Conserved Protein Domain Family
Complex1_LYR_ETFRF1_LYRM5
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cd20265: Complex1_LYR_ETFRF1_LYRM5 
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins
ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.
Links
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Statistics
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PSSM-Id: 380760
Aligned: 38 rows
Threshold Bit Score: 73.7705
Created: 4-Apr-2019
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6IPR1         8 RGEVLKLYKNLLYLGRdYPKGADYFKKRLKNIFLKNkd--------------vkNPEKIKELIAQGEFVMKELEALYFLR 73  human
TCD70237      69 RLRVLALYKELHRLGRdYPDPGYNFHRKLRGLFEKNkd--------------lkDEEEIEKAIKMGEYIRNETLALYSLR 134 Steccherinum oc...
XP_004336029   7 RTAARNLYKQMIWVGRdYPAGLDKLRPGAKRAFFATkd--------------etDPEKIDQAFRRGEYILQELEALVKLH 72  Acanthamoeba ca...
XP_022456600   2 NPKVRQLYKDLLWLAKnYPGDYPKIRDKLHDGFIRNar--------------vsSGEELEKCLEHGEFIAKELQSLYFLR 67  Kuraishia capsu...
XP_001690338  24 DPRIRQLYKRLIFLGRdYPRGLTDARNKLQSAFKRPl----------------aENTSLEQALGRGEYVARELEALVFLA 87  Chlamydomonas r...
PRP81092     105 IVRVPECYAQLIWAGRtYPGGQEFVRRRTKEAFFRQrd--------------emDNTKLDELVKRGEYVAGEVESFGPFH 170 Planoprotosteli...
XP_005702419   2 DYRVRLLYKRFLLVGRqYPEPFGIVREKIKRGFQANst--------------ncDKPSIERALEHGEFVLKEAQALVSLH 67  Galdieria sulph...
XP_002493707   2 HAKVRALYKELIYLAR-FHPNEKKLKDSIKAGFLKNkni------------sseNETELFGALAHGRYMCRELTSLYELQ 68  Komagataella ph...
XP_002181925  49 NPLVRNLYKRIITVGKdYPAGLDHVRVQWKKALRDPnncpacykspatceseqaCQEQLLHAVNRGRYMVKEMIGVIQLK 128 Phaeodactylum t...
PLW43235       8 RHQAVKVYKQLIRLSDhYPDPSYNLAGKTRECFRSTmsqleg------iqdgtlREEELAKSISKAIFIRKEVEALIFLS 81  Puccinia corona...

Q6IPR1        74 KYRAMKQR 81  human
TCD70237     135 KYRHLKRM 142 Steccherinum ochraceum
XP_004336029  73 KYRTLRKQ 80  Acanthamoeba castellanii str. Neff
XP_022456600  68 TYRAVKRN 75  Kuraishia capsulata CBS 1993
XP_001690338  88 KYRALFKR 95  Chlamydomonas reinhardtii
PRP81092     171 KYREMKKR 178 Planoprotostelium fungivorum
XP_005702419  68 KYRTLNKR 75  Galdieria sulphuraria
XP_002493707  69 TYRAVKRK 76  Komagataella phaffii GS115
XP_002181925 129 KYRTLKQR 136 Phaeodactylum tricornutum CCAP 1055/1
PLW43235      82 RYRELKRR 89  Puccinia coronata var. avenae f. sp. avenae
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