4OMJ,1AUA,1OIP


Conserved Protein Domain Family
SEC14
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cd00170: SEC14 
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Sec14p-like lipid-binding domain
Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.
Links
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Statistics
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PSSM-Id: 469559
Aligned: 1118 rows
Threshold Bit Score: 49.6401
Created: 1-Nov-2000
Updated: 4-May-2023
Structure
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Program:
Drawing:
Aligned Rows:
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phospholipidsalt bridge
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:phospholipid binding pocket
Evidence:
  • Structure:1AUA: Saccharomyces cerevisiae Sec14p bound n-octyl-beta-D-glucopyranoside, contacts at 4A
    - View structure with Cn3D
  • Comment:required for phospholipid transfer activity
  • Citation:PMID 9461221
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              # # #                                 #    
4OMJ_A         80 PEVIQQy--------lSGGMCGy---------DLDGCPVWYDiigp--ldaKGLLFsa--skQDLLRTKMRECELLLQEC 138  human
1AUA_A         94 YDEKPLiak-----fyPQYYHKt---------DKDGRPVYFEelga--vnlHEMNKvt--seERMLKNLVWEYESVVQYR 155  baker's yeast
XP_001440203  115 VFIAFKk--------kGVIFSLg--------rDKQYRPLIFIqvskistniEQLPPi-----LNAMCVLLNYIQKFMLVP 173  Paramecium te...
SBT33524      304 KEILLK----------ANSFRCg--------fDLNSRPMLYIki------lEKLNMh----eDELFLSLVYHVDMCVNSV 355  Plasmodium ov...
Q55AR6        515 CTHMLEr--------sRFLFQGp--------nDKNDRSVFYLivnr--vkpEVFDNv-----NPLIAHIFKVMDICVNSP 571  Dictyostelium...
XP_006677392 2041 LQEFMRrqaalptkpsVVKYVKeqrvfyesgtSIDGRPVLYFi--------VCKVQpe---sIDMSMLIHVLIEQCANLI 2109 Batrachochytr...
XP_013762086  571 RSAVEAstdm---aaaRFFYKGl--------pNKDGIPTYYLim-----cqLKTMFm-----ADAEALAQFVRETMGADI 629  Thecamonas tr...
XP_051068098 2493 SEEFKHlk------nvNAFYQAg--------iSRLGNPVFYYiarr--yksREYQRve---yPFIICLVSMTLDAYRNKP 2553 Schistosoma h...
CAF1388757   1673 FKSLKAl--------nIFYQAGf--------sKQNNTPVFYYi--------ARRFKvnemncDLLIYHVLLTLKPFQAKP 1728 Adineta ricciae
XP_030848332 1488 EEDFKRlks-----lnIFYQDGi---------SRAGNPVFYYv--------ARKYKcseidfEQLMYHILLTLKPFDKNP 1545 purple sea ur...

Feature 1                                         # #                #   #   #   #  #  # #       #
4OMJ_A        139 AHqttklg---------------rkvetITIIYDCEGLGlkhlwk-paveaYGEFLCMFEENYPETLKRLFVVKAPk-LF 201  human
1AUA_A        156 LPacsraa--------------ghlvetSCTIMDLKGISissay--svmsyVREASYISQNYYPERMGKFYIINAPf-GF 218  baker's yeast
XP_001440203  174 YYve-----------------------kWRIIVDLNDISlfrl----phqiIKQIIDVTQSNYTASLEQLHLLNPPf-FL 225  Paramecium te...
SBT33524      356 DYkkcyvenngtnvsssegkkldesslqLVVVVDCLKFElnnmi---svecIKKIITVFNEFYTDVLYRIYIINVPs-FF 431  Plasmodium ov...
Q55AR6        572 YTlv----------------------vdMSWAHISNDLKkai------fthLPKLAEIFSRKYKKNIDKIFIVHPSa-YT 622  Dictyostelium...
XP_006677392 2110 TKp-------------------------FDLLVDLSFAGrehqw---qletLHTLEKMFPIEARQNLHTIFFLHANt-YF 2160 Batrachochytr...
XP_013762086  630 DAp-------------------------YALVIDMSWVKvtfemkrlmykqLSTFAGIFNRQQKKNSRAIYLIHPSs-FT 683  Thecamonas tr...
XP_051068098 2554 FEvv----------------------idFTHTSVENRFKnd---------lLNKWANIIGPVLREYLVAAYIYNCNs-WV 2601 Schistosoma h...
CAF1388757   1729 FElv----------------------vdFTHTCTDNRFKtd---------yLSKWFICMPDCFYYNLQACYIYNCNs-WV 1776 Adineta ricciae
XP_030848332 1546 FE--------------------------VVLDCTNFGPDnrf------kpqVLSRGVRFPEHVTQNLSAVYVYNCNsrLK 1593 purple sea ur...

Feature 1               #           #                           
4OMJ_A        202 PVAYNLIKPFLSEDTRKKIMVlganwkevLLKHISPDQVPVEYGGT 247  human
1AUA_A        219 STAFRLFKPFLDPVTVSKIFIlgssyqkeLLKQIPAENLPVKFGGK 264  baker's yeast
XP_001440203  226 VAAWKLVEKLMHPETAKKIQFckd--psyLQEYINEDQLMLRYKGT 269  Paramecium tetraurelia
SBT33524      432 KKVWSLFNMFIDNHTLKKIIFinkknismMYDHIDESVMKHIDRNP 477  Plasmodium ovale wallikeri
Q55AR6        623 RAVIYFMSAFTSRKLKRKIHDiyn--wkdLSQYIDIENIALPETSK 666  Dictyostelium discoideum
XP_006677392 2161 KVMAKHAPRLLHSRMAKRTVFcss--ikdLYEFIAKEKLHLPKTTL 2204 Batrachochytrium dendrobatidis JAM81
XP_013762086  684 STVLYFASRFTSAKLRKKIHEiye--weaLHEFIAPSAVALPESSK 727  Thecamonas trahens ATCC 50062
XP_051068098 2602 REYTKIHDRFFSPIKGSRKLVfidh-psrLNEYIEPDQQRLPAGTL 2646 Schistosoma haematobium
CAF1388757   1777 REYTKYHDRILSTIKGSRKLIfldh-isrLSDFIEPDQQKLPGHTL 1821 Adineta ricciae
XP_030848332 1594 EYIKRNERVFVLLKGTRRIIFies--vakLGEYIEPDQQRLHKATL 1637 purple sea urchin

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