Conserved Protein Domain Family
Med19

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pfam10278: Med19 
Mediator of RNA pol II transcription subunit 19
Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.
Statistics
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PSSM-Id: 287279
Aligned: 6 rows
Threshold Bit Score: 183.879
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q174D3        63 GPFYLMK-EPPGEGELTGATNLMAHYGLEHSYSKFSG-KKVKEQLSSFLPNLPGVIDGPGHL-DNSSLRSVIEKPPIGGK 139 yellow fever mo...
A0JLT2        63 GPFYLMR-ELPGSTELTGSTNLITHYNLEQAYNKFCG-KKVKEKLSNFLPDLPGMIDLPGSH-DNSSLRSLIEKPPILSS 139 human
Q07FY3        72 GPFYILR-ELPGLSDLTGSVNLILHYNLEHSFSKFCG-KKMKEKLSNFLPDLPGMIDTPGAQ-DNSSLRSLIEKPPICGN 148 tropical clawed...
Q9VVL6        50 GPFYSMK-EPPAKAELTGDKDLMTEYGLHHTLTKFKE-KKFKESLASFLQNIPGINDLITHPvENSTLRSVIEKPPIGGK 127 fruit fly
XP_001639559  18 SPFYLLRnEPPTPTDINGSSNLLVQNGLEQSYQKFCG-KKVKENLSAFLPHLPGYIDEKGTP-ENS-LRSVIDKPPIGGK 94 
Q9N4F2        20 EPFYTLKaLLPPYSEIQGNHDLLMSYELGPVEGGFSGsRRVKEKISSFLPHIIGEFHLDATK-EASSLRALIEKPPI-HK 97  Caenorhabditis ...
Q174D3       140 DLLPLTSVQLAGFRLHPGPLPEQYKHL---KSV-PTRKHKNKHKKHKYKEgvaPLS------------EQSALEAsgldt 203 yellow fever mo...
A0JLT2       140 SFNPITGTMLAGFRLHTGPLPEQCRLM---HIQpPKKKNKHKHKQSRTQD---PVP------------PETPSDS----- 196 human
Q07FY3       149 SFTPLTGALLTGFRLHTGPLPEQCRLM---HIQpPKKKNK-KHKQSRTQE---PAP------------PETPSDS----- 204 tropical clawed...
Q9VVL6       128 ELLPLTPVQLAGFRLHPGPLPEQYRTT---YVT-PARKHKNKHKKQKHKDgvtTGQ------------ESTLLDSaglet 191 fruit fly
XP_001639559  95 ELLPLPSHALSGFRLNPGPIPEQFRFM---TQQ-PTKK-KHKHKKHKSQDgerAKSlvdtviatglpgQPSPADSkldgg 169
Q9N4F2        98 EISNLTSSSMQGFKLSAGPVDERYRHLferRKEePNLAYSEKLNLIRVRQ---QYD------------AYGFDDDetekg 162 Caenorhabditis ...
Q174D3       204 hEKKHKKQKrHEDDKERKKRKKEKKRKKQRHSPEHPGSGA 243 yellow fever mosquito
A0JLT2       197 -DHKKKKKK-KEEDPDRKRKKKEKKKKKNRHSPDHPGMGS 234 human
Q07FY3       205 -DHRKKKKKqREDDPERRRKKKDKKKKKSRHSPEHPGAGs 243 tropical clawed frog
Q9VVL6       192 yEKKHKKQKrHEDDKERKKRKKEKKRKKKNQSPE-PGVGL 230 fruit fly
XP_001639559 170 hERKHKKQK-KHDDGERKKKKKDKKKKK-RHTPD--PVGP 205
Q9N4F2       163 fPKKHKKKK---KDKKRKKEKEELGDAEKRKRAADEPMEF 199 Caenorhabditis elegans
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