Conserved Protein Domain Family
CF222

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pfam15661: CF222 
C6orf222, uncharacterized family
This family of proteins is found in eukaryotes. Proteins in this family are typically between 618 and 652 amino acids in length.
Statistics
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PSSM-Id: 464786
Aligned: 10 rows
Threshold Bit Score: 738.622
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_022281686  47 RRARSLERSHSPKKDSESWNCKGHSLPmsTPPSKRVLHQTASDGTRCPQSPAHG-------HGALSLEETKKFLsSDQRP 119
XP_015324358  26 RRAKSLDRLQNAKKDSESWDCQGPSLP--TGPFRGGLCRTASDGARCLKSPVQSveaqdttAAAPSPEETKDLL-SEQRP 102
XP_013833300  14 RRARSLDRSQDPRRDSEPGDCQCLSMP--ATRSRRMLRRTASDGTRCAKSLAQSseaqgptATALSPEETREFLpSEPRP 91 
XP_016810836  14 KKARSLDRPQAPGKGSESWDCHCLSLP--TAPSRKALHWTTSDWARHSDSPAPSaeahcttAAAPTPEETGEFLpSEQRP 91 
XP_003789355  14 RRTKSLDRLQAPRKDSESRDGQCLSVA--TASSRKTPRRTASDGAR------RSteaqgpvAAALTLEETREFLsNEQSP 85 
Q8CC96        31 KRARSLDRQVPRKKDPESSNTRCPS----SATCR----RTASDGARSSESPSHFaeaqgatAAALPPGEGRGFLpSEQGP 102 house mouse
XP_005318947  14 RRAQSLDRPQAPRKDSGSGNCQclsfst--apcrrPLRRTSSDGARHSGIPAQSaeaqgtvTTALTLEGMRGLLpSEQRP 91  thirteen-lined ...
XP_023110484  10 RRARSLDRSQSPKKVR-----RCFSLP--TTPSRRMLHQAASDGSRSPQSPAQSveaqdatATAHSLEETREFLpTDQRL 82  domestic cat
XP_023620551  14 RRARSWDRSQKPRKDLESREGQYLSLP--ATPPRPAPAGRAHDGSRHLSGPGS--------QEALSLEAARELLtSEQRP 83  little brown bat
XP_023402127  14 RRTRSLERSQDPRKDSESWDCPCLSLH--STYSKKELRRTSSDGAGCFQSLAQPaeaqgtmATALSLEETNKPIrSEQSS 91  African savanna...
XP_022281686 120 PQDTKKDKTQKRGQQGWLKTIINFFLRTGP----------------------EEPKDKASRKAKGKEGLPKSAETPEAPG 177
XP_015324358 103 LQDAKKDKAQWQAPQGWLRFVVNLFFRTGP----------------------EEPKEKTNKKAKGKEGPSEPTETPESLG 160
XP_013833300  92 PQDTKKDKAQWRTQQGWLRTMMNFFFGTGH----------------------EESKEKASKRAKGKEGPPEPAETPETLG 149
XP_016810836  92 LQDTKK---------GWLKTMLNFFVRTGP----------------------EEPREKASRRPRGKEGISQHPEPLEAAG 140
XP_003789355  86 PQDTKD-----KAQQGWLKKMLNFFLRTGP----------------------EEPREKASRQTKGKEG---PVHLTESPR 135
Q8CC96       103 PEDTKKERLPREAQQSWLRLVLNILLMR-I----------------------EEPREKASRASKGK------GDLPEAAE 153 house mouse
XP_005318947  92 QQDAKKHKAQRRAQQGWLKAVLNFFLRTGP----------------------EEPREKASKRPKGKEE---PSEPPDGPG 146 thirteen-lined ...
XP_023110484  83 PQDTKKEKTQRRGQQGWLKTLMNFLLRTGP----------------------EEPKEKASRKAKGKEGLPKPAETPEAPG 140 domestic cat
XP_023620551  84 PRDKKD-----------------------KaqsrsqqgllktvlnfflrtspEEAKDKAARRARAKEGLPPPAETSE--- 137 little brown bat
XP_023402127  92 PQDTKKDKAHRRAQPGLLKVLFNFFLRTSP----------------------EEPKDKASRRPKRKESLSQPVESPVAPG 149 African savanna...
XP_022281686 178 DTAPRKKA-HDKKASRKK-HSHKKHAAEETKGAQDHEAEGQETglpNLAATPCSKEADRGPAPKggegsdlpqslciedg 255
XP_015324358 161 EPAPRKKA-HSKKASRKK-HSQRKRCAEEARGARDQEAEGQEA---KAAEASLSEGADLGPAAR---------------- 219
XP_013833300 150 EPAPRKKA-HHKKASRKK-HSHKKHSAEEVKGAEGQEA--------KAAAASCCGEADLGPGAG---------------- 203
XP_016810836 141 EPALRKKAhHDKKPSRKK-QGHKKHAAEVTKAAQDQEARGQEEglsKAAAALRSGEADLGPARRggedsdhqsflievdg 219
XP_003789355 136 EPDLKKKA-HDKKASRKK-HGHKKHVAEEPKGAHDEDARGPEAglsKTAAALHSEEVDLGPARGgredsdlhqslvvees 213
Q8CC96       154 EPALRKKS-HEKRTSRKK-HSHRKPIAEEPPGPQTAEAQGREDvppSLAASSAPHEIALGLICRggpdsdlpqalptegd 231 house mouse
XP_005318947 147 EPALRTRA-RDKKASRKR-HSHRKH-----------DAEDPEAglpRTEAAS-TEEADPGPAGRgghghdsflhpslpie 212 thirteen-lined ...
XP_023110484 141 ETAPRKKA-HDKKASRKK-HSHKNHVAEETKGAQDQEAEGQEIglpKMAAAPRPEEADLGPAPKgeqtmpgnptaptpra 218 domestic cat
XP_023620551 138 ---PRKKA-HDKKAGRKK-HGHRKHGDGDARGAPGQEAGGRD-----TAAAWRSQEADPGPGPRggadpdphqsaliegr 207 little brown bat
XP_023402127 150 QPAVRKKS-QDKKPSRKKaSGHKKHVTEETKGVQDQEA------------ASHPEESDLGPARKgrenpdlpeclftegr 216 African savanna...
XP_022281686 256 vpga------------------aeispqatghrwgedlkntdKD-----------------------------TIIKMIV 288
XP_015324358 220 ------------------------------------------ED-----------------------------IIIQKIV 228
XP_013833300 204 ------------------------------------------ED-----------------------------TIIQKIV 212
XP_016810836 220 tgal-------------------dvsphatghqqeeelkkpdQD-----------------------------AIIQMIV 251
XP_003789355 214 gaaa-------------------lnvspqasdhqreeikkpdKD-----------------------------AIIKMIV 245
Q8CC96       232 haet------------------pdsfgqasgppleedprkpdQD-----------------------------DVIWQIV 264 house mouse
XP_005318947 213 vggag----------------fsgvspqaagaqpeehlrkpdQD-----------------------------AVIQRIV 247 thirteen-lined ...
XP_023110484 219 rlcgkgsgphqsllieaggpaasevssqatghrpeeelrkldQDkiikmiveflqkvgdqweeeslplssrsrA--RRFL 296 domestic cat
XP_023620551 208 gaga------------------sepssqatgprpeeepqkldQD-----------------------------TIIQMIV 240 little brown bat
XP_023402127 217 cagv-------------------qtdssqatghkweaerqlsED-----------------------------AIIQMIV 248 African savanna...
XP_022281686 289 EFLQRVGDQWEEE-QLQAPQLVLVSQ-NPAP---AVRKKSQEKKSNFKRAFS--HKKH--SSEEPKRAGPGEVSSPESRP 359
XP_015324358 229 ELLQKVGDQWEDE-QHQALQSVVTPR-NPAP---VVKKKSQEKMSSLKRAFS--FKKY--VSEEPKRAGAAHVSSAESRQ 299
XP_013833300 213 ELLQKVGDQWEEE-QRQASQPEVAPH-PPAP---VAGRKSQERKSSVTRAFS--HKKH--SREEPKRTVAAEVSSPESRP 283
XP_016810836 252 ELLKRVGDQWEEE-QSLASQLGVALP-NPAP---AVRKKSQEKKTSLKRTSKtnPKKH--GSEEAKR-GAADVSSPEARP 323
XP_003789355 246 ELLKKVGDQWEEE-QLRAPQPVVAMQ-NPVP---ASRKKSQEKKSSPKRDFS---KKH--SSEEPKRAGATDVSTLEARP 315
Q8CC96       265 ELLKKAGDQLEEE-QVQIPQPEAVPPrKPTP---LPRKKSQEKKSSLKRVLS--LKKP--ASEEPKRVGTATTLGPETR- 335 house mouse
XP_005318947 248 ELLKKVGDQWEEE-QLQVPRLEVALQ-NPSP---VCKRKSQERKASLKRAFS--LKKYgpGPEESRRAGAADVPSAEARP 320 thirteen-lined ...
XP_023110484 297 SFLPQ---------QLQAPQPEVVVQ-IPVS---VDRKKFQEKKSSFKRAFS--HKKH--GSEEAKRAGPADVSSPESRP 359 domestic cat
XP_023620551 241 QLLQAVGDEWDEEvRSQG-EREVAPQ-NPAPapaVVRKKSQERKPSLRRTSS--HKKQ--GSEEPRRAGAADAPSPESRP 314 little brown bat
XP_023402127 249 ELIKKIGDEWEEE-RLRTQQLETGLQ-NQAP---VFRKKSQEKKSSFRRAFI--LKKQ--GSEEPKRVGAADVPSLETRT 319 African savanna...
XP_022281686 360 LKRPSFLPL----CVGGHQPSTSSSPGLEEHNIQEAASTDSGGPSPFQLSSQAGG-QEPEEDVQTNTALEFKEFIQEIIA 434
XP_015324358 300 PKRPNFLPL----CVGGHRPSSSSLPGVEEPEVQEAVTTDGGDPSPFELCTPAES-GGPDKDLQQDRATEFKEFIQKIIA 374
XP_013833300 284 PKRPSFLPL----CVGSHRASNSSSLGMEAPEVPVAPSTADGDPSPLELSTPAGS-RGPEEDLQLDRASEFKEFIQKIIA 358
XP_016810836 324 PKKSSFLPL----CVGGHRPSISSSYGLEEPEVQEAPSTEAGAPGPSVLPTPSES-QEPGEELPLDRASEYKEFIQKIIS 398
XP_003789355 316 PKRPSFLPLhlpqCVGGHRPSISSSLGLEEPEVQGVLSTDSGSSSPFKPSTQPES-QRPGEELQPDRASESKEFIQKIVA 394
Q8CC96       336 PKRPSFLPL----CVSSQRASTSSSLDLEAPEFQEVPSVDGGGSHPSELHTPAAIfQGPEEKPLLDRASESREFRRKILV 411 house mouse
XP_005318947 321 PKKSSFLPM----CVGSHRSSISSSPGLEGPEVHEALSADGEGPSPSEPPTHARC-QGPVEELPLDGASESNKFFQK--- 392 thirteen-lined ...
XP_023110484 360 PKRPSFLPL----CVGGHQPSTSSSPGSEEPKVQEVLPTDSGGLSPLELSTPAGS-QGPEEDLQANRALEFrefirkiia 434 domestic cat
XP_023620551 315 SKRPSFLYM----CVGGHRASISSSVDLEEPEVQEASSTDCGGPSPFELSIHSGS-PEPGEDLQPDKASECKEFIQKIVA 389 little brown bat
XP_023402127 320 PKRPSFLPL----CVGGHRPSTSSSTDLEEPQVPDVRS-----PTALKITPGARS-RWPEEELEPDRASESKEFTQRIFA 389 African savanna...
XP_022281686 435 LLPDAEEQWGVKQLQ-------------VQEPEVAVENLSLPYRRKSHEKKSSFRKAFsHKKHGSKDQKRAGAA---GAT 498
XP_015324358 375 LLQDAEEQCRDKQLQ-------------VQEPEVAVENLAPAYRKKCQERKSNFRKAF-YKKHSSKDPKRAGAA---GAA 437
XP_013833300 359 LLQDAEEQVADKQ---------------VQEPEVAVENLAPVCRKKCQEKKSSFRKAFsHKKHSFKETKRTGAA---GAA 420
XP_016810836 399 MLQDAEEQQGEEQPQ-------------VQQEEVGVENPAPHCRRKSQEKKSSFRRAFyHKKHTSKEPRRTGAA---GAA 462
XP_003789355 395 LLHDAEEQGREKQTH-------------IQEVEATVESLAPPCRRKSQEKKSSFRRGFsSKKHSSKEHQKAGSSgatGAA 461
Q8CC96       412 LLQSAEDERGEQEAQ-------------AQEAEKAGENPTPAGKVKSQVKKSNLRRAFsLRKHSSKDSKKTEASgtpGSG 478 house mouse
XP_005318947 393 ----------ILALLqdaeeqegeqqpqVQEVEVAVENPAPVCRKKSQEKKSSLRRAFsHKKHSSKEPRRAGTV------ 456 thirteen-lined ...
XP_023110484 435 llqdae-------eqggeflsppprqlrVREPEVAVENLAPAYRRRSQEKKSSLRKAFsYKRHGPKEPRRAGAA---GAA 504 domestic cat
XP_023620551 390 LLQDAEEQEGEKQLQ-------------VQEPEVASENPAPPYRKKSQEKKSSFRKAFsHKKHGSKEPKRAGAA---GAA 453 little brown bat
XP_023402127 390 LLQDAEEQGTQKRLQ-------------TQQPEVDVENPASIFRKKSQEKKSSFRRAFiYKKQSSKESKRVGAA---DVS 453 African savanna...
XP_022281686 499 SPESRPHRRPSFLPLCVGGHQPSTSSSLDL--DGVEFRESLPTEGAPVRPSDAPSQTRGHKPEEGPQPDEVFESKEMIIQ 576
XP_015324358 438 SPDSRPPKKPSFLPLCVGGHWPSVSSDSDP--EDLEFQGSPPTEGEPVGAPEALSQARSHKPEAGRQPDGANESKELIIQ 515
XP_013833300 421 SPESRPPKRPSFLPLCVGGHRASTCSNPDL--EDLEFQEFSPAEGSPGGCSEAPFQARSHKPEVGLQPEGANESKELNIQ 498
XP_016810836 463 SPEARRPKRPSFLPLCVGGHRPSTSSSLDP--EDLKCRERLPAEGEPVVISEAPSQARGHTPEGAPQLSGACESKEIIIQ 540
XP_003789355 462 SPEARRPKRPSYLPMCVGGHRPSTSSSLDP--ECSEFQEPSPAEGGPVGISEAPSKARSHKPEGGPQQDGASEEKEVIIQ 539
Q8CC96       479 SLEARPPKKHGFLPMCVSGHRASISSS--P--ESLEFQKTEAAGGAPAGSPGAPFQARSHTPDEGPSPERAWESKEFMIQ 554 house mouse
XP_005318947 457 -PEAGTPKRPSYLPLCVGGHRSSISSS--SdpEHSEFQEPLAAEGFPA----ASSQTRSHTPEGGALPEDTCESKEGIIC 529 thirteen-lined ...
XP_023110484 505 SPESRPPKRPSFLPLCVGGHQPSTSNSPDL--EDVEFQESSPAEETPVGSSDAPSQTRSHQPEGGPQPDGVFESKELVIQ 582 domestic cat
XP_023620551 454 SPESRRPRRPTYLPLCVGGHRPSISSSVDP--EGPEFRESSPAEGGRVGSSESPSQARSHEPEGRPLPDGACESRELVIQ 531 little brown bat
XP_023402127 454 SPEARTPKRPSFLPLCVGGQRPSVP-DLDL--EDIEFQKLSPAERGPIGSPEPASQTRSHKPEGEPQLEGACESKEQVIQ 530 African savanna...
XP_022281686 577 RLADLLQEVDGQLGEQIKRHPSFKRFLYRLSDSSLRKLAATLHSQQAHSTESdrkliKGPYHFAFGLPNKFAGNNSHAVL 656
XP_015324358 516 ELVALLQEVDGQLGKQIKRHPSFKKFLYEPSVSSLRKLVATLRSRGAHTTEP-----KRTYPFVFGLGNQGAGNNYHPVL 590
XP_013833300 499 KLVALLQEADGQLGEQIRRYPSFKRFFYRLSDSSLRKLVATLHCQEAHSAEPdrnlaEGSYPFVFDLANKPAGNNYQAVL 578
XP_016810836 541 KLVALLQEVDGQLGQQIRRHPSFKRFFYEFSDSSLSKLVATLRSQVAHSSKLdrnraRRLYQFDVSLANKFAGSNSHAMC 620
XP_003789355 540 KLVVLLQEVDGQLGQQIRRHPSFKKFFYEFSDSSLNKLVATLCSQAAHFSELdknlaKRPYQLGFGMANKFANHKSHAFS 619
Q8CC96       555 KLVASLQEVDRDLGRQIRKYPSFKRFFNEFSDASLRKLVATLERQKASLSEEgrslaNRPPPCAFGTLNKFAATRSCTIC 634 house mouse
XP_005318947 530 TLVELLQEVDGELGDQIGRHPSFKSFFYEFSDSTLRKLVATLRRRKTHSPGGarslaQRPSPYAFGLVHKFAGSHSRTIC 609 thirteen-lined ...
XP_023110484 583 NLVALLQEVDGQLGEQIRRHPSFKRFFYKVSDSSLRKLAATLHSQKARSPELgrnltKRPYQLAFGFTNKFASNNSHAVF 662 domestic cat
XP_023620551 532 QLVALLPGVDGHLGEQIRRHPSLKKFFYQLPDASLRKLAATLRRRGACSPAPcrglpERPYQFAFDLANKYAGRSGHTAL 611 little brown bat
XP_023402127 531 KLVALLQKVDNQLGKQIRRHPSFETFLYKLSDSSVTKLIATLQSREAHPPEPdksldEKRYQFAASLANKFAGNNSHVIC 610 African savanna...
XP_022281686 657 SLMGLRYS--QHSYSHFPCREAQQNITSPETGSPD 689
XP_015324358 591 SLTGLHYR--RPSYGQFPYEEAQQNITSSQIQSPD 623
XP_013833300 579 SLVGLRYR--QSSYGQFPYREAQPNITSPQSQSPD 611
XP_016810836 621 ILMGLRDH---YNCTQFPYREDQPNITSPEVESPD 652
XP_003789355 620 ILMGLRSH---YSSTQFPYRESQLVREV---GKGN 648
Q8CC96       635 TLMQSRGEykGHSYAHFLSRKAEQDITNLDSQSPD 669 house mouse
XP_005318947 610 SLMGSRGHcvQHNFTQFPSREAQPnmpspecqspd 644 thirteen-lined ground squirrel
XP_023110484 663 SLMGLCYS--HASYTHFPYREAQQvrksqtaqakt 695 domestic cat
XP_023620551 612 SLMGLR-------YPQLPHTEAQQNITSLDFQSPD 639 little brown bat
XP_023402127 611 LL----GHysWHLYPWFPYEEAQLNITSPESQSPD 641 African savanna elephant
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