Conserved Protein Domain Family
VPS9

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pfam02204: VPS9 
Vacuolar sorting protein 9 (VPS9) domain
This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.
Statistics
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PSSM-Id: 460489
Aligned: 43 rows
Threshold Bit Score: 73.7844
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011392254  773 VQQCGDELQRLESAmcRSPQAKLDVLVRAHKIAVEGVaqlpsikmrdddtavegqekeqtarpssgkkgDGSTSADLILP 852 
Q8IHX3        268 IKVISFHIKQIEKY--RDPINKIHILDNISKIICEVVsaennnl-------------------keqniaIYDINSDTLIS 326  Plasmodium fa...
Q2HFI4        381 LGRAVEEFRKMPHA--SCPQEMMEILLATTKAATQLSdapqpgqa----------------lgsatekpPMTINADTLVS 442  Chaetomium gl...
Q6BJ87        366 IYKAIDEFSKLSDAsiLNSSGKTQILKNTVNILTNNVkqiseies----------------mtektgsdGITVNADILIG 429  Debaryomyces ...
Q75CA6        312 VVQATECFSKLTLT--NSHHEKARILISTFQKLTTKTsqa---------------------------tlDPMIDADTLLG 362  Eremothecium ...
Q60I27        834 FLSATECLQKIMTT--VDPREKLEVLERTYGEIEGTVsrv--------------------------lgrEYKLPMDDLLP 885  human
XP_004764228 1552 fASAVECLQQISTT--FTPSDKLKVIQQTFEEISQSVlas--------------------------lqeDFLWSMDDLFP 1603
Q22BJ9        878 YYKAIKKLQNLTFY--NSPVHKMKLLVQCFELIPQCVsefyek--------------------nidyleQNLIASDDLIN 935  Tetrahymena t...
Q24BB5        653 YYKCFKYILKIKKQ--QSPIGKMKMIVKASENILVCInnfykm--------------------ygiqqnN-FLDADDVLS 709  Tetrahymena t...
Q24CA2        842 fDLCINALKQVLVE--KKPIGKLRLILKVFDNIQRCIhkfyhk---------------------nnsneKVQIGPEDLMD 898  Tetrahymena t...
XP_011392254  853 ILIYSIVSSNPSHLASNLLYIQRF--R-AESLVQGETSYCLVNVQAAVAFLENVDV 905 
Q8IHX3        327 VLVAAISFGEIQNLISHSLHLHMYidNlSTSEKIDKLSYIFTIFHSAIMYLCDVKN 382  Plasmodium falciparum 3D7
Q2HFI4        443 LLLYVVIKAQIKHLQARLAYIQNF--VfIDDVESGEMGYALSTCEAVLSYLDRDSG 496  Chaetomium globosum CBS 148.51
Q6BJ87        430 LLIMVIVHARVDNLEAHLYYIKHF--NsVDYTNDGYFCYILSNFDAVIYHLSSSMN 483  Debaryomyces hansenii CBS767
Q75CA6        363 LMVVVVCRAQVKNLKSHLDYLREFa-QnSDDVKFGLLGYSLSTLEAVVGYFDIGGS 417  Eremothecium gossypii
Q60I27        886 LLIYVVSRARIQHLGAEIHLIRDM--M-DPNHTGGLYDFLLTALESCYEHIQKEDM 938  human
XP_004764228 1604 VFLYVVLRARIRNLGSEVHLIEDL--M-DPYLQHGEQGIMFTTLKACYYQIQRekl 1656
Q22BJ9        936 ILVFIVLKSKCTQINSHLKLISSF--L-SKSTQQSKIGYYCTTLQIVCGYLESDKI 988  Tetrahymena thermophila SB210
Q24BB5        710 IFSYFTCKCFQHEMNTHIKLISKF--I-TSNLLNSISGYYLTTLSASLQNILEFRN 762  Tetrahymena thermophila SB210
Q24CA2        899 ITVYILAKSQQYQIIHDINIVRSF--ItKNTEYSDKAGYYLQTLEAAFQYIIETEf 952  Tetrahymena thermophila SB210
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