Conserved Protein Domain Family
GPN2

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cd17871: GPN2 
GPN-loop GTPase 2
GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). It forms heterodimers with GPN1 or GPN3.
Statistics
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PSSM-Id: 349780
Aligned: 43 rows
Threshold Bit Score: 259.391
Created: 7-Aug-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:contains P-loop characteristic for ATP/GTP-binding proteins
  • Comment:based on homology to other members of the family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ########                                                                 
BAA91556      10 FGQAVTGPPGSGKTTYCLGMSEFLRalg--rrVAVVNLDPANEGLPYec------------------aVDVGELVGLGDV 69  human
XP_003377717  10 FGQVVIGPPGSGKTTYCKQMRNVLQslr--rkTILVNMDPANEFLSNdy------------------dIDICKLMNVKTV 69  Trichinella spi...
XP_001313582  12 YGACLIGPPGSGKTSAIKALKEMCEkls--rhVIVMNLDPANDQLPYqa------------------dFDICSTINVKDV 71  Trichomonas vag...
XP_651332      5 FGQVITGAPGSGKTTFIKGMYTFLKlmg--rePTIINLDPANEPNDYpi------------------sVSLPNLLSLDDA 64  Entamoeba histo...
XP_002785347  10 FGQLIIGPPGSGKSTYCRALRAYLRaag--rqCSIVNLDPASEEPINpsilqeengddsedlettyfdVDVRELVRVDDV 87  Perkinsus marin...
CBY11647       4 FGQAVVGAPGAGKSTYAKAIFNHILgqn--kdVAIINLDPAVSFPEAt--------------------VDICTLVEHADV 61  Oikopleura dioica
XP_001748538   3 FAQLIIGPPGTGKTTYAQQLREFLGslg--rdVLLVNLDPSCDDERAtan---------------afdVDIRDLISAREV 65  Monosiga brevic...
EGB10392       2 FGCVVVGPPGAGKSTMCAGLCRYHAlsk--rpVALVNLDPACEGEGLtt-----------------faIDVRDFCSVDRA 62  Aureococcus ano...
XP_766536      4 FGQVVIGPPGSGKSTYCAAMKSKLLskn--rkCIIINLDPQVTLHELpyq----------------pdINITNLIDAEHV 65  Theileria parva...
CBH12171       2 FGELVCGPPGSGKTTYCEGKRQFLSvyeptrpVVLLNLDPANEDIFPyp-----------------cdVDIREVVSHVRV 64  Trypanosoma bru...
Feature 1                                                                                        
BAA91556      70 MDalrLGPNGGLLYCMEYLeanldWLRAKLDPLRg------------------HYFLFDCPGQVELCTHHgALRSIFSQM 131 human
XP_003377717  70 MDdmqVGPNGGMVLCMEYVeknleWLVEEIKGKQred-------------ntcRYIIFDFPGQAELYTHC-TMNQLDFRL 135 Trichinella spi...
XP_001313582  72 MAttaLGPNGGLIYCMESLaenidAVADVIRPRVqk----------------aSYFLIDFPGQVELYTHSeCIRQFLDKF 135 Trichomonas vag...
XP_651332     65 MKdtqLGPNGGMLYCLEYLnenidWLIDKIIEIHp------------------SYLLIDCPGQTELFATHpTLPTILHRL 126 Entamoeba histo...
XP_002785347  88 AEehgLGPNGAMIFAMQELelnsaWLKDRIEALPi-----------------dDYVLFDCPGQIELYTHLtVMPHLVQLL 150 Perkinsus marin...
CBY11647      62 MEeleLGPNGALVYCMELLlenidWLLAEIEKIPk-----------------sSYLVFDFPGQAELYSVHdCVEKLVFQL 124 Oikopleura dioica
XP_001748538  66 MErleLGPNGGLMFCMEYLhehldWLEERVKAVDr------------------PYILFDCPGQVELYTHHsAMRDFLHTL 127 Monosiga brevic...
EGB10392      63 MAeqgLGANGALLFCMKELeq-stWLRDEVEKLAvde--------------cfPYVIFDLPGQTELFTHDgSLRRILDDL 127 Aureococcus ano...
XP_766536     66 SNtlnLGPNASLLYCMEYLfenldWLLEQISLHKd------------------SYLLYDLPGQVELFIHHnALKDIISKL 127 Theileria parva...
CBH12171      65 MEteeLGPNGSYLFCAALMerridWIIQKVEEAVdrrlrdvvttgggsvhprpPYLIIDCPGQVEFYLGSpVMHTLFRAL 144 Trypanosoma bru...
Feature 1                                                           ## ##                        
BAA91556     132 Aqwd---lrlTAVHLVDshyct--dpakFISVLCTSLATMLHvelpHINLLSKMDLiehygklafnldyytevldlsyll 206 human
XP_003377717 136 Avvn----liDSTACLDps--------qFLAALMVSLNMMVRleapHINVLSKFDLfernehqldfntefytev------ 197 Trichinella spi...
XP_001313582 136 Qkdlk--lklATVNLVDvvlas--tkqgYLGQSLMSIGMMLRlytpHINVLSKFDLvetgevelpfetetcdfedmv--- 208 Trichomonas vag...
XP_651332    127 Qqin---crlTAVHLIDsihig--npsiYLAAVLQGLACNMNlelpFVPFLSKADLlggygfnvkledvingnvaelin- 200 Entamoeba histo...
XP_002785347 151 TnrrgldirlTALNLTDcsvlaseggnnFISAALSSLAVMLHvelpHLNVLTKCDTlsqfgnqlkpksalverqdklvrt 230 Perkinsus marin...
CBY11647     125 Qknh---irlCAVYFTEarhaa--nahhFTAALLATLSSMLRlalpAVNVLSKLDVaprlaarlevftepvdlerffids 199 Oikopleura dioica
XP_001748538 128 Qhkwh--frvCTVNLIDsymcs--dagnFIAALLASLSMMVQletpHVNVLSKVDLveaygrldfnlefytdvldlryll 203 Monosiga brevic...
EGB10392     128 Krtfd--arlVAAHLVDvahcg--vpshYVAACLLSLTAMLRlelpHINVLSKVDLadryelamnleffkdarelhrivp 203 Aureococcus ano...
XP_766536    128 Qskn---qrlVQMNLIDstlcc--dpfkYVASLLSSLSSQIFiqlpHINVLSKLSLlkeveaemayrleyytevqdlqsl 202 Theileria parva...
CBH12171     145 Qkrly--ctlCTVHLVDasvst-rdistYVSSCLLSITTMIDhelpHINVFSKWDTlsvedseegeaylhassfmaedfd 221 Trypanosoma bru...
Feature 1                                                                                     ###
BAA91556     207 dh-------------------------------------------lasdpffrhyrqlneklvqliedyslVSFIPLNIQ 243 human
XP_003377717 198 -----------------------------------------------------cmpnrrfaakykklsealCEIIEDFGL 224 Trichinella spi...
XP_001313582 209 --------------------------------------------------csgtpsklhqkivellcdydlVSYEYFSVT 238 Trichomonas vag...
XP_651332    201 -------------------------------------------------dlpskfttlneqlaeiidqyslIKPIPFAIE 231 Entamoeba histo...
XP_002785347 231 dt--------------------------------------------aafimfdgyasssgslceliddygeVKFIPLSVD 266 Perkinsus marin...
CBY11647     200 sddecdte--------------------------------qtgrkriktrrrrirervsaqladvatsyglVRFHPLVVT 247 Oikopleura dioica
XP_001748538 204 dr-------------------------------------------lptsplferhrafnaalcdlvedfslVQFYTLCID 240 Monosiga brevic...
EGB10392     204 fcg------------------------------------------vrprapeprlqkltgricelvddfglVCYQPLDVS 241 Aureococcus ano...
XP_766536    203 mial---------------------------------------rynfklpnlkkferftstlceiiedfnlVSFHTMDVQ 243 Theileria parva...
CBH12171     222 rlwkkqlrqrrrnqrlaklyptgaekldardepsaaarddmeveaidlekdgghlyryskavmevvdgyglIGFLPLDVQ 301 Trypanosoma bru...
Feature 1                      
BAA91556     244 dkESIQRVLQAVDK 257 human
XP_003377717 225 dsTTMTRVLVKADR 238 Trichinella spiralis
XP_001313582 239 deSSVMHLIELIDK 252 Trichomonas vaginalis G3
XP_651332    232 dkNDLALAIAVIDK 245 Entamoeba histolytica HM-1:IMSS
XP_002785347 267 dkESISNLLAHADK 280 Perkinsus marinus ATCC 50983
CBY11647     248 deKLLQVVLSHANS 261 Oikopleura dioica
XP_001748538 241 nkELLWNLTRAVDK 254 Monosiga brevicollis MX1
EGB10392     242 dgDSVARLVRMLDK 255 Aureococcus anophagefferens
XP_766536    244 ddESIEFILSNADK 257 Theileria parva strain Muguga
CBH12171     302 sqDMMMRLTQQIDD 315 Trypanosoma brucei gambiense DAL972

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