Conserved Protein Domain Family
Strumpellin

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pfam10266: Strumpellin 
Hereditary spastic paraplegia protein strumpellin
This is a family of proteins conserved from plants to humans, in which two closely situated point mutations in the human protein lead to the condition of hereditary spastic paraplegia. Strumpellin contains one known domain called a spectrin repeat that consists of three alpha-helices of a characteriztic length wrapped in a left-handed coiled coil. The spectrin proteins have multiple copies of this repeat, which can then form multimers in the cell. Spectrin associates with the cell membrane via spectrin repeats in the ankyrin protein. The spectrin repeat is a structural platform for cytoskeletal protein assemblies.
Statistics
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PSSM-Id: 463035
Aligned: 33 rows
Threshold Bit Score: 1086.86
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003721974                    38 STIVATLQRLAAHIPAEFt---APSRTPYARLIFDFRYFKHQDQIET--NIADSAELLVMDKEFYDTHMGLLEKFMALFR 112 
Q386S7                          30 SAIIVELLRLSQHIPREFv---HPEESEYAAIISDFSYFKATEAFEE--NISKSEVLLQRDEVFGNTHVEFLDRCFKLFR 104  Trypanosoma brucei...
XP_001418393                    54 qALAAELLRLGENAPRAL----SREDSKFARVLFDYEYFDARERAED--AAARDGSTYELDEEVRGSYGHVFERYWNAFD 127 
XP_006844422                    30 QTLISELLLLSGRVPHEF------GDSRFDSVLFDLRYLDSPDDFEE--KIESNSHLAALDDQLRETCSVFLQRFLLLMN 101 
EFJ34129                       165 QALIAELLRLSDRVPEEF----KSPGSIFAPLLFDFRYFKSPDVFEE--RIESNAELSSLDDEFRDKYSYLLERFFQLFN 238 
EAY01964                        22 SSIIAEIQRLSQYIPEDFtfpkNQLNHPYAKIIYDFSYFGHETEIEN--LIESDPDLNELNEECRETHIEIVTRFCRLFE 99  
WGS:AAFB:cds.EHI_045500A        22 NTICSELFRVKDLIPEDF----INPSNCCKDLIFDYSYIPKSESIDM--KINSSRELRIIDMKIKEKYERIIWRTFQVFE 95  
EED92001                        20 hSILADIKILSEREPSQD----TDDVKKYVPFLFDFSYLHNPQEWEAtpAAESSESLLELEREFAVNHRKAIEEFYELFY 95  
WGS:AAGF:cds.TTHERM_00145500A   23 STILAEMQRLSENIPKVFy--eNSQTSRYKNILFDFDYFKNIDTYED--VIQKNPDLVDLDELFKSNYMELLQRFYILFE 98  
A0DY11                          22 SAILAEIQRLSENIPKIIts-kAQEYKKYEKILFDFEYLKNIDVLED--EIQRNQEINELDENFKKSYLPLVERFYRLFE 98   Paramecium tetraurelia...
XP_003721974                   113 GIYGYATELNRYVREIQDGQYVAQTLDTVLESLDGRQLLCELYHLYGVMLLLMDHKIGGLVRERIIVSYVRYRGSGe--A 190 
Q386S7                         105 GVFGYVVELNRFVEEILDGMYVSHTIESILADIDGKQILCEIYHLYGVMLLLLDHRFGGKIREYILVSYIRYKGTSe--P 182  Trypanosoma brucei...
XP_001418393                   128 AVVRWHQDFVRFAEDVAEGTYVSETWEKILSDEDGRQYVCEAIAMFGVILKILDAKFDWRFRERMVVAYYRMRGASediA 207 
XP_006844422                   102 GIALYYRDLVKYLNDLQEGVYVQSTLDSVLEMQRCRQLLSESLVLFGVLLLLLEHRMGGTLREKLLVAFMRLDGSFg-tS 180 
EFJ34129                       239 GIVNYYVDLTRYLEDLQEGVYIQSTVESVLHNEDGCQLLVEALVLLGVVLILLEHRLDGTLRENLLVSYFRCKGTFd-vP 317 
EAY01964                       100 SIVRYALDFLHYLEQLNQHVFLQITVESLLNETQGKQLLGEALYYYGVMLLQMDYYIPGLVRERLLVTFNRWRGSSm-lL 178 
WGS:AAFB:cds.EHI_045500A        96 SIYQYTKQVEEFYDKIIEGEYLQYNAETLLVDVEGKQLVCETLSFVVRLLLLLDILIPGIVRERILIFVLRHKRSNe-fG 174 
EED92001                        96 SIYDYQVALNQFSSDLTKGFFIQYTVESVLLDLEGRALLCEAVWLYGVMLMLMERLLPGPVRERLIIAYFRFCGRDgdiS 175 
WGS:AAGF:cds.TTHERM_00145500A   99 SIYLYHKDLNVFIEQVQEAIYIQYSFEVILQDPEGKKLITEAFYLFGCMLLLMERLIIGPVRERIVIAFYRYSGGQsaqE 178 
A0DY11                          99 SIYLYYSDLMAFIQELEEAVFMQYSVETVLQDPEGKRLFAESFYLYGCMLLLVDILIPGKAREKLIISYYRYKGGQtaiE 178  Paramecium tetraurelia...
XP_003721974                   191 HTVEVAELCRATSQGAdggaaiagssveRtpvspraaagsgTGISNYP---------IDYFERVPVQKGVVARLLACIRS 261 
Q386S7                         183 NMMDVTSLCRTTGYRCds---------------------anGLPPNYP---------LSYFNRVPVDKKVVGTIIGRIRS 232  Trypanosoma brucei...
XP_001418393                   208 NADEIVTLCARTGYDAar----------------------kTRPEGYP---------ELYFARFEMPEWLIYMVIGRLRT 256 
XP_006844422                   181 NLDLIRLLCRAYAPGPgssfpsstafipSqcvllk-ssfgsMISVQKP---------EDLFARFPFPKTVVDSIVSCLLH 250 
EFJ34129                       318 NFDSISTLCRHYPQPTsspvva-------------vtaflqSSPPPVPatmlnlhrpEESFSRFPLPSSLVKTVIGRLKS 384 
EAY01964                       179 NYSKVCEVCRQSGYVVg-----------------------qPYPMGYP---------LEFVNRLEIPVDFVNVLIGKYRN 226 
WGS:AAFB:cds.EHI_045500A       175 DLDKIIPLVKRTEYIVgs----------------------sKKPSNYP---------DEYLKRIHVNDYIVQMAIGRMLS 223 
EED92001                       176 QIDTICKLCKSTGIQPpkstds--------------vnmseQLSHKYPmd------eDKLFNRYPLPVDLVRNIVGCLIS 235 
WGS:AAGF:cds.TTHERM_00145500A  179 NINQVIKLTANTGYLPaiyn-----------------ngeeKRPLEYP---------DFLFDRFPFKNELIDQILYQIKE 232 
A0DY11                         179 FINEVTKLCAETGYSKs-----------------------gTRPAFYP---------EEYMARFQLPEKLITEVINSIKD 226  Paramecium tetraurelia...
XP_003721974                   262 DDIYRMSSHYPNPDHRSAAMALQGGIAFVLLFFCGDVLAQQLPVMKELVEKHFADNWVVHYYGGYTADLSVAWAAFPAAR 341 
Q386S7                         233 DDIYQMSYNFPVPEHRSAALSLQGAVLYVLLFFKPEILQHEGPVMREIVDKHFADNWIINYYMGFTVDLMVAWREFPAAR 312  Trypanosoma brucei...
XP_001418393                   257 DDVYNHAPHYPNPDHRSTALAAQGGLLYIILYWAPKILNRGTSAMREIVDRHYADNWVVAYGAGLTVDLLTEWEPYEAAS 336 
XP_006844422                   251 DDLYSQICHYPDPEHRTVALATQAGYLYILLCYSPHFLH-DAFVMREIVDRLFKDSWVVPIFMYFTIDLSLSWEKYKVAR 329 
EFJ34129                       385 HDLYNQVGHYPSPDHRTTALLGQAASLYVLLYFAPTILHSDSVMMREIVDKFFRVYWVL-----------------STAK 447 
EAY01964                       227 DDCYLMLQNYPEAEHRSVALAQQASMLFIFLFFSPNTLNNENFIMREIVDKFFFDNWIIPYFMGDVVDLSVIWKDFKAAN 306 
WGS:AAFB:cds.EHI_045500A       224 DDIYNTTKSFPLPDHRSSALSAQGSLLTMILFLSPQTLNNNISFMNEVVNKFFGDCWIVPIYIGHCIDLTFFWDSYKSAR 303 
EED92001                       236 DDIYQQSSAFPNIDHRSTRLSRQASMLYVIMYFDPIVLRDETSKLREIVDKYFLDTWVIHIYAGLTADLSLEWDKFPAAK 315 
WGS:AAGF:cds.TTHERM_00145500A  233 QDIYKHKTAYPDKDHRSFAYAAQASMAYVLLYFVHDTLNSKKQLMREIVDKHFYDNWVIAFYLGYTVDLTSEWARYNAAK 312 
A0DY11                         227 EDIYKYTSIYPSADHRSIALSVQGSMLYVLLYFTPTILNNKKAKMREIVDKHFYDQWVISFYLGYFVDLSEQWNPYGAAR 306  Paramecium tetraurelia...
XP_003721974                   342 AALRRTLESHSVTYHLQRMRGALARSTERVQAVLEEGMLTENYVLDNVhASLLPIITESNVVLRWFVLQGVCSASASSPp 421 
Q386S7                         313 NAISGTVTLENIGYYMTRQRQSMSSVYDSIEEVLRQGVLTEQYVLDNIhSTLLPLIREANVVLRWFVLHTHRLDGRNFY- 391  Trypanosoma brucei...
XP_001418393                   337 TAMRNAVTPKAARELIDNASTRVGELKTAFKTYLTEGVLTEEFVLSNE-KVLMNVVRDANVVARFVLLHNL--------- 406 
XP_006844422                   330 SSLSFCLSPANVRDICQMHYAKVKDLSSKITSAKSDITHSVDYVLSNS-QTLLSLVRNCNVSLRWLFLHRS--------- 399 
EFJ34129                       448 NAISSSITLSAVRVVSQEQISKVQTLLSDLSAFLSEGVLNQDFVLNNI-STLLSCARDCNATLRWLLLHKI--------- 517 
EAY01964                       307 IAIQNTMKQ-NSMRYAQRYMELYEPIHTKIKQVLSDGFTKTEQLLDGI-NDFFKLDRDANVCIRFLLLHTQ--------- 375 
WGS:AAFB:cds.EHI_045500A       304 QALQRVVTPSHIENIWKGHQQVMAKCKVELQGYLEEGGMTDEKVMLNM-QKLINCQRNCNVVLRWALLHGT--------- 373 
EED92001                       316 SALDNVLREDNVKRMHIGNAKLIGQCMAELRAYLTMGILTDRFVLDNR-HDLLNCLRRCNIAAKWRILHRR--------- 385 
WGS:AAGF:cds.TTHERM_00145500A  313 EALGFIFDLEYIPQLVKYFQENLSKAYLKCKEYLNDGVLNEEYVLDKI-QNLLSCLRECNITVRWLMLHKNTTN------ 385 
A0DY11                         307 EAIKNTINFDYIQELGTFYRNKLTEQINKVQEYLYEGQMTQEFVLDKI-SSLMNCVRESNIAIRWILLHSNTSI------ 379  Paramecium tetraurelia...
XP_003721974                   422 aspvcgdpdeaslRAAASAAGQAVRASF-----ENDELLTLLLATAQLERDVYSRFAVVLQEKTARWAGARRQAVSRVQK 496 
Q386S7                         392 -------------HEKSRQIYEMIAGCV-----RDDDIIMLLLRTAQLEFTLRAMFANLLKQKRARWESSRQEGAMKMAK 453  Trypanosoma brucei...
XP_001418393                   407 --------------TTHKSVSSLVSYMP-----SKENIIDLLLDCAELENELKKIYTSLLSGKHELWEKCKHEAGERMKE 467 
XP_006844422                   400 --------------TSNKKLRDIVISVGdaqqiGEDAMIILFLETSKVEFEVKKLYSELLGGKDSQWKQSKNKAAHNMLQ 465 
EFJ34129                       518 --------------TTSRKLRELVSN-------QDMALLTLLLDTSRLEFELKNVYGELLKKKESRWAESKTIVAECMND 576 
EAY01964                       376 --------------EPGKKVQFPF---------SRDKLLAFLLDLGEFEFELKNAIETALNTKPEIWTDTRNNAVSILKQ 432 
WGS:AAFB:cds.EHI_045500A       374 --------------YPIKKLRDIFVKPK-----YHEDIIDFLLETAQFEFELKRIIGNIVKEKPLQWENLKNESSKRMKD 434 
EED92001                       386 --------------TSNPIFYDIVCFAV-----NDTHLVSLLLLSSQLEMQLKDIFQQLLEKKENIWISCRSKAGKMMDD 446 
WGS:AAGF:cds.TTHERM_00145500A  386 --------------KKAKAICDKI---------SQKDILQLLLLSSKFEEKLKTSLKNLIDTKVPRWDQDKKRCCKRMEE 442 
A0DY11                         380 --------------PKAKELLNKI---------DKQEVLQLLLQSSKFENRLLKAIKAIIDNKQQYWDEDKVKCVERMQE 436  Paramecium tetraurelia...
XP_003721974                   497 LSHFFSEDNLLDTSVHDAELERWFAEVGARITNLHMKRQsakAT---RRKLQRLVAALENIQEFAQVNQQLQVLQYVRET 573 
Q386S7                         454 LSTFFSGKHVLSDDMCDPQLEAWFMEISQRIEGLEYANSt--IA---SRKIQKLIKALENVQEFHQVDSNLQVIQFVQDT 528  Trypanosoma brucei...
XP_001418393                   468 LSAYFGGTAGLSRNAKDENLRLWFANLSVEVERLSYDDAv--AA---GRTIQELETALTEVEQFHQIVDNIHAKQYLLDS 542 
XP_006844422                   466 LSEYLSSSGNLSSEFKDESLKGWFGDLSSQINSLDYKTTt--NV---GQKLNHMIFALKEVGSFHQIEGDFQVKQHLCEI 540 
EFJ34129                       577 LSAFFSGVKVLSRTIRDENLQQWFSQMCSEVNSLDYSEAv--TA---GRKIQHIITALEEVEHFHQIQGSLQTKQYLSEA 651 
EAY01964                       433 LALSFSGTLSLASLQKDEKLQQWFENMAGEVNILEIDNSv--GN---VQKIYQLTTALESILPFHQISSSIFIKESVAKV 507 
WGS:AAFB:cds.EHI_045500A       435 LSNYFNDENKLSE-HSNSGLMKWCLFMSEQIDKLDv------KEissGKSLSKLIQAMEEVETNYLNDLSLVVVETVRKT 507 
EED92001                       447 LAHYFKGDQTLARVSRHDGLITWFTAMGEEIRALTYEDGd--HFtvtGRKIQLCVQALEEVEQYDSIDRDVQVKTFLVEA 524 
WGS:AAGF:cds.TTHERM_00145500A  443 LTNYFGGSSTLQEIQANKSFEAWFTEMKNQIERLSFEDIt--YA---GRKIKQLTEALDDIEQYNVMSENIQIKQYLLDT 517 
A0DY11                         437 LSDYFSG-KALGKVKADESYMQWFTEMGSQIQSLNYSDSt--HA---GRKIQRLIQALEDIEQYPQISTSIQVKHYLNET 510  Paramecium tetraurelia...
XP_003721974                   574 CADLHQMLHYLNAERRVLGRFATVTDFSYAWELLSaRgyLVRELQARIRRQPVVAAQMQALFAKLSSLLHLPCIRIDEGV 653 
Q386S7                         529 RFLLLQMIRYINIENKVLITIATVGDVSYAWESMAyYnnYVIAMQLKIKQKPDLAVQMRAVFMKLASLLELPCNRIDQGA 608  Trypanosoma brucei...
XP_001418393                   543 RGYLGKMMMTSNVADSALNTLTIVSDAAYAWRVLD-P--YTEQLQQRIRKDPFAVRKLRFTFLKLKSILEMPLLRISQME 619 
XP_006844422                   541 QTYLQDMFKTLSLQKRTLDTISVISNSTYVWGFVG-S--FVEKLHKSIEKDSSTVLKLQPFFLKLHSMLEAPVFRLSQGN 617 
EFJ34129                       652 RMQLQEMIRTLNVQESTLATISVISDCSYSWGLIG-E--FTLLIQSQIQNDPFTVSKLQCLFLKLRSVMDIPLLRLYQSQ 728 
EAY01964                       508 IEALKILARLLNIDEKFVPLIGTLSDFSYGFSLVR-S--FIPLMQKRIKKDPFSVLKLRATFLKMTSILDLQLVRIIQSE 584 
WGS:AAFB:cds.EHI_045500A       508 KDMLTKMFRLLNVNDTVRGLLDNISDCSYANELLS-TqvYVEYLQQIIKKNPRNSLKLRSLILKMSSILHLALLRMMQAK 586 
EED92001                       525 RGLLLQMARAVGINEDICEDIRWISDMSYGIESVK-S--YVKIIHSRVTKDPSNVNLLQGFFMKLSSSLDAPVERLKQLN 601 
WGS:AAGF:cds.TTHERM_00145500A  518 KKDLKRMVRIVNIQEEYLTHIDLISDITYSWQSLQgI--YVTNMQDKIKKNPQLSLLLKTTFMKLSSILNTPMVRIVQSE 595 
A0DY11                         511 RKDLTHMVKIVHIKSTLPSHISYISDFSYSWQCLK-G--YKELMQAKVQSNPHSALSLKTTFQKLSSILNTPTIRIIQAG 587  Paramecium tetraurelia...
XP_003721974                   654 AvtaasalgVDvrleraLQFTSTFYSEEVVSFLRSVLQVIPTSIFEVLNKVMYLLTNALRECPSKLQRDEWKRWSQLETR 733 
Q386S7                         609 Q--------NDarllvaLESTSEYYSGELVAFARRVLHIIPTSIFSILRQVMDILTNHLHECPTKLARKEMKGQSQLNVR 680  Trypanosoma brucei...
XP_001418393                   620 S--------PD------IYSVSEYYSSQLVSYVRSVVEVVPISMFEILNEIIGVQTNALKELPTKLEKTALSDYAQPAER 685 
XP_006844422                   618 S--------VD------LQFVSEYYSSELVAYICAILEIIPVTMFNILNDDFACNLQPLNF-QHRMEKDNLQNLLVIGTQ 682 
EFJ34129                       729 S--------AD------LDSVSEYYSSELINYVRNVLEIVPASMFTILNGVIKEQMMNLSEIPGRFEKDSLKDYAKLDER 794 
EAY01964                       585 S--------KD------VDSVSEHYSNIIVQFVRDVLEIVPISIFGVLDQIIQLRTNVLKELPNRIERAQLKQYAQLEER 650 
WGS:AAFB:cds.EHI_045500A       587 T--------DEq-----MENVSKYYSEVLVNYVQRVLEVIPEQVFLLINSIAKLQVTSIPETPVFVEKKDIISFALFDER 653 
EED92001                       602 S--------PD------ATRVTDYYSLQLVSFVRKVLEIVPISVFGLVVQMSDIIERRLLRLPKKVAADQLIAFSQTGER 667 
WGS:AAGF:cds.TTHERM_00145500A  596 S--------DD------LVSVSKFYSGLLIKFVKNVLQIIPISVFDILQNIINLLTNSMKKLPPKLKKEELKEYLQPEDR 661 
A0DY11                         588 S--------PD------LNSVTKYYSGELVKFVKEVLQIIPIQVFEVLQDIITLITSVLKPLPSRINKIELKDYAQYEDR 653  Paramecium tetraurelia...
XP_003721974                   734 EQLCACTADIARYAAGLLAMEETTVGVVRVNPHQLLEDGIRKELVEHITRELHAGIWFDRs-------K------PSTV- 799 
Q386S7                         681 KALSTHTADIVKYASGILAMESTLVGIIQVDPHQLLEDGIRKELLQQITMELHNSLLFDAk-------K------PPSA- 746  Trypanosoma brucei...
XP_001418393                   686 AQLSKATYEISIFAQGILAMERTFMGVIELDPKQLLEEGIRKQLVKQITETFHTALVFGDgakdalgwnnfvaamMKTN- 764 
XP_006844422                   683 YQLAKAATRIATLSKGILCMSRTFQGIIDLDVAKWLEREIRKELSKRISNILNSFRLLPSv-------K------L---- 745 
EFJ34129                       795 YALAKATQRVAVFTQGIMSMKRTFIGAIELDPRQLLEEGIRRKLAEEIDLALKKALVFST---------------GRTE- 858 
EAY01964                       651 SKLAHLTKEISILTSGVLAMKTTLMGVITVDPKQMLEEGIRKQLVKKIIKVLYEQLVQPNt-------Ke-----QITA- 717 
WGS:AAFB:cds.EHI_045500A       654 NYLAELTHAVSIYAEGILAMETTFVGIIQVDPVKLLEDGIRKALGRRLKNMFSKTLQF------------------KIKg 715 
EED92001                       668 YKLAMMAHEISIFADGILAMENSFIGGKEVNPRKLLDDGLRKEMVQHVSELMNNLLQFDFs-------AdtetitSMTNh 740 
WGS:AAGF:cds.TTHERM_00145500A  662 SKMADYTYKISLFTESILSMEKYLIGVIEINPKEILDDGIRKELIKCICKQLDQRLIFQSn-------Sd-----I---- 725 
A0DY11                         654 TQIAKLTNSISVFTESILTVDPYLLGSIEVNPREMLDQGIRKELMALIHKILDSQLIFPK----------------KDI- 716  Paramecium tetraurelia...
XP_003721974                   800 ---EdLDKELVQLGARLRGVRNSFEYIQDFVNVHGLKIWMEEFQRIVRFTLQMECNAFWPKK-VYPWSSPYQSASIT--I 873 
Q386S7                         747 ---AsFNEGLARLAQKLNGIRASFEYIQDYVNVHGLRIWLEEFSRIVNFNVEMECNAFLQKK-LYPWESQYQSESIP--I 820  Trypanosoma brucei...
XP_001418393                   765 ---P-FEDRLNSLANRIEGFRRSFEYIQDYVNIYGLQVWQEETNRVVSYHVEQECNSFIKRKqVNDWESEFQSVAIP--I 838 
XP_006844422                   746 ---QeLEENVRALMVSLHTQFQLLEILLGFVHVQGQHIWEEELTFILNHSLQQEYCKYVERR-KQDLCCMQEINNLS--N 819 
EFJ34129                       859 ---D-LEDKLEALSASLSSQRQSMEYFQDYAHVHGLKLWQEEYTNIVNHNTELGCKHFLTKV-HKQPTSILDSGSVN--- 930 
EAY01964                       718 ---ErFNKIIDRVGRAIDGIRHSFEYMGDYVNIDGLRIWHHEYSRIMCYLVEQESNKFVKKK-ILGWQSEYQSKVAPikI 793 
WGS:AAFB:cds.EHI_045500A       716 nlgE-TLTQLSELSNQIGGFSTSFRYIQDYLHIDGLKVWQEEFTNVISTCVNEECNSFLANGld---------------- 778 
EED92001                       741 --qSaAMRSLSSLSSRLEGFQSALECVEDYVCINSLKMWHGEMSRIINYNVEQEVNKYLLKK-VLDSDSKFQLRVIP--I 815 
WGS:AAGF:cds.TTHERM_00145500A  726 ---TqFQTTLFNLAEHLSGFKRALEYIQDFIGNFGLKIFHEEFDRLILTYIDMEQIAFVTNK--LDYEELLYDDDIP--M 798 
A0DY11                         717 ---QdFQTKLSKLGEEINGFKLAMEQIQDFVNAQGLKMFTEEFNRLIECYTSMELKGLITGN--KEYEELSYDEDIP--M 789  Paramecium tetraurelia...
XP_003721974                   874 PHFAPAnP-KDAYSFLGHLVQHLLYLTDPRESI-YFPAYGAWFTRRQLCECVGPRLFSRVADAVDCTGLACLDELLSSIA 951 
Q386S7                         821 PYFEPTpG-RSTYSFLGGISQHLIAITDPSHAL-FLKSYGAWFERNSLEEVVGSRTFASIGEAIGSMGLVALDRMLCFII 898  Trypanosoma brucei...
XP_001418393                   839 PDYPALd--GESKNFMGRLLRELMRQTDPKTTR-YVSPHSGWFDTE-GSEVVGIRTFSLLTSAVGNVGLAGLDRLLSFMV 914 
XP_006844422                   820 PE-----------TFLGRLLHQILLLTHPSQSM-FLEPMSGWFDAG-GHELLGLHFFDLFESCVGPFGLSSLDCALYFLI 886 
EFJ34129                       931 -----------DDNFMNRVVLKLLNLTNPSKSM-YLAPMTGWFNAE-GQELVGLRTFITLQESLGPVGVSGIDSIVSSHA 997 
EAY01964                       794 PKME-----GKYATCIGSLAFSLIDLTRQTNSV-YCGITGGWLNPQTGEEVLGTKTIDRLCNAIGIEGTSSIDLLLSFTL 867 
WGS:AAFB:cds.EHI_045500A       779 --------tVNSQTFIGKLTSQIMSIVDYRKNVfYLSAANGWFYKD-GKEVIGYVFMRKLVSALSVLGVTGINQLCAFKC 849 
EED92001                       816 PRFARTpNePTCINFMGRILSMLLKITDTQYTT-YSLERIGWFLGD-GTEVCGLKNVSLLRKAIGIYGLTGVDRLLCYRI 893 
WGS:AAGF:cds.TTHERM_00145500A  799 PDKSVMeK-QGSVNFMGRLLRELMRITDYRQCV-YVEQNLGFYHYSKGTEIISLKTMDLLYRCVGVGGLNGLDQLFSFMI 876 
A0DY11                         790 PDDKSKq--YGAINFIGRLLNQIILITNPREVV-FVESTLGFYDSN-GKDILNLKTIGLILKCIGVSGLNGIDLLLSQHL 865  Paramecium tetraurelia...
XP_003721974                   952 TKDMQLLVqRLAESVASLESAQRGAVQEVWARCMpTSSTPEKDa-fLKDYDQLASILEAsAAAq---------------- 1014
Q386S7                         899 AKNLQQLL-KTIRATL---EPLEETVMNLAEELCsSSHDPRKL---IEIYEKLMKLINSsGGEgsvpletkeynnrvvik 971  Trypanosoma brucei...
XP_001418393                   915 TQKLQMCIeSYSERL---RGDLGATIRALDNALRpLGSVPEGS---IEAYEQAIRASSS-AWD----------------- 970 
XP_006844422                   887 VGHLEQAL-SGLRSLL--DTRFMEDFEALGNALGpATSIPLLG---LSSYDRIIKMTEK-SWE----------------- 942 
EFJ34129                       998 ARVLGKCI-SSFRSEI--EVKLLDHLQALEGAVRpLSVTPNGA-----VYAECIALIST-STEc---------------- 1052
EAY01964                       868 ARQLRQFFeKF-------EKGHFGNYTNLLNKLLdMWPSPPES---MEVYNDLLTRIKQdSHD----------------- 920 
WGS:AAFB:cds.EHI_045500A       850 VKELNDII-TTVNLIVEKYSVFNQMTQNFNENKLnEQNI-------FKVIDNGLSVVTK-IGR----------------- 903 
EED92001                       894 LHELHRFV-KFFRNNVSKQGVL---FEQLRDELYpEWKTPHNV---VSIYASGSKKTEMlMLP----------------- 949 
WGS:AAGF:cds.TTHERM_00145500A  877 ASQIKTVI-RQIKKEL--NTETKAELAELIQSIKdLNQFTEKFdkqIQSTKKIFKQISN--------------------- 932 
A0DY11                         866 SKAVKDIV-RILKQEL--NQENRNIIDTLIKQVRlFTNYDENY---DKVYKQLAKQFRPlISK----------------- 922  Paramecium tetraurelia...
XP_003721974                  1015 ----EVGVVAMRLGRIALIRQLIAHQLRSDSKQDSSALVACTQAVNTAVVATLnSHLAKDPfearaagssrscadvSEGL 1090
Q386S7                         972 dhlaEVTKLMVLVGRIQIMRVMIAHELRSFCKLNSGSLFAALSTVNEALLTDL-QHHYHSPdsh----------pmpGEI 1040 Trypanosoma brucei...
XP_001418393                   971 ----DMLAAFATIGQAQLLRRQLNAELVANIRIDSHTLSRALDTANKAILTDI-RSHYKSPdtvp-------ypdeANAI 1038
XP_006844422                   943 ----QWVVCLAYVGQLQLLRCVISSKLKSACKVNAGAVSFAVEQLVDSLF----HCNGKDVdherps---qekytdMESF 1011
EFJ34129                      1053 ---vTWVESLAHIGQLQLIRCLLSSQLRAASQLESGMVSFALEGLGTALFSTMeTNSERTNg-------------kSNGV 1116
EAY01964                       921 -----WTILICSIGQLQLLKMTIDAHMELKCKLEAESLNFMLENTNTTVLQAI-KQFYRDPthn---------pypSSNL 985 
WGS:AAFB:cds.EHI_045500A       904 ----SLIDTLHNLGTLQLLREQLNCQLCSENRTKATSLHFALKSFDQALVHDFf----ENPnkk----------erEPLI 965 
EED92001                       950 -----MLTCFRRVGQAQLLRRMIRFELQRCARVDAKELQHSVSTLNASLL----STQQRDGp-------------eETKM 1007
WGS:AAGF:cds.TTHERM_00145500A  933 ----AIQDKILKIGQMVLLRRLICLQLQIKAKVGSNRLFLSLETLNDSIINDIlNRPTTEAmntve------aqekQNEL 1002
A0DY11                         923 -----ILYPLQQIGQYINLRKLICLVLQMKAKVGSTKLFLCLETLNNTIINDFiNRQYDSTmesdv------ktqmENNL 991  Paramecium tetraurelia...
XP_003721974                  1091 VCGMAPLLSSVGLTDPFATVYEVADgggggspsgddtagefsfgapppapatagsgaarpvavptklP-LPLLVLPLCVV 1169
Q386S7                        1041 INAVSPFLDCAGISDALTKVYVTSK------------------------------------------P-IPSFVFYLIAL 1077 Trypanosoma brucei...
XP_001418393                  1039 VPKLSAYLSASGMQNPLRQIYCTVA------------------------------------------AvDDDWGLAAFVF 1076
XP_006844422                  1012 LHQMNKQRMLCGSLSPLRIQYIAGS------------------------------------------P-PSQIGRFASIV 1048
EFJ34129                      1117 LKELARQLQACGMFSPMKTTYITAK------------------------------------------P-PAHISLFLFLI 1153
EAY01964                       986 IAAISTYLENCGMCRPLEKIYTMSK------------------------------------------P-LPEISLVIFSL 1022
WGS:AAFB:cds.EHI_045500A       966 YNEINRFLDVAGFVPALSKVYITCA------------------------------------------EgGDQIASVLSSF 1003
EED92001                      1008 ICDFTT---AVGLGNPLDTVFMATN------------------------------------------P-LEGLPVLLLFF 1041
WGS:AAGF:cds.TTHERM_00145500A 1003 LFDTTKLFSYVGISDPIKKVYLTTE------------------------------------------P-IEGLSLMMLGL 1039
A0DY11                         992 LFDLTKLFNYVGLSDPIRKIYALCE------------------------------------------M-PEHTPLILALV 1028 Paramecium tetraurelia...
XP_003721974                  1170 VLLHV--QKCTYSARFDSCIPAEk-ED-DVDPTVLAVGVAILLQQFPLEATRLLLQLLAQVV 1227
Q386S7                        1078 TLRNI--PRMRYDDKLASMVPSEl-KY-LLDPEALVIALALLLKQFHSDQLVLFLNHLSRVV 1135 Trypanosoma br...
XP_001418393                  1077 TLTQL--ELYRFDDVASTLVPINqsVT-KLDAHVLILAVSTTLRQFHADQTTSYLSHLGAFa 1135
XP_006844422                  1049 TISQL--SRYVLDIHLGALTCRTk-KL-VLDFCPLIIGLGTFLRQ-NDSSLRDYVKYMGQYV 1105
EFJ34129                      1154 TINQL--TRFVLDKHLGTLVSKAk-KT-ALDCCPLVAGFATLLHQFHPSHSILYIQartphy 1211
EAY01964                      1023 TLLNLnnQKLQEYDRLHMLHRPNi-YA-HFE---FIVGIITILRQLNVNHQYAYLTFIGQYa 1079
WGS:AAFB:cds.EHI_045500A      1004 ILYCS--QFFIFDSKYQTLMLRPkaPV-PYDPYVLAVGIVTVFRQFHPSTMWASFSYLSLYV 1062
EED92001                      1042 VITYV--PKLSYDSNYGSLAKVKg-GY-PIDGCPIVAGTASLLKQFHPSYTKSFLAYVGQFI 1099
WGS:AAGF:cds.TTHERM_00145500A 1040 VLNNI--NLMDYSYQLKSLIAKKseRI-NLEPNYLLNGIIVFMNQFHPSVQEIFTGLIG-YF 1097
A0DY11                        1029 ILHQL--PLMDFDKKLNCLVKKAkdNQlQFEPNCLLMGIVGFLNQFNQLHSSLFVSYLGFYI 1088 Paramecium tet...
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