Conserved Protein Domain Family
ASD2

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pfam08687: ASD2 
Apx/Shroom domain ASD2
This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.
Statistics
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PSSM-Id: 462561
Aligned: 46 rows
Threshold Bit Score: 224.831
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFN86985      340 DLASQLSPNDK-LLPILVPAPEHKKPTDYVSGLFrVEATLQprprrRLSleestascgedadadekkhetipsapvtpLs 418 
EDW31941     1272 ELLQLLAPNDK-LVDILTPK-SCRPTSHYVSNLYnPNVPLRltkrdVGTs------------------------------ 1319
EDX07069      152 ELVKLLPPGDK-IADILTPK-ICKPTSQYVSNLYnPDVPLRlakrdVGTs------------------------------ 199 
XP_002063289 1367 ELLKLLQPSDK-LVEILTPK-SCKPTHEYVSNLYnPDVPLRqakrdVGTs------------------------------ 1414
XP_005335822  547 ELVQELARLDPsLSDTLTSQPCPEPPLGLLDGLIpLAEVWAamkpgCGEa------------------------------ 596 
XP_010588279  568 ELVQELARLDPsLSDILAPHPSPEPPLDVLDGLIpLAEVWAamrpaCGEa----------------------------G- 618 
XP_015327683  535 ELVQELARLDPsQSDTFTSYPSPEPALGLLDGLIpLAEVWAamrpaCREa----------------------------G- 585 
XP_004745125  563 ELVQELARLDPsLGDTLTSCPSPEPPLDLLDGLIpLAEVWAamrplCGEa----------------------------G- 613 
EHB00064      345 ELVQELARLDPsLSDTLASEPSPEPPPGLLDGLIpLTEAQAtvwpaFREp----------------------------G- 395 
XP_016809283  544 ELVQELARLDPsLCDPLASQPSPEPPLGLLDGLIpLAEVRAamwpaCGEa----------------------------G- 594 
EFN86985      419 AD---PTSPLSPTSAYFTTSEGKARFLT--RYSRDvtvegltrQEDApAIVPTNs---LDLRQKKEELMMRLDRKLVVLR 490 
EDW31941     1320 -----------------TLMRMKAAAAPteTTkvv-----sveLQLGd----ASgegaNVIKQKLDELIKRLKQKIGALK 1373
EDX07069      200 -----------------TLMRMKSITSSaeIrvv------sveLQLAe----PSeeptNLIKQKMDELIKHLNQKIVSLK 252 
XP_002063289 1415 -----------------TLMRMKSDSSEasTPEISgkminivqLHLTd----PSgegtNLIKQKMDELLRRLNQKIGSLK 1473
XP_005335822  597 GEegpGTSEPGSYQFNFTQLLPTSQEMT--RPENSpscpmpdcPNAQ-T---SN----NSVQAKKVELAGLLQEMLQDLH 666 
XP_010588279  619 -EeagGTSEPQSCLPSSAQLLTTSQDET--RAENFtmcpvpeqPYGQgPPEPTN-----SIQAKKAELADLLQKMLRDLQ 690 
XP_015327683  586 -EeaaGNSEPGSYLLNSTQHLPTSQEET--RPENLtthvapdqPCDQdVPKPNN-----SIQAKKAELADLLQKMLRDLQ 657 
XP_004745125  614 -KkagGSPEPGFYLFSSSQLLSTSLEET--RFENHtthpvpdqACGQgLPQPNS-----SIQAKKMELADLLQKMLRNLE 685 
EHB00064      396 -EevaSTSEPGSCLFSFTQLLPASQ-ET--RPENAtllpvpnqPCGQgLPAQNV-----SIQVKKVELAGLLQKMLQDLH 466 
XP_016809283  595 -EeaaSTFEPGSYQFSFTQLLPAPQEET--RLENPathpvldqPCGQgLPAPNN-----SIQGKKVELAARLQKMLQDLH 666 
EFN86985      491 AEQEAVREEGEVNEALGARVSARVSAVARPPEASKYRLHVEEVGKITSLLLGLSGRLARAENALYGMPADHA--ERKILE 568 
EDW31941     1374 HEQQTIGEECSMNDKLGQDLFAKLAESVRPSQASKFRTYIDDVGHITSLLLSLSERLAHTECSLE---SRQQ--DKSVLE 1448
EDX07069      253 REQQTISEECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLE---TRQQ--EKGALE 327 
XP_002063289 1474 REQQTIGEESSMNDKLGQELFAQLAEKVRPSEASKFRTYIDDVGHITSLLLSLSERLGQTESSLE---SRPQ--DKSILE 1548
XP_005335822  667 IQEERLQDAAQEWTRRRLALESAVGQACAPRELERFSRFLADLERVLGLLLLLGSRLARVHHALARMGSDGDpdERDSLL 746 
XP_010588279  691 AEQERLRGAAQACARRRAALESAMGQACAPQELERFSRFMADLERVLGLLLLLGSRLARVRCALVRAGSNGDpdERASLL 770 
XP_015327683  658 AEQKQLQGAAQAWARRGAALEAAVGQACAPHELERFSRFMADLERVLGLLLLLGSRLARVHRALARVGADSDpeEQASLL 737 
XP_004745125  686 AEQEQLHGAAQAWARRGAALEAVVGQSCSPRDLERFNRFMADLERVLGLLLLLGSRLARVRRALARDGVDCDpdEQASLL 765 
EHB00064      467 ARQEQLQGVAQAWARRRAALEAAVAQACAPRELERVSRFMADLERVLGLLLLLGSRLARVHRALARVGSDGDpeERASLL 546 
XP_016809283  667 TEQERLQGEAQAWARRQAALEAAVRQACAPQELERFSRFMADLERVLGLLLLLGSRLARVRRALARAASDSDpdEQASLL 746 
EFN86985      569 SKRDKLMDQLEEAKILKSNIDKRSVNVSAILAKYLNQEEFADYQHFINMKAKLIMDGREIQDKVKLGEEQLAALKEAI 646 
EDW31941     1449 SKRTRLYEQLEEAQRLKSDIDRRGTSIAGLLGKHLSADLCADYDYFINMKVKLIADARDLADRIKGGEEQLGALTDAL 1526
EDX07069      328 SKRDLLYEQLEEAQRLKSDIERRGVSIAGLLGKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDAL 405 
XP_002063289 1549 SKRERLYEQLEEAQRLKSDIDRRGTTIASLLGKHLTADMCADYDYFINMKAKLIADARDLAERIKSSEEQLTTLNDAL 1626
XP_005335822  747 QRLGLLQRQQEDAKELKEHVARRERALREVLARALSAEELCSYSELLVGKATLLTQQRCLEEHVRLFQNQLDTLGSNL 824 
XP_010588279  771 QRLRLLQQQQEDAKELKEHVARRERVLREVLMRTLPVEELHAYCALLAGKAAVLAQQRSLDERVRLLQDQLDAVKSDL 848 
XP_015327683  738 QRLGLLQRQEKDAKELKQHVARRERALRELLARALPAEELSAYRTLLAGKAAVLAQQRSLDERVRLIQDQLDAVRNDL 815 
XP_004745125  766 QRLGLLQRQQEDAKELKEHVARRERALREVLVRALPTEELSAYRALLAGKAAVLAQQRSLDERARLLQDQLDAIRSDL 843 
EHB00064      547 QRLGLLRRQQEDARELKEHVSRRERALREVLARALPAEEVRAYCTLLADKAAVLAQQRSLDERVRLLQDQLDAVRSDL 624 
XP_016809283  747 QRLRLLQRQEEDAKELKEHVARRERAVREVLVRALPVEELRVYCALLAGKAAVLAQQRNLDERIRLLQDQLDAIRDDL 824 
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