1GSZ,1W6K


Conserved Protein Domain Family
squalene_cyclas

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TIGR01787: squalene_cyclas 
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squalene/oxidosqualene cyclases
This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Statistics
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PSSM-Id: 273809
Aligned: 8 rows
Threshold Bit Score: 855.97
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GSZ_A        14 TLDRAVEYLLSCQKDEGYWWGPLLSNVTMEAEYVLLCHILD---RVDR-DRMEKIRRYLLHEQREDGTWALYPGGPPDLD 89  Alicyclobacillu...
AAA91023      77 GALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAH---IPLPaGYREEMVRYLRSVQLPNGGWGLHIEDKSTVF 153 Norway rat
Q10231        73 SAEYGYEFFRRLQLPDGHWASPYEGPMFLICGAVFAFYISQ---TPFPkGWAPEIIQYLINHTNDDGGWGIHTEGVSTVF 149 Schizosaccharom...
BAA25185      14 TLDRAVEYLLSCQKDEGYWWGPLLSNVTMEAEYVLLCHILD---RVDR-DRMEKIRRYLLHEQREDGTWALYPGGPPDLD 89  Alicyclobacillu...
CAA71098      27 AIRQAKDRLLSLQHLEGYWVFELEADCTIPAEYILMMHFMDeidAAL----QAKIANYLRHHQSADGSYPLFRGGAGDIS 102 Methylococcus c...
WP_010994949  15 AIAASQKYLLSLQNPAGYWWAELESNVTITAEVVLLHKIWG---TDKT-RPLHKVEAYLRSQQKQHGGWELFYGDGGELS 90  Nostoc sp. PCC ...
BAA33461      99 TLRRAVHFFSALQASDGHWPAENSGPLFFLPPLVMCVYITGhldTVFPaEHRKEILRYIYCHQNEDGGWGLHIEGHSTMF 178 Panax ginseng
1W6K_A        76 GALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVAR---IPLPaGYREEIVRYLRSVQLPDGGWGLHIEDKSTVF 152 human
1GSZ_A        90 TTIEAYVALKYIGMSR---DEEPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWEKVPMVPPEIMFLGK-RmpLNIYE 165 Alicyclobacillu...
AAA91023     154 GTALSYVSLRILGIGP---DDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPE-W--FPAHP 227 Norway rat
Q10231       150 GTSMNYVVLRILGMDA---GHPVATRARNRLHELGGAIGCPHWGKFWLATLNCYDWDGVNPIPPELWLLPD-W--IPFHP 223 Schizosaccharom...
BAA25185      90 TTIEAYVALKYIGMSR---DEEPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWEKVPMVPPEIMFLGKrMp-LNIYE 165 Alicyclobacillu...
CAA71098     103 CTVKVYYALKLAGDSI---DAPHMKKAREWILAQGGAARSNVFTRIMLAMFEQIPWRGIPFTPVEIMLLPK-W--FPFHL 176 Methylococcus c...
WP_010994949  91 TSVEAYMALKLLGVPA---TDPAMIQARDFILQRGGISKTRIFTKFHLALIGCYNWRGLPSLPAWVMLLPNqFp-VNIYE 166 Nostoc sp. PCC ...
BAA33461     179 CTTLSYICMRILGEGPdggVNNACARGRKWILDHGSVTAIPSWGKTWLSILGVYEWIGSNPMPPEFWILPS-F--LPMHP 255 Panax ginseng
1W6K_A       153 GTALNYVSLRILGVGP---DDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPD-W--APAHP 226 human
1GSZ_A       166 FGS--WARATVVALS--IvmsrqpV----F----PLPERARVP----------ELYETd-VPP--R--RRGAKGGGG--- 215 Alicyclobacillu...
AAA91023     228 STL--WCHCRQVYLP--M------S----Y----CYATRLSASedplvqslrqELYVEdyASIdwP--AQKNNVCPDdmy 287 Norway rat
Q10231       224 GKW--WCHVRLVYLP--M------G----Y----MYGERLKCPkdslimqlrkELYVEnyDSInfA--DHRNTISDVdly 283 Schizosaccharom...
BAA25185     166 FGS--WARATVVALSivM------SrqpvF----PLPERARVP----------ELYET--DVP------PRRRGAKGggg 215 Alicyclobacillu...
CAA71098     177 DKVsyWSRTVMVPLF--Il----cS----H----KVTARNPSRihv-----reLFTVEp---Q------------KErhy 222 Methylococcus c...
WP_010994949 167 MSS--WARSSTVPLL--I------V----FdqkpVYQVNPTITl--------dELYAEg---V--E--NVRYELPRSgdw 217 Nostoc sp. PCC ...
BAA33461     256 AKM--WCYCRMVYMP--M------S----Y----LYGKRFVGPitplilqlreELYGQpyNEInwR--KTRRVCAKEdiy 315 Panax ginseng
1W6K_A       227 STL--WCHCRQVYLP--M------S----Y----CYAVRLSAAedplvqslrqELYVEdfASI--DwlAQRNNVAPDely 286 human
1GSZ_A       216 W-IFDA--LDRALHGYQKlSVHPF------RRaAEIRALDWLLERQAG-----DG------SWGGIQppWFY--ALIALK 273 Alicyclobacillu...
AAA91023     288 T-PHSW--LLHVVYGLLN-LYERFh-----STsLRKWAIQLLYEHVAA-----DDrftkciSIGPIS--KTV--NMLIRW 349 Norway rat
Q10231       284 F-PHTQ--ILDRLNWILEk-YFTYl----rPSwLKKLGTRRAYELIKI-----EDqntdysCIGPVN--AAM--NTVCVY 346 Schizosaccharom...
BAA25185     216 W-IFDA--LDRALHGYQKlSVHPFr-----RA-AEIRALDWLLERQAG-----DG------SWGGIQppWFY--ALIALK 273 Alicyclobacillu...
CAA71098     223 F-DHVKtpLGKAILALER-FGRmle--pliPKaVRKKATQKAFDWFTArlngvDG-------LGAIF--PAMvnAYEALD 289 Methylococcus c...
WP_010994949 218 TdLFLT--LDEGFKLAES-FNF-Ip----fREeGIKAAEKWIIERQEA-----TG------DWGGII--PAMlnSMLALR 276 Nostoc sp. PCC ...
BAA33461     316 Y-PHPL--IQDLLWDSLYvLTEPLltrwpfNK-LREKALQTTMKHIHY-----EDensryiTIGCVE--KVL--CMLVCW 382 Panax ginseng
1W6K_A       287 T-PHSW--LLRVVYALLNlYEHHh------SAhLRQRAVQKLYEHIVA-----DDrftksiSIGPIS--KTI--NMLVRW 348 human
1GSZ_A       274 ILD-Mt-QH-PAFiKGWEGLELYGVELDYGGWMFQAS-ISP-VWDTGLAVLAL----RAAg---LPADHDRLVKAGEWLL 341 Alicyclobacillu...
AAA91023     350 SVD-Gp-SS-PAF-QEHVSRIKDYLWLGLDGMKMQGTnGSQ-TWDTSFAVQAL----LEAgahrRPEFLPCLQKAHEFLR 420 Norway rat
Q10231       347 FHE-Gp-SS-KAF-QKHIQRLHDFMWVQPEGMLMRGTnGLQ-VWETSFTLQAL----VESglyeKEAFKPDIAKALEFLD 417 Schizosaccharom...
BAA25185     274 ILD-Mt-QHpAFI-KGWEGLELYGVELDYGGWMFQAS--ISpVWDTGLAVLAL----RAAg---LPADHDRLVKAGEWLL 341 Alicyclobacillu...
CAA71098     290 FLGvPp-DD-ERR-RLARESIDRLLVFQGDSVYCQPC-VSP-IWDTALTSLTLqevaRHTadlrLD---AALSKGLKWLA 361 Methylococcus c...
WP_010994949 277 SLG-YdtND-PIV-ERGLQALDNFAIETVDCYRVQPC-VSP-VWDTAWVIRAL----IDSgi-aPD--HPAIVKAGEWLL 344 Nostoc sp. PCC ...
BAA33461     383 VED-P--NG-DYF-RKHLARIPDYIWVAEDGMKMQSF-GSQ-EWDTGFSIQAL----LDSd--lTHEIGPTLMKGHDFIK 449 Panax ginseng
1W6K_A       349 YVD-Gp-AS-TAF-QEHVSRIPDYLWMGLDGMKMQGTnGSQ-IWDTAFAIQAL----LEAgghhRPEFSSCLQKAHEFLR 419 human
1GSZ_A       342 DRQITV--PGDWA-VKRPNLKpGGFAFQFDNVYYpDVDDTAVVVWALNTLRLP-----D------ERRRRDAMTKGFRWI 407 Alicyclobacillu...
AAA91023     421 LSQVPDnnPDYQK-YYRHMHK-GGFPFSTLDCGW-IVADCTAEALKAVLLLQE-----Rcps-itEHVPRERLYDAVAVL 491 Norway rat
Q10231       418 RQQIRTq-YEGSG--YRYNSL-GAWPFSNITQGY-TVSDTTSEALRAVLLVQSl----Pdfe---klVDIPRLRLSVDVI 485 Schizosaccharom...
BAA25185     342 DRQITVp--GDWA-VKRPNLKpGGFAFQFDNVYYpDVDDTAVVVWALNTLRLPd-----------ERRRRDAMTKGFRWI 407 Alicyclobacillu...
CAA71098     362 SKQIDKdaPGDWR-VNRAGLEgGGWAFQFGNDYYpDVDDSAVVA--HALLGSE------------DPSFDDNLRRAANWI 426 Methylococcus c...
WP_010994949 345 QKQILd--YGDWN-VKNRQGKpGAWAFEFENRFYpDVDDTAVVVMALHAAKLPn-----------EQLKQKACDRALQWV 410 Nostoc sp. PCC ...
BAA33461     450 KSQVKDnpSGDFKsMYRHISK-GSWTFSDQDHGW-QVSDCTAEGLKCCLIFST-----MpeeivgKKIKPERLYDSVNVL 522 Panax ginseng
1W6K_A       420 LSQVPDnpPDYQK-YYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcphvT------EHIPRERLCDAVAVL 490 human
1GSZ_A       408 VGMQSSNGGWGAYDVDNT----SDLPNHIPFCD--F--GEvtDPP--SEDVTAHVLECFGSF-----G-----Y--DDAW 465 Alicyclobacillu...
AAA91023     492 LSMRNSDGGFATYETKRGgyllELLNPSEVFGD--I--MI--DYT--YVECTSAVMQALRHF-----ReyfpdHraTEIR 558 Norway rat
Q10231       486 LGMQNENLGFASYEPARTgewmELLNPAEVFGN--I--MV--EYS--YPECTTSVILALRAF-----TkydpgYrrDEIE 552 Schizosaccharom...
BAA25185     408 VGMQSSNGGWGAYDVDNt----SDLPNHIPFCD--F--GE--VTDppSEDVTAHVLECFGSF-----Gy-------DDAW 465 Alicyclobacillu...
CAA71098     427 AGMQSRNGGFGAFDADNTyyylNSI-P---FADhgA--LL--DPP--TADVSARCAMFLARW-----V-----NrqPELR 486 Methylococcus c...
WP_010994949 411 ASMQCKPGGWAAFDLDNDqdwlNSV-P---YGD--LkaMI--DPN--TADVTARVIEMLGAC-----N--------LSID 467 Nostoc sp. PCC ...
BAA33461     523 LSLQRKNGGLSAWEPAGAqewlELLNPTEFFAD--I--VI--EHE--YVECTSSAIQALVLF-----KklypgHrkKEID 589 Panax ginseng
1W6K_A       491 LNMRNPDGGFATYETKRGghllELLNPSEVFGD--I--MI--DYT--YVECTSAVMQALKYFhkrfpE-----HraAEIR 557 human
1GSZ_A       466 -KVIRRAVEYLKREQKPDGSWFGRWGVNYLYGTGAVVSALKAVG-IDT--RE----PYIQKALDWVEQHQNPDGGWGEDC 537 Alicyclobacillu...
AAA91023     559 -ETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMG-HIYqnRTa--cAEVAQACHFLLSRQMADGGWGEDF 634 Norway rat
Q10231       553 -NTIENALEYVVKMQRPDGSWYGSWAICFTYAAMFATGSLASAG-RYY--ENc---PVQKKACEFLLSKQRPDGGWSESY 625 Schizosaccharom...
BAA25185     466 -KVIRRAVEYLKREQKPDGSWFGRWGVNYLYGTGAVVSALKAVG-IDT--RE----PYIQKALDWVEQHQNPDGGWGEDC 537 Alicyclobacillu...
CAA71098     487 -PVLERTIDYLRREQEADGSWFGRWGTNYIYGPGAVL--LAYEG-RRV--PNd--dPSVRRAVAWLKSIQREDGGWGEDN 558 Methylococcus c...
WP_010994949 468 sHNLERALTYLLNEQEAEGCWFGRWGVNYIYGTSGVLSALALINpQKY--Q-----RHIQQGATWLVGCQNPDGGWGETC 540 Nostoc sp. PCC ...
BAA33461     590 -NFITNAVRYLEDTQMPDGSWYGNWGVCFTYGSWFALGGLAAAG-KTY--YNc---AAVRKAVEFLLKSQMDDGGWGESY 662 Panax ginseng
1W6K_A       558 -ETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG-QTY--RDgtacAEVSRACDFLLSRQMADGGWGEDF 633 human
1GSZ_A       538 RSYEDPAYAG-KGA-STPSQTAWALMALIAGGRAESe----AARRGVQYLVETQRPDGGWDEPYYTGTGFpGDFYLGYTM 611 Alicyclobacillu...
AAA91023     635 ESCEQRRYVQ-SAG-SQVHSTCWALLGLMAVRHPDIs----AQERGIRCLLGKQLPNGDWPQENISGVFN-KSCAISYTN 707 Norway rat
Q10231       626 MACVTGVYTE-TES-SLVTQTGWALDALINAKYPDRk----PIEKGIKFLMASQKSDGSWQQKSMEGIFN-KNVAIAYPN 698 Schizosaccharom...
BAA25185     538 RSYEDPAYAG-KGA-STPSQTAWALMALIAGGRAESe----AARRGVQYLVETQRPDGGWDEPYYTGTGFpGDFYLGYTM 611 Alicyclobacillu...
CAA71098     559 FSYHDPSYRGrFHT-STAFQTGFALIALMAAGEXGSp----eVQAGVDYLLRQQRPDGFWNDECFTAPGFpRVFYLKYHG 633 Methylococcus c...
WP_010994949 541 FSYNDPSLKG--QGdSTPSQTAWALIGLIAAGEATGnfahdAIERGINHLVSTQQPDGSWFEAYFTGTGFpCHFYLKYHY 618 Nostoc sp. PCC ...
BAA33461     663 LSCPKKVYVPlEGNrSNLVHTGWALMGLIHSEQAERdp--tPLHRAAKLLINSQMEDGDFPQQEISGVFM-KNCMLHYAA 739 Panax ginseng
1W6K_A       634 ESCEERRYVQ-SAQ-SQIHNTCWAMMGLMAVRHPDIe----AQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTS 706 human
1GSZ_A       612 YRHVFPTLALGRYKQ 626 Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446
AAA91023     708 YRNIFPIWALGRFSS 722 Norway rat
Q10231       699 YKLYFSIYTLGKFAK 713 Schizosaccharomyces pombe 972h-
BAA25185     612 YRHVFPTLALGRYKQ 626 Alicyclobacillus acidocaldarius
CAA71098     634 YDKFFPLWALARYRN 648 Methylococcus capsulatus str. Bath
WP_010994949 619 YQQYFPLIALGRYQA 633 Nostoc sp. PCC 7120
BAA33461     740 YRNIYPLWALAEYRR 754 Panax ginseng
1W6K_A       707 YRNIFPIWALGRFSQ 721 human
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