Conserved Protein Domain Family
MAGP
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pfam05507: MAGP 
Microfibril-associated glycoprotein (MAGP)
This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils.
Links
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Statistics
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PSSM-Id: 461667
Aligned: 10 rows
Threshold Bit Score: 145.009
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P27424         1 MRAASLFLLFLPAGLLAQGQydldplppypdhvqyth--------yseqienpdyydypemTPRPPEEQFQFQSQQQVQQ 72  cattle
Q28022         2 TFFGPKVLLLLTALIMSSGR-----------------------------------------TPLGVSGQRGDDVTTVTSE 40  cattle
Q9QZJ6         2 LFLGQKALLLVLAISIPSDW-----------------------------------------LPLGVSGQRGDDV----PE 36  house mouse
2_pfamImport   1 LLLGPKVLLFLTALIISSDW-----------------------------------------TPLGVSGQEG--------R 31 
4_pfamImport   1 LLLGPKVLLFLTVLIVPSEW-----------------------------------------IPLWVNGQRGDDVTQVTQE 39 
Q13361         2 SLLGPKVLLFLAAFIITSDW-----------------------------------------IPLGVNSQRGDDVTQATPE 40  human
XP_012406157   2 LPLGSKLLLCLIALFISSDW-----------------------------------------ILLGINGQRGDETTQ---E 37 
3_pfamImport   1 MRVAYLFLLVLPAGLLAQGQydldplppfpdhvqythysdqidppdyydyqgkglgqlgwgYPRDPREGVD-------PY 73 
XP_005996362   1 MRTVCLFLLYLPALLKAQQQqydldeifyneqaqysqy-----dsqfgnsqynpdfdypdaTLNNLDNTGYSQSQLQVQQ 75 
XP_022267218   2 LLTGPKVLLYLTVLIIPSewtplg-----------------------------------------vsgqrgDDVTPVTPE 40  dog

P27424        73 EVIPAPTL---EPGTVET--------EPTEPGPLD------------CREEQYPCTRLYSIHKPCKQCLNEVCFYSLRRV 129 cattle
Q28022        41 TFTEDPNLv-nDPATDETv------lADIQPSTDDlaslndknttteCRDEKFACTRLYSVHRPIKQCLHQICFTSSRRM 113 cattle
Q9QZJ6        37 TFTDDPNLv-nDPSTDDTa------lADITPSTDDlagdk--nataeCRDEKFACTRLYSVHRPVRQCVHQSCFTSLRRM 107 house mouse
2_pfamImport  32 CVTTGWEIgsnSPPSSHLlfcafsalADIVPSTDDlgeilniqasseCRDEKFACTRLYSVHRPVKQCVHQLCFTSLRRM 111
4_pfamImport  40 TFTDDPNLv-nDPPTDETafs---vlADVEPSIDDlassndkntttgCWSHIL---RVASLNPPRLNCIRKTFFLNLRRM 112
Q13361        41 TFTEDPNLv-nDPATDETvla---vlADIAPSTDDlaslseknttaeCWDEKFTCTRLYSVHRPVKQCIHQLCFTSLRRM 116 human
XP_012406157  38 TFTDDPNLmvnDPPTDDTv------lVDVVPSMDDqaissdknasaeCREEQFPCTRLYSVHRPVKQCIHQLCIVNVRRM 111
3_pfamImport  74 QLLLSPPLltpEPGHPET--------EPTEPGPLD------------CREEQYPCTRLYSIHKPCKQCLHEVCFYSLRRM 133
XP_005996362  76 QIIPAPTT---DGIFDET--------EPTEPGPLD------------CREEQYPCTRLYSVHKPCRQCLKSLCFYSLRRV 132
XP_022267218  41 TFTEDPNLv-nEPSTDETv------lADIEPSTDDl----------dCRDEKFACTRLYSVHRPVKQCIHQLCFTSLRRM 103 dog

P27424       130 YVVNKEICVRTVCAQEELLRADLCRDK 156 cattle
Q28022       114 YVINNEICSRLVCKEHEAMKDELCRQK 140 cattle
Q9QZJ6       108 YIINNEICSRLVCKEHEAMKDELCRQM 134 house mouse
2_pfamImport 112 YIINNEICSRLVCKEHEAMKDEICRQM 138
4_pfamImport 113 YIINNEICSRLVCKEHEAMKDELCRQM 139
Q13361       117 YIVNKEICSRLVCKEHEAMKDELCRQM 143 human
XP_012406157 112 YIINKEICTRLICKEHEVMKDELCRQI 138
3_pfamImport 134 YIINKEICVRTVCAHEELLRADLCRDK 160
XP_005996362 133 YVINKEVCIRTVCAHEELLRADLCRDK 159
XP_022267218 104 YIINNEICSRLVCKEHEVMKDELCRQM 130 dog
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