3QBQ,3ME2,4GIQ


Conserved Protein Domain Family
TNFRSF11A
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cd13411: TNFRSF11A 
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Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), also known as receptor activator of nuclear factor-kappaB (RANK)
TNFRSF11A (also known as RANK, FEO, OFE, ODFR, OSTS, PDB2, CD26, OPTB7, TRANCER, LOH18CR1) induces the activation of NF-kappa B and MAPK8/JNK through interactions with various TRAF adaptor proteins. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. The receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Juvenile Paget's disease (JPD) of bone. Alternatively spliced transcript variants have been described for this locus. Mutation analysis may improve diagnosis, prognostication, recurrence risk assessment, and perhaps treatment selection among the monogenic disorders of RANKL/OPG/RANK activation.
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Statistics
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PSSM-Id: 276916
Aligned: 11 rows
Threshold Bit Score: 244.698
Created: 8-Nov-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide ligand binding site [polypeptide binding site]
Evidence:
  • Structure:3ME2: Mus musculus TNFRSF11A (also called RANK) binds ligand RANKL; contacts at 4.0A
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  • Structure:4GIQ: Mus musculus TNFRSF (also called RANK) binds ligand RANKL; contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                  #             #        
3QBQ_B          3 PCTQERHYEh---------lGRCCSRCEPGKYLSSKCTp--tSDSVCLPCGP----DEYLDTWNEE-DKCLLH------- 59   house mouse
3ME2_R         32 PCTQERHYEh---------lGRCCSRCEPGKYLSSKCTp--tSDSVCLPCGP----DEYLDTWNEE-DKCLLH------- 88   house mouse
4GIQ_R          4 PCTQERHYEh---------lGRCCSRCEPGKYLSSKCTp--tSDSVCLPCGP----DEYLDTWNEE-DKCLLH------- 60   house mouse
XP_001233219   28 PCESEQHYEy---------sGRCCKKCEPGKYMSAKCTe--tSDSVCQPCGP----NEYMDVWNEE-DKCLLH------- 84   chicken
AAI36134       34 QCDPEKQYEs---------nGRCCSKCQPGFYMTSKCTa--sKNTTCNPCGP----NEYMSSWNDD-YKCISH------- 90   western clawe...
XP_001514545  132 PCSSERHYEq---------sGRCCNKCEPGTFMTAKCTa--aSESVCSPCNP----DEYLDTWNEE-DKCLLQ------- 188  platypus
ETE71140       16 SCSSEQQYEy---------sGRCCTKCEPGKYMAKKCTv--fSETVCKPCGS----NEYMDIWNEE-EKCFLH------- 72   king cobra
EGV98668     1076 GHSPAVHLKpsvl----qllSAGTLLKETSAPGDGTVNpsvfLFPMLSPCLEgvgeDEYLDTWNEE-DKCLLH------- 1143 Chinese hamster
ELK35464       67 PSALTRAGRrqqglaarsraLEETPWPANGTYMSAKCTt--tSESVCLPCGR----DEYLDSWNEE-DKCLLH------- 132  Myotis davidii
ELW71284       31 PSKLEGRYV-----------EEDVGKRVDGKYMSSKCTt--tSDSTCLPCGP----DEYLDTWNEE-DKCLLH------- 85   Chinese tree ...
EPQ17387        3 GCFFSINCAmi--------rSRKLAQMEKATWKPSGGKv---LRKGQNRKGPpkhqDELKGQRFDSkLKCFSTlpgyhws 71   Brandt's bat

Feature 1          # #     ###                    #       ####                                    
3QBQ_B         60 KVCDA----GKALVAVDPGNHTAPRRCACTAGYHWnsDCECCRRNTeCAPGFGAQHPLQlNKDTVCTPCllGFFSDVFSS 135  house mouse
3ME2_R         89 KVCDA----GKALVAVDPGNHTAPRRCACTAGYHWnsDCECCRRNTeCAPGFGAQHPLQlNKDTVCTPCllGFFSDVFSS 164  house mouse
4GIQ_R         61 KVCDA----GKALVAVDPGNHTAPRRCACTAGYHWnsDCECCRRNTeCAPGFGAQHPLQlNKDTVCTPCllGFFSDVFSS 136  house mouse
XP_001233219   85 KICDQ----GKALKEVNPGNSTFQRQCACTTGYHWneDCDCCQRNSiCGPGFGIGHPVQqDKDTKCMPCprGYFSEVASS 160  chicken
AAI36134       91 HICDS----GKALKVAFRGNSTSPRKCVCEKGYHFsqDYEFCNENTkCPPGYGVVYTVQrNTDTICETCtvGYFSNSSSS 166  western clawe...
XP_001514545  189 RVCDA----GKALVAVHPGNSTSQRQCACTQGYHWsdDCDCCRRNRdCGPGFGARHPLLpNRDTACEPCppGYYSNSFSA 264  platypus
ETE71140       73 KICDR----GKALIEVIPGNSTFQRQCACTAGYHWnrDCDCCRRNTkCSPGSGVKFPIQqDKNTVCVPCptGYFSNVSSA 148  king cobra
EGV98668     1144 KVCDA----GKALVAVDPGNHTAPRRCACTAGYHWnpDCECCRRNMeCAPGFGAQHPLQlNMDTVCMPCllGFFSDVFSS 1219 Chinese hamster
ELK35464      133 KVCDT----GKALVAVEPGNRTAPRRCACMAGYHWseDCDCCRRNAeCAPGLGARHPVQlNKDTVCEPClvGYFSDAFSS 208  Myotis davidii
ELW71284       86 KVCDT----GKALVAVEPGNRTAPRRCACTTGYHWsqDCGCCRRNTeCAPGFGAQHPLQlNKDTVCTPClaGYFSDAFSS 161  Chinese tree ...
EPQ17387       72 EDCDCcrrnTECAPVGGARHPVTWRPKVLRRGYHWseDCDCCRRNTeCAPGLGARHPVQlNKDTVCEPClvGYFSDAFSS 151  Brandt's bat

Feature 1                                         
3QBQ_B        136 TDKCKPWTNCTLLGKLEah--qGTTESDVVCS 165  house mouse
3ME2_R        165 TDKCKPWTNCTLLGKLEah--qGTTESDVVCS 194  house mouse
4GIQ_R        137 TDKCKPWTNCTLLGKLEah--qGTTESDVVCS 166  house mouse
XP_001233219  161 TDECKSWTNCSALGLAEiv--pGTDKSDAVCS 190  chicken
AAI36134      167 DEPCKPWTNCSKLGHPEln--pGTDHSDVVCD 196  western clawed frog
XP_001514545  265 TDKCEPWTNCTILGQEEid--pGTNKSDVVCR 294  platypus
ETE71140      149 TDACKAWTNCTALGTEEki--pGNNWSDAVCK 178  king cobra
EGV98668     1220 TDKCRPWTNCTLLGRIEah--pGTKKSDVVCS 1249 Chinese hamster
ELK35464      209 TEKCKPWTNLIIVLLFVsvalvAAVTSAVYYR 240  Myotis davidii
ELW71284      162 TAKCKPWTNLIILLLFVsvalvAAVIFGVYYR 193  Chinese tree shrew
EPQ17387      152 TEKCKPWTNCTSLGQMEvr--hGTNKSDVVCS 181  Brandt's bat

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