Conserved Protein Domain Family
LSm10
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cd01733: LSm10 
Like-Sm protein 10
The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. LSm10 is an SmD1-like protein which is thought to bind U7 snRNA along with LSm11 and five other Sm subunits to form a 7-membered ring structure. LSm10 and the U7 snRNP of which it is a part are thought to play an important role in histone mRNA 3' processing.
Links
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Statistics
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PSSM-Id: 212480
Aligned: 27 rows
Threshold Bit Score: 88.3658
Created: 20-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative RNASm1 motifSm2 motif
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Residues within loops 3 and 5 of the SM1 motif bind RNA
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                   # #                           #      
Q969L4         8 KERTIS----ENSLIiLLQGLQGRVTTVDLRDESVAHGRIDNVDAFMNIRLAKVTYTDRWGhqv--kldDLFVTGRNVRY 81  human
CAE17865       5 NEKKRL----ESGCGaVLQGMAGKKVFVELRNDVYVIGILESCDSNLDIRIQYATIIRDAQkte---epEYLVIGKHVRF 77  nematode
EFX79721       8 RDRYNA----ANSLLcLLQALEGRVAVVELRNEMAVKGLISQVDGFMNVSLQNATVQGNDDqhy--hfeEFFVKARNIRY 81  common water flea
EFA07013       8 KEKYYF----HNYLTsLVKALENKHTVIDLRNESCVSGLIKHVDGLMNVEMGDVVFYDPRGqrh--yfkDFFVSARNIRY 81  red flour beetle
XP_002427958  12 QENIIL----QNSLLcLVKALENRCTTIDLRNEMSVTGKITEVDAYMNIVLSDAAVFDTDGecq--yfpVLHVQARNIRN 85  human body louse
XP_001896959   9 FRQKRT----ANTMAcLLQAMEGSSVVVELKNYSTVHGILAGCDDAMNIEMKAVTVHDSKRysaplhcdSFYIQGKFIRF 84  agent of lympha...
ADE75934       6 LKLRRS----ERSLAcAIQALVGTELLLELRNDTCIRGLLDDCDDAINVIIKDSLIEDVQGvek--klpLIFVRGSHIRF 79  Sitka spruce
XP_001416610   3 GKPPRN----ERSLVcFIQALVGTTVVIECRDDVALRGHLEQCDEGMHCTLTNAIRVTPEGhkt--kleRVFVRARMIRY 76  Ostreococcus lu...
XP_001763462   3 KRGQRAf---ERTLVcVIQALMGLELLVELRNDLSIRGILDDCDNAMNVIIKDATVEDVEGvqk--qlpLVFLRGSNIRF 77  Physcomitrella ...
XP_001948103   3 RKTRRMkmktVESLVcLVKSVENQYTTIDLQNETSVYGLVKEVDCDMNVTLCDVTVTDPNGqry--scdNFFLKSRLIRY 80  pea aphid

Feature 1            
Q969L4        82 VHIP 85  human
CAE17865      78 VHFE 81  nematode
EFX79721      82 VQIP 85  common water flea
EFA07013      82 VHIP 85  red flour beetle
XP_002427958  86 VHIP 89  human body louse
XP_001896959  85 VHFD 88  agent of lymphatic filariasis
ADE75934      80 IHIP 83  Sitka spruce
XP_001416610  77 VHFA 80  Ostreococcus lucimarinus CCE9901
XP_001763462  78 VHIP 81  Physcomitrella patens subsp. patens
XP_001948103  81 VHLS 84  pea aphid

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