Conserved Protein Domain Family
IER

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pfam05760: IER 
Immediate early response protein (IER)
This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.
Statistics
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PSSM-Id: 461732
Aligned: 17 rows
Threshold Bit Score: 236.719
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q99J55         1 MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQqqpphhqhq------- 73  house mouse
3_pfamImport   1 MECGADAQNLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEIYRMQQYEEV---------------- 64 
XP_011615873   5 AECAVDAESLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEVYRIQQYEEV---------------- 68 
CAF96710       1 MECAVDAQSLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEIYRMQQYEEV---------------- 64 
XP_003445593   1 MECAFEAQNLISISLRKIQSSRTQRGGIKLHKNLLVTYVLRNARQFYMSKNLSQMQRTNPYEDVtvvre----------- 69 
XP_022612745   1 MECAFDAQNLISISLRKIQSSRTQRGGIKLHKNLLVTYVLRNARQFYMSKNLSQTQRTHHYEDVatvre----------- 69 
XP_006635330   1 MEYKVEAHRIMSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSEYYQGVCLNAQHMDTapqwgegaivdstqdk 80 
XP_003785699   1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGPAGTPapppqqpgepaa---- 76 
Q5VY09         1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGPAGTPapppqqqpgepaa--- 77  human
XP_004072580   1 meCAFEAQNLISISLRKIQSSRTQRGGIKLHKNLLVTYVLRNARQFYMNKNVSQAQRSPPYEDAaavre----------- 69  Japanese medaka
Q99J55        74 ------hlayaapgMPASA-------ADFGPLQLgggg---daeAREPVARHQLHQLHQLHQLHLqqql-hqhQHpaprg 136 house mouse
3_pfamImport  65 --------------MTVCNe-----iQEL---------------DSHGSGRGDDCGDRAIQCVF---------VClprrg 101
XP_011615873  69 --------------MAVCNe-----iEELNPLETaae-----dmDNGDQARGGCCSEESSLCGS---------AChr--- 112
CAF96710      65 --------------MAVCNe-----iQELDPLELeag-----daDDGDQARGVCCGEESSPCGS---------AChr--- 108
XP_003445593  70 ----------rqeyLEWTGs-----fTEL--------------------ADDFYCNFTGVESDTW--------HCgah-- 104
XP_022612745  70 ----------rqeyLELTGs-----fTEL--------------------ADDFYCNFTGVESDTW--------HC----- 101
XP_006635330  81 agsdpagsaqgspdSGSTLppe-----ssHPLPAat-------------------------------------------- 111
XP_003785699  77 --vppagwgeppppAARAAwretepqPQPQPQPErtavldaqwvGGAEPATSVTRVGDALQGREAdaaeaawgSVegprg 154
Q5VY09        78 --gppagwgeppppAARASwpe------tePQPErssvsdaprvGDEVPVATVTGVGDVFQGGEAdateaawsRVegprq 149 human
XP_004072580  70 ----------kqeyLELTGs-----fTEL--------------------ADDFYCNFTGAESDSW--------HCga--- 103 Japanese medaka
Q99J55       137 ctAAApva------vaGAPAGCAGALSELPGCAalqpphgaPHRGQHL--EPlQPGpaplpppapaalcprdprvpaacs 208 house mouse
3_pfamImport 102 qpAA-----------------HARTASAVFGCA----------SLEEDtrEP-DPSyyrs-------------------- 133
XP_011615873 113 -dAA-----------------HARALSALPCCP----------RLEDVskEP-ENPyyrs-------------------- 143
CAF96710     109 -dAA-----------------HARAASALPGCP----------RLEDAnkEP-ESAyyrs-------------------- 139
XP_003445593 105 qpNGQ-----------PAEVAHQGASACAMDSPsd-----sDLMVSDAcwSCaDKSs----------------------- 145
XP_022612745 102 --GAHqpn------gqPAEVAHQDASACAMVSPnd-----sDLMVSEAcwSCaDKSs----------------------- 145
XP_006635330 112 ---------------aLESPAAGRQPETAEPGEqsapsapsSP--ACCcrPTgEPLg----------------------- 151
XP_003785699 155 aaAAGagdpvrgsdvfPEGP--ARRPSACPPGGedqrgaaaASPGADCccAP-RPVv----------------------- 208
Q5VY09       150 aaAREaegtaggwgvfPEVSRAARRPCGCPLGGedppgtpaATPRAACccAP-QPAe----------------------- 205 human
XP_004072580 104 hqHNGq----------LTEVQHQDASSCVLVSPnd-----sDLMLSEAcwSC-ADKs----------------------- 144 Japanese medaka
Q99J55       209 apsvlpgaapstvaassppastapssstgfyrGAYPAPs-----------------------------dFGVHCsSQTTV 259 house mouse
3_pfamImport 134 -----------------------------ccmEASPAPhcdq-----------------------lpasGSAHC-NKTTV 160
XP_011615873 144 -----------------------------cfmQPYPLSncaq-----------------------fvtnGSAQC-TKTTV 170
CAF96710     140 -----------------------------ccaQPYPAShcaqv----------------------taggGSAQC-TKTTV 167
XP_003445593 146 --------------------------------WELSIP--------------------------------NTQA-NQKTV 160
XP_022612745 146 --------------------------------WELPIP--------------------------------NTQA-NQKTV 160
XP_006635330 152 --------------------------------EPVPAPadlpcapvapfparshgaetppykeatppeeGAGGC-GEAEV 198
XP_003785699 209 --------------------------------DESPAPpavc-----------------------prkrGAAGV-G---- 228
Q5VY09       206 --------------------------------DEPPAPpavc-----------------------prkrCAAGV-G---- 225 human
XP_004072580 145 --------------------------------WELPVP--------------------------------NTQA-NQKTV 159 Japanese medaka
Q99J55       260 LDLDTHVVTTVENGYLHQD--CCASAHCPCcgQGAPGPgla-saAgCKRKYYPGQEEEDDEEDAgDlgaeppggtpFAPC 336 house mouse
3_pfamImport 161 LDLDTHVVTTVENGYLHQD--CCCDA-PPLg-QGAQTP------A-KKRKVEPGCYVSDVEEIS-D----------FTAA 218
XP_011615873 171 LDLDTHVVTTVENGYVHED--CFCDS-PQCg-QNTQSTt-------KKRKVEFSCCVSDAVDVS-D----------FIAT 228
CAF96710     168 LDLDTHVVTTVENGYLHQDccCCCDA-PQWg-QIAQSP------T-KKRKVEFGGCAPDAEEVS-D----------FTAT 227
XP_003445593 161 LDLDTHVVTTVTNGYFHTD--CCAQPKQP---QGAQC-------YtKKRKIDISYHIVDPEFYLpD----------FAPV 218
XP_022612745 161 LDLDTHVVTTVTNGYFHSD--CCAQPKQP---QGAQC-------YaKKRKMDTSYHIVDPEFYLpD----------FGPV 218
XP_006635330 199 KGGESESSETRLNHSAAAS--CCRKRS------AEKAPhaespvKkTKQTSPS--------------------------- 243
XP_003785699 229 -GGP-------------AG--C-------------QAPgat-plKkPRRNLEEq----QPGRg--E-------------- 258
Q5VY09       226 -GGP-------------AG--C-------------PAPgst-plKkPRRNLEQ-----PPSGg--E-------------- 254 human
XP_004072580 160 LDLDTHVVTTVSNGYFHSD--CCAQPRQP---QGAQCh--------KKRKMDTSYFIVDPEFYLpD----------FVPV 216 Japanese medaka
Q99J55       337 --KRARFEDfCPDSSP---DASNISNLISIFGS-GFSGLVSRQPDs-SEQPppLN----------------GQL-CAKQA 392 house mouse
3_pfamImport 219 r-KRAKRED-CSYHSLdytDTSNISNLISIFGS-GFSGLLSRQAD--LEQI------------------------CSKQV 269
XP_011615873 229 r-KRLKRDD-CPFSNPdytDASNITNLISIFGS-GFSGLLSRQSD--MEQI------------------------CSKQV 279
CAF96710     228 r-KRPRRED-GPFSGPdhaDASNITNLISIFGS-GFSGLLSRQSD--MEQI------------------------CSKQV 278
XP_003445593 219 pcKRMRSDD-DSHSDSdqlDSTNISNLISVLGSgGLSEFVSWQQTd-LEQI--FA----------------TQTiCLKHT 278
XP_022612745 219 pcKRMRTDD-DSYSDSeqlDSTNISNLISVLGSgGLSEFVSWQQTd-LEQI--FA----------------AQTiCLKHT 278
XP_006635330 244 ----------EEAEREeemDTSNVSSLITIFGS-SFSGLLSK------------DsapqaeppagdsdsasGQIcCEQ-M 299
XP_003785699 259 ------------DDDPedmETGNVANLISIFGS-SFSGLLRKSPGggREEEegAEsgpe--------aaepGQIcCDKPV 317
Q5VY09       255 ------------DDDAeemETGNVANLISIFGS-SFSGLLRKSPGggREEEegEEsgpe--------aaepGQIcCDKPV 313 human
XP_004072580 217 pfKRMRSDD-DSHSDSdqlDNTNISNLISVLGSgGLSEFVSWQQTd-LEQI--FG----------------TQTiCLKHT 276 Japanese medaka
Q99J55       393 LASLGAWTRAIVAF 406 house mouse
3_pfamImport 270 LASLGAWTRAIVAF 283
XP_011615873 280 LASLGAWTRAIVAF 293
CAF96710     279 LASLGAWTRAIVAF 292
XP_003445593 279 LLTGSGWTRAIEAF 292
XP_022612745 279 LLTGSGWTRAIEAF 292
XP_006635330 300 LKNMNPWSTAIVAF 313
XP_003785699 318 LRDMNSWSTAIVAF 331
Q5VY09       314 LRDMNPWSTAIVAF 327 human
XP_004072580 277 LFTGSGWTRAIEAF 290 Japanese medaka
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