Conserved Protein Domain Family
Miga

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pfam10265: Miga 
Mitoguardin
Mitoguardin (Miga) was first identified in flies as a mitochondrial outer-membrane protein that promotes mitochondrial fusion. Later, the mammalian Miga homologs, Miga1 and Miga2, were identified. They are found to promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.
Statistics
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PSSM-Id: 463034
Aligned: 21 rows
Threshold Bit Score: 582.805
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_012816054  22 LYNSFTQLKPTP-GLKKIIAVAAISG---VSLIFLARHLKRKRGKKKS---NMPQIEPGQFILQCSRHF----------- 83 
XP_003451554  31 GQSIFSQLRLTP-SLKKVLFATALGS---VALALTAHQLKRRGRKRKQgtqEKDGQKTVGIPESLMKTGrpssl-krapf 105
Q5BLE2        31 GQSIFSQLKLSP-SLKKVLFATALGS---VALALTAHQLKRRGRKRKQt-lGKEAQKPVGIPEQLLRSSrpasl-krgpv 104 zebrafish
XP_017952118  31 GQSTFSQLRLSP-GLRKVLFATALGT---VALALAAHQLKRRKHKKKQitaDKGGLKLGGVPSSVLPVRrsssa--kkgy 104
Q8BK03        31 GQSAFSQLRLTP-GLRKVLFATALGT---VALALAAHQLKRRRRKKKQvgpEMGGEQLGTVPMPILMARkvpsv--kkgc 104 house mouse
EOB05910      31 GQSVFSQLRLSP-GLRKVLFATALGT---VALALAAHQLKRRRRRKKQiapDKCGFKPGGITVPILPTRrvssv--kkgy 104
CAP39560       6 MQGLPVGLKINDiVTKRTVLSVAAGIgigIVFANFVRYWKQRRESRIP-----LSAFIDEVPKEVDTNPsqpapslrrsh 80 
EDW51314      12 G-GSLLPFRVST-TTKVVLFSLTAGV---ALMSVLSRFLRRRKPPRPPrra--------------------------rky 60 
XP_001847702   2 SVSRLLPFNLTT-SQKVIVVSVTAGM---AVLGVIASYLGRRRTPKPQqrrl-------------------------rkp 52 
XP_014341668  31 GQSIFSQLRLSP-SLKKVLFATALGS---VALALTAHHLKRRRRRRKQiaeEKDAQKPRDVAGHLLPAArptp---vkkg 103 coelacanth
XP_012816054  84 AEKGSSCSSSRQNLTLSLSSFKERGslshlngdlcsKYSGSVQSLASVQ-SINSCHSCACIH-SNSLNKTDE--DETRLV 159
XP_003451554 106 TGRQMMSPSTRSNDTMSGISSLAPS-----------KHSSSSHSLASTR-VPSSPNQSANP--STPWEAEPVveESGAVE 171
Q5BLE2       105 PARQMMSPSTRSNDTLSGVSSIAQS-----------KHSSSSHSIASMR-VPSSPNQSVNA--GAAWEAEPVaeEPAVGE 170 zebrafish
XP_017952118 105 SRSRVQSPSSKSNDTLSGISSLEPS-----------KHSSSSHSLTSVV-AVNSSSVNVAS--AGPWESPEMd-ETLEEE 169
Q8BK03       105 SSRRVQSPSSKSNDTLSGISSIEPS-----------KHSGSSHSLASMV-VVNSSSPTAAC--SGSWEARGMe-ESVPTT 169 house mouse
EOB05910     105 SSKRVQSPGSKSNDTLSGISSIEPS-----------KHSSSSHSLASMV-AVNSSSPTPAA--AGTWEAQAMg-DAGAGG 169
CAP39560      81 SGRGMRPSSSQGERSLRNSV-----------------RQNSQRSLS---------------------------------- 109
EDW51314      61 TGRRNRNSMRSPNDLISIAGSKASArs--------gSPVGSTLAYSDRL-SMASGSIGVGVLgVQNAGPGSSv------- 124
XP_001847702  53 GGRKTRNSVRSPNDIISLAGSKASGrs--------ySPGGSIHGLSDRM-SLASGSLAAAGAg--------------PIG 109
XP_014341668 104 SSKRVQSPSCRSNDTLSGISSIAPS-----------KHSSSSHSLASVSkSSAARGSXPFX--TLGRINNFPk-----CG 165 coelacanth
XP_012816054 160 NFPVTTPENLYLM-GMEL---FEEALRRWEQALTFRSRQA---EDEAnCSSIKLGAGDAIAEENVEDIISADFIHKLEAL 232
XP_003451554 172 D---ANAENLYLM-GMEL---FEEALRKWEQALNIRHQPH----STSsNNSLALQGATCGDVTT-GEAQNKVFAEKLETL 239
Q5BLE2       171 D---ANAENLYLM-GMEL---FEEALRKWELALNIRHRSH---SRASaSNS---QGSELVERHS-PEVRNHQFAERLETL 236 zebrafish
XP_017952118 170 D---SNAENLYIQ-GMEL---FEEALHKWEQALNLGQRSR----SNTpLSQVNEPLNKSYSEGLSEDSQSRQFAGRLEAL 238
Q8BK03       170 D---GSAESLYVQ-GMEL---FEEALQKWEQALSVGQRGDg-gSTPTpGDSLQNPDTASEALSE-PESQRREFAEKLESL 240 house mouse
EOB05910     170 D---SSAESLYVQ-GMEL---FEEALQKWEQALTIRQRDSastSTPVpWDGKKHQDTLSESIAE-EESQKREFAEKLESL 241
CAP39560     110 ----MNPIEADITnGQEMctdLRKTIERVHHNLEMVKNRS---------------------------SKDMERSIKIEGI 158
EDW51314     125 -VTQLTAQQLGMM-GMEA---LDTVINFWEDALAAHYSPG-------------------GLPALLTTAEDSEFCREIQNL 180
XP_001847702 110 GTTPLTPQQLGVM-GMEA---LETVISYWEDALTGRNDID--------------------IPSRLS-ADQEEFCRELQNL 164
XP_014341668 166 G---AF-ISLGFA-GMEL---FEEALLKWEQALNIRQHRG---SDMGaKMKVIQPGASGDSVSE-QEFRNKDFAQKLEGL 233 coelacanth
XP_012816054 233 LQRAYRLQEEFEATLGAsDPASLANDI--DKDTDITVMNNgGDFQ------QRDTLSIAST-----------------DS 287
XP_003451554 240 LHRAYHLQEDFGSSI---PADNVLADFesEGTLILPQVESfHRLQ------EDDATTVTSD-----------------DS 293
Q5BLE2       237 LHRAYHLQEDFGSTI---PPDSLLADLesEGTLILPTLGSsHPIQ------DDDATTVTSD-----------------DS 290 zebrafish
XP_017952118 239 LHRAYNLQEEFGTSI---PPDSLLMDL--EGSLMFPLAESrRALL------TYEEGSTTSE-----------------DS 290
Q8BK03       241 LHRAYHLQEEFGSTF---PSDSMLLDL--ERTLMLPLTEGsLRLR------ADDEDSLTSE-----------------DS 292 house mouse
EOB05910     242 LHRAYHLQEEFGSSL---PSDSMLLDL--EKTLMLPLADGsLRLR------TDDEDSSISE-----------------DS 293
CAP39560     159 LKGLKQVEDEITMLIPHmEDFR-------DDNTEFYSVSGgTGYAgsvrtgRSRTLSVLSD-----------------DS 214
EDW51314     181 LEMAYTLQEQSELLFLD------------QRSVLFREEHSiDEVEeeageaDDDRRSHKSGsvlsrags--dpnfdsaES 246
XP_001847702 165 LDAAYNLQENGELLFLD------------ERSVLYR---------------DDENKATQAAslsnghrsssdpnmdsaES 217
XP_014341668 234 LHRAYHLQEEFGVAL---PPESLMLDFenEGTLALPLSGSsERLY------LDDEASVTSE-----------------DS 287 coelacanth
XP_012816054 288 FLSAAE--LSD-NQELRPTRGLGSLYHNA-----LYEEAMQLVEE-------GKVHCRVLRTEMLECLGDSDFLAKLHCI 352
XP_003451554 294 FFSAAE--LLD-------AMSLGEVcqp----aaLYEEALSLVHE-------DKVAYRTLRTELLECYSDQDFLAKLHCV 353
Q5BLE2       291 FFSAAE--LFE-------TFSLEDS-FHLlkpaaLYEEALSLVKD-------GDVACRSLRTELLECYSDQDFLAKLHCV 353 zebrafish
XP_017952118 291 FFSAAE--LFD-------TLQLNEVPFRPpkpaaAYEEALMLVHT-------GEVACRTLRTELLGCYNDQDFLAKLHCV 354
Q8BK03       293 FFSATE--IFE-------SLQIGEYPLPLsrpaaAYEEALQLVKE-------GRVPCRTLRTELLGCYSDQDFLAKLHCV 356 house mouse
EOB05910     294 FFSAAE--LFD-------SLHFEEIPFHLskpvaAYEEALQLVKE-------GKVACRTLRTELLGCYSDQDFLAKLHCV 357
CAP39560     215 FQSAVEefAVDiDDIDFVSEAAN-----------LEKEELKFLDEgmraamnGEVKYRKSRMDFCNCESETDFAAKLYCV 283
EDW51314     247 FASALDq-VADlREFDGFIET--SYEEYP-----LFQSALKHHDE-------YTVPCRTIRAELMHCSTDTEYLAKLHCV 311
XP_001847702 218 FASALDqvQSDlREFEDYGEVFSDVENYP-----LYQSALELLDD-------QPIPCRTIRTDMVGCNSDAEYYAKLHCI 285
XP_014341668 288 FFSAAE--LFE-------SLQFSGDSFQPakpaaLYEEALGLVRD-------RKVDCRTLRTEVLGCYNDQDFLAKLHCV 351 coelacanth
XP_012816054 353 RQAFQEIFLQRENRIFLMGTGRKLLSTLIVKARKNPKKFEDAYFEMMCFLEQSESWDTAEIELFSRGVKCINFYDIVLDF 432
XP_003451554 354 RQAFQILLLDETHRTFFMETGKQMIVGLMVKANKSPKAFLESYEDMLLYTQREETWPITKMELEGRGVVCMNFFDIVLDF 433
Q5BLE2       354 RQAFQVLLLDETHRMFFMETGKQMISGLLVKANKSPKAFLESYEDMLQYTQREETWPVSKMELEGRGVVCMNFFDIVLDF 433 zebrafish
XP_017952118 355 RQAFEVLLLDERNRLFFGEVGKQMVSGLMQKAEKNPKGFLENYEEMLRYALKEDTWTTTQKELKGRGVVCMNFFDIALDF 434
Q8BK03       357 RQAFEGLLEERSNQIFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVACMSFFDIVLDF 436 house mouse
EOB05910     358 RQAFQELLEDESNQLFFGEVGKQMVIGLMTKAEKNPKAFLESYEEMLHYALKPETWPTTQQELEGRGVVCMSFFDIVLDF 437
CAP39560     284 RHALTNALKDEHKRVWLAKCGRTLLADFIRHTKQDPVKFFNAYDEMLEYVSNDRNQEQLRQDVEGRGVCETGFYDVAVDF 363
EDW51314     312 RLAFQFLFKDPAVGQWICDAGRQILTDLLCLGDKDTKEFLVGYEDMVNYLHDSNNWPCIQMELEQRNVKAMTFYDICLDF 391
XP_001847702 286 RLAFQLLFKDPKISRWVADTGRQVLTDLLCLGDKDPKDFLVSYESMLEFLQNQDNWPDIEAELESRQVKAITFYDIVLDF 365
XP_014341668 352 RQAFQVLLEDESQRLFFSEIGKEMITGLMTKAGKSPKGFLESYQEMLRYTVKEETWPTTQRELEGRGVVCMNFFDIILDF 431 coelacanth
XP_012816054 433 IVMDSLEDLENPPLSIQNVVRNRWLNSSFKETAVTSSCWSVLKQKKQQIKVANGFFANFYTVCEQLCPVLAWGFLGPRSS 512
XP_003451554 434 ILMDAFEDLESPPSSVVAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYAISEHVSPVLAFGFLGPRQH 513
Q5BLE2       434 ILMDAFEDLESPPSSVVAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFIAHFYVISEHVSPVLAFGFLGPHQH 513 zebrafish
XP_017952118 435 ILMDAFEDLESPPSSVIAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKEH 514
Q8BK03       437 ILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQ 516 house mouse
EOB05910     438 ILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKQQ 517
CAP39560     364 IILDAFEDLKSPPSAVYSVTKNYFMSMSMKYSTLNTIIWSIIKSKRQRLKNPDGFIAKFYNISETVMPAITLGFLGTDER 443
EDW51314     392 IILDSFKDLDAPPASVTAVVQNRWLSNGFKETALTTAVWSVLKAKKRMLKFPNGFMSHFYVISEQISPLMAWGFFGPNEN 471
XP_001847702 366 IILDAFRDLDTPPNSVLAVINNRFLSNSFKETALTTAVWSVLKAKKRLLKFPNGFMSHFYCVTEQLSPLMVWGFFGPDED 445
XP_014341668 432 ILMDAFDDLESPPSSVVAVLRNRWLSDSFKETALATACWSVLKAKRRLLLVPDGFISHFYSISEHVSPVLAFGFLGPKPQ 511 coelacanth
XP_012816054 513 LHDLCCFYKDQVMFFLKDIFDFEKVRYSNVEHLAEDIMQCLQRRAELTVVYT 564
XP_003451554 514 LSEVCTIFKQQIVQYLKDMFDHDKVRFTSAQCLAEDILNLSHRRSDILLGYL 565
Q5BLE2       514 LSEVCTIFKQQIVQYLKDMFDHDKVRFTSVPSLAEDILRLSHRRADILMGYL 565 zebrafish
XP_017952118 515 LAEICNFFKHQIVQYLTDMFDLDKVSYTTIQSLADDILHLSRRRSDILLGYL 566
Q8BK03       517 LSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYL 568 house mouse
EOB05910     518 LSEVCGFFKHQIVQYLKDMFDFDNVRYTTVQLLAEDILQLSRRRSEILLGYL 569
CAP39560     444 LGELCQYFKEQVVQFVLDVFNTQRVCYRSLEEMTEDVWIVMRNRLEAVQTRM 495
EDW51314     472 LRDICHYFREELLAFLGDIFSFQKSRFTTIEEFSQDVLQHMQTRVNNIGVKF 523
XP_001847702 446 LKEVCKYFKDQMVGFMIDMYNFQKMRYTTVEELAEDIHTNMRMRVNNIGVKF 497
XP_014341668 512 LCEICTFFKQQIVQYLKDVYDLDQVRYTTVQSLADDILQLSQRRSEILLGYL 563 coelacanth
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