5O9Z


Conserved Protein Domain Family
MFAP1
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pfam06991: MFAP1 
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Microfibril-associated/Pre-mRNA processing
MFAP1 was first named for proteins associated with microfibrils which are an important component of the extracellular matrix (ECM) of many tissues. For example, MFAP1 has been shown to be associated with elastin-like fibres at the base of Schlemm's canal endothelium cells, in the juxtacanalicular tissue, and in the uveal region. Based on its role in the ECM and the proximity of the MFAP1 gene to FBN1 it was hypothesized that mutations in MFAP1 contributed to heritable diseases affecting microfibrils, Marfan syndrome but this has now been shown not to be the case. MFAP1 has also been shown to interact directly with certain pre-mRNA processing factor proteins, Prps, which are also spliceosome components and is thus required for pre-mRNA processing. MAFP1 bound to Pr38 of yeast is necessary for cells in vivo to progress from G2 to M phase.
Links
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Statistics
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PSSM-Id: 462060
Aligned: 103 rows
Threshold Bit Score: 120.741
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5O9Z_K                   190 DSEDEME---PRLKPVFIRKKDRVTVQEr-eAEALKQKELEQEAKRMAEE-RRKYTLK---------IVEEETKkeleen 255
EPY50352                 153 EDESDRRrqlLLTAPKFVGKGAKSQTTT-------------GDSSEAAEIdRKQLSQK---------ILEETIQ------ 204
WGS:AAFB:cds.EHI_098310A  31 EEESNEe---EDEEPIFVPMRKEI--------IKKEQIEEKEIKENVFPP-YKQQTQDintneinkkLIQMTIQ------ 92 
KDE02392                 162 EEEELQAr-aPIYKPVFVSKRNRDTLATr--DAALDPSFVEAQREQELQA-RKQQSHD---------LVAQSIV------ 222
EDP43785                 180 ESDE--Mp-aPLPKPIFVSKRDRVTHAS----GPTEHVESTRRGVEEKRI-HRERAHE---------LAAQRIV------ 236
GAC75553                 161 SEDEA-Ap-pPLAKPIFVPKRARTTIAAgtaDTEAAQEDAEAKAEEEAAK-RRQEAHD---------LAAATIK------ 222
EST08318                 147 SEEEESAp-qPLLKPIFVPKRARTTTQP---DPAPSQASVEHAAEALAAQ-RRQEAHD---------LAASTIK------ 206
EIE90947                 163 SSEEEDTl-sRLPKPVFIPKAKRETILEq-eKLAKEREEREKRLEEEMEE-RKKQSHT---------MLADELK------ 224
EPB93130                 175 SSEEEDTi-aSLPKPVFIPKARRETILQq-eKLAKEAEEREKKLEEELEA-RKKQSHD---------MLAEELR------ 236
EXX58906                 181 SEEEEQTs-rKLLKPVFIPKAHRETVLEr-eRMEKLEEEAERKRLQELEE-RKKESHA---------MVEEYVQ------ 242

5O9Z_K                   256 kRSLAALDALNTDDENDE----------EEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEE--ERRAELRANG 323
EPY50352                 205 -REMKQREMENTNELLKDvddtdglnpqGEYEAWQVRSLRRKKRDKEKLLSLEKERMSVEERRLMDPE--EREKLDRREA 281
WGS:AAFB:cds.EHI_098310A  93 -KELEQKENEEST---EEfssgdeyggkDEFEAWQQRELERLKK---EYIEQLNYQHDLEKLKEICSTesQNHEEEK--- 162
KDE02392                 223 -RELAQKEVQAVF---PDvddtdgldpeAEFEAWKLRELMRIKRDKESRYAKEKEREQVEARRAMPEQ--LRLKEDLDYA 296
EDP43785                 237 -RDMQEREHEDSQ---CEvddtdgmdpeAEFAAWRIRELARLERIRQAERMRESQEAEKARRRAMPEH--ERLAEDLAHA 310
GAC75553                 223 -RQLAEKEYQETHA--TDvddtdgldpeAEFEAWRQRELARLQRDREALDEKRKAQAELDAFRALPESekERLGRERAKQ 299
EST08318                 207 -RSLAEAEHADTLR--TDvddtdgldpsAEFEAWRQRELSRLHRDRDALLTLQAEQAEIEAFKSLPEAekERLGRERAAQ 283
EIE90947                 225 -REQEELLAKDLTEHEDMpddtdgldeeAEYEAWKLRELARIKRDREARITREKEEEELERRRALPEE--VRLKEDLERA 301
EPB93130                 237 -REQEEAAHKDTNEYEQSvddtdgldeeAEFNAWKVRELTRIKRDREERIAREKEEEELERRRALPED--VRLKEDLERA 313
EXX58906                 243 -KALQKEVNEDTGL--QEvddtdgldeqAEYEQWKLRELLRIKRDKEERIAREIEREEIERRRNMSEE--QRLKEDMERI 317

5O9Z_K                   324 KVITNKAVKGKYKFLQKYYHRGAFFMD-EDEEVYKR--DFSAPTLEDHF-NKTILPKVMQVKN--FGRSGRTKYTHLVDQ 397
EPY50352                 282 EESRQEKKKKPVQFLQKFYHKGAFYQD--QDIVRNR--DYSEAA-EGEIqHKELLPKAMQVRGntFGLAGQTRWTHLANE 356
WGS:AAFB:cds.EHI_098310A 163 -----KKERKKWKFMQKYYHIGSFFRDgGKWDVSKGnwDFDAATGDDWM-DKSLLPKILQTKD--WGKKGRSKHTNLKEE 234
KDE02392                 297 KKTRDEKKKGSQVFGQKYHHKGAFYA---DAEILTKh-DFTAPTVSTVK-DMSSLPKAMQNKN--FGKMSQSKYTHLADQ 369
EDP43785                 311 RHTRAAKQRGHQGFMQKYYHKGAFFQ---DMDILQR--DYTHSTVDAV--DKSQLPHIMQKRN--FGKRSQSKWTHLAGE 381
GAC75553                 300 QAAEKREQRGNPAFLQKYYHKGSFFQ---DMDILQR--DYTEATSSQV--DVSKLPKMMQVRN--FGAKGRSKWTHLANE 370
EST08318                 284 LQAEKREQKGNPAFLQKYYHKGSFFQ---DMDILKR--DYTEKTSKDV--DVSQLPKMMQVRG--YGVKGRSKWTHLANE 354
EIE90947                 302 KESK-NKEKGQHTFLQKYYHKGAFYHn-PDDEIFQR--DYSAPTVDEVR-NKELLPKVMQVKN--FGLAGRTKYTHLVDQ 374
EPB93130                 314 EASK-NKDRGQHTFMQKYYHKGAFYQ--DDSEVLQR--DYSAPTVDEVR-NKDVLPKIMQVKN--FGLAGRTKYTHLVDQ 385
EXX58906                 318 KKQREEKPKGQYKFLQKYYHKGSFYLk-EDDEILKR--DYTLSTPDEVA-HREILPKVMQVKN--FGRAGQTKWTHLADQ 391

5O9Z_K                   398 DT 399
EPY50352                 357 DT 358
WGS:AAFB:cds.EHI_098310A 235 DT 236
KDE02392                 370 DT 371
EDP43785                 382 DT 383
GAC75553                 371 DT 372
EST08318                 355 DT 356
EIE90947                 375 DT 376
EPB93130                 386 DT 387
EXX58906                 392 DT 393
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