Conserved Protein Domain Family
XRN1

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COG5049: XRN1 
5'-3' exonuclease [Replication, recombination and repair]
Statistics
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PSSM-Id: 227382
Aligned: 5 rows
Threshold Bit Score: 911.999
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
125342      1 MGIPKFFRYISERWPMILQLIEGT-----------------QIPEF---DNLYLDMNSILHNCTHGNDddVTKRLTEEEV 60   baker's yeast
19173198    1 MGVPSLFRWLQLSHKETIHSIMEK-------------------PSV---DALYLDFNAIIHTCIKPGL--GSEEEIERDL 56   Encephalitozoon c...
729456      1 MGIPKFFRWMSERYPLCSQLIEND-----------------RIPEF---DNLYLDMNGILHNCTHKNDdhSSPPLPEEEM 60   fission yeast
729332      1 MGVPALFRLLSRKFAKVITPVIEApteklpdgteiepdlslPNPNGvecDNLYLDMNGIVHPCSHPED--RPAPETEDEM 78   fission yeast
417592      1 MGVPSFFRWLSRKYPKIISPVLEEqpqivdgv-ilpldysaSNPNGe-lDNLYLDMNGIVHPCSHPEN--KPPPETEDEM 76   baker's yeast
125342     61 FAKICTYIDHLFQTIKPKKIFYMAIDGVAPRAKMNQQRARRFRTA---MDAEK--ALKKAIENGDEIPKGE-P------- 127  baker's yeast
19173198   57 YKTVGDFIDHILLKTRPRKLLYIAVDGVAPRAKLSHQRARRYKSAlgkKEGSAviAAAKADPTMSSPSEKKdEipneeft 136  Encephalitozoon c...
729456     61 YIAIFNYIEHLFEKIKPKKLLYMAVDGCAPRAKMNQQRSRRFRTA---KDAHD--ARLKAERNGEDFPEEQ--------- 126  fission yeast
729332     79 MVAVFEYTDRILAMVRPRQLLFIAIDGVAPRAKMNQQRSRRFRSS---RE-----AALKEE-ELQAFIEEAkQqgipide 149  fission yeast
417592     77 LLAVFEYTNRVLNMARPRKVLVMAVDGVAPRAKMNQQRARRFRSA---RD-----AQIENE-AREEIMRQReEvgeiidd 147  baker's yeast
125342    128 ----------------------------FDSNSITPGTEFMAKLTKNLQYFIHDKISNDSKWREVQIIFSGHEVPGEGEH 179  baker's yeast
19173198  137 gesslydkfiaedpsessslaidvetekFDLNCITPGTPFMERLHKVLISYIQCKLSSDPEVSNLRIIYSSYLVPGEGEQ 216  Encephalitozoon c...
729456    127 ----------------------------FDSNCITPGTTFMERVSRQLYYFIHKKVTNDSQWQNIEVIFSGHDCPGEGEH 178  fission yeast
729332    150 ---------------------natkkksWDSNCITPGTPFMDTLAKSLRYYIINKLNSDPCWRNVRFILSDASVPGEGEH 208  fission yeast
417592    148 ---------------------avrnkktWDSNAITPGTPFMDKLAAALRYWTAFKLATDPGWKNLQVIISDATVPGEGEH 206  baker's yeast
125342    180 KIMNFIRHLKSQKDFNQNTRHCIYGLDADLIMLGLSTHGPHFALLREEVTFGRRNSEKK------------------SLE 241  baker's yeast
19173198  217 KIMSFIRSQ---GSIARNDVHMIYSPDGDLIFLGLSLQRNRVLIMR-DYFSPSKERRKRtctkcgrt--ghsdeecgVFT 290  Encephalitozoon c...
729456    179 KIMEYIRTQKAQPSYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGPASRNRSk-----------------ELA 241  fission yeast
729332    209 KIMEFIRSQRVKPEYDPNTHHVVYGLDADLIMLGLATHEPHFRVLREDVFFQQGSTKKTkeerlgikrlddvsetnkVPV 288  fission yeast
417592    207 KIMNFIRSQRADPEYNPNTTHCIYGLDADLIFLGLATHEPHFKILREDVFAQDNRKRNNlkdtinmte-eekqflqkQNS 285  baker's yeast
125342    242 HQNFYLLHLSLLREYMELEFKEIADEMQfeYNFERILDDFILVMFVIGNDFLPNLPDLHLNKGAFPVLLQTFKEALLHTD 321  baker's yeast
19173198  291 NYHFVYVNISELRTRLIREFRRHTAQR---FSEERILDDWIFLCFLLGNDFVPPIPCLDIRFHSIETITEIMMKSFSEMK 367  Encephalitozoon c...
729456    242 HQKFYLLHLSLLREYLEFEFQECRSTFTfkYDLEKILDDFILLAFFVGNDFLPHLPGLHINEGALALMFSIYKKVMPSAG 321  fission yeast
729332    289 KKPFIWLNVSILREYLEVELYVPNLPFP--FDLERAIDDWVFFIFFVGNDFLPHLPSLDIRDGAVERLTEIWRASLPHMG 366  fission yeast
417592    286 EQPFLWLHINVLREYLSAELWVPGLPFT--FDLERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILLDIWKVVLPKLK 363  baker's yeast
125342    322 GYINEHGKINLKRLGVWLNYLSQFELLNFEKDDIDV-EWFNKQLENISLEGERKRQRVGKKLLVKQQ--------KKLIG 392  baker's yeast
19173198  368 SYITCNKMINYQALRNFYAILASKEDGLY---H-----RKSQSLDKF--R----EGLKGMPRIVYEK------------- 420  Encephalitozoon c...
729456    322 GYINEKGVINMARLELILLELENFEKEIFKAEVSETkNNGNSDKPSFDFLKYITESTNDIKAMTGEQ------------- 388  fission yeast
729332    367 GYLTLDGSVNLARAEVILSAVGNQEDDIFKRLKQQE-DRRNENYRRRQQRESNQESESYVDNVVIQRsve--tqsTEVVT 443  fission yeast
417592    364 TYMTCDGVLNLPSVETLLQHLGSREGDIFKTRHIQE-ARKKEAFERRKAQKNMSKGQDRHPTVATEQlqmydtqgNLAKG 442  baker's yeast
125342    393 SIKPWLMEQLQEKLSPDLPDEE-IPTLELPKDLDMK-----DHLEFLKEFAFDLGLFITHS-KSKGS------------- 452  baker's yeast
19173198      --------------------------------------------------------------------------------      Encephalitozoon c...
729456    389 ---K---NYFLQIKKFLSSREPfIDFSANISSVDQR---------FLRRLCNDLHLSFSKIiKVDG-------------- 439  fission yeast
729332    444 SSKSTSVDTKPPKKTQKIDAPApVDLVNLSEKTSNRslgatNRELINNRAANRLGLSREAAaVSSVNklaasalkaqlvs 523  fission yeast
417592    443 SWNLTTSDMVRLKKELMLANEGnEEAIAKVKQQSDK-----NNELMKDISKEEIDDAVSKAnKTNFNlaevmkqki-ink 516  baker's yeast
125342    453 ------YSLKMDLDSINPDETEEEFQNRVNSIRKTIKKYQNa---------------------iIVEDKEELETEKTi-- 503  baker's yeast
19173198  421 ----------------------------------Ip-----------------------------------I---HT--- 425  Encephalitozoon c...
729456    440 ------THLLRITFRDLEFNDEDEDEIEQDEIERVLQKYDNi----------------------pLLNEEQALKEKN--- 488  fission yeast
729332    524 netlqnVPLEDSIASSSAYEDTDSIESSTPVVHPI-DTKVSnvgqk--------------rkapDSTEENEN--TDT--- 583  fission yeast
417592    517 khrlekDNEEEEIAKDSKKVKTEKAESECDLDAEIKDEIVAdvndrensettevsrdspvhstvNVSEGPKNGVFDTdef 596  baker's yeast
125342    504 YNERFERWKHEYYHDKLKFTTDSEEKVR-DLAKDYVEGLQWVLYYYYRGCPSWSWYYPHHYAPRISDLAKGLDQDIEFDL 582  baker's yeast
19173198  426 ----KTGKVQ-YYTSKLNATTES--DIK-NICYEYVKGLYWVYSYYVLGWTGWDWYYPYHFAPLAADLSKLSINDIQISP 497  Encephalitozoon c...
729456    489 VEKDFIQWKDDYYRSKVGFSYYDEEALK-AMAERYVEGLQWVLFYYYRGCQSWGWYYNYHFAPKISDVLKGLDVKIDFKM 567  fission yeast
729332    584 VRLYEPGYRERYYEQKFHISPDEPEKIR-EAVKHYVHGLCWVLLYYYQGCPSWTWYYPYHYAPFAADFKDLASIDVKFEL 662  fission yeast
417592    597 VKLFEPGYHERYYTAKFHVTPQDIEQLRkDMVKCYIEGVAWVLMYYYQGCASWNWFYPYHYAPLATDFHGFSHLEIKFEE 676  baker's yeast
125342    583 SKPFTPFQQLMAVLPERSKNLIPPAFRPLMYDEQSPIHDFYPAEVQLDKNGKTADWEAVVLISFVDEKRLIEAMQPYLRK 662  baker's yeast
19173198  498 GHPLRPLEQLLVVLPPMSRGMVPEGLQPIFDDYK----DYYPEDVKTDMFDKVYLWQEIVLLPFMDFRPILSENAVKFNT 573  Encephalitozoon c...
729456    568 GTPFRPFEQLMAVLPARSQALVPPCFRDLMVNSESPIIDFYPENFALDQNGKTASWEAVVIIPFIDETRLIDALASKDKF 647  fission yeast
729332    663 NQPFKPYEQLLGVLPAASKNNLPEKLQTLMTDENSEIIDFYPENFTIDLNGKKFEWQGVALLPFIDENRLLNAVSKIYPQ 742  fission yeast
417592    677 GTPFLPYEQLMSVLPAASGHALPKIFRSLMSEPDSEIIDFYPEEFPIDMNGKKMSWQGIALLPFIDQDRLLTAVRAQYPL 756  baker's yeast
125342    663 LSPEEKTRNQFGKDLIYSFNPQVDnlykspLGGIFSDIEHnHCVEKEYITipLDSSEIRYGLLPNAKLGAEMLAgfPTLL 742  baker's yeast
19173198  574 LGYEDLSRNLRSLDLLFTTDKKS--------SEVILGMYS-KLKP-------MCSIRSP-GYFGTI-------------- 622  Encephalitozoon c...
729456    648 LTEEERKRNSFNAPTVFSLAEDYTsfypssLPSLFPDLVT-RCIQKPYSLpsMEGKEYLVGLCPGVFLGAFGMVgfPSFH 726  fission yeast
729332    743 LTEEESKRNEDGSTLLFISEHHPM------FSELVKQLYS-KKRQGKPLK--LSGKMAH-GLFGKVNTN-DSVI--PNVS 809  fission yeast
417592    757 LSDAERARNIRGEPVLLISNKNAN------YERFSKKLYS-KENNNNNVV--VKFQHFKSGLSGIVSKDVEGFE--LNGK 825  baker's yeast
125342    743 SLPFTSSLEYNETMVFQQPSKQQSMVLQITDIYKTnnVTLEDFSKRHLNKVIYTRWPYLRESKLVSLTDGKTIYEYQESN 822  baker's yeast
19173198  623 --CPYSFASFPG--DVLEYN---GARFV-----------NKTVVA--FIEPRN--------------------------- 655  Encephalitozoon c...
729456    727 TLKHKAELVYHGINVFGNESRNPSVIVNVEDVKSA--LTSEQIAMQYVGKRIFVDWPYLREAYVESAMDESYMYLASNST 804  fission yeast
729332    810 VQCPIDVTSADALQKYGSIDDNQSISLVFEVPKSH--FVHKSMLLRGVKMPNRVLTPEDINQVR---AERSFSSRRNNGN 884  fission yeast
417592    826 IVCPIQGGSLPNLSTTLILK--MSYRLI-PLPS-----RNKSIILNGFIPSEPVLTAYDLDSIMYKYNNQNYSRRWNFGN 897  baker's yeast
125342    823 DKKKFGFITkpaetqdkklfNSLKNSMLRMYAKQKAVKIgpmeaIATVFPVTGLVRDSDGGYIKTFSP-TPDYYPLQLVV 901  baker's yeast
19173198      --------------------------------------------------------------------------------      Encephalitozoon c...
729456    805 IEKRDLAEIeks------qwGRKCSHKIREYSKRFGVLFgdislLLQVRPIKGLEYTREGALVKIFNEsVLEDYPAQLVV 878  fission yeast
729332    885 SYRGGHQSY-----------GVRRSYQSQSYSSRQSYTG-----VTNGFANGGVQPPWSGNGNFPRSNaSYNSRGGHEGY 948  fission yeast
417592    898 DLKQNIVPV-----------GPKGITQYKPRTGGYRAFF-----YFAELSRNNVQP----AHNYGRN--SYNSQPGFN-- 953  baker's yeast
125342    902 ESVVNEDERYKERGPIPIEEEFPLNSKVIFLGDYAYGGETTIDGYSSDRRLKIT 955  baker's yeast
19173198      ------------------------------------------------------      Encephalitozoon cuniculi
729456    879 EKIAIDDPRFTEREAPPVEVEYPPGTKAFHLGEYNYGRPAQITGCKDNKLIIWL 932  fission yeast
729332    949 GGRSRGG--GYS-NGPPAGNHYSSNRGKGYGYQRESYNNNNRNGYY-------- 991  fission yeast
417592    954 NSRYDGGNNNYRQNSNYRNNNYSGNRNSGQ-YSGNSYSRNNKQSRYDNSRANRR 1006 baker's yeast
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