Conserved Protein Domain Family
Amnionless

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pfam14828: Amnionless 
Amnionless
The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.
Statistics
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PSSM-Id: 464340
Aligned: 32 rows
Threshold Bit Score: 322.416
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007473591  23 YKQWIPNTNFEDAANWDRNRTPSETDIVMFDSNKMVSVFV-G--STHVLMGAHLPLDGEFILAP-GA--GFTAFDGVSDP 96 
EDW36866      97 TKWYSGGADFNSPSAWVDDYMPCPEDLVVFPKYFPAVLPL-P--EEISIDGIVFPRDGAILIAE-EStiTFGAPRNT--K 170
XP_016022903  21 TKWYGGGMDFNDPSAWLDDHLPCAQDLVVFPEYYPALLPL-P--EDISIDGLVFPREGAILLAE-EStiTFGSDKQP--S 94 
XP_002001791  22 IKWHSAGAAFDNADAWLDGYLPCAQDKVVFPSYYPAVLPL-P--KELAVGGFLLPRLGGLLLAE-DAtiQLGVGSGLNRD 97 
EDW03987      27 IRWHSAGAPIDSPAAWLNDYLPCAHDLIVFPKYYPAVLPL-P--PQLSIGGFVLPREGGILLAE-DAtiELRAGVGLNPD 102
XP_001864252  20 sKVWRHNLNYDNPLNWQSQRVPQPGRDVYLPAKLNSIVKL-P--TTVNVASITLPLKGALLIPDsDFsmVFQSGHRS--- 93 
EDO63297      24 VKVWVPHVSFSDAANWVSANLPTAGQTIVFPSKLNALVSL-Pv-GIWTVSSLILPQQGGLLFPDhSFslNVVSRDPAA-- 99 
EEB16430      17 LKIWLPNTGMNNTQNWENNEIPKNCDQIYFPSKSEIATYWnI--KDLEISNLVLSKSGELILSN-YInlLFKDKEKCLN- 92 
XP_001604404  22 eKRWTGNVDWDVANNWLGGSVPTIDSQVIFPLEMRHAVGLpPrlDQQRLMGMKLPNDGLVALPE-DGkiLVAANKGHFH- 99 
XP_011067707  28 qKYWLPDLEWRTASNWANNRIPEIDSHVIFPHQTRHAVGI-SgmDNLRLSGIDLPWQGLLVLPR-DGklQLSNSRTDAK- 104
XP_007473591  97 S-SDSDHIHFLNADRFSWYNPTLWHT-----DLKNSDRLFSMDTELIPCRQDDVIFP-PET-SFRVDLGAGgRTISLHSI 168
EDW36866     171 CdSDEKTAHLKPPKSSKWFDPHTWKw----aDISKSVSSPVPELERVPCDDEQVIVK-GHA-PLAFDLENV-QHLRLGQL 243
XP_016022903  95 CeSEEKRAYLKPPKSSKWFDPGTWT------DKSKEFSTFTPELERIPCDDEQVIIK-GHG-PLSFDLENV-QYLRLGQL 165
XP_002001791  98 CeSDEKRAYLKPAKTSKWFDPSSWSGqpnsaSSSSSAIDSYFDLDRVPCDDEHVVIS-GNSgPLSFDLENV-EYLRLGQL 175
EDW03987     103 CgNDKGRAYLKPPKTSKWFDPGSWSMqpdssSSGSS--SLMPELERVPCDDEHVVIP-SNRgALAFDLENV-QFLRLGQL 178
XP_001864252  94 ----QDSASFNAPPRRPYYSTSNWRTftdpgSKELQHNSAIPHTERIPCQYETANF--PDA-PGPVDLQYH-EAIELKDV 165
EDO63297     100 ----ISVAIFNAPGRTPYYSGSNWATydeqrSTHSTPNGAVPHSERVPCQYELVVFEvGKNmPKPIDMQYH-ESIEVGNV 174
EEB16430      93 ----ARKMKFTRNDIKGWLDPYNWMSd---------SNQWLPHSERVPCTGEIINFP-SIN-TISVQLPS--ILLPYKSF 155
XP_001604404 100 ------TAVWLRETPFFWLDPDNWHV----------ESEAVPHMERLPCQSDVVVLP-SSSrTFSAKLPVS-RDVEVQAV 161
XP_011067707 105 ------VSRWSKEGSIFWADPANWNG----------SSIAAPHLERVPCSYDNIVLP-SENrTLSILLPV--REVGVKSI 165
XP_007473591 169 SILDQT-------FSVDKELATYLASSTGKLQFHGAGSLRLSS----APCEDPSGCECGNDE---------------VEA 222
EDW36866     244 ILAGSS--------ISKFYLEQLLARDLGRFLFHNALDVQVEY-------YRGELCGCHKDFd-------------rLIE 295
XP_016022903 166 ILAGSS--------ISKTYLEQLISRDLGQFLFYNAEYVQVEY-------YRGELCGCHKDFe-------------rLLE 217
XP_002001791 176 ILAGSS--------ISRNYLQELLSRDLGQLLFHNAQNVFVEY-------YRGELCGCHIDYe-------------nLLE 227
EDW03987     179 ILAGSS--------ISRRYLQELLGRDLGQLLFHNAEAVFVEY-------YRGELCGCHKDFe-------------kLIE 230
XP_001864252 166 VFGSAQ---------GLDEFRAFLPTELGQMVFLNADETITRE----GKCSNPDKCKCQPDWi-------------tNGG 219
EDO63297     175 RFGDTI--------EGLDSFHNFVSSELGQFLFYNAEDTLIRQ----GKCANADKCPCQEPR---------------QMD 227
EEB16430     156 NFGEQV--------LNGEEWQEFLKTELGYMLFKGSDELREKPwrtdESCSKGKKCTCIRSAytfrdgiykevnrhiFQE 227
XP_001604404 162 RLENENstmarweWRALRDKAEFLGSRFSVSYG---------------ALSNCKNCPCQEGDis------------dYWE 214
XP_011067707 166 RLSNERqpftkweWQNFQDRREFSRDRFTVKYS----DLVWRP----ISTLDCKKVFCQGNTqd------------dYLE 225
XP_007473591 223 WICASLLQtsggRCPKPACQVALKPVGQCCEICGAMIFLNYT-QA--FDLHQYKQRLLHNFL---DRPQALGVRMAISKV 296
EDW36866     296 PVCHNVQE----QCEAPHCLSPVRPFGSCCLICGAVLTMPRQ-HCseEDRKTLQNQLNSMIT---KQDLAAEIQLHVDYV 367
XP_016022903 218 PVCHNVQE----QCETPHCLSPVRPLGSCCLICGAILSTPTT-HCteGSRKEFVAQINNLIS---QESLKDQIGLHVDFV 289
XP_002001791 228 LVCSHVEP----LCEVPHCVSPLRTNDGCCLVCGAMMHVKSE-HCveEDRKTLTGLINSFMV---KEQLQDELQLHVNYV 299
EDW03987     231 PVCHNVEQ----QCPVPHCVAPLRPFGSCCLVCGATLTIPSE-HCmeEDRKSLTSFISKTIA---AEDLADELQFHVNYV 302
XP_001864252 220 VICDNE------VCPIPRCVDPIVPSGHCCAVCGSMLTMDLTnFDghFVKKVFVEKLDQKIKlsdVDISTIDYHVGI--- 290
EDO63297     228 AICSNV------RCTVPHCLSPIHPPGHCCPICGSWFRMDMAtIKgvFNMQTFMDKLRRKINtgeVDDSGVEFHIGVDRS 301
EEB16430     228 AVCLYAMP----KCKKVPCYFPVVPEGHCCGICGAVLKLEDK-TKegFDLNEIKRKVNEEIK---KHKLNKELKTYVGRT 299
XP_001604404 215 EVCNVQRP----KCGPQACEYPLKVEGHCCHYCGGRVRFS------------------------------KKTLLSSATR 260
XP_011067707 226 EICAIQRS----RCGFMGCEYPLTVEGHCCPYCGGRVSIS------------------------------QQISLTTIQT 271
XP_007473591 297 HKEHRLrgsahtargKRqteTTTHIQVVLTDdgsgpeAGRAAVRVAQAILTDVAEQGAAYGVLQGDAEYSDGGSSTAGLT 376
EDW36866     368 SSEQ----------------YGSFLQAIVTD------RGGYSERSVEFMQYLSEHR------NQSTFLAKQS-GLELKSS 418
XP_016022903 290 GSQQ----------------FGNCLQAVVTD------RHKYSERSLEFLQQNEHKW------NKT--------GTTLKVS 333
XP_002001791 300 GSRA----------------FGNALQAIVVD------RNGYSERSVEFMRRFAAQR------NQSKFLAQQK-NLKIFYA 350
EDW03987     303 GSSSQ---------------YGNHLQAIILE------RGSYSERSVKFMEHLSALR------NQSNLLKQQSQQLMLHYA 355
XP_001864252 291 --------------------QNDALQLVILD------KEETSATASKAYLP-----------QHPLLLTISQTGHIVLSA 333
EDO63297     302 A-------------------GANVVQLIIVD------KGEYGEKSTRMMDS-----------LRPFFEKQFSSGFQVTHA 345
EEB16430     300 --------------------KDENIQIVILA------DDSDATTSSHFLSSVIAQKLKGQKLKLSISQLSGLALSNYL-- 351
XP_001604404 261 VARNILagyekslswHSrqtSDGFGEILIAE------KGVYSGSNVVLGVADVEAALREQNIELLSSETSGGPFVDHR-- 332
XP_011067707 272 VADEALegytekvawHTrctWNGGVEILIKE------KGDYSGITIEEAVENLREMLQNTGINVTNAETAGAAMKDTR-- 343
XP_007473591 377 G----ESLSSGMVTSLAIAIvlg---lmvVLLGGLLLLHWTGW-----V-RLWP-LSVPtLWQRSEPALD-QGNLGFDNP 441
EDW36866     419 GrphnPNVSFASVLLILFCMalv---gvvSVIILAHFMPENPY-----LnRIPQwIHDP-RRWRWRHLGV-RLRRNPLFN 488
XP_016022903 334 GrpynPNVSFSSIVLILFCMalv---glvSVVILAHFMPENPY-----LnRIPQwIHDP-RRWRWRHLGL-RLRRNLLFN 403
XP_002001791 351 GhpynPNVSFASVLLILFCIvlv---gvvSLIGLAHFMPQNPY-----LnRIPQwIHNP-RRWRWHHMDL-RLPQHLLFN 420
EDW03987     356 GhpynPNVSFGSVLLILFCLvlv---gfvALIMLAHFLPQHPY-----LnRLPQwLHDP-RRWRWPHLDLrRLRRNLLFN 426
XP_001864252 334 GhpymPYESGQLFFAVFFSLlvv---sifFTTLYVYYYDDSVVprvtaMiRSRRfFTSP-----------------FVFA 393
EDO63297     346 GqphtPLEGGQLLAFVMLTLiva---stfFSIIYVYYYDDVLLprlraAvRNRQfFTTP-----------------FVFA 405
EEB16430     352 ---------FNSITGIIFGTlfgvlllfvILFYQYVKIPQKII-------------------------NM-DQNKPFVFA 396
XP_001604404 333 ---------LTMALAPFLGSfallvllviLVFPAFGYTYSQVWdaareVg---------sVICIERRVNG-HKRKSFAFA 393
XP_011067707 344 ---------LAVTLGPLFGIplvvitlllLAFLYFGYSLEQVLsgcmeAvs--------sVRDGIRADKQ-K----YGFA 401
XP_007473591 442 IFDSpg--lASVLAPGPREEVVv-------eDAAPSPKGPPssg-----------syFINPLFE 485
EDW36866     489 RFENvv-agGGSIEDPRGGVVGv-------dRVTVMGYDPGndev--------rersFDNPMFE 536
XP_016022903 404 RFDNgg-agGGSSE---GGASGv-------dRLGIMAYDPEsgev--------reraFDNPMFE 448
XP_002001791 421 RFDNvt-agMGTGG---AGGSAv-------eRLAVIGYDAEneev--------reraFDNPMFE 465
EDW03987     427 RFDNaaqaeRGRTG---SAGSGv-------eDLAVIGYDAQsgvv--------reraFNNPMFE 472
XP_001864252 394 RFDPnrengESTLDINFAAPSGi-------eNLNSS---------------------FNNPMFD 429
EDO63297     406 RFDPnn--dVDGLSVDVTYPSAvqlaneereESAALADDVEnhh----------assFNNPMYE 457
EEB16430     397 RFDNvs--nEDNCNENIHIESAcdpqnsydtNIKVESKEKEkedvtpg---ksssqeYHNLTYT 455
XP_001604404 394 RFENlfegnVQ------------------------LAEEEQeeeqassaeqssggetFENPLYR 433
XP_011067707 402 RFENipegnIQIG------------------NVPGTSGREAddnvegi--kqiavgrFENPLYR 445
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