Conserved Protein Domain Family
LIM_bind

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pfam01803: LIM_bind 
LIM-domain binding protein
The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.
Statistics
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PSSM-Id: 426444
Aligned: 92 rows
Threshold Bit Score: 108.132
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KDE05539      355 RLTAFNESLALAL-EDTDILDSLRTLVADYFTDSGLIKFGLFD------------------------------------- 396 
XP_002496107  161 SFNEFS--------RNMADSKIWEEYMPNVFNKNTKIIISGQS------------------------------------- 195 
ABN66134      232 RVLEFIEQISNESpENLTSIEYWQRLIHTYCMPTSIFRISTAAtlpsssgifshgaamk-----------pnlfnvsfld 300 
Q6BUM0        245 RILNLIDQISNESyDNLSKLGFWQKVIQLYCVPTCTMRLTTTPpsskytntnnk---------------------psndk 303  Debaryomyces ...
XP_004194693  285 RIINLIDMISNESiNNLSKIEYWQNIVSIYASPSCVLKLTTPPvptmggispnm---------------------nnpts 343 
EEQ38408      279 RILDLIDLVSNESrENLSSIDFWNRLVYSYFSSTSVMRFTTTGatvnqpmt----------------------------g 330 
Q59Y46        342 RVLDLIEFISNQHyENLSNIEFWTKITPANFLPTAILKFNTTNitggngnkslnditglnlnflnsnkatsnnnnnntnt 421  Candida albic...
XP_002547637  368 RILDLIDFISNQSyENLSNIDFWTRITPANFLPSAILKFNFLgngssgtslhevtg-----------------lnlnflq 430 
EMG50537      887 RILDLIDFISNQQyENLSSIEFWTKITPANFLPSAILKFNTINtsgsntgsnnlsihd-------------itglnlnfl 953 
XP_011276321  377 KFLDFCELIGVRT-DSNKNILYWRKIITDYFSEIGVLRYSVKS------------------------------------- 418 
KDE05539      397 ------RTAqLHKIFEIPCSAFPRFQHL-NTLCGVLLTSVQPSFVREFFLsAHHPVTgqpvhvgylLRADEAVWSSRYSN 469 
XP_002496107  196 -------NG-ENKCFNLCFPMLCVIWEV-LRRCGQESLETKTSRPRAQVL-SNGSII---------IEDDTCCTGHW-KG 255 
ABN66134      301 anldttSGV-SSKFFELTTAFAARFFVTnVIIGNVAKFYVALPGLKFQVM-NNGSI----------FLISRLQQQYIYND 368 
Q6BUM0        304 ftldpeQNR-VPRQFELNTLTAPRFFLAqILSGQVSKLSITLPGLKFQVM-NNSSI----------FIISRLSIQYNYVD 371  Debaryomyces ...
XP_004194693  344 faldkgPTG-APKQYELAGVSIPRLAVAhLQANDTTNFTIALPGLKFQVM-NNGSI----------FLLSKLALQFTYMD 411 
EEQ38408      331 llegfaHGS-EPYSYELNAATAPRFLLAvVLAQNVATHQVTLPGIKFQVM-NNGSL----------FIVSRLQALITYLD 398 
Q59Y46        422 ntnnsnNNN-KPHQFELTTSTAPRFFAScIQTESILKCNISLSGSKFQVL-SNGSI----------VIVSKIGLHFHYKD 489  Candida albic...
XP_002547637  431 lnadsnNPN-SPHQFELNTSTAPRFFVScVQAKTIIRCSITLSGSKFQVL-NNGSI----------IIVLKIELHFNYQD 498 
EMG50537      954 kinpnnNGN-GVQQFELNTSTAPRFFVScVKAKNILKCNINMSGSKFQVL-NNGSI----------IIVSKIELNFGYQD 1021
XP_011276321  419 -------GV-DSRQFEFSVPIIPRFFFS-IIQSGVTRMDIQPDLLRTQVL-ANGTTY---------LESSRCCFTHYYSD 479 
KDE05539      470 GTKVELNGTLTVHFvvvphtatgpggsatgssisgsagggaGAgSLRIESMDFESRGHE------------EWVVKDSVV 537 
XP_002496107  256 GSNIERRICTRASL---------------------------DL-NFMVQWLEVRFMDRAaddwyaldemlrASISNSYMM 307 
ABN66134      369 GSIANLTGNVKLVM---------------------------NR-DLRIESVDIQYLSYQ------------PSISFPALE 408 
Q6BUM0        372 GSVSNVTGTFKMLM---------------------------NR-EFRIEWIDCQCFNIQ------------SSIGFETLE 411  Debaryomyces ...
XP_004194693  412 GSIAHINGACRMLL---------------------------NG-AFRIEWIDCRCMEYK------------ATVSIEGLE 451 
EEQ38408      399 GSVGNLQGTCRILL---------------------------SR-DFRIEWLDCRCLNYQ------------SSITMRALE 438 
Q59Y46        490 GSNSALHGTIKILM---------------------------SK-DLRIEWVDLNFSDYQ------------SNISVSALE 529  Candida albic...
XP_002547637  499 GSNSVSRGTVKILM---------------------------SR-DLRIEWIDLNCADYQ------------GNISMSALE 538 
EMG50537     1022 GSNSVIRGAIKILM---------------------------SR-DLRIEWIDLNCSDYQ------------SNISIQALE 1061
XP_011276321  480 GSYVNIHGNIRGIL---------------------------NQ-NLKLDYLDFQTHVFI------------PGVEWPSLE 519 
KDE05539      538 DELIETFYDVdgegggisqYLKEEEARTTAQSRRSSgLMTTRRKSTNKdeaangknasmggpqstkghvlkpstiewnee 617 
XP_002496107  308 NKLAQLVELTq--------MLSGTPQTIPQVLTDGSiSSSAASSNE---------------------------------- 345 
ABN66134      409 AGWKLYMESKs-------kEMNKGPYDSK--------------------------------------------------- 430 
Q6BUM0        412 KQWTNFS-------------QSQSENDKKEHGKSQQ-------------------------------------------- 434  Debaryomyces ...
XP_004194693  452 KQWGNLLLG-----------HSLGQPD----------------------------------------------------- 467 
EEQ38408      439 THWASFDNTSg--------G------------------------------------------------------------ 450 
Q59Y46        530 EKLKSI--------------ITDNTSITKKDIKRQK-------------------------------------------- 551  Candida albic...
XP_002547637  539 TKLKAI--------------IDSKKDFKKQK------------------------------------------------- 555 
EMG50537     1062 PKLKSL--------------IDTKKDLKKQK------------------------------------------------- 1078
XP_011276321  520 KI------------------LSDE--------QKVKdIFLNQENNKKAdnpe---------------------------- 545 
KDE05539      618 krppglqtkfRKTSHSPSAGVG-----SFGITEMGMRCLEIAESVASLQEVVTHS--LRNGVGPLQSLA 679 
XP_002496107  346 ----------TAVEEFHSHMKEfsnlsDTSRHQKARRTFQMTDVMSSLTDLLIYRk-EKQIVSPLEALD 403 
ABN66134      431 ----------EFLSQIHRTAEAirntpGSGMHENVMRILQVGDVMSQLKPLMGFSt-INSINSPLKSLE 488 
Q6BUM0        435 ----------EFFNYLHQSSSAislsdTCGLHEDAFRVLQVGDVMSNLRALMGFSa-ANNVASPMKALE 492  Debaryomyces hansenii
XP_004194693  468 ----------DMMNRLRERLVAtrvakSSGFAPDVMRLVQVGDIFSHLRALIGFSa-ANNLTSPLKAIE 525 
EEQ38408      451 ----------NFVESLSKNSESvraasNSGIHPNAMRVMQLGSLMSYLKPLMSFAa-ANNHASPLSALE 508 
Q59Y46        552 ----------ELLDELVKNSQAsklqlTFGIEPQSLRILQLGDVMSSMKSLMEFSm-VNNIPSPMKSME 609  Candida albicans SC5314
XP_002547637  556 ----------ESLDEMISTSHAvrlgaTSGIDAQSMRILQLGDIMTSMKSLMEFSv-VNNVSSPLRSLE 613 
EMG50537     1079 ----------ELVDEILSSSHAvqaglTSGIDSQSMRILQIGDIMTSMKSLMEFSm-VNNISSPLKSLE 1136
XP_011276321  546 ------arrlQLLTKFRSNYKVfhsmsNFGLQESVMRVMQVSDVMAHLKSLMLFSitSEDPTGPLNSLd 608 
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