Conserved Protein Domain Family
DUF4592
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pfam15262: DUF4592 
Domain of unknown function (DUF4592)
This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.
Links
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Statistics
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PSSM-Id: 464602
Aligned: 19 rows
Threshold Bit Score: 92.4817
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005037638  144 PTMKLGPPPPFgLHAKRTDDAGTSSEDDGLPRSPPEMSLLHESLISgMRTRFSDSHKHLSSLSLAGTGSEEEEQITLGSS 223 
XP_015201228   44 HNIKFGQKPTS-TSFRRSDAAEGSSDDEDVPRSPLKVVAQIEAEPVdTEMKDSADLPKNGHTTEASTRTSEVKQDTPVKS 122 
XP_025758974   19 QGIKFGQRPPS---LRRSEGDEGSSDEEEVPRSPLKVLAQVEAEPL------------RTEPKQVQGGQPFGPHSPPVKS 83  
XP_016153505  115 KNIKFGQPPQMtVSARTMGEANASAEDDALLSSPMETETQQDTVISdCSNKSTDTPDFLRKMNFLGPGHEMEEKVTPVKS 194 
XP_010708422   45 KNIKFGQPPQMtISGRTMGEANASVEEDMFLGSLMEIDSQQDTVLSeSGNKSADTPDLLRPMNLPGTG-QMEEKVTPVKS 123 
XP_020957017   19 KNIKFGQHPPSaIPMKKADSGEPRFEEHPFLTCPVESVPEQALVLVdTESKPSETPGTPSPLNLPAARSEMEEKAAPVKP 98  
XP_017202756   38 KNIKFGQRPANaLPVRKADGGEASLEEGPLLPRPMETQTPWDVVLSdTENKAGHTPGSPGAVNPPGGGSDMEEKVAPVKP 117 
XP_005456404  155 QAIKLGSPPSL-MCVKRAEDPATMSEDDGLPCSPPEYTTVH-----------TNQAQANSSISLEGIDSDEDRLSC-AAS 221 
XP_006003940  138 QNIRLGSPPVV-ITTKKLDDTGTLSEDDGLPRSPPEISTLHDVLTC-STSRSSNPVQRHSSLSIGGTDSEDEQMSS-GAS 214 
XP_004940902  127 QNIRLGSPPLV-ITGKKMEDAGTVSEDDGLPRSPPDISTLHEVLTD-SPSKSSNPVQRHSSLSLGGTDSEDEQIPS-EAS 203 

XP_005037638  224 SRSRSTDgqlftrhgststesprtsTDSTISPTANFDTPPELSAFLDNSAAKHKLLIKPRNQRFSRM 290 
XP_015201228  123 PRQRRAV------------------LASGTIESINLDAVPRSASRLDNTAAKHKLAIKPKNQRASKK 171 
XP_025758974   84 PRSKRVL------------------PLTGTIESINLDAVPQSVPRLDNAAAKHKLSVKPKNQRVSRK 132 
XP_016153505  195 ARPKRQF------------------SCSGTIETINLDSVPQALARLDNSAAKHKLSVKPKKQRMSRQ 243 
XP_010708422  124 SRPKRQF------------------SCSGTIETINLDAVPQAVVRLDNSAAKHKLSVKPKKQRMSRK 172 
XP_020957017   99 SRPKRLF------------------SSAGTIESVNLDAIPLAIARLDNSAAKHKLSVKPKNQRVSRK 147 
XP_017202756  118 SRPKRHF------------------SSAGTIESVNLDAIPLAIARLDNSAAKHKLAVKPKNQRVSKK 166 
XP_005456404  222 SRAVSPL-----------------------VVPGDFSQPASPFVCLDNSAAKHKLALRQKARRRPAS 265 
XP_006003940  215 SRPISPVpssvs---------miptLPGNSILPVDFSSAATTLGCLDNTAAKHRIALNPRKQKAFTK 272 
XP_004940902  204 SRPISPSasaav---------gaagSRGSSSLPIDFTIPASPLGCLDTSAARHRIAINPRRQKGFTN 261
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