ubiquitin-like (Ubl) domain found in microtubule associate protein 1 light chain 3A (MAP1LC3A)
Autophagy is an essential intracellular process that targets large protein complexes, bacterial pathogens, and organelles for degradation. MAP1LC3A is belong to MAP1LC3 (short name LC3) family proteins. MAP1LC3 has a ubiquitin-like fold (Ubl) that belongs to the autophagy-related 8 (ATG8) protein family. A Ubl conjugation of MAP1LC3 by the phospholipid phosphatidylethanolamine (PE) is an essential process for the formation of autophagosomes. MAP1LC3 is cleaved by cysteine protease ATG4 and then conjugated with PE by E1-like enzyme ATG7 and ATG3, an E2-like enzyme. The Ubl conversion of MAPLC3 is known as a marker of autophagy-induction. MAP1LC3A staining patterns are used for different cancer diagnostic.
Feature 1:Atg13 interaction site [polypeptide binding site]
Evidence:
Comment:LC3-Atg13 interaction site
Comment:Autophagy is a bulk degradation process that degrade cytosolic materials to maintain cellular homeostasis. Atg13 and LC3 proteins are required for making autophagosome.
Comment:based on the structural evidence that Homo sapiens Homo sapiens LC3 (3WAO) interacts with ATG13 LIR
Jiyao W et al.(2023). "The conserved domain database in 2023.",