2GK9


Conserved Protein Domain Family
PIPKc_PIP5K2C
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cd17311: PIPKc_PIP5K2C 
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Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP5K2C) and similar proteins
PIP5K2C (EC 2.7.1.149), also known as 1-phosphatidylinositol 5-phosphate 4-kinase 2-gamma, or PI5P4Kgamma, or diphosphoinositide kinase 2-gamma, or phosphatidylinositol 5-phosphate 4-kinase type II gamma, or PI(5)P 4-kinase type II gamma, or PIP4KII-gamma, or PIP4K2C, may play an important role in the production of phosphatidylinositol bisphosphate (PIP2) in the endoplasmic reticulum. It contributes to the development and maintenance of epithelial cell functional polarity. It also plays a role in the regulation of the immune system via mTORC1 signaling. Moreover, PIP5K2C is involved in arsenic trioxide (ATO) cytotoxicity. It mediates PIP2 generation required for positioning and assembly of bipolar spindles and alteration of PIP5K2C function by ATO may thus lead to spindle abnormalities.
Links
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Statistics
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PSSM-Id: 340448
Aligned: 6 rows
Threshold Bit Score: 528.667
Created: 8-Mar-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic core residues [active site], 3 residue positions
Conserved feature residue pattern:K D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Lys proposed to bind the alpha-phosphate of ATP; mutation of this residue in PIPKI-alpha and PIPKII-alpha destroys enzyme activity.
  • Comment:1st Asp functions as a weak base
  • Comment:2nd Asp binds catalytic Mg2+ or Mn2+
  • Citation:PMID 9753329
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2GK9_A        17 PLVGVFLWGVAHSINELSQVPpPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFgiDDQDYLVS 96  human
Q8TBX8        46 PLVGVFLWGVAHSINELSQVPpPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFgiDDQDYLVS 125 human
Q6IQE1        41 PMLSVFMWGVNHSINDLNQVPvPVMLLPDDFKANTKIKVNNHLFNKENLPSHFEFKEYCPQVFRNLRERFgiEDLDYQAS 120 zebrafish
Q5PQ01        49 PLISVLMWGVNHSVNELIQVPvPVMLLPDDFKANSKIKVTNHLFNRENLPSHFKFKDYCPQVFRNLRERFgiDDQDFQVS 128 African clawed ...
KYO47968      93 PFLAVLCWGIHHQINELSQVPlPIMLLPDDFKANSKIKVNNHLFNRENLPSHFKFKEYCPQVFRNLRERFgiDDQDFQVS 172 American alligator
XP_007907527  19 VFVRSGSPGLSPQVNELNHVPvPVMLLPDDFKANSKIKVTNHLFNKENLPSNFKFKEYCPQVFRNLRERFgiDDMDYQVS 98  elephant shark

Feature 1                                    #                                                   
2GK9_A        97 LTr-nPPSESEg-sDGRFLISYDRTLVIKEVsSEDIADMHSNLSNYHQYIVKCHgntlLPQFLGMYRVSVdNEDSYMLVM 174 human
Q8TBX8       126 LTr-nPPSESEg-sDGRFLISYDRTLVIKEVsSEDIADMHSNLSNYHQYIVKCHgntlLPQFLGMYRVSVdNEDSYMLVM 203 human
Q6IQE1       121 LArsaPMKGDGq-gEGLLFTSYDRTLIVKQIsSEEVADMHNILSEYHQHIVKCHgstlLPQFLGMYRITVeSEDTYLIVM 199 zebrafish
Q5PQ01       129 LTrssPYCESEg-hDGRFLLSYDKTLVIKEIsSEDVADMHIILSHYHQHIVKCHestlLPQFLGMYRLSVdNEDSYIIVM 207 African clawed ...
KYO47968     173 LTrspPQYEGEg-sDRRFLLSWDRTLVVKEIsSEDVADVHSLLSHYHQYVVQCHgntlLPQFLGMFRTGVdSEERYVLAM 251 American alligator
XP_007907527  99 LTrspPYNECEsrnGMLFLKSCDGNFVIKQIsSEDVADMHGFLSGYHEYIVNCHgnsvLPQFLGMYRLGVdGEETYMLVM 178 elephant shark

Feature 1                                                                                    #   
2GK9_A       175 RNMFshrLPVHRKYDLKGslvsreasdkekvkelPTLRDMDFLNKnqkvyigeeEKKIFLEKLKRDVEFLVQLkimDYSL 254 human
Q8TBX8       204 RNMFshrLPVHRKYDLKGslvsreasdkekvkelPTLKDMDFLNKnqkvyigeeEKKIFLEKLKRDVEFLVQLkimDYSL 283 human
Q6IQE1       200 RNMFshrLLVHRKYDLKGslvdreasdkekvkelPTFKDMDFRNNmqkvyvteeQKEKMMEKLNRDVEFLVKLkimDYSL 279 zebrafish
Q5PQ01       208 RNMFshrLTVHRKYDLKGslvsreasdkekvkelPTLKDMDFLNKsqkvyvdeeQKRNFMEKLKRDVDFLVQLklmDYSL 287 African clawed ...
KYO47968     252 RNMFshrLPVHRKYDLKGslvsreasdkekgkdlPTLKDMDFLNKnervyvgeeAKREFLEKLKRDVEFLVQLkimDYSL 331 American alligator
XP_007907527 179 RNVFghrLTVHTKYDLKGslvsreasdkekgkelPTLKDVDLLHRcqklyiddeQKRLFLEKLKRDVEFLANLkimDYSL 258 elephant shark

Feature 1                                                                                        
2GK9_A       255 LLGIHDIirgsepeeeapvredesevdgdcsltgppalvgsygtspegiggyihshrplgpgefesfidvyairsaegap 334 human
Q8TBX8       284 LLGIHDIirgsepeeeapvredesevdgdcsltgppalvgsygtspegiggyihshrplgpgefesfidvyairsaegap 363 human
Q6IQE1       280 LLGIHDVargereeeeaeepcyeddadpenglapalqvgsygtsp-egiagymnsikplgpgefdpyidvyavksapgap 358 zebrafish
Q5PQ01       288 LLGIHEVfraeqeeeeeleednaenecsphvnvgsygtspeg------iagylnshkplgpgefepiidvyaikssdnap 361 African clawed ...
KYO47968     332 LLGIHEVpraeeedepededggdngtaglygaspeglgia-----------gdfgahralgpgdfdsrvdvyavrsqggp 400 American alligator
XP_007907527 259 LLGIHDMqraeqeeeleqhavssetenggnisvnqfitvhspd----aafsfhsfqksagsvdyepfmdcyaiksaegap 334 elephant shark

Feature 1                  #                                            
2GK9_A       335 qkeVYFMGLIDILTqYDAKKKAAHAAKTVKHGAgaeiSTVHPEQYAKRFLDFITN 389 human
Q8TBX8       364 qkeVYFMGLIDILTqYDAKKKAAHAAKTVKHGAgaeiSTVHPEQYAKRFLDFITN 418 human
Q6IQE1       359 qreVYFMGLIDVLTqYDTKKKAAHAAKTVKHGAgaeiSTVHPEQYAKRFREFISN 413 zebrafish
Q5PQ01       362 qkeVYFMGLIDILThYDAKKKAAHAAKTVKHGAgaeiSTVHPDQYGKRFLEFVTN 416 African clawed frog
KYO47968     401 cceVYFMGLIDILTqYDAKKKAAHAAKTVKHGAgaeiSTVHPEQYAKRFLDFITN 455 American alligator
XP_007907527 335 qraVYFMGLIDILTqYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYAKRFMDFISN 389 elephant shark

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