1NLW


Conserved Protein Domain Family
bHLHzip_Mad1
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cd18931: bHLHzip_Mad1 
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basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max-associated protein 1 (Mad1) and similar proteins
Mad1, also termed Max dimerization protein 1 (MXD1), or Max dimerizer 1, or protein MAD, is a bHLHZip transcriptional repressor that binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. It thus antagonizes MYC transcriptional activity by competing for MAX.
Links
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Statistics
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PSSM-Id: 381501
Aligned: 7 rows
Threshold Bit Score: 108.167
Created: 12-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:1NLW; Homo sapiens Mad transcription factor basic region binds the DNA, contacts at 4.0 A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ##  ## ##   #                  ###                                          
1NLW_A         1 SRSTHNEMEKNRRAHLRLSLEKLKGLVPLGPDSSRHTTLSLLTKAKLHIKKLEDSDRKAVHQIDQLQREQRHLKRQLEKL 80  human
NP_001034399  90 GRSTHNEMEKNRRAHLRLCLEKLKVLVPLGPESSKHTTLSLLMKAKLHIKKLEDYDRRALHQIEQLQREQRHLKRQLEKL 169 chicken
XP_698607     55 SRSTHNEMEKNRRAHLRLCLERLKSLVPLGPESNRHTTLSLLMRAKEHIKRLEDSERKAQHTIDQLQREQRHLRRRLEQL 134 zebrafish
Q0VH34        56 SRSTHNEMEKNRRAHLRLCLEKLKMLVPLGPESNRHTTLSLLMRAKLHIKKLEDCDKRSVHQIEQLQREQRHLTRQLEKF 135 African clawed ...
Q05195        57 SRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKL 136 human
XP_007905682  94 NRSMHNEMEKNRRAHLRLCLERLKELVPLGPETAKHTTLSLLMRAKLHIKKLEESDRRAVHQIDQLQREQRHLKRQLELL 173 elephant shark
XP_005988267  59 SRSTHNEMEKNRRAHLRLCLEKLKMLIPLGPESNRHTTLSLLTKAKLHIKKLEENDKKAVHQIDHLQREQRHLKRRLEQL 138 coelacanth

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