Conserved Protein Domain Family
Mlf1IP

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pfam10248: Mlf1IP 
Myelodysplasia-myeloid leukemia factor 1-interacting protein
This entry is the conserved central region of a group of proteins that are putative transcriptional repressors. The structure contains a putative 14-3-3 binding motif involved in the subcellular localization of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions.
Statistics
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PSSM-Id: 463022
Aligned: 27 rows
Threshold Bit Score: 125.155
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q566M7        28 MRHMFsGDYGv------SPF---------------------LSLT-DGSVrglPRPApsr-----tiqQGAVTPYG---- 70  tropical clawed...
EFX89103      24 MDSMM-NSMM-------DPFas------------------mMSMHhQMMGiqpPPQQhh--------pAGAMVPFGgmp- 68 
NP_001246355  36 MNRLM-NSFMp------DPF-------------------------------------------------MQVSPFDqg-- 57 
5_pfamImport   1 MNNLM-SSFFr------DPFsdmmfggnggrsggmlgiggpL--------------------------GGDLLPFT---- 43 
XP_796343     31 MGSMFpQQFM-------------------------------PSIEaRGVRrppQPFRpnp-----annPMAMAPFGm--- 71 
EKC37456      23 MRNMD-RLFQ-------DPFgmf---------------gghPMLQgPGRSdpqRGTRava-----qwnPAEMSPFGf--- 71 
2_pfamImport   1 MDQMM-NQMM-------DPFgvfgmap-------rhpfmasNALE-DGMQr-sRGSAvafp----rqeMMMRDPFGfggf 59 
XP_002124907   2 FRNMF-KEFEe------DPFfnefstrfp----khddfgfrFAIEdDKRDhrrRSKAn----------DEVMDPFQg--- 57 
XP_002610805  34 MDQMF-SGFGmarapfhDPF---------------------LSIT-DGRGhrgQRNQghggeldmyrhRRPGDPFSm--- 87 
XP_015193410  25 MRSLF-GSFGf------DPFpl------------------sPQIQ-PSRT---PQIQa----------AGALSPFG---- 61  spotted gar
Q566M7        71 --MMG--MgggFMDMFGM-MND-----LVGNMEQM-T----SGSN-CQT--FSS----STVISYSNMpGGNT-PKVYQET 127 tropical clawed...
EFX89103      69 gfPMG--MgmsPFGMPS--VGQ-----MFQSF---------GQPGfGASpmYSS----SSVMTMTTG-PDGQ-PQVYQAS 124
NP_001246355  58 -fQQN--AlmeRPQMPAMpAMGlfgmpMMPNFNRLlNa--dIGGNsGAS--FCQ----STVMTMSSG-PDGR-PQIYQAS 124
5_pfamImport  44 ---------------GGRhLQSpvammLSGGFPSI------LDPM-GSTgtGSHvsamSTVMTMTQG-PDGR-PQVYQAS 99 
XP_796343     72 --MGG--MgsmFANMNSM-MGN-----MQSHMERV-A----SDPN-SHC--YSS----SSVMSYSNT-GNGA-PQYYQAS 127
EKC37456      72 --GNM--FgsmFMNMNGM-MSN-----MERSFETA-R----NDPN-AQM--FSQ----SSVYSYTNTgGEGSrPRVYQAT 129
2_pfamImport  60 gaFGG--MpdiFAQRRPRrVFGip--rIFREMNGM-AqaamNDPN-GTV--YSS----STMISMDGS-G-RA-PRIVETS 124
XP_002124907  58 ----------mFRHMNKA-IEE-----MHSGMEKM-K----NDPN-VHM--YSS----CSTMSYMND-GKSK-PKIYQAA 107
XP_002610805  88 --MDQ--M---MSNMHSM-MGN-----MHRNFQHM-AqgaqNDPN-CYS--YSS----SNFYSYSNT-GNGP-PKVYQAS 144
XP_015193410  62 --MMGmgAgggFMDMFGM-MSG-----MMENMERM-S----GS----QM--YSS----STVISYSSS-GSGA-PKVYQQT 116 spotted gar
Q566M7       128 TQTRMAPGGIRETRRAVRDSNSGMEQMSIGHHIRDRSHIVQRSHNRRTGDQEERQEFINMDENDAASFDEEWSRQ 202 tropical clawed frog
EFX89103     125 TTTRTAPGGVREVQRSVSDSRSGVRKMAVGRHLGERGHVVEKEQNCYTGDSEEREDFINIEEEEAHQFDEEWRRR 199
NP_001246355 125 TSTKTGPGGVRETRRTVQDSRTGVKKMAIGHHIGERAHIIEKEQDMRSGQLEERQEFINLEEGEAEQFDREFTSR 199
5_pfamImport 100 QSVRQGPGGIRETKKTVADSRTGVKKMSIGRHVYDRGHIIEREQNVYSGEREENEEFINMDEEEADDFNKEWESR 174
XP_796343    128 SSTRQAPGGIRETRKTVRDSAQGIEKMAIGHHINDRGHVIEKSKNTRTGDQEEKQDFLNIDESDAPTFDNEWKQK 202
EKC37456     130 SSVRQGPGGVKETRKSERDSERGTEKMAIGHHIRDRAHVVERTR-RRGGDIEENQELINLDEGEKESFDREFQEK 203
2_pfamImport 125 TRR---SGDVKETRRRVQNGDE--EEMVIGHTIGDREHILEKKRD-KDGNVRNQQRFRNLDQAEAEAFDREFKTR 193
XP_002124907 108 SSTRQAPGAIKETHRAVRDSETGVEKMAVGQHIGPRGRIVEKRK-QKGGQVEEERKFLDMEEKDTSDFEREWKLK 181
XP_002610805 145 SSTRNAPGGVKETRRTVRDSEAGLQKMAIGHHLGERAHIVERSRDRHG--EEEKQDYINLDESDKDSFNQEWQQR 217
XP_015193410 117 SEMRAAPGGIRETLQTIRDSESGLERMSIGHHIRDRGHVMERSRNRKTGDREERQDFINLEESEAAAFDEEWRRE 191 spotted gar
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