Conserved Protein Domain Family
Fry_C

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pfam19421: Fry_C 
Furry protein C-terminal
This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
Statistics
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PSSM-Id: 466072
Aligned: 15 rows
Threshold Bit Score: 975.777
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014017386 2320 SSKALPGKTLDFTFDISETPVIGRRYEELQGSPGREGKSRAI-AVTCSTSSTSSGSTSn-NVLVPVSWKIPQSSQKRTRE 2397
ELW71629     1125 VSKELPGKTLDFHFDISETPIIGNKYGEQHAAAGRNGKPNVI-AVTRSTSSTSSGSNS--NALVPVSWKRPQLSQRRTRE 1201
XP_029133375 2310 SSKALPGKTLDFHFDISETPVIGRRFDDLQRSPGQDVKSRTT-AVTRSTSSTSSGSTTn-NVLVPVSWKRPQSSQKRTRE 2387 ballan wrasse
XP_023817120 2308 SSKALPGKTLDFHFDISETPLIGRRFDDLQCSPGRDAKSSKT-AVTRSTSSTSSESNSn-NVLVPVSWKRPQSSQKRTRE 2385 Japanese medaka
XP_022524509 2345 ASKSLPGKTLDFTFDISETPVIGRRYDELHGSPGQDGKVRGVvAVTRSTSSTSSGSNNnnHALVPVSWKRPQSSQKRTRE 2424 Mexican tetra
XP_026082518 2344 PSKALPGKTLDFHFDISETPVIGQRYDELHGSPRQDGKNGGWvTVTRSTSSTSSGSYQnnHVLVPVSWKRPQSSQKRTRE 2423 goldfish
XP_020367654 1086 ASKELPGKTLDFHFDISETPIIGQKYGDQHSAACRNGKPKVI-AVTRSTSSTSSGSNS--NALVPVSWKRPQLSQRRTRE 1162 whale shark
KAE8629553   2347 TSKELPGKTLDFKFDISETPIIGH--GDQHSAAGRNGNPKVI-AVTRSTSSTSSGSNS--NALVPVSWKRPQLSQRRTRE 2421 tropical claw...
XP_005998614 2333 SSKELPGKTLEFHFDISETPIIGHKFADQHTTTGTNGKPKVI-AVTRSTSSTSSGSNS--NALVPVSWKRPQLSQRRTRE 2409 coelacanth
XP_019219288 2374 SAKALPGKTLDFTFDISETPVIGRRFDELQGSGGREGKARAM-AVTRSTSSTSSGSNSn-TILVPVSWRRPQLSQKRTRE 2451 Nile tilapia
XP_014017386 2398 KLVNVLCLCGQGVGLTKNPSVIFSSCGELDLMDLQPSLVSS-EEGTQEQDNnMEDTTSEQQFRVFRDFDFLDVELEEGEe 2476
ELW71629     1202 KLMNVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEAaVEDNSSEQQFGVFKDFDFLDVELEDAE- 1280
XP_029133375 2388 KLVNVLSLCGQEVGLTKNPSVIFSSCGELDLMDHQPSLVSS-DDGTREPEN-MDDNTSEQQFRVFRDFDFLDVELEDGEe 2465 ballan wrasse
XP_023817120 2386 KLVNVLSLCGQEVGLTKNPSVIFSSCGDLDLMEHQPSLVSS-DEGNREQDN-MDDVTSEQQFRVFRDFDFLDVELEDGE- 2462 Japanese medaka
XP_022524509 2425 KLVNVLTLCGQEVGLTKNPSVIFSSCGELDLIDHQPSLVSS-EDGTRDPDN-MDDTASEQQFRVFRDFDFLDVELEDGE- 2501 Mexican tetra
XP_026082518 2424 KLVHVLTLCGQEVGLTKNPSVIFSSCGELDLIEHQPSLVSS-EDGTRDTEN-MDDTTSEQQFRVFRDFDFLDVELEEGE- 2500 goldfish
XP_020367654 1163 KLMNVLSLCGQEVGLPKNPSVIFSSSEDLDIAEQQTSLISTtEEPIREEEVpVEDANTEQQFGVLKDFDFLDVELEDAEe 1242 whale shark
KAE8629553   2422 KLMNVLSLCGPDSGLPKNPSVVFSSNEELEAGDQQTSLISStEEAIQEEEVaVEDTGSEQQFGVFKDFDFLDVELEDAE- 2500 tropical claw...
XP_005998614 2410 KLMNVLSLCGPESGLPKNPSVVFSSNEDLDGGDQQTSLISTtEEAIREEEVvVEDAGSEQQFGVFKDFDFLDVELEDAE- 2488 coelacanth
XP_019219288 2452 KLVSVLSLCGQEVGLTKNPSVIFSSCGDLDMMEVRESGVSS-EDGGTREDT-LDDTASEQQFRVFRDFDFLDVELEDGEe 2529 Nile tilapia
XP_014017386 2477 iqGETMDSFNWGVRRRSMDSLDRSDMVPLDD-SELSSSTPSLGQFTHQD-SEESSEEE-SITASQILSHSQV-------- 2545
ELW71629     1281 --GESMDNFNWGVRRRSLDSTDKGDTPSLQG-YPCSSSTPSLSLTNQED-TDESSEEEaALTASQILSRTQM-------- 1348
XP_029133375 2466 lqGETTDNFNWGVRRRSMDSLDRSDLQPLEE-SQLSNSMPSLSKITHED-SDESSEED-SLTASQILSHSQL-------- 2534 ballan wrasse
XP_023817120 2463 --GETMDSFNWGVRRHSMDSLDQSDLQPLEE-SQLSSSMPSLSKITHED-SDDSSEED-SLVTSQTLSHSQLnvslspta 2537 Japanese medaka
XP_022524509 2502 --GETMDSFNWGARRRSMDSLDQVEPQPLEEeSRFSGSSPSLGPIARDDeSDESSEED-SLTVSHILSTSQL-------- 2570 Mexican tetra
XP_026082518 2501 --GETADSFNWGARRRSIDSLDQTEAQPMEEdSQLSGSSPSLCPIVHDD-SDESSEEE-SLTASQNLSASQL-------- 2568 goldfish
XP_020367654 1243 lqGESMDNFNWGVRRRSLDSIEKGDTPSLQE-FQYSGSTPSLTLTNQED-TDESSEEEv-LAESQMLTQSQI-------- 1311 whale shark
KAE8629553   2501 --GESMDNFNWGVRRRSLDSIDKGDTPSLQE-CQYSGSTPSLNLTNQED-TDESSEEE-ALTASQILSHRHM-------- 2567 tropical claw...
XP_005998614 2489 --GESMDNFNWGVRRRSLDSIDKGDTPSLQE-YPYSGSTPSLNLTNQED-TDESSEEEv-LTASQLLSSSQM-------- 2555 coelacanth
XP_019219288 2530 lqGETVDNFNWGVRRRSLDSTELGD--LLEE-SQHSGSTPSLGHEDPHD-SDESSEEE-ESSTSQSLSHSQL-------- 2596 Nile tilapia
XP_014017386 2546 -------IVNLS----------------PTEE--VNQLDSLYTSIDN-SA--ADPPLpp---lH---TRTSSFE-----V 2586
ELW71629     1349 -------LNSDP----------------TAEEavPEPPDSLLQSQDS-SSsnVTEDMla---aR---DETPSVE-----A 1393
XP_029133375 2535 -------TVNLS----------------PTAE---RRVDSPSAFFDS-SS--APSTPl-----N---TKNPSFE-----V 2572 ballan wrasse
XP_023817120 2538 eissmdaPSAFSdktstdstppstknpsFDVQ--LPDDSKQRSEFSQ-ED--EDTN-----------VHEDDLS-----L 2596 Japanese medaka
XP_022524509 2571 -------TVSMS----------------PTEQ--VNHMDCLSTSLDA-TP--VEPLSv-----PedsTPRTQLSvededG 2617 Mexican tetra
XP_026082518 2569 -------NVSLS----------------PTEE--LNPMDSPPVSFDR-SH--AGQIPl-----S---SPTPSFE-----I 2607 goldfish
XP_020367654 1312 -------LNSDS----------------IIDDaaPNHVESLQQSRETtTNelSDEALl----pR---AETPNLE-----T 1356 whale shark
KAE8629553   2568 -------LHNDS----------------TAEEsvPDHVDSLQHSIDS-VSsaLTEEVlp---tR---AETPSLE-----V 2612 tropical claw...
XP_005998614 2556 -------LNSDS----------------ATDDavPNHVDSVLQSQES-TSsvATEETpppqppR---AETPILE-----P 2603 coelacanth
XP_019219288 2597 --------TNPS----------------PSEE--TNHTDSLSTSYDT--S--ADPQSl-----N---ATTPSQG-----V 2633 Nile tilapia
XP_014017386 2587 S--------LAENSMPRaeisvededtniheddlsisdllprfdcsgdsfsl------------------enlapgdyre 2640
ELW71629     1394 Ldna--ssqLPEDEEEQd-------------------------------------------------------------- 1409
XP_029133375 2573 Q--------LPEDSKQRhdssqeeedtnvheeelslcitelppefnsgdsl--------------------------tmd 2618 ballan wrasse
XP_023817120 2597 S--------ISDLHLEChsedslttdlissgcka---------------------------------------------- 2622 Japanese medaka
XP_022524509 2618 S--------VHEDDISLcinesfghsdsltldiqgdekgdme-------------------------------------s 2652 Mexican tetra
XP_026082518 2608 S--------APEGSNHRaedsaeeeeavvnendislcicesppafsspdiltv---------------dtsqrennfftd 2664 goldfish
XP_020367654 1357 LlpdsannqLPEDASAVmkdelvitvgedtgsdsnqdxpqkfedavisgsypef--------------iceedvtlalke 1422 whale shark
KAE8629553   2613 TppdsansqLPEEASVSgkdeqlstasedtgsyvtqeqhdqllfqepleveepcdlleppapesppdsvceedvtlalke 2692 tropical claw...
XP_005998614 2604 SppnsansqLPEDDSATakeeqnstvsediglyiiqepqecqeteetpdaqecaapes------apesiceddvtlalke 2677 coelacanth
XP_019219288 2634 L--------HDDHIGLHvrvcgededtqaqddelslsvnelppssdcgesftldlp---------gqpqnqlpnldrgln 2696 Nile tilapia
XP_014017386 2641 eldldfsalpryialfslgeeerdELMES-RSSLPPSPFFSAILAAFQPAVCDDADEAWRRHINQLVSDSDGSCAIYTFQ 2719
ELW71629     1410 ------------------------GFSEV-QTSPPPSPFLSAIIAAFQPVAYDDEEEAWRCHVSQMLSDRDGSCAVFTFH 1464
XP_029133375 2619 mihidykgeldldgclpslaeeerddmlesRSSPPPSPFFSAILAAFQPAVCDSAEEAWRSHINQLVSDSDGSCAVYTFH 2698 ballan wrasse
XP_023817120 2623 -------eldldscalslaeeemdNLLES-HSSPPPSPFFSAILAAFQPAVCDDAEEAWRSHVNQLVSDSDGSCAVYTFQ 2694 Japanese medaka
XP_022524509 2653 ehtclpsgfleessaamgeeerddLLLESgSSSPPPSPFFSAILAAFQPVVCDDAEEAWRTHLNQLVADTDGSCAVYTFH 2732 Mexican tetra
XP_026082518 2665 etccvpsgfgdqqssvaqaeeekdELLQEsRSSPPPSPFFSAILAAFQPTVCDDAEEAWRNHLSQLVADSDGSCAVYTFQ 2744 goldfish
XP_020367654 1423 lderceeeeadlsghssqdegdqeEFPEI-QASPPPSPFLSAILSAFQPVAYEDEEEAWRCHVNQMLSDTDGSCAVHTFH 1501 whale shark
KAE8629553   2693 lderceeeeadfsdlssqdegeqdCFAEV-QSSPPPSPFLSAILAAFQPVAYEDEEEAWRCHVNQMLSETDGSCAVYTFH 2771 tropical claw...
XP_005998614 2678 lderceeeeadfsglssqddgeqdGFPEV-QASPPPSPFLSAILAAFQPMAYDDEEEAWRCHVNQMLSDTDGSCVVATFH 2756 coelacanth
XP_019219288 2697 pdycqppldfldpsclpslrddvdDLEDL-GFPPPPSPFFSAILAAFQPTVCDDAEEAWRCHINQLVTDSDGSCAVYTFQ 2775 Nile tilapia
XP_014017386 2720 VFSSFFQSIQSKFCSLTCDAAGYLGDGLRGIGSKFLRSSQMLISCSECPTLFIDADTIISYGLLEKIKFSVLELQEYLDT 2799
ELW71629     1465 VFSRLFQTIQRRFGEITNEAVGFLGESLQRIGAKFKSSLEVMMTCSECPTVFVDAETLMSCGLLETLKFSVLELQEHLDT 1544
XP_029133375 2699 VFSSLFQniqTKFCSLTFDAVSYLGDGLRGLGSKLLRSSQMLTSCSECPTLFIDADTIMSYGLLEKMKFSVLELQEYLDT 2778 ballan wrasse
XP_023817120 2695 VFSSLFQSIQSKFCLLTCDAVNYIGDGLRGLGSKFIKSSEMLTSCSECPTLFIDADTIMSYGLLEKMKFSVLELQEYVDT 2774 Japanese medaka
XP_022524509 2733 VFSSLFQSIQTKFCSLTCEAASYLGESLRGIGAKFIRSSQMLTaHSKCPTLFIDADTIVSYGLLEKMKFSVLELQEYLDT 2812 Mexican tetra
XP_026082518 2745 VFSSLFQNIQAKFCTLTCDAAGYLGDGLRGIGVKFVKSSQMLTSCSECPTLFVDADTIVSYGLLEKMKFSVLELQEYLET 2824 goldfish
XP_020367654 1502 VFSRLFQNIQKKFCAITHDSVSHLGDSLQKIGSKFKSSLEVMMMCSDCPTVFVDAETLVSCGLLETLKFSVLELQEHLDT 1581 whale shark
KAE8629553   2772 VFSRLFQTIQRKFGALTNDSVSFLGESLHRIGTKFKSSLEVMMACSQCPTVFVDAETLMSCGLLETLKFSVLELQEHLDT 2851 tropical claw...
XP_005998614 2757 VFSRLFQSIQRKFCAITNDSVSFLGESLQRIGVKFRSSLEVMMVCSECPTVFVDAETLLSCGLLETLKFSVLELQEHLDT 2836 coelacanth
XP_019219288 2776 VFSSLFKNIQGKFCTLTKDVATYLGEGLRGIGSKFLRSSQMLTTCSDCPTIYIDADTIMSYGLLEKMKFSALELQEYLDT 2855 Nile tilapia
XP_014017386 2800 YNNRKEAAIA---------------------WL--------TNCKTTFPRGsgGVMITNQPGEY-EEK------QLELCQ 2843
ELW71629     1545 YNAKREAAEQngrrpsqrhgpqqnsivfrgrYVcasphtamPCCPLSLRTGr-DRAAGWSAAGPePQRw----tPSSHGQ 1619
XP_029133375 2779 YNNRKEAALS---------------------WL--------SNCKATFPRSaeGKVITCQPAEL-EDK------QLELCQ 2822 ballan wrasse
XP_023817120 2775 YNNKKEAALS---------------------WL--------KDCKATFPRSteDSTITCHPAQH-EEK------QLELCQ 2818 Japanese medaka
XP_022524509 2813 YNNRKEAAVS---------------------WL--------KNCKATFPKPsgDGVITYQPAET-EEKqmeslaQLELCQ 2862 Mexican tetra
XP_026082518 2825 YNNKKEAVIS---------------------WL--------RNCKTSFPKCtgDGVITYQPAET-EEK------QLELCQ 2868 goldfish
XP_020367654 1582 YNAKRDGAEQ---------------------WL--------ENCKRTFGTV--DALQRTNREAQqme----vlaELELCR 1626 whale shark
KAE8629553   2852 YNAKREAAEQ---------------------WL--------DNCKRTFGLG--ESAHTANTDAQ----------ELELCR 2890 tropical claw...
XP_005998614 2837 YNAKKEAAEQ---------------------WL--------DNCKMTFGAG--DGIQRNNTDAQ----------ELELCR 2875 coelacanth
XP_019219288 2856 YNTKEEAAVS---------------------WL--------RNCKDTFPRCpgDSVVTCQPGDS-EEKqmeslaQLELCQ 2905 Nile tilapia
XP_014017386 2844 RLYKLHFQLLLLFQSYCKLIGQVHAISSVPE-------LMNMSKELNELKGSLLAAAaSVtSSElqa--------aqETS 2908
ELW71629     1620 RIRQPRTDVLLVSPQWLDSCQRTFGPKDDTCrintdaqVINMSEGLAQLERILKEAE-SA-SEN-------------EEI 1684
XP_029133375 2823 RLYKLHFQLLLLFQSYCKLIEQVHAISSIPE-------LTNMSRELNELKSSLRGAAaSVtDEEia----------aCES 2885 ballan wrasse
XP_023817120 2819 RLYKLHFQLLLLFQSYCKLIEMVHAICSVPE-------LTDMSQELSQLKSNLRIAAaSVtADEia----------vCES 2881 Japanese medaka
XP_022524509 2863 KLYKLHFQLLLLFQSYCKLIGQVHAISSIPE-------LVNMSKELNDLRSNLRAAAaWVeGEQaa----------qGGD 2925 Mexican tetra
XP_026082518 2869 KLYKLHFHLLLLFQSYCKLIGQVHAINSVPE-------LQNISRELNELRSNLRAAAaSVtNESaa----------eLRE 2931 goldfish
XP_020367654 1627 RLYKLHFQLLLLYQAYCKLISQVDTIKQKVE-------VINMSEELARLEASLKEAE-DF-SNE---------------V 1682 whale shark
KAE8629553   2891 RLYKLHFQLLLLFQAYCKLINQVDSIKREDE-------VINMSEELSQLESCLKEAE-SS-SDVg-----------iEDC 2950 tropical claw...
XP_005998614 2876 RLYKLHFQLLLLFQAYCKLISQVDTIKSEAE-------VMNMSEELAQLETCLKVAE-CA-SVNs-----------nDEI 2935 coelacanth
XP_019219288 2906 RLYKLHFQLLLLFQSYCSLIGQVHAISSVPE-------LLNMSRELTDLKSSLQAAEaAVaSDLehkhlahthshatQVA 2978 Nile tilapia
XP_014017386 2909 SSSEPTFLSSEEAVQAILEALKNHEFTTAIRYIRECRRVWPSDIFGSSSEDETQTLLNIYFRYQTLGQMGTFALVGSQQD 2988
ELW71629     1685 DISKAAQATIETAIHSLIETLKNKEFVSAVAQVKAFRTLWPHDIFGSCEDDAVQTLLHIYFHHQTLGQTGSFAVIGSNLD 1764
XP_029133375 2886 -CSEPTFSTSETAVQAILESLRNNEFQTAIRNIRECRTMWPNDIFGSPSEDEVQTLLNIYFRHQTLGQTGTFALVGSKQD 2964 ballan wrasse
XP_023817120 2882 SRSEPVFSSSEAAVQAILENMKIKEFQTAIRCIRECRTTWPNDIFGAHSEDEVQTLLNIYFRHQTLGQTGTFALVGSKQD 2961 Japanese medaka
XP_022524509 2926 VSSTPSFSSSEAAVQAILESLRNSEFSTAIRSIQECRRTWPSDIFGSSSENETQTLLNIYFRHQTLGQTGTFALVGSRQD 3005 Mexican tetra
XP_026082518 2932 PTTESPFSSSEVAVQAILESLKTNEFSRAIRYIQECRKMWPSDIFGSSSENEVQTLLNIYFRHQTLGQTGTFALVGSKQD 3011 goldfish
XP_020367654 1683 EVSEALQTCTEIAIHSLIETLRNKEFPSALSQVKVFRSRWPNDIFGNCDDDPVQTLLHIYFRHQTLGQTGSFAVVGSNQD 1762 whale shark
KAE8629553   2951 YISEFCQGS-EAAVHSVIESLRGKDYASAIAQVKAFRSVWPNDIFGSSDDDPVQTLMHIYFRHQSLGQTGSFAIIGCKHD 3029 tropical claw...
XP_005998614 2936 DFLEASQSSTETAIHSLIETLRIQDFSLALAQVKAFRSIWPNDIFGNPEDDPVQTLLHIYFRHQTLGQTGSFAVVGYNQD 3015 coelacanth
XP_019219288 2979 AMVVPSFPTSEAAVQAILECLRNHEFTKAVRYIQECRRQWPNGVFGGSSESEVQTLLNVYFRHQTLGQTGTIALVGSRQD 3058 Nile tilapia
XP_014017386 2989 LSEICVKLMELNGEIRDMIRRAQgyraitTFLPDSGVSGSSL 3030
ELW71629     1765 MSEANYKLMELNLEMRESLRMVQsyqlltQAKPVGNMVSTGF 1806
XP_029133375 2965 LTEISIKLMELNGEIRDMIRRAQgyraitAFLPDSSVSGSTL 3006 ballan wrasse
XP_023817120 2962 LTEISAKLMELNGETRDMIRQAQgysaitAFLPDSRISGSTL 3003 Japanese medaka
XP_022524509 3006 LSEACGRLTELNCEIRDMIRRAQgyraitAYLPDSSVTGISL 3047 Mexican tetra
XP_026082518 3012 LSEICNRLTELNCEIRDMIRRAQgyraitAFLPDPSVTGISL 3053 goldfish
XP_020367654 1763 LSKVCSKLMELNLQIRESLRTVQsyqllaKTS-ASDIQRPGF 1803 whale shark
KAE8629553   3030 MSKASSKLMELNLEIRLSLRVVQsyqllsKADPLADMTSSEC 3071 tropical clawed frog
XP_005998614 3016 LSEASSKLMELNLEIRESLRMVQsyqllaKAKPAESVMSSGF 3057 coelacanth
XP_019219288 3059 LSLICSKLLELNGEIRDMIRHAQgyrvvtTYLPDSSASATSL 3100 Nile tilapia
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