6W2T,6ZVJ


Conserved Protein Domain Family
eIF-3_zeta

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pfam05091: eIF-3_zeta 
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Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
This family is made up of eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta/eIF3 p66/eIF3d). Eukaryotic initiation factor 3 is a multi-subunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilization of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits. These functions and the complex nature of eIF3 suggest multiple interactions with many components of the translational machinery. The gene coding for the protein has been implicated in cancer in mammals.
Statistics
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PSSM-Id: 461547
Aligned: 96 rows
Threshold Bit Score: 356.154
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6W2T_9        22 FIRPMVQNNPD-GWGPC-ELPDQ--FK-------DIP---YQPFSKSDRLGKISDWTGTAyqdkKFQNkynsQ------F 81 
XP_001018258   8 adlenlksFTKqTWGPDrNyvf-tkFD-------NLP---FTPFSRLEKLGACCDLQNIMatrtGLKQ----TqvirstA 72 
XP_004030408   8 qdlenlqiSQKqNWGPDpNykf-prFE-------NMA---FAPFSRLEKLGKCCDFANMMavrtGQKQiq---------- 66 
Q5CPM5         3 KFNYILNFSPD-TWTPTiE---SkaGEnclggikNFP---FAPSMKIDRLGAVCDFSYT--------------------- 54  Cryptosporidium...
XP_001614386   3 AFKLIGVANNR-TWGPDsK--NEelVNqcmgelkKYQ---FEPSMKFEKIGKICDFTSS--------------------- 55 
Q8IJW4         3 SFNLVGVINNR-TWGPDsK--NEelVNycmpdikKYQ---FEPSMKFERIGKVCDFTMN--------------------- 55  Plasmodium falc...
Q7RGS7         3 TFKLFGVVNNR-TWGPDiK--NEelVNscmedikKYQ---FEPSMKFEKIGKICDFTTT--------------------- 55  Plasmodium yoel...
Q4MYQ4         3 NLNIVANFNSN-GWGPDeE--DDqtINtclhtinKFP---FDPKLKLDKQIHICDFTFS--------------------- 55  Theileria parva
EDO07617       3 RLRIVTNLNAS-GWGPDeS--DDqtVVsslgslsKLP---LEPRLKFDRQLRVCDFTYF--------------------- 55 
EFC42669       9 saislLEQSKE-GWGPI--HPASssVEqskseilSLPtnlFHIIPSKISIGKIADWTSEQsaptTSTTt----------- 74 
6W2T_9        82 GG----Sg-mKAY-AYEH----------------DEDEtTFHLVDTTRVQKp-P--------YQrgrfgqrnqrmrgRG- 129
XP_001018258  73 PAnaptNtveSVQvTTTA----------------VDAEnDFHTVTAKKDKN--Lyaq--kiiKQ-------------GL- 118
XP_004030408  67 ---------sSNMpQLQQ----------------QQNNq--------------------------------------QQ- 82 
Q5CPM5        55 --------------SYSRgrda---------kssQADNqDFHLVDSRPFPKtkVryv---qrkF-------------QKe 95  Cryptosporidium...
XP_001614386  56 --------------SYQKnvkdank--nsnegnaFEDElQFQTVDLRAGQKqkGpmygkkkiMN-------------KQ- 105
Q8IJW4        56 --------------SYQKntkdink--nsndvnaFEEElQFQTVDLRTGQKqkGsifnkkkiHN-------------KQn 106 Plasmodium falc...
Q7RGS7        56 --------------SYQKnikdinkn-sgdgdnaFEEElQFQTVDLRTGQKpkGtlfnkkkiIN-------------KQ- 106 Plasmodium yoel...
Q4MYQ4        56 --------------TYQRnaregnrl-nrvnstsMDEElQFQTVDSRTIVKikPtthykkktPI-------------KQ- 106 Theileria parva
EDO07617      56 --------------TYQKnirdagrygrqpvpvvVDEEmQFQTVDGRSLMKakNmqhyrrkaVP-------------KQ- 107
EFC42669      75 ------HsvaAAIaNVTG----------------AND--DFNLVVSNTQSQ--------------------------RK- 103
6W2T_9       130 GQRGGMSQMQalgklkIherdrr---------gqnkrwT-RR---NQAPIK-MRDASVTVRPDWVTIEEMDFPRLSKLTl 195
XP_001018258 119 RDQKINKQREqeqkeqEknskiqnvk----kpkiisanN-KK---QVIIKT-KFKEYTNIKVDWEVLHESQKLNIEQHPi 189
XP_004030408  83 QQQVPLPEIPqeeeqySnsyvkqpsr----qrqkinpnK-TK---IVVIRT-KFKDSSNIQANWVLLTESQKINIEQHPi 153
Q5CPM5        96 TAQAYHQKQQqqekaeMllrqgkrsakm--rqagtqqyqySRhrfVSRMRT-LTEWSIEPLSSWISVAEIPLSSLPKQF- 171 Cryptosporidium...
XP_001614386 106 TTQAFAQKQEeennlySsriktaeq------kkqkllqQaKTarmNARHRI-FTEWSIEPTPVWTVECEVMFNELPKKL- 177
Q8IJW4       107 TTQAFTQKQQeednlySsriktaeq------kkqkllqQaKTariNARHRI-FTEWSIEPTPLWTVECEIMFNELPKKI- 178 Plasmodium falc...
Q7RGS7       107 TTQAFTQKQQeednlySsriktaeq------kkqkmlqQaKTarlNARHRI-FTEWSNEPTPSWTVDCEIMFNELPKKL- 178 Plasmodium yoel...
Q4MYQ4       107 TTQAFNQKVMeeeqlqFskqkqypd-----lrrqkyiaKnRSlrlPTRYHP-LNEWSIEPTPAWNVVAEIPFNILLKQE- 179 Theileria parva
EDO07617     108 TTQAFNQKQMeeeamiMsakqkhpe------mrkqrmmHsRGnrpTARHHT-FNEWSIEPSHSWHLLSDIPFSQLSK--- 177
EFC42669     104 SYTNYNQNKRrpttqsQppkaaynqeqnkqnkqkkkkaTlSY---YQKTKTqNYKPSIKVKKSWVLIDKFLFGTLKKATt 180
6W2T_9       196 ------PGVK--E-GEDVLCCGAVEYYDKSYDRVNVKNEKPLQR--IDRIFHTV--TTTDDPVIRKLSk--T-------- 252
XP_001018258 190 ------NNVT----ITPIKITGKLKQYEKAFDRID---PRGIKKldASKNLSVVnsSTLKDDILIELLq-qDvde----- 250
XP_004030408 154 ------KEVK----FTELECTGTLKKYNRSYDKID---PRYIKKveCNQTVILPsaSSLKDPVLIRLLe-eDlen----- 214
Q5CPM5       172 ------LDVSksT-IEDIGWFGTLKSYNKSMDRISPKLPMVLKDfgNME-FLQP--TTSDDEILRDALlqpEr------- 234 Cryptosporidium...
XP_001614386 178 ------IKMEnfQ-MQDIYFRGRLLYYDKKFENINVKSPPGLVNqsKDSINLVC--KTMDDQSLMEILldeDkkskaaaa 248
Q8IJW4       179 ------IKIDnlK-VEDLFFKGKSLFYDKKIENINVKNPPLLFHhtKEGINLIP--KTKEDHNLINILnneNknkiisne 249 Plasmodium falc...
Q7RGS7       179 ------IKIDhlK-IEDIFFRGKVLYYDKRFENINVKNPPFLAHlnKDANVLVC--KASDDQTLMEILdneEkkake--- 246 Plasmodium yoel...
Q4MYQ4       180 ------MDSSqvT-VEDLFWRGKLGIYDRKMDQITPKNEVYLLHlsNSYDYYWT--STHDDDCIADVLletYktspskpl 250 Theileria parva
EDO07617     178 ------VDLPgkVvGTDVTWRGKLGVYDKRMDHISAKSEVPLQNlnDQFDYYWT--STNDDDCIMDYLlstQrqesa--- 246
EFC42669     181 eplesgKGYKtpE-PIDRHICGSLGYYDKKFDRASAKQPLTLEKpqKLNGYILQppASSEDPLLNNKTa----------- 248
6W2T_9       253 ------------------------------------------------EGNVYATDAILATIMCCTRSNYSWDIVIEKIG 284
XP_001018258 251 ---------------------------------------------ksdKPTVYTTDALLLALMTCKKNEFPWDILVQKDG 285
XP_004030408 215 ---------------------------------------------kiqKPTVYTTDALLLALMTLKKGEFPWDIYVQKDG 249
Q5CPM5       235 ------------------------------------------------NIDVAITDQILACLVAAAQSKYSWHILVTNVD 266 Cryptosporidium...
XP_001614386 249 v---------------------------------------aedgvnssNIIVVSTDQILSCLMSAAQSKYSWHLLITKEG 289
Q8IJW4       250 -----------------------------------------edpnninNIIVISTDQILSCLMSCVQSKYSWHLLIKKKG 288 Plasmodium falc...
Q7RGS7       247 --------------------------------------------nnstGLIIVSTDQILSCLMSCVHSKYSWHLIIKKKG 282 Plasmodium yoel...
Q4MYQ4       251 eseyqngvegedefdsgdkkqagnmplqgdsasydqamkverdllrydKIVLAATDQILSVLMTAGRSKHSWHLNVTKIE 330 Theileria parva
EDO07617     247 --------------------------------------------dagdHIILGATDQILAVLMTAARSKYSWHLNVTKID 282
EFC42669     249 -----------------------------------------------pEANVFATDDAIATLMAASKSELPWDMAVRVSE 281
6W2T_9       285 NKLFFDK----R--DNTEF----DLL-TVNETSVEPPqd---dGNSLNSPRNLALEATFINHNFSQQVLKSNe--PR-YK 347
XP_001018258 286 NAIVFDTyeeeRmn-------ymDFQ-SVNENSNILPe----eEKDLN---KLCVEATTITKKFQAQTCKEDngeIWdIS 350
XP_004030408 250 NQIILDKyeadKyeGNNKLfdymEYQ-TVNENGNILPe----eERELN---KLCIEATTVTRQFQYQTTQGEt-eLWeIS 320
Q5CPM5       267 GKLIFDK----Q--DGSII----DLI-TVNETSAEPPlp--dnVNKNNRPHLLGLEALKSNQNYTQNIQIFGdegII-KQ 332 Cryptosporidium...
XP_001614386 290 NKIIIDK----D--EDSIV----DLL-TVNENSIDAPtq--dnENKINSLQALGFEAIKINQRFRKQVLLKNeq---aEQ 353
Q8IJW4       289 NQIIIDK----D--DDSII----DLL-TVNENSIDAPtq--dnENKINSLQALGIEAVKINQRFRKQVILKNdi---aEE 352 Plasmodium falc...
Q7RGS7       283 NRIIIDK----D--DDSII----DLL-TVNENSLDAPtq--dsENKINSLQALGLEAVKINERFKNHVQLNNqi---aEQ 346 Plasmodium yoel...
Q4MYQ4       331 NQIIIDK----A--NGSII----DML-TVNETAPDPPqp--dcEIKINRPSSLRYEAVKVNQNLRQQVLLQDey---sET 394 Theileria parva
EDO07617     283 NKIIIDK----A--NGSII----DML-TVNETSPEPPlp--daEIKINRPPALGYEAVKVNQCLRQQVLVSGqf---sDE 346
EFC42669     282 GKIYLDM----RklEGRNI----NLWhSVSETSSNPPsvdeknVQSINSAFSLSKEATLVNAYLQKQAFKEDe----vKK 349
6W2T_9       348 FDEPN-PFIseEeeG-E-VASVAYRYRKWDLNNG------------ITLIARCEHDAVMQGPNNe----------TqfLT 402
XP_001018258 351 EGEPN------QidE----QNIAFKYVNVNIDDk------------VNLKVRVQIDGYDIVNKVdpeta-epyqeKvpIL 407
XP_004030408 321 EGKEN------QveN-MeNENVAFKYINCNIDDk------------IDIKVRVQIDAFDYVKEYdpenndvvseqKvpIL 381
Q5CPM5       333 FEPI--PFS--EenQdTnIESKCYRYRIFSLPPRagasssenaqktVRVAIRTEIDAQIPNAESe---------nSgfIF 399 Cryptosporidium...
XP_001614386 354 FDNA--SFT--AknCk--NFDVLYRYRKILVPPIvngs----skkkCTLITRGEIHSKLKGTANs------------yVY 411
Q8IJW4       353 FEPG--NFN--IknIk--INDILYRYRKFQIPPLvqsn----nkktYTLITRGEIHSQIKGLNKs------------yVY 410 Plasmodium falc...
Q7RGS7       347 YDNT--SFN--SkqC-NnNSNILYRYRKINLPPLihgs----sktnCTIITRGEIHSKIKGSNNa------------yVY 405 Plasmodium yoel...
Q4MYQ4       395 FLDP--PFV--EesDn--PATIAYRYRKFTLPGTpnatn--feklpILVITRCEVHAKLQGTDTy-------------TY 453 Theileria parva
EDO07617     347 FELP--PFV--EegDn--PSTMAYRYRTFMVPGDnhghg--wsrvpIHVITRGEVHARIPGVSN-----------GgyTY 407
EFC42669     350 LGNEAvPFS-------TgVFNLAYKYREFKLSDs------------INLLVRCEINGLSKETSG-----------DeeMS 399
6W2T_9       403 IKALNEWDSKLANG--V--EWRRKLDTQRGAVLANELRNNACKLAKWTVQALLAGSDQLKFGYVSRASVRDSSKHVILET 478
XP_001018258 408 VRALNEFDSAA--------QWKTKLLNQKGSVTSTEYINNITLFMKWLIQMKLSGAERLKLAYTSRASPKDTQNHNILCV 479
XP_004030408 382 IRTINEYDHSN--------QWKNKLLTQKGTVTGGEYINNCCNYIKWLIQMEMTGAKMLKLGFTSRVSSKDNTTHDILCV 453
Q5CPM5       400 ARALNEYDPKTVK------TWNTQLETQKGALLATEIRNNACQLTKWATQALLSSCDILKLGYIVRRTPNDRESHQIISV 473 Cryptosporidium...
XP_001614386 412 ICALNEYDIKSHK------NWRSQIENQKGALLANEIRNNTSKLQKFICQALISGCEDIKLGFISRKNANDAENHHILSI 485
Q8IJW4       411 VCALNEYDIKSHK------NWRSQIENQKGALLANEIRNNTSKLQKFISQALLSGCDDVKLGFISRKNANDPDNHHILSI 484 Plasmodium falc...
Q7RGS7       406 ICSLNEYDIKSHK------NWRSQIENQKGALLANEIRNNTYKLHKFICQALLSGCDDIKLGFISRKNANDYENHNILSI 479 Plasmodium yoel...
Q4MYQ4       454 VCALNECPNKNNK------SWRSQIETQKGALLANEIRNNTTKLQRFVACANMAGCGVFKLAYVTRRSPNDAENHSIIGI 527 Theileria parva
EDO07617     408 VCALNELPHKTQK------SWRIQIETQKGALLANEMRNNTAKMQRFAACAIISGCDTLKLAYVSRRSPGDAEHHSIIGI 481
EFC42669     400 LKVLNEYFPAEQNQyhNvaDWKTSMESQKTSIIMAEFKNNSAKMAKWTAQALLSSSKQFKLGFVSRQSPKATKTHLILGT 479
6W2T_9       479 QQYKPNEFATQINLNMDNAWGILRCIIDICMNQKD--GK----YLIMKDPNKPMIRLYD 531
XP_001018258 480 DSFDLQTLTNIIQFKFKDQWQVVKYFIDQILNEKD--GK----YMFVKTAFKQSVKTYl 532
XP_004030408 454 DSFTFEDLFKNIQFRSLDQWQVVKYFIDFICKQPD--GN----YMFVKGAFKQSIRTYE 506
Q5CPM5       474 QSYKTKELSAQMGLKEENAWGIVRALVDLLSEQPE--GQ----YVILRTPVKHVLRVYR 526 Cryptosporidium parvum
XP_001614386 486 QSHKTKDLSTQIGLKYENIWGILRYIVDIISEKPD--GK----YVILKDPLKALLRLYC 538
Q8IJW4       485 QSHKTKDLSTQIGLKYDNMWGIFRFVIDNLADKPN--GN----YVILKDPLKPLLRLYC 537 Plasmodium falciparum 3D7
Q7RGS7       480 QSHKTKDLSTQIGLKYENIWGILKFIVDNISDRSD--GK----YVILKDPLKSLLRLYC 532 Plasmodium yoelii yoelii
Q4MYQ4       528 HTHTTQNLALQMGFSLDNAWGSIKAIVHLVMRRPD--GQ----YVLLKDPMKPIIRLYS 580 Theileria parva
EDO07617     482 HTYTTENLAVQMGLNMRNAWAVVRHICALIMDRPD--GQ----YILVKDPLKANIRFYA 534
EFC42669     480 EKYRPEDFADQLQLHLYNMWGVVKLIIEYVQRYLQenNKqdceFVLLKHPNRDRLDLYE 538
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