5A63


Conserved Protein Domain Family
Presenilin

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pfam01080: Presenilin 
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Presenilin
Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.
Statistics
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PSSM-Id: 460052
Aligned: 54 rows
Threshold Bit Score: 267.937
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A63_B        76 KYGAKHVIMLFVPVTLCMVVVVATIKSVSF-------YT--RKD-----GQ-LIYTPFTEDTETVGQRALHSILNAAIMI 140
XP_015632905  27 DSLGEDITRIVTPVSTCMLLVVLLVSLL----------SspSSPspftaAFsAAAG-----PGGGGDDITTALITAVTFV 91 
EFH55498      12 DSLGEELIAILTPVSICMFTVVLLVCILN--------SDpsSSSasfssIAtAAYAES--DSDSSWDKFVGALLNSVVFV 81 
XP_001299078  12 EIYSKRIYKIAVPVILTLVIDVWLTRTLEEkfdntalSTsfASVv---------------SQSSGGVSTAVAIYIAIGFI 76 
XP_001326572  12 EFYARKVAKIAVPVVLTLILDAVCIRFIERthgsaelNRnfVDTm---------------SRNDSGISVTASIWSAVGII 76 
EPB83259      49 QFYVEQLTLLFYPLIVTFALTCWIEITLNI-------DSsqISN------PlMVYDEL--PSDSVGTRLGGSVLNAIIVV 113
7_pfamImport   1 LNRSSQLKWTLFSVIVNMLLTLSVWIGV---------YGmeVNS-----ELsRLYFLDTASNSTTGNPVLDGAINGMFTI 66 
Q01608        11 LVRSSQLRWTLFSVIANMSLTLSIWIGV---------YNmeVNS-----ELsKTYFLDPSFEQTTGNLLLDGFINGVGTI 76  Caenorhabditis ...
EFO85358       9 FRRSSQLQWTLFSVIVNMSLTLSIWIGI---------YQmqVNS-----ELsKLYFLDDSFERTTGNTTLDGLINGFATI 74 
CAP30997       9 LRRSSQLQWTLFSVVVNMSLTLAIWIGI---------YHmeVNS-----ELsKMYFLDDSFNWTTGNPALDGLINGFCTI 74 
5A63_B       141 SVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTY-------NVAVDYITVALLIWNFG-VVGMIS 212
XP_015632905  92 VAVTAATFLLAFLFYLRCTPCLRAYLGFSSLSVLLLLGGHVALLLLSRL-------RLPLDAASFALLLPNAAaALALAA 164
EFH55498      82 AAITVATFVLVLLFYLRCVKFLKFYMGFSAFIVLGNLGGEILVLLIDRF-------RFPIDSITFLILLFNFS-VVGVFA 153
XP_001299078  77 VAIALVTGLLLLLYWFNCVKCIYVWMVVAVSLLLSYYVYLAVGKIPSLY-------NIPIDYIAVVIFLLNGV-VVGGMS 148
XP_001326572  77 FMIIVVTAILLTLYYFGCMKIIFGWLILAVSLLLSMYFLVGFGTYPSIV-------NIPVDYLSLAVFLLNLV-VVGNMS 148
EPB83259     114 CGITLMTFMFVLCFKYRLYKFLFFWLGLSVLSILGVTASALWIEMLNVY-------NMPMDYLTMLFCTWNVA-VVGVVA 185
7_pfamImport  67 VVLGIVSFVMLGFVLYDFQNLVKTWLIFSCLLILFGVSGQTFYDLFSQLvdqetenGRNLTLVLTILPTLVYG-LAGIVA 145
Q01608        77 LVLGCVSFIMLAFVLFDFRRIVKAWLTLSCLLILFGVSAQTLHDMFSQVfdqddnnQYYMTIVLIVVPTVVYG-FGGIYA 155 Caenorhabditis ...
EFO85358      75 LVLGCVSFVMLAFVLYDFQRVVKAWLTLSCMLILFGVSGQTLYDLFTQIldqndenQYILTVALTVIPTTIYG-VLGIYA 153
CAP30997      75 LVLGCVSFVMLAFVLYDFRRIVKSWLTFSCLLILFGVSGQTIYDLFSQIfdqndenQFILTVALTVIPTVVYG-CLGIYA 153
5A63_B       213 IHW-KGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSST 291
XP_015632905 165 LSPaSVPIALHQAALVAIAVLTAFWFTL-LPEWTTWALLVAMAVYDLAAVLLPGGPLRLLLELAIERNEEI-PALVYEAR 242
EFH55498     154 VFMsKFSILITQGYLVWIGVLVAYFFTL-LPEWTTWVLLVALALYDIAAVLLPVGPLRLLVEMAISRDEDI-PALVYEAR 231
XP_001299078 149 IFW-RAPPIVTQAFMIWISVMTACVFLT-LPDWTVWILLVLLIIWDCCVVLCPNGLLHLLIKKSQERGDAI-PALVYSSA 225
XP_001326572 149 IFW-RAPQRITQAFLVLISILTSIVFRY-LPDWTVWILLVLLIIYDACVVLCPNGLLILLLKKSEERGDAI-PALLYSAA 225
EPB83259     186 IFW-KSPLWVQQVYLVLVSAATSISMLR-MPPWTTWTVLIAVAIYDLFAVLCPAGPLRLLITMAEERQENI-PALVYSAG 262
7_pfamImport 146 FLA-NGSLLLHQCFVVSNCSLIAVFYLRAFPRHTTWFVLFIVLFWDLFAVLTPMGPLKRVQEKASDYSNNILKFLMFAAD 224
Q01608       156 FFS-NSSLILHQIFVVTNCSLISVFYLRVFPSKTTWFVLWIVLFWDLFAVLAPMGPLKKVQEKASDYSKCVLNLIMFSAN 234 Caenorhabditis ...
EFO85358     154 FFA-NGSLALHQFFVISNCSLISVFYLRAFPRYTTWFVLWMVLFWDLFAVLAPMGPLKKVQEKASDYSNNILKFLMFAAE 232
CAP30997     154 FLA-NGSLLLHQFFVVSNCSLIAVFYLRAFPKHTTWFVLWTVLFWDLFAVLAPMGPLKKVQEKASDYSNNILKILMFAAE 232
5A63_B       292 MVWL-----------VNMAEGDPEAQRRVSKNSKYNAESTERESQDT----Vae-nDDGGFSEe---------WEaqrds 346
XP_015632905 243 PVDPrhghnwrlwreRTQSGAELDANSTVEVLGEVLGTNLGASSAGNlgvsAirsdERVGLAGdar----nlrLG----- 313
EFH55498     232 PVIRndsr----lvqRRVWRERRSNDAENHANRNEVRAVRSEEve----------------------------------- 272
XP_001299078 226 AFFWkea-----ddgEEQNEEGEDHENLDNYDEEYDSASEDESTDPDssasSddalPINPDEFvgl-----snNP----- 290
XP_001326572 226 AWEEadpekgnqnneEGDGNEGNQEDPAEQADNQDNNEEEEEEEEAE--------------------------------- 272
EPB83259     263 MASFdteddfiggyrTQESNRASKNHKKWLPFTNANKGYRPIH------------------------------------- 305
7_pfamImport 225 DNRQsagadr---aeevnEGDGTIRRGVKQLIAMYSKQEAQDEEFAQkirqRrsawNPDSGLTeqsplvetepSP----- 296
Q01608       235 EKRLtagsnq---eetneGEESTIRRTVKQTIEYYTKREAQDDEFYQkirqRraaiNPDSVPTehsp---lveAE----- 303 Caenorhabditis ...
EFO85358     233 DKREtagidatedssENLNDERKLRKDVKQLIELYSKKEAQDDEFLRkirqRrtaiNPDSALTetsp--vhtePS----- 305
CAP30997     233 DKREsagmdmaqdsqENLNDERKLRKDVKELIQLYSKQDEKDDEFLQkirqRrnaiNPDSGSTahsp---mvtTE----- 304
5A63_B       347 HLGPHRSTPESRAAVQELSSSILAGed-----------------------------------------------pEE--- 376
XP_015632905 314 TSMPNLSSDSASAQVEVLPASPEISvsvpemrvpliqprper-------------------------------------- 355
EFH55498     273 -----eEHVGSSERAEISVPLIDRRpeqaensetf--------------------------------------------- 302
XP_001299078 291 EDQPPPQPKPEQQPESELAQPAGEPtkpkkkrpnqdnqhgdpen------------------------------------ 334
XP_001326572 273 ------NNQPQENANGEAQNGNQNNnkkkknm------------------------------------------------ 298
EPB83259     306 ------NNELDENATLSIALSTLEQsrdverrnsnea------------------------------------------- 336
7_pfamImport 297 SVPTEHQQEEKEDKQMDSESSSESCsesasiasgdsnaddkekeeeddeyqssnietaeecdmetwqqlvneanaKQgdn 376
Q01608       304 PSPIELKEKNSTEELSDDESDTSETssgssnlsssdssttvstsd-----------istaeecdqkewddlvsnsLPnnd 372 Caenorhabditis ...
EFO85358     306 DALIQLKSKNSDEEHTDDESDTTESstttsssdvttsevstae--------------evapeewnelmeqqekqaEFdqr 371
CAP30997     305 PSPIVLKEKNSDEELFDNESDTTESssesstssesvfsssdvs--------------taaecapeewnelihqqnEFdqn 370
5A63_B       377 ------------------------------RGVKLGLGDFIFYSVLVGKASatASGDWNTTIACFVAILIGLCLTLLLLA 426
XP_015632905 356 --------------trdeeddedgiglsssgAIKLGLGDFIFYSVLVGRAA--M-YDYMTVYACYLAIIAGLGITLLLLA 418
EFH55498     303 ---------------------legiglgssgAIKLGLGDFIFYSVLVGRAA--M-YDLMTVYACYLAIIAGLGITLMLLS 358
XP_001299078 335 -------------pdkrkkksgsakstptseGVKLGLGDFIFYGILVTRAA--R-VGWDIAILDILAVMDGLALTLICLA 398
XP_001326572 299 -------------------------skrdneGIKLGLGDFVFYGILVSRAA--R-IGWDITILCIFAVILGLSLTLVCLA 350
EPB83259     337 -------------------gqdedeeedelnAIKLGLGDFIFYSVLVGKAA--K-TDSVTLCLCIIAILTGLSLTILILT 394
7_pfamImport 377 ksnlt-----------------aadalndgETVRLGFGDFVFYSLLIGQAA--ASGCPIAVVFAAAGILFGLLVTLTVLS 437
Q01608       373 krpat-----------------aadalndgEVLRLGFGDFVFYSLLIGQAA--ASGCPFAVISAALGILFGLVVTLTVFS 433 Caenorhabditis ...
EFO85358     372 yvpvt-----------------aadalndgETVRLGFGDFVFYSLLIGQTA--TGGSALAVACSALGILFGLVATLTVFS 432
CAP30997     371 datvtaadalndgvksknsgrlfseicrfpETVRLGFGDFVFYSLLIGQAA--TGGCPISVGFAAFGILFGLIATLTVLS 448
5A63_B       427 IFKKALPALPISITFGLVFYFATDYLVQPFM 457
XP_015632905 419 FYRKALPALPVSIALGVVFYVLTRTLLETFV 449
EFH55498     359 VYQKALPALPVSIMLGVVFYFLARLLLEVFV 389
XP_001299078 399 YFERPLPALPFSLALGIIFYLIGAYTFRGFS 429
XP_001326572 351 VWERPLPALPFSLALGIVFFIIGAMTFRQFC 381
EPB83259     395 LNRKALPALPISILLGCITYATAYYMTSPMI 425
7_pfamImport 438 TEESTTPALPVPVLCGTFCYFTSKFVWENLI 468
Q01608       434 TEESTTPALPLPVICGTFCYFSSMFFWEQLY 464 Caenorhabditis elegans
EFO85358     433 SGESTTPALPLPVICGTFCYFISKFVVDQVY 463
CAP30997     449 SEESTTPALPLPVICGTFCYFVSRFLVDSIQ 479
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