Conserved Protein Domain Family
SH2_SH2D2A
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cd10416: SH2_SH2D2A 
Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
SH2D2A contains a single SH2 domain. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.
Links
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Statistics
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PSSM-Id: 198279
Aligned: 10 rows
Threshold Bit Score: 202.577
Created: 31-May-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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phosphotyrosinehydrophobic
Feature 1:phosphotyrosine binding pocket [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #                 #                   # #              
Q9NP31        87 LQHGAAPAWFHGFIT----------RREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGE 156 human
NP_001154914  69 LQHGAAPAWFHGFIT----------RREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGE 138 human
NP_003966     87 LQHGAAPAWFHGFIT----------RREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGE 156 human
EAW52906      69 LQHGAAPAWFHGFIT----------RREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGE 138 human
EAW52907      87 LQHGAAPAWFHGFIT----------RREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGE 156 synthetic const...
NP_001154915  59 LQHGAAPAWFHGFIT----------RREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGE 128 human
EAW52905      83 LQHGAAPAWFHGFIT----------RREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGE 152 human
NP_067284    108 LLLKTAPLWFHGFIT----------RREAERLLQPQPLGCYLVRFSESAVTFVLSYRSQTCCRHFLLAQLGDGRHVVLGE 177 house mouse
NP_001020742 108 LLLKTAPLWFHGFIT----------RREAERLLQPQPLGCYLVRFSESAVTFVLSYRSQTCCRHFLLAQLGDGRHVVLGE 177 house mouse
NP_001154913  87 LQHGAAPAWFHGFITrrvrpplsvtHREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGE 166 human

Feature 1                                        
Q9NP31       157 DSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 188 human
NP_001154914 139 DSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 170 human
NP_003966    157 DSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 188 human
EAW52906     139 DSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 170 human
EAW52907     157 DSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 188 synthetic construct
NP_001154915 129 DSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 160 human
EAW52905     153 DSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 184 human
NP_067284    178 DSAHAQLQDLLEHYTECPLSPYGEILTQPLAR 209 house mouse
NP_001020742 178 DSAHAQLQDLLEHYTECPLSPYGEILTQPLAR 209 house mouse
NP_001154913 167 DSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 198 human

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