Conserved Protein Domain Family
SCGB3A

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pfam20490: SCGB3A 
Secretoglobin 3A
This family includes secretoglobin family 3A member 1 (SCGB3A1) and member 2 (SCGB3A2), also known as uteroglobin-related proteins. They are a small secreted proteins expressed in airway epithelial cells. SCGB3A2, also known as UGRP1, has an important anti-inflammatory activity and is involved in asthma. SCGB3A2 mediates its anti-inflammatory action through inhibition of ERK and JNK activation. It is also involved in lung development and has anti-fibrotic activity in lung.
Statistics
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PSSM-Id: 466639
Aligned: 31 rows
Threshold Bit Score: 61.8663
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
VCX36865      36 AAFF---GN-----------SMA---K-P--VA---SAlnaAE-AgaeavagA------GAR-----I-----------Q 69 
XP_005339389  20 SFFVdsvVK-----------PVA---Q-P--VA---AV---AP-A-------V------ETV-----Agav------pkL 51 
XP_012886336  21 VDSV---VK-----------PVA---E-P--VA---AL---AP-S-------A------VQA-----A-----------V 44 
2_pfamImport   1 VAFF---MD-----------LMA---K-P--VA---PV---AAaLeag-aeaG------VGA-----Va----------H 32 
XP_008273226  20 VAFF---MD-----------TDA---K-P--VA---QP---AA-A-------L------ASA-----VeagagavgspaF 54 
ELK03190      20 MGFW---MNwmakpaaptvaTVP---T-A--VE---AG---AG-A-------V------ANS-----Y-----------F 54 
XP_016045515  20 VAFF---LG-----------KAP---D-P--SK---VV---ST-V-------QdgagavASP-----W-----------L 49 
XP_027723066  20 LAFF---KGfl--------aRPPt--L-PpeIQ---KA---VV-K-------P------VVEsvpnpV-----------L 54 
XP_012408589  20 FASF---QD-----------YLPkphI-P--SDeiqKS---IA-K-------P------VME-----A-----------V 49 
XP_007474238  20 FAFF---LDsp--------iKPP---IqPteIQ---NS---IA-K-------P------VVEsvpnpV-----------L 54  gray short-tail...
VCX36865      70 P-----F---Lgs--fNPLKFMLTALGIPVEHLVEGSRKCVAELGPEAVEAmgaMKTLLG 119
XP_005339389  52 P-----Ft-yF-----NPLKIMLASLGIPVEHLIEGSRKCVTELGPEAVGA---VKTLLG 97 
XP_012886336  45 P-----S---LplssyTLLKMILASVGIPVEHLIEGSRKCVTELGPEAVGA---VKTLLG 93 
2_pfamImport  33 P-----FfrgF-----NPLTFILASLGIPVEHLVEGSRKCVTELGPEAVGA---VKSLLG 79 
XP_008273226  55 S-----R---F-----SFLKFILASLGIPVEHLIEGSRRCVAELGPKSMGA---VKTLLG 98 
ELK03190      55 K-----G---L-----NPLRIMLTSLGIPVEHLVEGSRKCVAELSPEAMRA---MNSLLv 98 
XP_016045515  50 M-----G---F-----NPLRFILAGLGIPVDHLVEGSRKCVNELGPEAVGA---VKTLLG 93 
XP_027723066  55 S-----N---F-----GLLRLILRSLGIPVDHLVEGSKKCVQELGPESVEA---LKTLLG 98 
XP_012408589  50 PnpifsN---F-----SLLKLILRGLGIPVDHLVEGSKKCVEELGSESVEA---VKSLLG 98 
XP_007474238  55 G-----N---F-----SLLKLILRGLGIPVDHLVEGSRKCVEELGSDSVGA---VKNLLg 98  gray short-tailed opossum
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