Conserved Protein Domain Family
Vma12

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pfam11712: Vma12 
Endoplasmic reticulum-based factor for assembly of V-ATPase
The yeast vacuolar proton-translocating ATPase (V-ATPase) is the best characterized member of the V-ATPase family. A total of thirteen genes are required for encoding the subunits of the enzyme complex itself and an additional three for providing factors necessary for the assembly of the whole. Vma12 is one of these latter, all three of which are localized to the endoplasmic reticulum.
Statistics
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PSSM-Id: 463329
Aligned: 91 rows
Threshold Bit Score: 58.4024
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAA85329      69 SLLRGT--KVYVPPPPKKPEpvstylspthpptlytnkinkpdikkSPE------------------------------- 115
EGF83862      71 RLIKGSriEFVCPKPre----------------------------iTPE------------------------------- 91 
ELV12086      78 ELLEGS--EIYLPEVVKPPR--------------------------NPE------------------------------- 98 
Q19259        16 DLVAGSkeKI------------------------------------TPEvsksckefykkdvvsykdlvniktklpdgip 59  Caenorhabditis ...
EEB20463     283 ELMKGS--DVILPKNEVVER--------------------------NPD------------------------------- 303
EGK96271     152 ALLAGC--RLKLPENPICKR--------------------------NPE------------------------------- 172
XP_002013492 149 ELIESS--DLVLPENEMKPR--------------------------NPD------------------------------- 169
XP_008205783  80 QLLEGV--DIILPEPKVTPR--------------------------NPE------------------------------- 100
EFN73800       6 ELFNDC--DVILPIPKESPR--------------------------NPE------------------------------- 26 
XP_022623343  69 ELLEDS--SLHLPEVVKPPR--------------------------NPE------------------------------- 89  greater amberjack
GAA85329     116 ----------------------YLALKARLLAAAETDAYNRMTSSfssssffppssrtpastkpsiftsstptlealhnk 173
EGF83862      92 ----------------------YIKFMEKVKIKLENKEYEDIVGKmphgksrdalgsi---------------------- 127
ELV12086      99 ----------------------LVARLEKIKIQLANEEYKRITRNvtcqdpr---------------------------- 128
Q19259        60 vfvffdrltlrredhtyhasveFRKKTEELRIQQEQDSYKRLIRDvdpvqkygktdhm---------------------- 117 Caenorhabditis ...
EEB20463     304 ----------------------LLKRIEKLKKEQEEREYKAMTQNvnldkkhfpeds----------------------- 338
EGK96271     173 ----------------------LEARCQRLRKEQEDREYHRMTKNvdsirkhmpeet----------------------- 207
XP_002013492 170 ----------------------LEARCERLRAEQHNREYHKMTKNvdaglkhypedt----------------------- 204
XP_008205783 101 ----------------------LEARIKKLQAQQDARDYQAMTKGvdnfrkhipedt----------------------- 135
EFN73800      27 ----------------------LEARIQKLKAQQNAREYQTMTKNidsmrkflpeds----------------------- 61 
XP_022623343  90 ----------------------LVARLEKIKAKLANEEYNRITRNvntqeinrngtla---------------------- 125 greater amberjack
GAA85329     174 hnpkndddNgTDPLT--------------PGLVLNIFLSVLITGFSVYWALRSFrspemlvstvarvwrgkgtgqgvSES 239
EGF83862     128 ----------------sgdlvelrkvsgqMMSLLNIFISMAAVFTALYIFAERLw---------------------eDQG 170
ELV12086     129 --hsgtlsDlGKQVFfpgvlskvrsvkalVVTIFNFIVTVVAAFVCTYLGSQYVf---------------------tEMA 185
Q19259       118 ----------------enfgvemravnrqMISVINVVITVVGSFFFGFSGITYAyph-----------------lnlDLP 164 Caenorhabditis ...
EEB20463     339 ------------------vsyqmnmmnrhLIAVGQLLVSVGAGFAFGFLGVELIvg-------------------nlNFG 381
EGK96271     208 ------------------isyqmkqinrhLIAVAQFLFSVAAGFAFGFIGIELLig-------------------qlDFG 250
XP_002013492 205 ------------------iayqikslnkqIIAVLQFVFSVAAGFTFGFFGVNLMvg-------------------plPFG 247
XP_008205783 136 ------------------iafqmklmnkqLIAVAQFVFSVMAGFAFGFIGVELIvg-------------------nlDFG 178
EFN73800      62 ------------------iayqmkqinkqLIAVAQFIISVITGFVFGFIGIELMvg-------------------nlDFG 104
XP_022623343 126 -----------------dfgrevrsvkavVVTVFNFLVTVVAAFACSYMGSQYLf---------------------tETT 167 greater amberjack
GAA85329     240 VKVLVSLGAAVVVGVAEVMIYAIYLRKVEV 269
EGF83862     171 FRVLFGLFGALVVGFAEGWFYTRDWLMDEv 200
ELV12086     186 SRVLAALIVASVVGLAELYVMVRAVEgelg 215
Q19259       165 TRFIFGLVPATIVFFCDLYFVVKGMDMGES 194 Caenorhabditis elegans
EEB20463     382 IRLLLGIACALIIAVAEFYFLAKHLNEEDK 411
EGK96271     251 FRLLLGIIIALIIALAEIYFLAKKLNEEye 280
XP_002013492 248 FRILLGVIVALIIALAEMYFLAKKLHEYDe 277
XP_008205783 179 FRLLLGVICSIVIALAEIYFLAKKLSEDye 208
EFN73800     105 FRLLLGIICALIIALAEIYFLAVKLSETdt 134
XP_022623343 168 ARVISAVIAASVVGLAELYVLVRTMEGelg 197 greater amberjack
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