Conserved Protein Domain Family
DUF1387

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pfam07139: DUF1387 
Protein of unknown function (DUF1387)
This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.
Statistics
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PSSM-Id: 462100
Aligned: 17 rows
Threshold Bit Score: 269.3
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008112610  94 WTVTGKK-KNKKKKTKPKPSAESSASLHDPSKPVSTEEEQSvassekGGINGYHVNGLT-NDTESVDSLSEGLDTLSIDA 171
XP_005986317  81 WTVTGKK-KNKKKKPKPMPQAEVPGNQTEPSDPVSLDGEQStassekGGINGYHINGSG-NDSESVDSLCEHLDTLSVGD 158
XP_005799009  84 WNVTSKK--KPKKKKKPKPQPEVSSEAPQPEAASPDESKDD-------EMNGFHANGSV-MDGESLDSLSEQLDSASLDA 153
XP_011600994  81 WNVTGKK--KPKKKKKPKPQPEAPAEPAPPEATPPADGKDE--------MNGFHANGSV-MDGESLDSLSEQLDSASLDA 149
XP_004071021  81 WNVTGKK--KPKKKKKPKPQPEPSAEAVQPEAAMSEEGKDE--------INGFHANGSV-MDGESLDSLSEQLDSASLDA 149
XP_003439141  81 WNVTGKK--KPKKKKKPKPQPEAPAEPAPPEATSPEEGKDE--------LNGFHANGSV-MDGESLDSLSEHLDSASLDA 149
XP_001641070  84 WSFQGKKnKNGSSKKKRNKKKLNNKEASKEETTKEGQANYFd----dSSLSNGATSSQAqDETESTEN--LLLDLKSTEA 157
Q86XZ4        81 WTVTGKK-KNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSapssekGGMNGYHVNGAI-NDTESVDSLSEGLETLSIDA 158 human
XP_005989586  60 WNLTGKK-KNYKRKRNKAKHKDMKETPDKSEDQe------------aRGIKSYQVNGCD-VNISLVEPLSGRLETISIEE 125 coelacanth
KAA8591344    81 WNVTGKK--KPKKKKKPKPQPEASAEPAPPEATLPEEGKDE--------VNGFHANGSV-MDVESLDSLSEQLDSASLDA 149 orangethroat da...
XP_008112610 172 RELEESEPTMPEVSHGA--VTLELENGIMDFSPRSatmRSSQNAQSPRVQPEL--KNPGKSFSRPVSSNQSPAPS-SMTI 246
XP_005986317 159 RELEPLESATPETPDTTa-SELESSKPSPDLRSQP---SPPQNSHHSHSSQQH--RNANKSRVQNSSNSRSAATSlDLQM 232
XP_005799009 154 AELDSEPATPETP--------------GVEAESNV---SAPSPAPQQGRRNHHqvSRGNKPRHRTGSNLHPSSSS--LAA 214
XP_011600994 150 AELDSEPASSETT--------------GVEAESQG---SAPSPSLQQGWRNHQg-PRGYKPRHRHGSSSHPPASS-LAPT 210
XP_004071021 150 AELDSEPATSETT--------------GAEAESPG---SAQSPASQQGGRNHQg-PRGNKSRHRLGSNSHPPt---FPTA 208
XP_003439141 150 AELDSEPATSETTG--------------AEAESQG---SAPSPISQPGGRNHQa-PRGNKSRQRPNSNSHHP-PAsLASN 210
XP_001641070 158 VASLAPPSPSSSETSGL--SDLIASHDEFQSSPEHtakLHPSSAQHKNAKKYV-----SKPEQPVTPNNSHH-------- 222
Q86XZ4       159 RELEDPESAMLDTLDRT--GSM-LQNGVSDFETKSltmHSIHNSQQP--------RNAAKSLSRPTTETQFSNMG----- 222 human
XP_005989586 126 KSPVTEEKQEQSNSEIRvnHSLQCDRLVVETGHQLvqdSGAPELSKPAAEQQ---HNPGRPKTRNPVAKTHGPTDqTEVM 202 coelacanth
KAA8591344   150 AELDSEPATSETTG--------------AEAESQD---SIPSPPLQQGGRNHQv-PRGNKNRHRPGSNSHPLTLF-FPPN 210 orangethroat da...
XP_008112610 247 LDEVPVSSG-NKKLGSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELQSCLMDREVALLGEMDKVKAEAM 325
XP_005986317 233 LDDMFLSSGgSKKLGSTIDKSVKDLQRCIVSLTRYRIVIKEEMDASIKKMKRTFAELQSCLMDREVALLTEMDKVKAEAM 312
XP_005799009 215 TFDEQGSSG-GKKMAPNIDRSVKDLQRCTVSLTRYRMVVKEEMDSSIKRMKLTFAELQSCLMDREVTLLAEMDKVKAEAM 293
XP_011600994 211 INEHG--SA-AKKIASNIDRSVKDLQRCTASLTRYRMVIKDEMDSSIKRMKLTFAELQSCLMDREVTLLTEMDKVKLETM 287
XP_004071021 209 TSDDPGSSG-GKKIASNIDRSVKDLQRCTASLTRYRMVVKEEMDSSIKRMKQTFAELQSCLMDREVTLLGEMDKVKAEAM 287
XP_003439141 211 T-DEQGSSG-VKKMASNIDRSVKDLQRCTASLTRYRMVVKEEMDSSVKRMKQTFAELQSCLMDREVTLLGEMDKVKAEAM 288
XP_001641070 223 --------------HETLKKTIKDLSRSTFSLARYNVILEEECESSLKRISSTFNTLRKCLCEREAALVKELEEFKVQSV 288
Q86XZ4       223 MEDVPLATS--KKLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAM 300 human
XP_005989586 203 PEDLR------KK-GPNIEKSVKDLQRCTVSLTRYRMMIKDEMDASVKRIKANFAELQSCIIDREVALMAEMDKVKEEAM 275 coelacanth
KAA8591344   211 T-DEHGSSG-VKKMAPNIDRSVKDLQRCTASLTRYRIVVKEEMDSSIKRMKQTFAELQSSLMDREVTLLGEMDKVKAEAM 288 orangethroat da...
XP_008112610 326 EILSSRQKKAEALKKLTDVAVRMSEEQLVELRADIKHFVSERKYDEDLGRVARFTCDLDALKRSIDSFGQVSHPKNSYST 405
XP_005986317 313 QILDSRQKKAEELKRLTDGALRMSEQQLSELRADIKHFVSERKYDEDLGKAARFTCDLESLMNSVQSFGEVSHPKNSYSN 392
XP_005799009 294 MILDTRQKRAEELKRLTDRSGSMSEEQLTELRADIKHFVSERKYDEDLGKALRFTFDLEPLKTSISRFGSVYHPRTGYSD 373
XP_011600994 288 LTLDTRQKRAEELRRLTDRSASMSEEQLSELRAEIKHFVSERKYDEDLGKAVRFTFDLEPLKSSITGFGSVYHPRTGYSN 367
XP_004071021 288 LILDARQKRAEELRRLTDKSASMSEEQLTELRADIKHFVSERKYDEDLGRALRFTFELEPLKTSISGFGSVYHPRTGYSN 367
XP_003439141 289 MILDARQKRAEELRRLTDKSASMSEEQLTELRADIKHFVSERKYDEDLGKALRFTFDLEPLKTSIGGFGSVYHPRTGYSN 368
XP_001641070 289 HLLEERLEDASALKLKAERAGTMGDEQVVLLRADIKSFVGQRKLDEELAQTTRFVCDEEEMLKVINTYGQVVPIKHNYTP 368
Q86XZ4       301 EILLSRQKKAELLKKMTHVAVQMSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYST 380 human
XP_005989586 276 EILNARQRKAEELRRLADLAIQMSEEQLSQLRAEIKLFVSERKYDEELGRSARFSCDGEQLKTQIQSFGEVSHPKNNYSI 355 coelacanth
KAA8591344   289 GILDSRQKKAEELRRLTDQSASMSEEQLTELRADIKHFVSERKYDEDLGKAVRFTFDLEPLKASILGFGSVYHPHTGYSH 368 orangethroat da...
XP_008112610 406 RSRCS 410
XP_005986317 393 RSRCS 397
XP_005799009 374 RSRCS 378
XP_011600994 368 RSRCS 372
XP_004071021 368 RSRCS 372
XP_003439141 369 RSRCS 373
XP_001641070 369 AVLNH 373
Q86XZ4       381 RSRCS 385 human
XP_005989586 356 RIPCN 360 coelacanth
KAA8591344   369 RSRCS 373 orangethroat darter
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