1JB3


Conserved Protein Domain Family
NtA

?
pfam03146: NtA 
Click on image for an interactive view with Cn3D
Agrin NtA domain
Agrin is a multidomain heparan sulphate proteoglycan, that is a key organizer for the induction of postsynaptic specializations at the neuromuscular junction. Binding of agrin to basement membranes requires the amino terminal (NtA) domain. This region mediates high affinity interaction with the coiled-coil domain of laminins. The binding of agrin to laminins via the NtA domain is subject to tissue-specific regulation. The NtA domain-containing form of agrin is expressed in non-neuronal cells or in neurons that project to non-neuronal cell such as motor neurons. The structure of this domain is an OB-fold.
Statistics
?
PSSM-Id: 460825
Aligned: 7 rows
Threshold Bit Score: 136.376
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1JB3_A          1 CPERELQRREEEANVVLTGTVEEIMNVDPVHHtYSCKVRVWRYLKGKDIVTheil-------ldgGNKV-VIG--GFGDP 70  
XP_015785065   42 CRDKVPRKLTDLSNVVLTGFIEQTYPSLDNGEiYSGSVLVKRVFRGPSKFQ--------------GNRV-TID--GLGDA 104 
ESN94520       36 CFDLTIEEKVNNAEFIFSGTVREVRY-NVDKKaQKASVEIKRIFKGQHKLTqlflseikgrflpiVHKVcTVE--GLGLD 112 
XP_026691468   62 CLDRTTTEKNSTSTVILTGTVQYCDVIRAGS--YKCNIKIWRVMKGNSLAMnlitiqkqgiltsmYKKK-YVDvyGLGNS 138 
EKC34958        1 -----MEIREEMADVVVTGTVKSVSALQRGSKlYSAVVEIKRVMKGEDLLGessv-------snaGQEV-LVQ--GFGDP 65  
XP_026306511   30 CPERALERREEEANVVLTGTVEEILNVDPVQHtYSCKVRVWRYLKGKELVAresl-------ldgGNKV-VIS--GFGDP 99  
EEN70054       36 CHEDNLMKRVRRATAIVTGTVEQKMNGYPDGK-YKAKVRVWRVMKGTNEIPtanrvqplrdpsrgVAEV-MVD--GFGDP 111 
1JB3_A         71 LICDNQVSTGDTRIFFVNPAP----QymwpahrN---ELMLNSSLMRITLRNL 116 
XP_015785065  105 SYCQSKGQRGESWIFQLSQIS----D-------G---YFRLNGTLLKLNLDNL 143 
ESN94520      113 GLCSSHTRVFDTWLFFTNPVD----D-----------KLQLNSSLVRLSVMSI 150 
XP_026691468  139 AFCKSNVERADTRIFFLNKLN----N-----------RLVVSASLDRITLKNL 176 
EKC34958       66 RFCENTVRVFDTRILMLSLDD----G-------G---ILRLNSSVVRISLRNL 104 
XP_026306511  100 LICDNQVSTGDTRIFFVNPAPpylwP-------AhknELMLNSSLMRITLRNL 145 
EEN70054      112 HICDNEVDQGDTRIFLLDKKP----A-------GppdEFELTSSLIRVTLDNL 153 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap