-------------------------------- 186 
CCA72541             146 FGEIATFFAICVWAIPLFLFLGLSANENTLPIQQTTDMSGSSTAGR---------------------------------- 191 
Q5KP20               147 FGDVAAFFAVCVWFVPLYLFLSLSANDNALPSFDSSAPPSPSSSHVNLGSprl--------------------------- 199  Crypto...
Q1MTR8               143 FSQVASFMGVCVWSVPIGIFVSFTAADNTLPTITTPSSSSPDAYSS---------------------------------- 188  Schizo...
EMF10243             223 trhKRSNTQTGMAKAAVNGVRE 244 
XP_002434873         172 --fSQRNKRYGLL-FFFNKAKE 190 
ETN66050             226 ---fSSRKKAGLL-SLFTYAKE 243 
WGS:AANI:GJ20961-PA  174 ---fSRNKKLGLL-SFFNYIKE 191 
EMR08870             188 ---SDKYKRIGMIKSIFSKIKI 206 
CCJ29403             193 ---NDKYKRIGLIKSIFSKVKI 211 
EAU84659             187 ---RQKASRVSLLRSMLSfmsf 205 
CCA72541             192 ---GEARTRASLLRRILDPlls 210 
Q5KP20               200 hahADRKHATSLIKSALLPlls 221  Cryptococcus neoformans
Q1MTR8               189 ---GSSRRTSNVLRQAYKKLgi 207  Schizosaccharomyces pombe 972h-
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