Conserved Protein Domain Family
B56

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pfam01603: B56 
Protein phosphatase 2A regulatory B subunit (B56 family)
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.
Statistics
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PSSM-Id: 460264
Aligned: 107 rows
Threshold Bit Score: 242.907
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5CQL1       250 SPNEILLLIKKKLIACCITFNFtNN-----TYSNL---KEKKRETLLELVEYI--------NNnd--hIFQEEIIPDVLL 311 Cryptosporidium...
XP_001321072  71 KENEVKDLIVSKCKIAKQNVDL--------SRQDLavyATGKEGYLFDILETL--------QDknfnlPQDPDVYSAIIS 134
EAX89245      99 LNNNTNDLIMRKIEVCNIICDF-SD-----PDSDKk-aKKEKKTALKELLALF--------SNkdncqAVAPPIIDSLFK 163
XP_001325425  92 ITANNLDLLIKKCQQCCVLCDF-SD-----NESDVs-aKPLKTNTLKEIGDAL--------ANss-pdYLTDEAFNAIYG 155
EAY02819      90 FSQKDLDNFAKKCEQCSVLCDF-TD-----TESDVq-aKPAKTATLKEICDVI--------TEss-ivVLTGESIDALFN 153
XP_001317876  97 sDPEFVNTLQKHSQVCNVILDF-TC-----AEFDAe-aKQIKTDSLTQIAALV--------DTeasynTLNPDAVQIILD 161
EAX95490     194 KDPQFGRILEQKLEICKNVYDF-ND-----NGPTAa-dRDIKSRSLCEIVQFF--------ENpnevkKLNEDLQVKIFK 258
XP_001311651  93 NNINPSKVLLDK-------VNYmIEnpvisPLTEFe----RKIETLSSINHLVpriwdgqpSN-------IPRLLDPLFR 154
EAY18052      78 lspaatSHLVEILQYCKTIIDFnNP-----QTMNSr---cKKADYLTRLFNSV--------NNvhvfrNLTDDIRAEIFE 141
XP_001317699  20 lspalaTQFVEALQFCKTIVDFdNP-----QTINMr---sKKADYLTKIFNTV--------NNvhvfrSLDESLRVELFD 83 
Q5CQL1       312 MITSNIFRP---FN-----QChanlNTGnsflqsnnasgnssiqssnsnnngsslngsvgnslsDSKDDEqLLEPSWPHL 383 Cryptosporidium...
XP_001321072 135 LVAFHIFRTvtiLP-----DLwn-sVHDd----------------------------------yYFEMDT-FSDPQWPHR 173
EAX89245     164 MFEVNIYRP---FPsvsekYLaf-dEEP-------------------------------------L-----MSEVSWPHL 197
XP_001325425 156 MITANLTRC---IPsipkkYMwy-dDEP-------------------------------------L-----IFDINWPHL 189
EAY02819     154 MFYANLNRS---IPpvekkYLcy-dDEP-------------------------------------L-----IYEINWPHL 187
XP_001317876 162 IVEHHVFRP---VDqvqpkFLis-dDLA-------------------------------------T-----FTDCSMPHL 195
EAX95490     259 MIKKNIFDQdliFPdplisQSy---VNV-------------------------------------------VIETGWHHL 292
XP_001311651 155 MIKMHIFQP---LPkfspfLLys-eTKV-------------------------------------A-----VSRQFWPAL 188
EAY18052     142 MIKINLIRE---IPpipltIIya-dSRV-------------------------------------P-----LNTNSWLHL 175
XP_001317699  84 MIKVNILRE---IPpipltIIya-dSRI-------------------------------------P-----INTNSWLHL 117
Q5CQL1       384 LVIYEFFLRFVISP-QFSTKVAKKYIDNTFILKLIDLFQSFDPRERDY---LKTILHRIYGKIMPRRSCIRKAMKH---- 455 Cryptosporidium...
XP_001321072 174 VIIYDTAIALFKRS-DFNIEKCKLLATDLFKL-VVYLMRTPNKEEQRK---LTELYVCMIPKLGEFRSFAINVTNS---- 244
EAX89245     198 SLVYDILIQYQTNFpRDPH------FTELFMNKLLSAFDSCDSNERG-------KLITIFTNYSTTNPNLVHKLVEyygh 264
XP_001325425 190 QLVYVILFNTIKLNtTDKR-------LHDMRKTILTIINSADPNERDq---iFQFYMEYLKNFPDQFESLFNDLSY---- 255
EAY02819     188 SIVYNIIKNYQKLVpNDTR-------YHTLRKTLSNLLRSADPNERDf---iLGFFTSYVTNFPDQLDSVMTDFAY---- 253
XP_001317876 196 SLVYGILSKMVTFD---------KTITIDYITRVIDRFWVIDLDERKlladvVTKWAQIQKKESDIKKIVSSKIND---- 262
EAX95490     293 FYCYQILNRFAQLFpESPL------LNMRLIKKIFHLIDIPDNNERLQ---LLSFLRTYYDFHNAERPILLQMTYD---- 359
XP_001311651 189 SIIYKTLAYIIKNTsHQEL---NNYINQDFIKSLMGVLQSPDANESLA---SEDCITEIFDKFLRYQVFIFKSAVS---- 258
EAY18052     176 SLIHRILFSFVSNSeVSQL---QNLLTKEFLTNFVALLESPDPKETAA---VETFVLLVFDSVSGYRQILFQIILR---- 245
XP_001317699 118 STVHRILYSFVSNSeISAL---QNLLTKDFLTRYITLLESPDPKEIQA---VESFILLVFDTVSGYRQIIFQIILR---- 187
Q5CQL1       456 IFLRVIIDGEPYNG------IAELLEIFVSIVNGFTIPLKEEHKIFLETALIPLHKAKYISSFHQQLIYCLIQYIEKDTK 529 Cryptosporidium...
XP_001321072 245 ALARIAFSDENFIA------TKPLLQVMRSHAEGFHTPLKKVHQIFYLDVILPLHKHKHSHYFWQDLVSTVTAFLDKEPN 318
EAX89245     265 VCREYID------GhsysfaLTPALRLFNISLKTAPNNEMEFYYNIILTNIVPLLKKQHVTTILPLLNPIFDFIIPKEPK 338
XP_001325425 256 KLIEYMEgdl-------pfcVTPILRLYHEQLKI--VKLTDYMARFWNTDIIPLISCQHILTVYPPMMDIAETIYTMDPD 326
EAY02819     254 KLVEYHEggl-------pfvVLPILKFFSEQLKL-SKKISPLMEKIWSNSILPLISCQHNATIYPAFLEIVDTMATINPS 325
XP_001317876 263 YLCKQISph----------vLIPCLIVITNLLNL------EEDKYMLQKFLIPLTASPHFVYFNNELFTLIDKICNSDKN 326
EAX95490     360 HLIEYQN------KmlppycVPPLLVFSSHMFTRLNRTFTPEILKLIRNAVFPLIKSPHIYLFGQHLQQLLTSLFTSDPL 433
XP_001311651 259 LLSSFVDGAINHVS------VAPCIRLSHYFLLFNKVDLHSIAF----NVVAPLISCHFSSDYFDDLEKIIMFLCDNDPG 328
EAY18052     246 QILKYQENFALYSC------VAPCLRFLLHFLKAQPLPLKPTFFQMYKTIIFPLMSSQLSSEFFSPFNQLAEFFVQQDPT 319
XP_001317699 188 QLLKYRDNYMLYPC------VAPCLRFLHHFLKAQTLPLKPPFFTLYKTIIFPLISSQMSSEFFGPFNQLAEFFESQDGT 261
Q5CQL1       530 LSVPIIEGVLKYWPITNSSKQILFLNELEELFEITPTNYIEPILIPIFERLASCIQSPHFH-VAERVLYLWNNDIIVNLI 608 Cryptosporidium...
XP_001321072 319 LVFPTYEFIVNVWPRMCTTKQLDFIDEIGILASFVPDEETSKVTKILLPQYCRTIVGVNAW-SSKRALALFDINDFVWLM 397
EAX89245     339 FAEIIVLYIVNHWPVSWPSKQLIFVDFINNTMEKMPLKNFSSICHKVFKLYATCLQSKSYK-VAEASMKVWDNHKLITLI 417
XP_001325425 327 IPKKTLRVMFHHWPESRPSKQISYLILMNFLIEQLNAEDFGYMCVPIFKLYSRLAMSTLHAkVTEATFRIWSNLKILQII 406
EAY02819     326 ITKSTLEIALHHWPESRPSKQISYFYLLNSLAEKLSLEDFSIMCKPLFKTYARCATTSQHAkVVETSFQVWANVKILQMI 405
XP_001317876 327 LYVDVIDFMVNHWPITRPSKLVIFLKKISVMLPKIPLREFKRMRVPVFTRYAEAACSPNYK-VAEAAASIWSEITLEPLI 405
EAX95490     434 IANEFYDYLLTHWQSDNTLIMSAHIEFLIYVCQKMTPEQMMNVSKRTFIILTICLLSTHLR-IINATLFLWLRPKLDQWV 512
XP_001311651 329 LNPFFSQYLIAHFPASDSAKSCLFLDLIARLDVKCPNEAF-------VRLVSDCVMSPNFR-VSLAALQVITRN----FI 396
EAY18052     320 ISTWTLQEMVKHWPKTDTNKECSFISHFTYIAPYIPPNDILESGKIIFSILKQSLESLNFK-TNVAALNVISNRNFIIVF 398
XP_001317699 262 ISTWTLYELVKHWPKTDTNKETAFLSHFSYLAPHLPPKDIESCGLIIFNILKESLDSLNFK-TNISALNVITNKNFLIVF 340
Q5CQL1       609 NEYKYEIYPVLIKALSCnGKKlHWNPTVHGLSFVVNKVLSDTDP----ELFSQ-IIEQYNDDSANIEIQKKEREE---YW 680 Cryptosporidium...
XP_001321072 398 TEVPGDVYPSLIPSLYEcAKI-HWDGDARNLALACLNVLRDNNR----KIFNVvGKA----MKMLENQRIVTDIKramKW 468
EAX89245     418 LDNTRSIYPVIMSPLIFtMKQ-HWNQSTRNCAISAYKQVHNIDP----FVFDEiSNK------LAKKMKTTDGNElikKW 486
XP_001325425 407 TDNTQAIYPVVYPVYQKiMKD-HWRASTKSAALNAMKAMHDLDP----FVFDEiAQS----KKEKTDDDGVSDATihkSW 477
EAY02819     406 MDNTHDVFPIVYPAYQRiMKE-HWKPATKNASLTAIKQMHDLDP----FVFDElTQQ----AKKGSQQEDDTAQKihkGW 476
XP_001317876 406 TDSAKYIFPIMAPSITSaLET-HWSSSVIDTLNRSIESMNKIDS----YLLH-----------EAVKQKPKNDKDlvkTW 469
EAX95490     513 ENDSRHAVTVMYDNVKRlSEL-HWSQSIREKASQVLAEMGKLNR----TAFLK-MRNKNTN--DSRRKRYEIEHQcmkNW 584
XP_001311651 397 QRNP-RAARLLVNNVSKaRS--HWCDMVRDLAQVIYKLLMDADRgamrAAL------------HLNEREAKKGKEkaqIW 461
EAY18052     399 SAFASQLIPLIMNGVNKcSQ--HWNVAVQKSAIDAVRVLVSVLS----DIEKGiDLS------LLEKEAQEKETVlisGW 466
XP_001317699 341 SSFSTKLVPIILKGVDRcST--HWNVVVSKAALDAARVLMSVNH----DVGSRlEIG------RIESERNRAIQSkrrNW 408
Q5CQL1       681 KYIIELA 687 Cryptosporidium parvum
XP_001321072 469 KELIdnf 475
EAX89245     487 ATVAKFS 493
XP_001325425 478 ASIARSA 484
EAY02819     477 ALIARTA 483
XP_001317876 470 ASVSRAA 476
EAX95490     585 AAIAKEA 591
XP_001311651 462 KEIFEKs 468
EAY18052     467 NFVLDEa 473
XP_001317699 409 EVLVEev 415
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