5N9J,5OQM


Conserved Protein Domain Family
Med10
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pfam09748: Med10 
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Transcription factor subunit Med10 of Mediator complex
Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription. Med10 is part of the middle region of Mediator.
Links
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Statistics
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PSSM-Id: 462879
Aligned: 96 rows
Threshold Bit Score: 89.1028
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5N9J_B        15 ASRLEDTTQAFYDLALIVYNLEDtTPSDAIPESLDTLIRDLKSLPDISR-KVNNLIPQDV-LEYIEQGRNPDVYARQFSE 92  fission yeast
CCD82369      11 EENIESIIDHCREAGIVVCDYQP---SVSFQKKINDLVYKLQDVDRMQVeMQDVHVPIEL-FSKIDAGQNPQLYTRECME 86 
XP_009024289  10 EQQLEMFIENTRQIGISVADMQP-QGQAVLNQKLHQLVIGLQEIDKLRSlVQDVQIPSDV-FEYIDEGKNPQLYTKDCME 87 
OWR41152       9 ETQLEMFIENVRQIRIIVSDFQP-QGQSVLNQKIQSLVTGLQEVDKLKAqVHDIHVPTEV-FDYIDQGRNPQLYTKDCID 86 
EDW30434       9 ETQLEMFIENVRQIRIIVSDFQP-QGQNVLNQKINSLVTGLQEIDKLRNqVQDVYVPFEVfFDYIDQDKNPQLYTKDCVE 87 
XP_006001826   9 EEHLEKFVENIRQLGIIVSDFQP-SSQTGLNQKLNFMVTGLQDIDKCRQqLHDINVPLEV-FEYIDQGRNPQLYTKECLE 86 
KJE90562      23 EEQLEEFVETLRQVGIVATSFQS-ESQPVLNAKLGSLVSQMQALDELRQ-AVDIDIPLDL-LRYVDDDMNPQVFTNDVVL 99 
XP_001639313  15 EQTIEQFVETTRQIGIIVSDFQP-GSQGVLNQKINMMVDNLREIEKCKAhVADVEVPLEV-FEYIDQGRNPQLYTKDCLE 92 
XP_002112039  15 QQQIEQLCETSRQVGIIASDFQA-TSQKVLNDKLRGLITNLREINDMKEkFDDIEVPLEV-FSYIDEGRNPELYTKACLD 92 
XP_003287426  35 lQTVEELVEELRRTIIVVEEFQS-QSQQLLFDKLNKIINLYEKIESNRNlFNDVEIPLEI-FRVIDQSKNPDLYVKETLQ 112

5N9J_B        93 LvqkdnqyvngkLYAIEGFQKAFAEEIKQAYPEVSSVVDK 132 fission yeast
CCD82369      87 QalakneavrgkLDSLRRFRVLLMSELSRQFPNEMAKYRA 126
XP_009024289  88 KslakneeikgkIEALKKFKSLLVVELSKVFPNEMAKYRQ 127
OWR41152      87 KalakneevkgkIDSYKRFKSHLLSELSKTFPNEIAKYKA 126
EDW30434      88 KalakneevkgkIESLKKFKSNLLLELYKTFPNEMNSYRA 127
XP_006001826  87 RalakneqvkgkIDTMKKFKSLLIQELSKVFPEDMAKYKA 126
KJE90562     100 EavqknrtasatVDMFQKFKTLLESELATTMPEDFALYQq 139
XP_001639313  93 KalvkneqvkgkIDAYKNFKSLLVDELSKVLPKDMKEYNK 132
XP_002112039  93 KvvmmnqemkgkVDAYKNFKTTLCEGLAKVFPKEMEAYle 132
XP_003287426 113 NclaanektkgkIESIKNFKSELESHISESFKEEYEQYKl 152
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