CDD Conserved Protein Domain Family: InaF-motif

pfam15018: InaF-motif

TRP-interacting helix

This highly conserved motif is thought to be a transmembrane helix that binds to transient receptor potential (TRP) calcium channel. It is known that proline-rich proteins inactivate tannins found in food compounds, and it is putatively thought that PRR24 does too. This is important since tannins often inhibit the uptake of iron. InaF is a protein required for TRP calcium channel function in Drosophila. TRP-related channels have been suggested to mediate store-operated calcium entry, important for Ca2+ homeostasis in a wide variety of cell types. The amino acid sequence of PRR-24 contains two completely conserved Y residues that may be functionally important. This domain family is found in eukaryotes, and is approximately 40 amino acids in length.

XP_002605206 53 GNVERALLVVGYLFSISLVAIPLTVYYGFFWvqEPWV 89 OWR44887 40 KKTVRVLTVIIYVFCVSLAAIMLSLYYVFFW--EPKD 74 EFN87438 51 QKVVRVLTVVAYVIFVSKAAILLSLYYTFVW--NPKD 85 XP_008196322 47 KKVVRVLTVIAYVFFVSLAAIMLSLYYVFLW--NGGQ 81 XP_002605207 42 NKVRRALLVAGYLFVISLAAIVLVIYYSFFW--FGDA 76 XP_002605208 44 NKVGRALLVVGYLFGISAGAIALVVFYSFFW--TGDA 78 EFX87978 37 TSLIRVFTVVAYICSVSIAAAVLSLYYFFIW--DPAT 71 Q6IIF2 92 ERFARYFVIVIYLCGLCSLGFFLSIYHIFFW--DSRM 126 fruit fly EDW51429 34 SKTFRLLTLMLYMGGVSGMGLTLAVYYLFIW--DSRM 68 EFX87977 29 EKLIRLITVIAYFCSVSGAAVMLSLYYIFLW--DPDP 63

Conserved Protein Domain FamilyInaF-motif

Conserved Protein Domain Family
InaF-motif