Conserved Protein Domain Family
MCLC

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pfam05934: MCLC 
Mid-1-related chloride channel (MCLC)
This family consists of several mid-1-related chloride channels. mid-1-related chloride channel (MCLC) proteins function as a chloride channel when incorporated in the planar lipid bilayer.
Statistics
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PSSM-Id: 461783
Aligned: 4 rows
Threshold Bit Score: 1040.68
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q96S66         3 CSLLLCECLLLVAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECE 82  human
XP_007635624   3 CWLLLCGCLFLMTGHAHDDDWIDPTDMLNYDAASGTMRKSQVKYCTSERKEMSPDLTNAEELSDCLNKLDSLTHKVDDCE 82 
Q9WU61         3 CSLLLCGCLLLITGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGTSEKKEVNPGLSDAQELSDCLQRLDSLTHKVDDCE 82  Norway rat
XP_006092673   3 fSLLLCECLWLIAGFAHDDDWIDPTDMLNYDAASGTMRKSQ------VRKEVSADSSYADELSGCYSKLDSVIHKVDECE 76  little brown bat
Q96S66        83 KKKREDYESQSNPVFRRYLNKILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINF 162 human
XP_007635624  83 RKKMKDYESQSNSVFRRYLNKILIEAGKLGLPDENKVDMRYDAEILLTRQTLLEIEKFLSGEEWKSGALDDALSDILINF 162
Q9WU61        83 KKKMKDYESQSNPVFRRYLNKILIEAGKLGLPDEDRVDVRYDAEILLTRQTLLEIQKFLSGEEWKPGALDDALSDILTNF 162 Norway rat
XP_006092673  77 KKKRKDCESQNNPVFRRYLNKILIEARKLGLPDENRGDMHYDAEIILKRQTLIEIEKFLNGEDSLPGALDDALSDILINF 156 little brown bat
Q96S66       163 KFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQA 242 human
XP_007635624 163 KWHDSEAWKWRFEDSFGVDPYNAFVVLLCLLCIVLLVTTELWTIVRWYTQLKRIFIISFLFSLGWNWIYLYKVAFAQHQA 242
Q9WU61       163 KSHDAEAWKWQFEDYFGVDPYNVFMVLLCLLCIVALVATELWTYVRWHTQLKRVCIISFLVSLGWNWIYLYKVAFAQHQA 242 Norway rat
XP_006092673 157 KFHDFERWKWRFEDSFGVDPYDVFMVLLCLLCIVMLVATQLWTYVRWYTQLRRILLISFLISLGWNWMYLYKVAFAQHQA 236 little brown bat
Q96S66       243 EVAKMEPLNN-VCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGE 321 human
XP_007635624 243 GIAKMATQTDsVCVEKMDWTGSLWEWFRSSWTYEDDPCQKYYELLLVNPIWFVPPTKALAITFTNFVTEPLKHIGKATGE 322
Q9WU61       243 NVAKMAPLND-VCAKKMDWTENLWEWFRISWTYKDDPCQKYYELLIVNPIWLVPPTKALAVTFTNFVTEPLKYIGKGTGE 321 Norway rat
XP_006092673 237 EVAKMEPRSN-VCAEKMDWSGSLWEWFRSSWTYKDDPCQKYYELLLVNPVLLVPPTKALAVTFTNFVVEPLKYIGKGTGE 315 little brown bat
Q96S66       322 FIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYR 401 human
XP_007635624 323 FIEALMKEIPVLLQIPVLVIMALAVLSFCYGAGMSVPMLRYVGGPEREPPRALEPGDRRWQKELDCRLCGGAGDADFSYM 402
Q9WU61       322 FIKALMKEIPVLLQIPVLVILALAVLGFCYGAGQSVPMLRHFRGPEREPPRALEPDDRRRQKELDYRFHGGAGDADFSYR 401 Norway rat
XP_006092673 316 FIKALMKEIPGLLHVPVLIVMALAVVSFCYGAGQSVFMLRPF-GPAREPPLALQPGDKRRQQEIDYRPRGGAGDADFGSR 394 little brown bat
Q96S66       402 GQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVL--DTKPKETGGILG 479 human
XP_007635624 403 GQAGSIEQGPYDKTHACKRDVLRQRDVDARFHTGNKSPEVLRAFDLPDTEAQEHPEVVPSHKSSSM--NTNLKEIGELPG 480
Q9WU61       402 GPAGSIEQGPYDKMHVCERDVLRQRQVNMRFPSGNKSPEVLRAFDLPDTEAQEHPEVVPSHKPSIV--NTSLKETSELPR 479 Norway rat
XP_006092673 395 GYLGLVEQGPYDRPCESRRDVGRERVVDVRFQTGHKSPEVLRAVDRPDAEAREHPAAPSARETDGApeRSAPREEAH--- 471 little brown bat
Q96S66       480 EGTPkessTESSQSAKPVSGQdTSGNTEGSPAaEKAQLKSEAAGSPDQGSTYSPArg-vAGPRGQDPVSSPCG 551 human
XP_007635624 481 ESTP----TEHSSSATAVSGQ-AAGTAEGSPI-KKVPLKLDSECSLQGGTTHSPG----AAVCGTDPVSSPCG 543
Q9WU61       480 ESTL----AECSQCAKDGSGQ-VPSTAESSPIvEKAQLKTDSECRPH--STEAAA----AAARGTDPVSSPCG 541 Norway rat
XP_006092673 472 PGRKaegsTESSRHPEPGSGQgAPGVAE-DPAaGKAPLRIQDEGSPEEGGTPRPAstavAEAGGRDPAggp-- 541 little brown bat
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