Conserved Protein Domain Family
Calcyon
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pfam06387: Calcyon 
D1 dopamine receptor-interacting protein (calcyon)
This family consists of several D1 dopamine receptor-interacting (calcyon) proteins. D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) and schizophrenia.
Links
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Statistics
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PSSM-Id: 461892
Aligned: 10 rows
Threshold Bit Score: 222.729
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_020929614   1 MVRLSCSF-GK-SSKDSGDLDGaaMDSVPLISPLDVSQLQPSFSDQVVIKTQTEYQLSSAdQ-PKKFSDleAQKLSGNPL 77 
P58821         1 MVKLGCSFsGK-PGKETGDQDGaaMDSVPLISPLDVSQLQPSFPDQVVIKTQTEYQLTSAdQ-PKKFADleGQRLACSHP 78  Norway rat
XP_015201898   1 MVKLGSNLaEK-PEKEQALEDG--FDNIPLITPLDVSQLQQPFPDKVIVKTTTEYQLQQKkK-RKLYVP--GIKKLNINL 74 
NP_001313394   1 MVKLGSNLnDK-NSKPPSSEDG--FQTVPLITPLEVNHLQFPAPEKVIVKTRTEYQPDQKnK-GKLRVP--KIAEFTVSF 74 
XP_022594629   1 MVKLGSNLqDK-GAKPVSVEDG--FQNVPLITPLDVGSLQSQAPDKVVVKTRTEYQTEKK----RLKVP--KVEEFTISF 71 
ERE89836       1 MVKLGNNFaEK-GTKQPLLEDG--FDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRK-K-GKARPP--KIAEFTVSI 73 
XP_006629661   1 MVKLGNNFcEKnNTKQPVSEDG--FDTIPLITPLDVNQLQFPPPDKVVVKTKTEYEGDHK-K-GRFRSP--KIAEFTISI 74 
1_pfamImport   1 MVKLGVNVsEK---KAAGSEEG--FDTIPLMTPLDAAQLQIPPPDMVRRHRATDTHFYCY-----WVSV--QLGLTSCSP 68 
TNN62124       1 MVKLGSNLsDK-LEKQPSADDG--FDNIPLITPLEVNQLQQPFADKIIVKTSTQYQLQQK-KkNKLYVP--NIRKLNINF 74  Tanaka's snailfish
XP_017818792   1 MVKLGCSFsGK-PGKDPGDQDAaaMDSVPLISPLDVSQLQPPLPEQVVIKTQTEYQLSSd-Q-PKKFPDleGQKSNCSHP 77  white-tufted-ea...

XP_020929614  78 EDGr-SRMPTGRMIAFTMALLGCV--LIMYKAIWYDQfSCPDGFLLRHKICTPLTLEMYYTEL--DPERHR----SILAA 148
P58821        79 EEG--RRLPTARMIAFAMALLGCV--LIMYKAIWYDQfTCPDGFLLRHKICTPLTLEMYYTEM--DPERHR----SILAA 148 Norway rat
XP_015201898  75 YDEvsEKVKLTGLILITMAFLACLllLVMYKALWYDQlSCPEGFVFKHKHCTPAALEMYYSEQ--EPGARG----GLYTA 148
NP_001313394  75 TDGvtERLKVTILVSLALAFLACIvfLVVYKAFTYDH-SCPDGFVYKHKRCIPASLDAYYSAQ--DSNSRG----RFYTV 147
XP_022594629  72 TDGvsERLKVTILIILALAFLACIvfLVVYKAFTYDH-ACPDGFIYKHKRCIPASLEAYYAAQ--DANSRG----RFYTV 144
ERE89836      74 TEGvtERFKVSVLVLFALAFLTCVvfLVVYKVYKYDR-SCPDGFVLKNTQCIPEGLESYYTEQ--DSSARE----KFYTV 146
XP_006629661  75 IEGvsERLKVTLLVLCALAFLVCVvfLVVYKVYQYDQ-TCPEGFFFQHNRCVPAGMDSYYSEQ--GPSARG----KFYTV 147
1_pfamImport  69 RYTgiTLEGMALLVVCALAFLVCVvfLVVFKVYQYEH----RGGVYRRG-CT-----SYYPPQ--GPAGRG----RLFTI 132
TNN62124      75 YSDvsDKAKITGLILITLAFLTSLllLLMYKAMWYDQlTCPEGFILKQKHCTPAALEMYYTQqqeDPGVRGgansGLYAA 154 Tanaka's snailfish
XP_017818792  78 EEG--RRLPTGRMIAFTMALMGCV--LILYKAIWYDQfSCPNGFLTRHKLCAPLTLEMYYAEM--DPERHR----SVLAA 147 white-tufted-ea...

XP_020929614 149 IGAYPVGRKHGTETP--WLANYHAFKEVPKA 177
P58821       149 IGAYPLSRKHGTEMPaiWGNSYRAGKEEHKG 179 Norway rat
XP_015201898 149 ISHLTQAKKTIPELPspWLPVINALKEAEKA 179
NP_001313394 148 ISHYSMAKQTSSRAVspWLSSGSVNHETKAA 178
XP_022594629 145 ISHYSMAKQTTSHSVspWLPGGVGGQQQQQQ 175
ERE89836     147 INHYNLAKQSITRSVspWMSVLSEEKLSEQE 177
XP_006629661 148 INHYNLAKQTITRSVspWMTVMSEEKVSAQE 178
1_pfamImport 133 INHYNVAKHTTTRAVspWLSITAEERRVSQL 163
TNN62124     155 LSHLNQVKRTGAELPspWLPVINALKEAEVA 185 Tanaka's snailfish
XP_017818792 148 IGAYPLSRKHGTEPPapWGDGHRANKEERKG 178 white-tufted-ear marmoset
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